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Attenuated psychosis syndrome

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https://www.readbyqxmd.com/read/28686559/-attenuated-psychosis-syndrome-a-new-diagnostic-category-for-further-study-in-dsm-5
#1
G Samiotakis, C Kollias, H Lazaratou, D Anagnostopoulos, V Kontaxakis
In recent years an increasing number of studies focus on the issue of early diagnosis and intervention. At the same time, a large number of special service units for early psychosis have been established around the world especially in Australia, USA, UK, Germany etc. Recently, similar units operate in Greece also. The Diagnostic Manual of Mental Disorders of the American Psychiatric Association in its latest edition in 2013 (DSM-5), introduced the category "Attenuated Psychosis Syndrome" (APS) for people with early psychotic experiences in the section: "Conditions for further study '...
April 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28617204/is-the-clinical-high-risk-state-a-valid-concept-retrospective-examination-in-a-first-episode-psychosis-sample
#2
Jai L Shah, Anne Crawford, Sally S Mustafa, Srividya N Iyer, Ridha Joober, Ashok K Malla
OBJECTIVE: One reason for worldwide interest in the clinical high-risk (CHR) state for psychosis is its potential as a target for prevention. However, the feasibility and utility of early intervention initiatives that are focused on this stage involve an untested assumption: that most patients with a first episode of psychosis (FEP) experience earlier CHR symptoms. The objective of this study was to identify and characterize the proportion of FEP patients who had experienced such symptoms prior to the onset of their psychosis...
June 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28521060/diagnostic-and-prognostic-significance-of-dsm-5-attenuated-psychosis-syndrome-in-services-for-individuals-at-ultra-high-risk-for-psychosis
#3
Paolo Fusar-Poli, Andrea De Micheli, Marco Cappucciati, Grazia Rutigliano, Cathy Davies, Valentina Ramella-Cravaro, Dominic Oliver, Ilaria Bonoldi, Matteo Rocchetti, Lauren Gavaghan, Rashmi Patel, Philip McGuire
Background: The diagnostic and prognostic significance of the DSM-5-defined Attenuated Psychosis Syndrome (DSM-5-APS) in individuals undergoing an ultra high risk (UHR) clinical assessment for suspicion of psychosis risk is unknown. Methods: Prospective cohort study including all consecutive help-seeking individuals undergoing both a DSM-5-APS and a Comprehensive Assessment of At Risk Mental States (CAARMS 12/2006) assessment for psychosis risk at the Outreach and Support in South London (OASIS) UHR service (March 2013-April 2014)...
May 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28468563/-developmental-aspects-in-the-early-detection-and-intervention-in-clinical-high-risk-states-for-psychosis
#4
Frauke Schultze-Lutter, Stefanie J Schmidt, Petra Walger, Benno G Schimmelmann
Developmental Aspects in the Early Detection and Intervention in Clinical High Risk States for Psychosis The early detection and intervention in psychoses, which are a main source of disability-adjusted life years already in children and adolescents, have made good progress within the past years. In particular the attenuated and transient positive symptoms of the ultra-high risk criteria and the basic symptom criterion "Cognitive Disturbances" open promising routes to an indicated prevention and have recently been considered as diagnostic criteria of a psychosis-risk syndrome by the European Psychiatric Association (EPA)...
May 2017: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/28456857/age-effect-on-prevalence-of-ultra-high-risk-for-psychosis-symptoms-replication-in-a-clinical-sample-of-an-early-detection-of-psychosis-service
#5
Frauke Schultze-Lutter, Daniela Hubl, Benno G Schimmelmann, Chantal Michel
Higher frequencies of perceptual and lesser clinical significance of non-perceptual attenuated psychotic symptoms (APS) have been reported by 8- to 15-year-old of the general population compared to 16- to 40-year-old. We examined if such an age-effect can also be detected in a clinical never-psychotic sample (N = 133) referred to a specialized service for clinical suspicion of developing psychosis. APS and brief intermittent psychotic symptoms (BIPS) were assessed using items P1-P3 and P5 (non-perceptual), and P4 (perceptual) of the Structured Interview for Psychosis-Risk Syndromes, current axis-I disorders with the Mini-International Neuropsychiatric Interview, and psychosocial functioning with the Social and Occupational Functioning Assessment Scale...
April 29, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28347521/-detection-and-early-treatment-of-subjects-at-high-risk-of-clinical-psychosis-definitions-and-recommendations
#6
C Michel, E Toffel, S J Schmidt, S Eliez, M Armando, A Solida-Tozzi, F Schultze-Lutter, M Debbané
In children and adolescents, psychotic disorders already represent one of the leading causes of disability-adjusted life years. During the past two decades, early detection of risk for psychosis has been intensively investigated, and in particular, predictive power for early signs of risk has been initiated and translated into clinical practice. In particular, the attenuated and transient positive symptoms of the ultra-high risk criteria, and the basic symptom criterion "cognitive disturbances", open promising routes to an indicated prevention and have recently been considered by the European Psychiatric Association (EPA) as diagnostic criteria of a psychosis-risk syndrome...
March 24, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28282534/clinical-presentation-of-attenuated-psychosis-syndrome-in-children-and-adolescents-is-there-an-age-effect
#7
Michele Ribolsi, Ashleigh Lin, Klaas J Wardenaar, Maria Pontillo, Luigi Mazzone, Stefano Vicari, Marco Armando
There is limited research on clinical features related to age of presentation of the Attenuated Psychosis Syndrome in children and adolescents (CAD). Based on findings in CAD with psychosis, we hypothesized that an older age at presentation of Attenuated Psychosis Syndrome would be associated with less severe symptoms and better psychosocial functioning than presentation in childhood or younger adolescence. Ninety-four CAD (age 9-18) meeting Attenuated Psychosis Syndrome criteria participated in the study. The sample was divided and compared according to the age of presentation of Attenuated Psychosis Syndrome (9-14 vs 15-18 years)...
June 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28249639/baseline-demographics-clinical-features-and-predictors-of-conversion-among-200-individuals-in-a-longitudinal-prospective-psychosis-risk-cohort
#8
G Brucato, M D Masucci, L Y Arndt, S Ben-David, T Colibazzi, C M Corcoran, A H Crumbley, F M Crump, K E Gill, D Kimhy, A Lister, S A Schobel, L H Yang, J A Lieberman, R R Girgis
BACKGROUND: DSM-5 proposes an Attenuated Psychosis Syndrome (APS) for further investigation, based upon the Attenuated Positive Symptom Syndrome (APSS) in the Structured Interview for Psychosis-Risk Syndromes (SIPS). SIPS Unusual Thought Content, Disorganized Communication and Total Disorganization scores predicted progression to psychosis in a 2015 NAPLS-2 Consortium report. We sought to independently replicate this in a large single-site high-risk cohort, and identify baseline demographic and clinical predictors beyond current APS/APSS criteria...
March 2, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28117104/are-current-labeling-terms-suitable-for-people-who-are-at-risk-of-psychosis
#9
Sung-Wan Kim, Andrea Polari, Fritha Melville, Bridget Moller, Jae-Min Kim, Paul Amminger, Helen Herrman, Patrick McGorry, Barnaby Nelson
Inclusion of 'attenuated psychosis syndrome (APS)' in the DSM-5 has been hotly debated because of the concern about stigmatising young patients with a 'psychosis risk' label. This study aimed to investigate whether current labeling terms such as 'at risk mental state', 'ultra-high risk' (UHR) and 'APS' are suitable for people who are at risk of psychosis. This study included 105 subjects (55 patients aged 15-25years who used an early interventional service to prevent psychosis and 50 professionals who worked with them)...
January 20, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28053131/a-severity-based-clinical-staging-model-for-the-psychosis-prodrome-longitudinal-findings-from-the-new-york-recognition-and-prevention-program
#10
Ricardo E Carrión, Christoph U Correll, Andrea M Auther, Barbara A Cornblatt
Clinical staging improved the possibility of intervening during the psychosis prodrome to limit progression of illness. The current study aimed to validate a novel 4-stage severity-based model with a focus on clinical change over time and risk for conversion to psychosis. One hundred seventy-one individuals at clinical high risk (CHR) for psychosis were followed prospectively (3 ± 1.6 y) as part of the Recognition and Prevention (RAP) program and divided into 4 diagnostic stages according to absence/presence and severity of attenuated positive symptoms...
January 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27996316/developmental-coordination-disorder-plus-oculomotor-and-visuospatial-impairment-as-neurodevelopmental-heralds-of-psychosis-proneness
#11
Michele Poletti, Eva Gebhardt, Andrea Raballo
Aiming at preventing transitions to more severe psychopathology and boosted by the availability of operational criteria to identify help-seeking subjects at increased risk for psychosis, research into the early prodromal phases of psychosis is attracting a growing clinical interest. Furthermore, the focus of early detection is gradually shifting from prodromal syndromes to the premorbid period. Although mainly driven by clinical-pragatic aims, such a shift is coherent with the neurodevelopmental hypothesis of schizophrenia that might offer a unifying, developmentally informed conceptual framework for early detection...
December 20, 2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27769349/-attenuated-psychosis-syndrome-in-dsm-5
#12
M-A Crocq
No abstract text is available yet for this article.
June 2016: L'Encéphale
https://www.readbyqxmd.com/read/27721394/correlation-of-social-cognition-and-neurocognition-on-psychotic-outcome-a-naturalistic-follow-up-study-of-subjects-with-attenuated-psychosis-syndrome
#13
TianHong Zhang, HuiRu Cui, YingYing Tang, LiHua Xu, HuiJun Li, YanYan Wei, XiaoHua Liu, Annabelle Chow, ChunBo Li, KaiDa Jiang, ZePing Xiao, JiJun Wang
Neurocognitive decline has been observed in patients with psychosis as well as attenuated psychosis syndrome (APS). We tested the hypothesis that APS increases dependence on neurocognition during the interpretation of others' mental states and that a combination index of Theory of Mind (ToM) and neurocognition improves the predictive accuracy of psychosis conversion. A sample of 83 APS individuals and 90 healthy controls (HC) were assessed by comprehensive cognitive tests. The cohort also completed a one-year follow-up...
October 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27705009/treatment-precedes-positive-symptoms-in-north-american-adolescent-and-young-adult-clinical-high-risk-cohort
#14
Kristen A Woodberry, Larry J Seidman, Caitlin Bryant, Jean Addington, Carrie E Bearden, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Daniel H Mathalon, Diana O Perkins, Ming T Tsuang, Elaine F Walker, Scott W Woods
Early intervention for psychotic disorders, a growing international priority, typically targets help-seeking populations with emerging psychotic ("positive") symptoms. We assessed the nature of and degree to which treatment of individuals at high risk for psychosis preceded or followed the onset of positive symptoms. The North American Prodrome Longitudinal Study-2 collected psychosocial treatment histories for 745 (98%) of 764 high-risk participants (M age = 18.9, 57% male, 57.5% Caucasian, 19.1% Hispanic) recruited from 8 North American communities...
October 5, 2016: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/27633376/improving-current-treatments-for-schizophrenia
#15
Nadja P Maric, Milica J Jovicic, Marina Mihaljevic, Cedo Miljevic
Preclinical Research After the identification of the schizophrenia as an illness over a century ago, treatment of affected individuals included unspecific, mostly very robust methods including deep insulin coma and lobectomy/leucotomy. The first relatively specific treatment of schizophrenia started about 60 years ago with the antipsychotic chlorpromazine. All currently approved antipsychotic drugs block dopamine receptors, indicating that manipulation of dopaminergic function is fundamental to a therapeutic response in psychosis...
November 2016: Drug Development Research
https://www.readbyqxmd.com/read/27490838/dsm-5-defined-attenuated-psychosis-syndrome-and-conversion-to-full-scale-schizophrenia-spectrum-disorders-an-institution-wide-retrospective-review
#16
Zachary Zuschlag, Alyssa Kennedy, Jeffrey Korte, Laura Franko-Tobin, Karen Hartwell, Mark Hamner
BACKGROUND: The objective of the study was to determine if DSM-5-defined attenuated psychosis syndrome (APS) could identify individuals with prodromal psychosis and predict conversion to schizophrenia spectrum disorders at a rate similar to that observed in previous studies that utilized structured interviews and specialized rating scales. METHODS: A retrospective review of patients' medical records was used to identify individuals meeting diagnostic criteria for the APS, followed by further evaluation 2 to 3 years after the initial diagnosis, to determine if they converted to schizophrenia spectrum disorders...
November 2016: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/27313553/emotional-experiences-predict-the-conversion-of-individuals-with-attenuated-psychosis-syndrome-to-psychosis-a-6-month-follow-up-study
#17
Fa Zhan Chen, Yi Wang, Xi Rong Sun, Yu Hong Yao, Ning Zhang, Hui Fen Qiao, Lan Zhang, Zhan Jiang Li, Hong Lin, Zheng Lu, Jing Li, Raymond C K Chan, Xu Dong Zhao
The present study explored the conversion rate in individuals with Attenuated Psychosis Syndrome (APS) and potential predictor for transition in mainland China. Sixty-three participants identified as APS were followed up 6 months later. The results showed that 17% of individuals with APS converted to full-blown psychosis. The converters exhibited significantly poorer emotional experience and expression than the non-converters at baseline. A further binary logistic regression analysis showed that emotional experience could predict the transition (Wald = 4...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27285723/persistence-or-recurrence-of-non-psychotic-comorbid-mental-disorders-associated-with-6-year-poor-functional-outcomes-in-patients-at-ultra-high-risk-for-psychosis
#18
Grazia Rutigliano, Lucia Valmaggia, Paola Landi, Marianna Frascarelli, Marco Cappucciati, Victoria Sear, Matteo Rocchetti, Andrea De Micheli, Ceri Jones, Erika Palombini, Philip McGuire, Paolo Fusar-Poli
BACKGROUND: Patients at ultra-high risk for psychosis (UHR) are a highly heterogeneous group in terms of clinical and functional outcomes. Several non-psychotic mental disorders co-occur together with the UHR state. Little is known about the impact of non-psychotic comorbid mental disorders on clinical and functional outcomes of UHR patients. METHODS: The sample included 154 UHR help-seeking patients (identified with the CAARMS, comprehensive assessment of the at-risk mental state), evaluated at baseline on the Ham-D, Ham-A (Hamilton depression/anxiety rating scale), and PANSS (positive and negative syndrome scale)...
October 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27259137/the-violent-content-in-attenuated-psychotic-symptoms
#19
Catherine Marshall, Stephanie Deighton, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, Ming T Tsuang, Elaine F Walker, Scott W Woods, Carrie E Bearden, Daniel Mathalon, Jean Addington
The relationship between psychosis and violence has typically focused on factors likely to predict who will commit violent acts. One unexplored area is violence in the content of subthreshold positive symptoms. The current aim was to conduct an exploratory analysis of violent content in the attenuated psychotic symptoms (APS) of those at clinical high risk of psychosis (CHR) who met criteria for attenuated psychotic symptom syndrome (APSS). The APS of 442 CHR individuals, determined by the Structured Interview for Prodromal Syndromes, were described in comprehensive vignettes...
August 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27252764/transition-to-psychosis-evaluation-of-the-first-degree-relatives-of-patients-with-schizophrenia-%C3%A2
#20
Mehdi Hormozpour, Homayoun Amini, Sara Pajouhanfar, Masoomeh Faghankhani, Arash Rahmani, Vandad Sharifi
OBJECTIVE: Schizophrenia and other psychoses have devastating personal and social impacts and many efforts have been devoted to study ‎prodromal syndromes for psychosis in order to achieve earlier detection and interventions. However, only few studies have been ‎performed in developing countries on this subject, and there is a dearth of evidence in the Iranian population. In this study, we ‎focused on conversion rate to psychosis and changes in prodromal symptoms in a group of first-degree relatives of patients with ‎schizophrenia and to compare the conversion rate in those with and without prodromal symptoms as assessed by the Structured ‎Interview for Prodromal Syndromes (SIPS) and Scale of Prodromal Symptoms (SOPS)...
January 2016: Iranian Journal of Psychiatry
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