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Attenuated psychosis syndrome

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https://www.readbyqxmd.com/read/29038030/dynamic-functional-connectivity-impairments-in-early-schizophrenia-and-clinical-high-risk-for-psychosis
#1
REVIEW
Yuhui Du, Susanna L Fryer, Zening Fu, Dongdong Lin, Jing Sui, Jiayu Chen, Eswar Damaraju, Eva Mennigen, Barbara Stuart, Daniel H Mathalon, Vince D Calhoun
Individuals at clinical high-risk (CHR) for psychosis are characterized by attenuated psychotic symptoms. Only a minority of CHR individuals convert to full-blown psychosis. Therefore, there is a strong interest in identifying neurobiological abnormalities underlying the psychosis risk syndrome. Dynamic functional connectivity (DFC) captures time-varying connectivity over short time scales, and has the potential to reveal complex brain functional organization. Based on resting-state functional magnetic resonance imaging (fMRI) data from 70 healthy controls (HCs), 53 CHR individuals, and 58 early illness schizophrenia (ESZ) patients, we applied a novel group information guided ICA (GIG-ICA) to estimate inherent connectivity states from DFC, and then investigated group differences...
October 13, 2017: NeuroImage
https://www.readbyqxmd.com/read/28935167/impact-of-lifetime-traumatic-experiences-on-suicidality-and-likelihood-of-conversion-in-a-cohort-of-individuals-at-clinical-high-risk-for-psychosis
#2
Margaux M Grivel, Wei Leong, Michael D Masucci, Rebecca A Altschuler, Leigh Y Arndt, Samantha L Redman, Lawrence H Yang, Gary Brucato, Ragy R Girgis
Recent research suggests that trauma history (TH) is a strong socio-environmental risk factor for the development of psychosis. While reported rates of childhood trauma are higher among individuals at clinical high-risk (CHR) for psychosis than in the general population, little research has explored the effects of trauma upon the severity of attenuated positive symptoms. We aimed to explore the specific relationships between TH and baseline symptom severity; likelihood of conversion to full-blown psychosis; suicidal ideation (SI); and suicidal behavior (SB) in a cohort of 200 help-seeking CHR individuals...
September 18, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28886901/perceptual-abnormalities-in-clinical-high-risk-youth-and-the-role-of-trauma-cannabis-use-and-anxiety
#3
Yun Lu, Catherine Marshall, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, Ming T Tsuang, Elaine F Walker, Scott W Woods, Carrie E Bearden, Daniel Mathalon, Jean Addington
Recent research suggests that perceptual abnormalities are a group of diverse experiences, which have been associated with trauma, cannabis use, and anxiety. Of the attenuated psychotic symptoms that are present in youth at clinical high risk (CHR) of psychosis, perceptual abnormalities tend to be one of the most frequently endorsed symptoms. However, very few studies have explored perceptual abnormalities and their relationships with the above environmental and affective factors in a CHR sample. Four hundred and forty-one CHR individuals who met criteria for attenuated psychotic symptom syndrome (APSS) determined by the Structured Interview for Psychosis-risk Syndromes (SIPS) were assessed on the content of their perceptual abnormalities, early traumatic experience, cannabis use and self-reported anxiety...
August 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28874223/premorbid-social-adjustment-and-association-with-attenuated-psychotic-symptoms-in-clinical-high-risk-and-help-seeking-youth
#4
S I Tarbox-Berry, D O Perkins, S W Woods, J Addington
BACKGROUND: Attenuated positive symptom syndrome (APSS), characterized by 'putatively prodromal' attenuated psychotic-like pathology, indicates increased risk for psychosis. Poor premorbid social adjustment predicts severity of APSS symptoms and predicts subsequent psychosis in APSS-diagnosed individuals, suggesting application for improving detection of 'true' prodromal youth who will transition to psychosis. However, these predictive associations have not been tested in controls and therefore may be independent of the APSS diagnosis, negating utility for improving prediction in APSS-diagnosed individuals...
September 6, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28837932/quality-of-life-in-individuals-with-attenuated-psychotic-symptoms-possible-role-of-anxiety-depressive-symptoms-and-socio-cognitive-impairments
#5
Tsutomu Takahashi, Yuko Higuchi, Yuko Komori, Shimako Nishiyama, Mihoko Nakamura, Daiki Sasabayashi, Yumiko Nishikawa, Tomiki Sumiyoshi, Michio Suzuki
Individuals with Clinical High-Risk state for Psychosis (CHR-P) are reported to exhibit impaired quality of life (QOL) similar to that observed in schizophrenia, but its determinants remain unclear. We investigated the QOL of 33 subjects with CHR-P, 45 patients with schizophrenia, and 63 healthy subjects using the Quality of Life Scale (QLS). The CHR-P and schizophrenia groups were administered the Brief Assessment of Cognition in Schizophrenia (BACS), the Schizophrenia Cognition Rating Scale (SCoRS), and the Social and Occupational Functioning Assessment Scale (SOFAS) for socio-cognitive functions; and the Positive and Negative Syndrome Scale (PANSS) and the State-Trait Anxiety Inventory for clinical symptoms...
August 16, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28794975/altered-structural-network-architecture-is-predictive-of-the-presence-of-psychotic-symptoms-in-patients-with-22q11-2-deletion-syndrome
#6
Maria C Padula, Elisa Scariati, Marie Schaer, Corrado Sandini, Marie Christine Ottet, Maude Schneider, Dimitri Van De Ville, Stephan Eliez
22q11.2 deletion syndrome (22q11DS) represents a homogeneous model of schizophrenia particularly suitable for the search of neural biomarkers of psychosis. Impairments in structural connectivity related to the presence of psychotic symptoms have been reported in patients with 22q11DS. However, the relationships between connectivity changes in patients with different symptomatic profiles are still largely unknown and warrant further investigations. In this study, we used structural connectivity to discriminate patients with 22q11DS with (N = 31) and without (N = 31) attenuated positive psychotic symptoms...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28771938/changes-in-symptom-content-from-a-clinical-high-risk-state-to-conversion-to-psychosis
#7
Catherine Marshall, Yun Lu, Kristina Lyngberg, Stephanie Deighton, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, Ming T Tsuang, Elaine F Walker, Scott W Woods, Carrie E Bearden, Daniel Mathalon, Jean Addington
AIM: There is an interest in the transition to psychosis for those at clinical high risk of developing psychosis. This transition is typically determined by a change in severity of the attenuated symptoms as they reach a psychotic level. However, any concomitant change in the content of such symptoms has not been examined. The current study aimed to examine potential qualitative changes in the symptom content from a clinical high-risk state to a first episode of psychosis. METHODS: Sixty-seven individuals, who had been identified as meeting the attenuated psychotic syndrome based on the Structured Interview of Psychosis-Risk Syndromes and who later developed a full-blown psychosis were included in the study...
August 3, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28745307/a-longitudinal-study-of-violent-behavior-in-a-psychosis-risk-cohort
#8
Gary Brucato, Paul S Appelbaum, Jeffrey A Lieberman, Melanie M Wall, Tianshu Feng, Michael D Masucci, Rebecca Altschuler, Ragy R Girgis
There is a lack of insight into the relationships between violent ideation, violent behavior, and early, particularly attenuated, psychosis. Our aims were to examine the relationships between baseline violent behavior and violent ideation and outcome violent behavior and conversion to psychosis in at-risk individuals. We longitudinally assessed 200 individuals at clinical high risk for psychosis for violent ideation and violent behavior using the Structured Interview for Psychosis-Risk Syndromes (SIPS), and rated these according to MacArthur Community Violence categories...
July 26, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28686559/-attenuated-psychosis-syndrome-a-new-diagnostic-category-for-further-study-in-dsm-5
#9
G Samiotakis, C Kollias, H Lazaratou, D Anagnostopoulos, V Kontaxakis
In recent years an increasing number of studies focus on the issue of early diagnosis and intervention. At the same time, a large number of special service units for early psychosis have been established around the world especially in Australia, USA, UK, Germany etc. Recently, similar units operate in Greece also. The Diagnostic Manual of Mental Disorders of the American Psychiatric Association in its latest edition in 2013 (DSM-5), introduced the category "Attenuated Psychosis Syndrome" (APS) for people with early psychotic experiences in the section: "Conditions for further study '...
April 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28617204/is-the-clinical-high-risk-state-a-valid-concept-retrospective-examination-in-a-first-episode-psychosis-sample
#10
Jai L Shah, Anne Crawford, Sally S Mustafa, Srividya N Iyer, Ridha Joober, Ashok K Malla
OBJECTIVE: One reason for worldwide interest in the clinical high-risk (CHR) state for psychosis is its potential as a target for prevention. However, the feasibility and utility of early intervention initiatives that are focused on this stage involve an untested assumption: that most patients with a first episode of psychosis (FEP) experience earlier CHR symptoms. The objective of this study was to identify and characterize the proportion of FEP patients who had experienced such symptoms prior to the onset of their psychosis...
October 1, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28521060/diagnostic-and-prognostic-significance-of-dsm-5-attenuated-psychosis-syndrome-in-services-for-individuals-at-ultra-high-risk-for-psychosis
#11
Paolo Fusar-Poli, Andrea De Micheli, Marco Cappucciati, Grazia Rutigliano, Cathy Davies, Valentina Ramella-Cravaro, Dominic Oliver, Ilaria Bonoldi, Matteo Rocchetti, Lauren Gavaghan, Rashmi Patel, Philip McGuire
Background: The diagnostic and prognostic significance of the DSM-5-defined Attenuated Psychosis Syndrome (DSM-5-APS) in individuals undergoing an ultra high risk (UHR) clinical assessment for suspicion of psychosis risk is unknown. Methods: Prospective cohort study including all consecutive help-seeking individuals undergoing both a DSM-5-APS and a Comprehensive Assessment of At Risk Mental States (CAARMS 12/2006) assessment for psychosis risk at the Outreach and Support in South London (OASIS) UHR service (March 2013-April 2014)...
May 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28468563/-developmental-aspects-in-the-early-detection-and-intervention-in-clinical-high-risk-states-for-psychosis
#12
REVIEW
Frauke Schultze-Lutter, Stefanie J Schmidt, Petra Walger, Benno G Schimmelmann
Developmental Aspects in the Early Detection and Intervention in Clinical High Risk States for Psychosis The early detection and intervention in psychoses, which are a main source of disability-adjusted life years already in children and adolescents, have made good progress within the past years. In particular the attenuated and transient positive symptoms of the ultra-high risk criteria and the basic symptom criterion "Cognitive Disturbances" open promising routes to an indicated prevention and have recently been considered as diagnostic criteria of a psychosis-risk syndrome by the European Psychiatric Association (EPA)...
May 2017: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/28456857/age-effect-on-prevalence-of-ultra-high-risk-for-psychosis-symptoms-replication-in-a-clinical-sample-of-an-early-detection-of-psychosis-service
#13
Frauke Schultze-Lutter, Daniela Hubl, Benno G Schimmelmann, Chantal Michel
Higher frequencies of perceptual and lesser clinical significance of non-perceptual attenuated psychotic symptoms (APS) have been reported by 8- to 15-year-old of the general population compared to 16- to 40-year-old. We examined if such an age-effect can also be detected in a clinical never-psychotic sample (N = 133) referred to a specialized service for clinical suspicion of developing psychosis. APS and brief intermittent psychotic symptoms (BIPS) were assessed using items P1-P3 and P5 (non-perceptual), and P4 (perceptual) of the Structured Interview for Psychosis-Risk Syndromes, current axis-I disorders with the Mini-International Neuropsychiatric Interview, and psychosocial functioning with the Social and Occupational Functioning Assessment Scale...
April 29, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28347521/-detection-and-early-treatment-of-subjects-at-high-risk-of-clinical-psychosis-definitions-and-recommendations
#14
C Michel, E Toffel, S J Schmidt, S Eliez, M Armando, A Solida-Tozzi, F Schultze-Lutter, M Debbané
In children and adolescents, psychotic disorders already represent one of the leading causes of disability-adjusted life years. During the past two decades, early detection of risk for psychosis has been intensively investigated, and in particular, predictive power for early signs of risk has been initiated and translated into clinical practice. In particular, the attenuated and transient positive symptoms of the ultra-high risk criteria, and the basic symptom criterion "cognitive disturbances", open promising routes to an indicated prevention and have recently been considered by the European Psychiatric Association (EPA) as diagnostic criteria of a psychosis-risk syndrome...
March 24, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28282534/clinical-presentation-of-attenuated-psychosis-syndrome-in-children-and-adolescents-is-there-an-age-effect
#15
Michele Ribolsi, Ashleigh Lin, Klaas J Wardenaar, Maria Pontillo, Luigi Mazzone, Stefano Vicari, Marco Armando
There is limited research on clinical features related to age of presentation of the Attenuated Psychosis Syndrome in children and adolescents (CAD). Based on findings in CAD with psychosis, we hypothesized that an older age at presentation of Attenuated Psychosis Syndrome would be associated with less severe symptoms and better psychosocial functioning than presentation in childhood or younger adolescence. Ninety-four CAD (age 9-18) meeting Attenuated Psychosis Syndrome criteria participated in the study. The sample was divided and compared according to the age of presentation of Attenuated Psychosis Syndrome (9-14 vs 15-18 years)...
June 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28249639/baseline-demographics-clinical-features-and-predictors-of-conversion-among-200-individuals-in-a-longitudinal-prospective-psychosis-risk-cohort
#16
G Brucato, M D Masucci, L Y Arndt, S Ben-David, T Colibazzi, C M Corcoran, A H Crumbley, F M Crump, K E Gill, D Kimhy, A Lister, S A Schobel, L H Yang, J A Lieberman, R R Girgis
BACKGROUND: DSM-5 proposes an Attenuated Psychosis Syndrome (APS) for further investigation, based upon the Attenuated Positive Symptom Syndrome (APSS) in the Structured Interview for Psychosis-Risk Syndromes (SIPS). SIPS Unusual Thought Content, Disorganized Communication and Total Disorganization scores predicted progression to psychosis in a 2015 NAPLS-2 Consortium report. We sought to independently replicate this in a large single-site high-risk cohort, and identify baseline demographic and clinical predictors beyond current APS/APSS criteria...
March 2, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28117104/are-current-labeling-terms-suitable-for-people-who-are-at-risk-of-psychosis
#17
Sung-Wan Kim, Andrea Polari, Fritha Melville, Bridget Moller, Jae-Min Kim, Paul Amminger, Helen Herrman, Patrick McGorry, Barnaby Nelson
Inclusion of 'attenuated psychosis syndrome (APS)' in the DSM-5 has been hotly debated because of the concern about stigmatising young patients with a 'psychosis risk' label. This study aimed to investigate whether current labeling terms such as 'at risk mental state', 'ultra-high risk' (UHR) and 'APS' are suitable for people who are at risk of psychosis. This study included 105 subjects (55 patients aged 15-25years who used an early interventional service to prevent psychosis and 50 professionals who worked with them)...
January 20, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28053131/a-severity-based-clinical-staging-model-for-the-psychosis-prodrome-longitudinal-findings-from-the-new-york-recognition-and-prevention-program
#18
Ricardo E Carrión, Christoph U Correll, Andrea M Auther, Barbara A Cornblatt
Clinical staging improved the possibility of intervening during the psychosis prodrome to limit progression of illness. The current study aimed to validate a novel 4-stage severity-based model with a focus on clinical change over time and risk for conversion to psychosis. One hundred seventy-one individuals at clinical high risk (CHR) for psychosis were followed prospectively (3 ± 1.6 y) as part of the Recognition and Prevention (RAP) program and divided into 4 diagnostic stages according to absence/presence and severity of attenuated positive symptoms...
January 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27996316/developmental-coordination-disorder-plus-oculomotor-and-visuospatial-impairment-as-neurodevelopmental-heralds-of-psychosis-proneness
#19
Michele Poletti, Eva Gebhardt, Andrea Raballo
Aiming at preventing transitions to more severe psychopathology and boosted by the availability of operational criteria to identify help-seeking subjects at increased risk for psychosis, research into the early prodromal phases of psychosis is attracting a growing clinical interest. Furthermore, the focus of early detection is gradually shifting from prodromal syndromes to the premorbid period. Although mainly driven by clinical-pragatic aims, such a shift is coherent with the neurodevelopmental hypothesis of schizophrenia that might offer a unifying, developmentally informed conceptual framework for early detection...
December 20, 2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27769349/-attenuated-psychosis-syndrome-in-dsm-5
#20
M-A Crocq
No abstract text is available yet for this article.
June 2016: L'Encéphale
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