Read by QxMD icon Read

PIP—(Potentially Inappropriate Prescriptions)

Romy Técher, Magali Houde, Jonathan Verreault
Developing bird embryos may be affected by a number of thyroid disrupting chemicals through maternal transfer. However, thyroid disruption in developing embryos of wild birds remains largely unstudied, especially with respect to exposure to ubiquitous environmental contaminant classes including halogenated flame retardants (HFRs). The objective of the present study was to investigate responses of the hypothalamic-pituitary-thyroid (HPT) axis of developing birds that are exposed to elevated concentrations of HFRs in their environment...
July 31, 2018: Chemosphere
Matteo De March, Susana Barrera-Vilarmau, Emmanuele Crespan, Elisa Mentegari, Nekane Merino, Amaia Gonzalez-Magaña, Miguel Romano-Moreno, Giovanni Maga, Ramon Crehuet, Silvia Onesti, Francisco J Blanco, Alfredo De Biasio
p15PAF is an oncogenic intrinsically disordered protein that regulates DNA replication and lesion bypass by interacting with the human sliding clamp PCNA. In the absence of DNA, p15PAF traverses the PCNA ring via an extended PIP-box that contacts the sliding surface. Here, we probed the atomic-scale structure of p15PAF-PCNA-DNA ternary complexes. Crystallography and MD simulations show that, when p15PAF occupies two subunits of the PCNA homotrimer, DNA within the ring channel binds the unoccupied subunit. The structure of PCNA-bound p15PAF in the absence and presence of DNA is invariant, and solution NMR confirms that DNA does not displace p15PAF from the ring wall...
August 8, 2018: Nucleic Acids Research
Akira Kodama, Toru Sunagawa, Yuko Nakashima, Rikuo Shinomiya, Yuta Hayashi, Mitsuo Ochi, Nobuo Adachi
BACKGROUND: Dynamic external fixation is a useful treatment option for unstable fracture-dislocations of the proximal interphalangeal (PIP) joint, because it simultaneously reduces axial pressure load on the joint surface, maintains congruent joint reduction, and permits early joint motion. However, most current devices are large, hindering finger movement, and unstable. To address these problems, we developed a dynamic external finger fixator, named the Micro Ortho Fixator® . The purpose of this study was to review the results of using the new external finger fixator to treat unstable fracture-dislocations of the PIP joint...
August 9, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Huidi Tchero, Pauline Kangambega, Lazarre Noubou, Beatrice Becsangele, Fluieraru Sergiu, Luc Teot
Diabetic foot infection is a common diabetic complication that may end in lower limb amputation if not treated properly. We performed this systematic review to assess the clinical efficacy of different antibiotic regimens, whether systemic or topical, in the treatment of moderate to severe diabetic foot infections. We searched Medline, Web of Science, SCOPUS, Cochrane CENTRAL and ScienceDirect for randomized controlled trials that evaluated the efficacy of antibiotic regimens in moderate to severe diabetic foot infections...
August 12, 2018: Wound Repair and Regeneration
S M Pérez-Moreno, M J Gázquez, R Pérez-López, I Vioque, J P Bolívar
The phosphogypsum (PG) stacks located at Huelva (SW Spain) store about 100 Mt of PG, and covers a surface of 1000 ha. It has been very well established in many studies that this waste contains significant U-series radionuclides concentrations, with average activity concentrations rounding the 650, 600, 400 and 100 Bq kg-1 for 226 Ra, 210 Po, 230 Th and 238 U, respectively. However, the radionuclide transfer from this repository into the environment by the aquatic pathway will depend on the mobility of each radionuclide...
August 2, 2018: Chemosphere
Maria Podinovskaia, Anne Spang
Endocytosis is a means for the cell to sample its environment for nutrients and regulate plasma membrane (PM) composition and area. Whereas the majority of internalized cargo is recycled back to the cell surface, select material is sent to the lysosome for degradation. Endosomes further play major roles in central cell activities as diverse as establishment of cell polarity and signaling, lysosomal storage and immunity. The complexity of endosomal functions is reflected by the extensive changes to endosome properties as they mature...
2018: Progress in Molecular and Subcellular Biology
Hicran Dönmez Özkan, Kubilay Metin, Zehra Burcu Bakir, Senem Yiğit Özer
OBJECTIVE: This study aimed to compare the debris removal efficacies of irrigation activation techniques using ex vivo biomolecular film. MATERIALS AND METHODS: Root canals of 50 human mandibular premolars were prepared, and freshly prepared collagen solutions were applied into the root canals using a peristaltic pump. Specimens were randomly divided into the five groups and irrigated with 3 mL of 5.25% sodium hypochlorite (NaOCl): G1 (needle irrigation and control group): a 27-gauge notched-tip irrigation needle (Endo-Eze; Ultradent, South Jordan, UT); G2, Vibringe sonic irrigation system (VSS) (Vibringe B...
August 10, 2018: Photomedicine and Laser Surgery
Osama F Harraz, Thomas Andrew Longden, David Hill-Eubanks, Mark T Nelson
We recently reported that the inward-rectifier Kir2.1 channel in brain capillary endothelial cells (cECs) plays a major role in neurovascular coupling (NVC) by mediating a neuronal activity-dependent, propagating vasodilatory (hyperpolarizing) signal. We further demonstrated that Kir2.1 activity is suppressed by depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP2 ). Whether cECs express depolarizing channels that intersect with Kir2.1-mediated signaling remains unknown. Here, we report that Ca2+ /Na+ -permeable TRPV4 (transient receptor potential vanilloid 4) channels are expressed in cECs and are tonically inhibited by PIP2 ...
August 7, 2018: ELife
Peng A, Xinyi Xu, Chenglin Wang, Jing Yang, Shida Wang, Jiewen Dai, Ling Ye
BACKGROUND: Proliferating cell nuclear antigen (PCNA), a ring-shaped homotrimer complex, promotes DNA replication via binding to DNA polymerase. Trimerized PCNA is critical for DNA replication. Enhancer of zeste homologue 2 (EZH2), which primarily acts as a histone methyltransferase, is essential for proliferation. However, how EZH2 promotes proliferation by controlling DNA replication through PCNA remains elusive. RESULTS: Here, we showed that low EZH2 levels repressed the proliferation of human dental pulp cells (hDPCs)...
August 2, 2018: Epigenetics & Chromatin
Ulf Michgehl, Boris V Skryabin, Samet Bayraktar, Beate Vollenbröker, Giuliano Ciarimboli, Barbara Heitplatz, Veerle Van Marck, Hermann-Josef Gröne, Hermann Pavenstädt, Thomas Weide
Intracellular trafficking processes play a key role for the establishment and maintenance of membrane surfaces in renal epithelia. Therefore, dysfunctions of these trafficking processes could be key events and important determinants in the onset and progression of diseases. The presence of cellular vacuoles - observed in many histologic analyses of renal diseases - is a macroscopic hint for disturbed intracellular trafficking processes. However, how vacuoles develop and which intracellular pathways are directly affected remains largely unknown...
August 1, 2018: American Journal of Physiology. Renal Physiology
Huawei Pan, Yang Shi, Shuo Chen, Yun Yang, Yuan Yue, Leilei Zhan, Lanzhi Dai, Haiyang Dong, Weiling Hong, Feng Shi, Yongfeng Jin
Alternative pre-mRNA splicing remarkably expands protein diversity in eukaryotes. Drosophila PGRP-LC can generate three major 3' splice isoforms that exhibit distinct innate immune recognition and defenses against various microbial infections. However, the regulatory mechanisms underlying the uniquely biased splicing pattern at the 3' variable region remain unclear. Here we show that competing RNA pairings control the unique splicing of the 3' variable region of Drosophila PGRP-LC pre-mRNA. We reveal three roles by which these RNA pairings jointly regulate the 3' variant selection through activating the proximal 3' splice site and concurrently masking the intron-proximal 5' splice site, in combination with physical competition of RNA pairing...
July 31, 2018: RNA
Weilong Kong, Mohammed Bendahmane, Xiaopeng Fu
Aquaporins (AQPs) are associated with the transport of water and other small solutes across biological membranes. Genome-wide identification and characterization will pave the way for further insights into the AQPs' roles in the commercial carnation ( Dianthus caryophyllus ). This study focuses on the analysis of AQPs in carnation (DcaAQPs) involved in flower opening processes. Thirty DcaAQPs were identified and grouped to five subfamilies: nine PIPs, 11 TIPs, six NIPs, three SIPs, and one XIP. Subsequently, gene structure, protein motifs, and co-expression network of DcaAQPs were analyzed and substrate specificity of DcaAQPs was predicted...
July 29, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Andrew E Federer, Evan M Guerrero, Travis J Dekker, Suhail K Mithani, J Mack Aldridge, David S Ruch, Marc J Richard
BACKGROUND: Unstable intra-articular proximal interphalangeal (PIP) joint fracture-dislocations present a difficult problem that requires congruous joint reduction and stable internal fixation or distraction. Though fractures with limited articular involvement may be treated successfully with less invasive procedures, fracture-dislocations with a volar shear component may benefit from joint reduction with subchondral support for maintenance of stability. The purpose of this article is to describe a volar transverse plate and screw technique and report the short-term postoperative results...
July 28, 2018: Hand: Official Journal of the American Association for Hand Surgery
Monica Ferreira, Monique Beullens, Mathieu Bollen, Aleyde Van Eynde
Protein phosphatase 1 (PP1) catalyzes more than half of all phosphoserine/threonine dephosphorylation reactions in mammalian cells. In vivo PP1 does not exist as a free catalytic subunit but is always associated with at least one regulatory PP1-interacting protein (PIP) to generate a large set of distinct holoenzymes. Each PP1 complex controls the dephosphorylation of only a small subset of PP1 substrates. We screened the literature for genetically engineered mouse models and identified models for all PP1 isoforms and 104 PIPs...
July 26, 2018: Biochimica et Biophysica Acta
Jong Hun Baek, Duke Whan Chung, Jae Hoon Lee
PURPOSE: This study aimed to investigate the incidence and prognostic factors for prolonged postoperative symptoms after open A1 pulley release in patients with trigger finger, despite absence of any complications. METHODS: We reviewed 109 patients (78 single-finger involvement, 31 multiple-finger involvement) who underwent open A1 pulley release for trigger finger from 2010 to 2016, with 8 weeks or longer postsurgical follow-up and without postoperative complications...
July 25, 2018: Journal of Hand Surgery
Sara Casaña-Granell, Laura Lacomba-Trejo, Selene Valero-Moreno, Vicente Prado-Gasco, Inmaculada Montoya-Castilla, Marián Pérez-Marín
A chronic illness in childhood has a negative impact on the paediatric patient and on family functioning. Psychological stress in parents influences the level of adjustment to the illness of their children. The Pediatric Inventory for Parents (PIP) was designed to measure stress in parents whose child has a chronic illness or requires prolonged medical monitoring. The main objective of this study is to provide a brief version of the Spanish translation of the PIP, across a sample consisting of 465 main familial caregivers (85...
2018: PloS One
Vladimir V Popov, Dmitry I Nechaev, Alexander Ya Supin, Evgeniya V Sysueva
The effects of prolonged sound stimuli (tone pip trains) on evoked potentials (the rate following response, RFR) were investigated in a beluga whale. The stimuli (rhythmic tone pips) were of 64 kHz frequency at levels from 80 to 140 dB re 1 μPa. During stimulation, every 1000 ms stimulus level either was kept constant (the steady-state stimulation) or changed up/down by 20 or 40 dB. With such stimulus presentation manner, RFR amplitude varied as follows. (i) After a stimulus level increase, the response amplitude increased quickly and then decayed slowly...
2018: PloS One
William G P Mayner, William Marshall, Larissa Albantakis, Graham Findlay, Robert Marchman, Giulio Tononi
Integrated information theory provides a mathematical framework to fully characterize the cause-effect structure of a physical system. Here, we introduce PyPhi, a Python software package that implements this framework for causal analysis and unfolds the full cause-effect structure of discrete dynamical systems of binary elements. The software allows users to easily study these structures, serves as an up-to-date reference implementation of the formalisms of integrated information theory, and has been applied in research on complexity, emergence, and certain biological questions...
July 2018: PLoS Computational Biology
Raphel A E Enow, Wei-Chih Lee, Travis D Cournoyer, Travis L Sunderland, Brian J Frost
A series of water-soluble and air-stable E-enamine derivatives of 1,3,5-triaza-7-phosphaadamantane (PTA), PTA═C(R)NH2 , 1-4, are reported along with data on E-Z isomerization and tautomerization to the imine form (PTA-CR═NH). Reaction of 1,3,5-triaza-7-phosphaamantane-6-yl lithium, PTA-Li, with aromatic nitriles afforded E-enamine derivatives of PTA in good yield (49-91%). Phosphines 1-4 are stable toward water and air, and do not appear to isomerize or tautomerize, unless coordinated to a metal or oxidized...
July 26, 2018: Inorganic Chemistry
Lana Van Damme, Jan J De Waele
BACKGROUND: Decompressive laparotomy has been advised as potential treatment for abdominal compartment syndrome (ACS) when medical management fails; yet, the effect on parameters of organ function differs markedly in the published literature. In this study, we sought to investigate the effect of decompressive laparotomy on intra-abdominal pressure and organ function in critically ill adult and pediatric patients with ACS, specifically focusing on hemodynamic, respiratory, and kidney function and outcome...
July 25, 2018: Critical Care: the Official Journal of the Critical Care Forum
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"