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Attenuated psychosis syndrome

M-A Crocq
No abstract text is available yet for this article.
June 2016: L'Encéphale
TianHong Zhang, HuiRu Cui, YingYing Tang, LiHua Xu, HuiJun Li, YanYan Wei, XiaoHua Liu, Annabelle Chow, ChunBo Li, KaiDa Jiang, ZePing Xiao, JiJun Wang
Neurocognitive decline has been observed in patients with psychosis as well as attenuated psychosis syndrome (APS). We tested the hypothesis that APS increases dependence on neurocognition during the interpretation of others' mental states and that a combination index of Theory of Mind (ToM) and neurocognition improves the predictive accuracy of psychosis conversion. A sample of 83 APS individuals and 90 healthy controls (HC) were assessed by comprehensive cognitive tests. The cohort also completed a one-year follow-up...
October 10, 2016: Scientific Reports
Kristen A Woodberry, Larry J Seidman, Caitlin Bryant, Jean Addington, Carrie E Bearden, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Daniel H Mathalon, Diana O Perkins, Ming T Tsuang, Elaine F Walker, Scott W Woods
Early intervention for psychotic disorders, a growing international priority, typically targets help-seeking populations with emerging psychotic ("positive") symptoms. We assessed the nature of and degree to which treatment of individuals at high risk for psychosis preceded or followed the onset of positive symptoms. The North American Prodrome Longitudinal Study-2 collected psychosocial treatment histories for 745 (98%) of 764 high-risk participants (M age = 18.9, 57% male, 57.5% Caucasian, 19.1% Hispanic) recruited from 8 North American communities...
October 5, 2016: Journal of Clinical Child and Adolescent Psychology
Nadja P Maric, Milica J Jovicic, Marina Mihaljevic, Cedo Miljevic
Preclinical Research After the identification of the schizophrenia as an illness over a century ago, treatment of affected individuals included unspecific, mostly very robust methods including deep insulin coma and lobectomy/leucotomy. The first relatively specific treatment of schizophrenia started about 60 years ago with the antipsychotic chlorpromazine. All currently approved antipsychotic drugs block dopamine receptors, indicating that manipulation of dopaminergic function is fundamental to a therapeutic response in psychosis...
September 16, 2016: Drug Development Research
Zachary Zuschlag, Alyssa Kennedy, Jeffrey Korte, Laura Franko-Tobin, Karen Hartwell, Mark Hamner
BACKGROUND: The objective of the study was to determine if DSM-5-defined attenuated psychosis syndrome (APS) could identify individuals with prodromal psychosis and predict conversion to schizophrenia spectrum disorders at a rate similar to that observed in previous studies that utilized structured interviews and specialized rating scales. METHODS: A retrospective review of patients' medical records was used to identify individuals meeting diagnostic criteria for the APS, followed by further evaluation 2 to 3 years after the initial diagnosis, to determine if they converted to schizophrenia spectrum disorders...
August 1, 2016: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
Fa Zhan Chen, Yi Wang, Xi Rong Sun, Yu Hong Yao, Ning Zhang, Hui Fen Qiao, Lan Zhang, Zhan Jiang Li, Hong Lin, Zheng Lu, Jing Li, Raymond C K Chan, Xu Dong Zhao
The present study explored the conversion rate in individuals with Attenuated Psychosis Syndrome (APS) and potential predictor for transition in mainland China. Sixty-three participants identified as APS were followed up 6 months later. The results showed that 17% of individuals with APS converted to full-blown psychosis. The converters exhibited significantly poorer emotional experience and expression than the non-converters at baseline. A further binary logistic regression analysis showed that emotional experience could predict the transition (Wald = 4...
2016: Frontiers in Psychology
Grazia Rutigliano, Lucia Valmaggia, Paola Landi, Marianna Frascarelli, Marco Cappucciati, Victoria Sear, Matteo Rocchetti, Andrea De Micheli, Ceri Jones, Erika Palombini, Philip McGuire, Paolo Fusar-Poli
BACKGROUND: Patients at ultra-high risk for psychosis (UHR) are a highly heterogeneous group in terms of clinical and functional outcomes. Several non-psychotic mental disorders co-occur together with the UHR state. Little is known about the impact of non-psychotic comorbid mental disorders on clinical and functional outcomes of UHR patients. METHODS: The sample included 154 UHR help-seeking patients (identified with the CAARMS, comprehensive assessment of the at-risk mental state), evaluated at baseline on the Ham-D, Ham-A (Hamilton depression/anxiety rating scale), and PANSS (positive and negative syndrome scale)...
October 2016: Journal of Affective Disorders
Catherine Marshall, Stephanie Deighton, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, Ming T Tsuang, Elaine F Walker, Scott W Woods, Carrie E Bearden, Daniel Mathalon, Jean Addington
The relationship between psychosis and violence has typically focused on factors likely to predict who will commit violent acts. One unexplored area is violence in the content of subthreshold positive symptoms. The current aim was to conduct an exploratory analysis of violent content in the attenuated psychotic symptoms (APS) of those at clinical high risk of psychosis (CHR) who met criteria for attenuated psychotic symptom syndrome (APSS). The APS of 442 CHR individuals, determined by the Structured Interview for Prodromal Syndromes, were described in comprehensive vignettes...
August 30, 2016: Psychiatry Research
Mehdi Hormozpour, Homayoun Amini, Sara Pajouhanfar, Masoomeh Faghankhani, Arash Rahmani, Vandad Sharifi
OBJECTIVE: Schizophrenia and other psychoses have devastating personal and social impacts and many efforts have been devoted to study ‎prodromal syndromes for psychosis in order to achieve earlier detection and interventions. However, only few studies have been ‎performed in developing countries on this subject, and there is a dearth of evidence in the Iranian population. In this study, we ‎focused on conversion rate to psychosis and changes in prodromal symptoms in a group of first-degree relatives of patients with ‎schizophrenia and to compare the conversion rate in those with and without prodromal symptoms as assessed by the Structured ‎Interview for Prodromal Syndromes (SIPS) and Scale of Prodromal Symptoms (SOPS)...
January 2016: Iranian Journal of Psychiatry
Jochen Kindler, Frauke Schultze-Lutter, Chantal Michel, Alexandra Martz-Irngartinger, Caroline Linder, Stefanie J Schmidt, Katharina Stegmayer, Benno G Schimmelmann, Sebastian Walther
BACKGROUND: Altered motor behavior has consistently been reported in medication-naive adult patients with schizophrenia and first episode psychosis and adults at clinical high risk for psychosis (CHR). This study is the first to evaluate the prevalence of abnormal involuntary movements in a community sample of children and adolescents with and without CHR. METHODS: We examined CHR in 102 children and adolescents aged 8-17years from the general population of the Canton Bern...
July 2016: Schizophrenia Research
T H Zhang, H J Li, K A Woodberry, L H Xu, Y Y Tang, Q Guo, H R Cui, X H Liu, A Chow, C B Li, K D Jiang, Z P Xiao, L J Seidman, J J Wang
BACKGROUND: Chinese psychiatrists have gradually started to focus on those who are deemed to be at 'clinical high-risk (CHR)' for psychosis; however, it is still unknown how often those individuals identified as CHR from a different country background than previously studied would transition to psychosis. The objectives of this study are to examine baseline characteristics and the timing of symptom onset, help-seeking, or transition to psychosis over a 2-year period in China. METHOD: The presence of CHR was determined with the Structured Interview for Prodromal Syndromes (SIPS) at the participants' first visit to the mental health services...
April 8, 2016: Epidemiology and Psychiatric Sciences
Kristin S Cadenhead, Heline Mirzakhanian
No abstract text is available yet for this article.
April 1, 2016: American Journal of Psychiatry
Edwin Ho-Ming Lee, Christy Lai-Ming Hui, Elaine Yee-Ning Ching, Jingxia Lin, Wing-Chung Chang, Sherry Kit-Wa Chan, Eric Yu-Hai Chen
OBJECTIVE: Attenuated psychosis syndrome (APS) has recently been included in the appendix of DSM-5 as a condition for further study. This study compared public stigma associated with four mental health conditions among study participants in Hong Kong. METHODS: The cross-sectional study involved 204 participants (154 members of the general public general public and 50 health care professionals) recruited through a public awareness campaign and the e-mail network of the University of Hong Kong...
July 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
Nella Lo Cascio, Riccardo Saba, Marta Hauser, Ditte Lammers Vernal, Aseel Al-Jadiri, Yehonatan Borenstein, Eva M Sheridan, Taishiro Kishimoto, Marco Armando, Stefano Vicari, Paolo Fiori Nastro, Paolo Girardi, Eva Gebhardt, John M Kane, Andrea Auther, Ricardo E Carrión, Barbara A Cornblatt, Benno G Schimmelmann, Frauke Schultze-Lutter, Christoph U Correll
While attenuated psychotic symptoms (APS) and basic symptoms (BS) are the main current predictors of psychosis in adults, studies in adolescents are scarce. Thus, we (1) described the prevalence and severity of positive, negative, disorganization, general, and basic symptoms in adolescent patients at ultra-high risk for psychosis (UHR), with other non-psychotic psychiatric disorders (PC) and with early-onset psychosis (EOP); and (2) investigated BS criteria in relation to UHR criteria. Sixty-nine 12-18-year-old adolescents (15...
October 2016: European Child & Adolescent Psychiatry
John R Richards, Dariush Garber, Erik G Laurin, Timothy E Albertson, Robert W Derlet, Ezra A Amsterdam, Kent R Olson, Edward A Ramoska, Richard A Lange
INTRODUCTION: Cocaine abuse is a major worldwide health problem. Patients with acute cocaine toxicity presenting to the emergency department may require urgent treatment for tachycardia, dysrhythmia, hypertension, and coronary vasospasm, leading to pathological sequelae such as acute coronary syndrome, stroke, and death. OBJECTIVE: The objective of this study is to review the current evidence for pharmacological treatment of cardiovascular toxicity resulting from cocaine abuse...
June 2016: Clinical Toxicology
Arthur Maciel Nunes Gonçalves, Clarissa de Rosalmeida Dantas, Claudio E M Banzato
BACKGROUND: Although values have increasingly received attention in psychiatric literature over the last three decades, their role has been only partially acknowledged in psychiatric classification endeavors. The review process of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) received harsh criticism, and was even considered secretive by some authors. Also, it lacked an official discussion of values at play. In this perspective paper we briefly discuss the interplay of some values in the scientific and non-scientific debate around one of the most debated DSM-5 category proposals, the Attenuated Psychosis Syndrome (APS)...
2016: BMC Medical Ethics
Paolo Fusar-Poli, Marco Cappucciati, Stefan Borgwardt, Scott W Woods, Jean Addington, Barnaby Nelson, Dorien H Nieman, Daniel R Stahl, Grazia Rutigliano, Anita Riecher-Rössler, Andor E Simon, Masafumi Mizuno, Tae Young Lee, Jun Soo Kwon, May M L Lam, Jesus Perez, Szabolcs Keri, Paul Amminger, Sibylle Metzler, Wolfram Kawohl, Wulf Rössler, Jimmy Lee, Javier Labad, Tim Ziermans, Suk Kyoon An, Chen-Chung Liu, Kristen A Woodberry, Amel Braham, Cheryl Corcoran, Patrick McGorry, Alison R Yung, Philip K McGuire
IMPORTANCE: Individuals can be classified as being at clinical high risk (CHR) for psychosis if they meet at least one of the ultra-high-risk (UHR) inclusion criteria (brief limited intermittent psychotic symptoms [BLIPS] and/or attenuated psychotic symptoms [APS] and/or genetic risk and deterioration syndrome [GRD]) and/or basic symptoms [BS]. The meta-analytical risk of psychosis of these different subgroups is still unknown. OBJECTIVE: To compare the risk of psychosis in CHR individuals who met at least one of the major inclusion criteria and in individuals not at CHR for psychosis (CHR-)...
February 2016: JAMA Psychiatry
Alejandro Szmulewicz, José M Smith, Marina P Valerio
Despite recent findings on the treatment of schizophrenia, it is an illness still associated with high morbidity and incapacity in social and work domains. There is a growing interest in examining the phases prior to the development of the illness so as to make early interventions that would potentially change its devastating course. The attenuated psychosis syndrome was included in the section III of the last version of the Diagnostic and Statistical Manual of Mental Disorders as a condition in which a patient exhibits mild psychotic symptoms, an intact reality testing and certain degree of social or occupational impairment...
May 2015: Vertex: Revista Argentina de Psiquiatriá
Miriam Gerstenberg, Marta Hauser, Aseel Al-Jadiri, Eva M Sheridan, Taishiro Kishimoto, Yehonatan Borenstein, Ditte L Vernal, Lisa David, Ema Saito, Sara E Landers, Morgan Carella, Sukhbir Singh, Maren Carbon, Sara Jiménez-Fernández, Michael L Birnbaum, Andrea Auther, Ricardo E Carrión, Barbara A Cornblatt, John M Kane, Susanne Walitza, Christoph U Correll
OBJECTIVES: DSM-5 conceptualized attenuated psychosis syndrome (APS) as self-contained rather than as a risk syndrome, including it under "Conditions for Further Study," but also as a codable/billable condition in the main section. Since many major mental disorders emerge during adolescence, we assessed the frequency and characteristics of APS in adolescent psychiatric inpatients. METHODS: Consecutively recruited adolescents hospitalized for nonpsychotic disorders (September 2009-May 2013) were divided into APS youth versus non-APS youth, based on the Structured Interview of Prodromal Syndromes (SIPS) and according to DSM-5 criteria, and compared across multiple characteristics...
November 2015: Journal of Clinical Psychiatry
Emily Kline, Elizabeth Thompson, Caroline Demro, Kristin Bussell, Gloria Reeves, Jason Schiffman
OBJECTIVE: Practice guidelines emphasize frequent clinical monitoring of patients at high risk for psychosis. No brief instrument assessing attenuated psychotic symptoms has been validated for this purpose. This study examined use of three self-report questionnaires, which were developed as psychosis risk screeners, for monitoring symptom severity in a naturalistic clinical sample of 54 adolescents. METHODS: Self-report measures (Prime Screen-Revised, Prodromal Questionnaire-Brief Version [PQ-B], and Youth Psychosis At-Risk Questionnaire-Brief) and clinician assessments (Structured Interview for Psychosis Risk Syndromes) were administered to participants at baseline and six months...
April 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
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