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PIP—(Potentially Inappropriate Prescriptions)

Sancar Serbest, Uğur Tiftikci, Erdoğan Durgut, Özge Vergili, Cem Yalın Kılınc
INTRODUCTION: Due to the continual increase in the number of children engaging in sports today, physicians encounter finger injuries at an increasing frequency. This study sought to investigate the effectiveness of the method of Kinesio taping versus classic finger splint technique on pediatric patients with PIP (proximal interphalangeal) joint sprains of the fingers. METHOD: This is a retrospective cohort study. Forty-nine pediatric patients with PIP joint sprains were included in the study...
January 15, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Concetta Federico, Valeria Vitale, Noemi La Porta, Salvatore Saccone
Petroleum refinery workers are potentially exposed to a wide range of petrochemical industry pollutants (PIP), such as benzene and 1,3-butadiene, cancer-related compounds classified as carcinogenic to humans. The aim of this study was to evaluate the cytogenetic effects of exposure to PIP from two industrialised areas in South/East Sicily (Italy) using a micronucleus (MN) assay and other nuclear anomalies (ONA) on exfoliated buccal cells. Results highlighted not only a statistically significant high level of increase of MN in petroleum refinery (PR) workers, but also in the subjects not working in PR but living in the industrialised area...
January 15, 2019: Environmental Science and Pollution Research International
Vanni Strigelli, Luigi Mingarelli, Giulio Fioravanti, Gianfranco Merendi, Antonio Merolli, Francesco Fanfani, Lorenzo Rocchi
OBJECTIVES: We retrospectively reviewed 1305 open-surgery for idiopathic trigger finger performed by 4 senior hand surgeons between 2014 and 2016. MATERIAL AND METHODS: Medical records and a telephone interview made with a minimum follow-up of 1 year were used to identify the recurrent rate of triggering and other complications. RESULTS: This retrospective study let us note that 169 fingers (13%) required simultaneous release of the A1-A2 pulleys because the sectioning of the A1 pulley alone did not lead to complete free sliding of the tendons...
January 11, 2019: Techniques in Hand & Upper Extremity Surgery
Sathapana Naowarat, Chanapong Rojanaworarit, Wanwimon Surinsak, Kanjana Umain, Dara Ruadreaw, Somkid Yuenprakone, Apirak Pisutaporn, Arongrag C Meeyai
BACKGROUND AND PURPOSE: We aimed to estimate TB prevalence among in-patients hospitalized with acute lower respiratory infection (ALRI) through a routine TB case finding approach (Patient-Initiated-Pathway, PIP) and among those without initial TB detection by PIP using a supplementary-Intensified-Case-Finding (supplementary-ICF) approach to determine the extent of active TB infection in patients enrolled in population-based surveillance in Sa Keao, Thailand. We also investigated secondary TB transmission through household contacts (HHCs)...
January 9, 2019: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Michelle F Rourke
Policy Points Securing access to pathogen samples for research purposes is crucial for pandemic preparedness and responding to infectious disease outbreaks. The Pandemic Influenza Preparedness Framework (PIP Framework) is the only pathogen-specific international access and benefit-sharing (ABS) instrument. This analysis reveals that during an influenza pandemic, the PIP Framework will safeguard access to virus samples but may not be as effective in delivering the associated benefits, like vaccines and antivirals, to countries in need...
January 13, 2019: Milbank Quarterly
Jing Kang, Austin Scholp, Jacob Tangney, Jack J Jiang
PURPOSE: This study investigated the effects of straw phonation therapy on the aerodynamic and acoustic parameters of the vocal folds at different levels of elongation and subglottal pressure. METHODS: 20 excised canine larynges were used in both experimental (straw phonation therapy simulation) and control conditions. Aerodynamic parameters, including phonation threshold pressure (PTP), phonation instability pressure (PIP), phonation pressure range (PPR), phonation threshold flow (PTF), phonation instability flow (PIF), phonation flow range (PFR), were obtained at different levels of vocal fold elongation (0%, 10%, 20%)...
January 10, 2019: European Archives of Oto-rhino-laryngology
Akiyo Hayashi, Nickolaos Nikiforos Giakoumakis, Tatjana Heidebrecht, Takashi Ishii, Andreas Panagopoulos, Christophe Caillat, Michiyo Takahara, Richard G Hibbert, Naohiro Suenaga, Magda Stadnik-Spiewak, Tatsuro Takahashi, Yasushi Shiomi, Stavros Taraviras, Eleonore von Castelmur, Zoi Lygerou, Anastassis Perrakis, Hideo Nishitani
The CRL4Cdt2 ubiquitin ligase complex is an essential regulator of cell-cycle progression and genome stability, ubiquitinating substrates such as p21, Set8, and Cdt1, via a display of substrate degrons on proliferating cell nuclear antigens (PCNAs). Here, we examine the hierarchy of the ligase and substrate recruitment kinetics onto PCNA at sites of DNA replication. We demonstrate that the C-terminal end of Cdt2 bears a PCNA interaction protein motif (PIP box, Cdt2PIP ), which is necessary and sufficient for the binding of Cdt2 to PCNA...
December 2018: Life science alliance
Gonzalo Zeballos Sarrato, Manuel Sánchez Luna, Susana Zeballos Sarrato, Alba Pérez Pérez, Isabel Pescador Chamorro, Jose María Bellón Cano
OBJECTIVE:  To investigate if the use of a visible respiratory function monitor (RFM) to use lower tidal volumes (Vts) during positive pressure ventilation (PPV) in the delivery room (DR) reduces the need of surfactant administration and invasive mechanical ventilation during the first 72 hours after birth of preterm infants <32 weeks' gestational age (GA). STUDY DESIGN:  Infants <32 weeks' GA ( n  = 106) requiring noninvasive PPV were monitored with a RFM at birth and randomized to visible ( n  = 54) or masked ( n  = 52) display on RFM...
January 8, 2019: American Journal of Perinatology
Meike Linnenschmidt, Lutz Wiegrebe
Hearing is the primary sensory modality in bats, but its development is poorly studied. For newborns, hearing appears essential in maintaining contact with their mothers and to develop echolocation abilities. Here we measured auditory brainstem responses (ABRs) to clicks and narrowband tone pips covering a large frequency range (5-90 kHz) in juveniles (p7 to p200) and adults of the bat, Phyllostomus discolor. Tone-pip audiograms show that juveniles at p7 are already quite responsive, not only below 20 kHz but up to 90 kHz...
December 27, 2018: Hearing Research
X T Xu, Q Sun, J F Xie, C Pan, Y Yang, H B Qiu, L Liu
Objective: To compare the trigger delay and work of trigger between neurally adjusted ventilatory assist (NAVA) and pressure support ventilation (PSV) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients with intrinsic positive end-expiratory pressure (PEEP) during mechanical ventilation. Methods: AECOPD patients with intrinsic PEEP (PEEPi) greater than or equal to 3 cmH(2)O (1 cmH(2)O=0.098 kPa) were enrolled during invasive mechanical ventilation. Subjects were ventilated with low, medium and high pressure under either NAVA or PSV mode...
January 1, 2019: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Vinicius Ide Franzini, Rosario Azcón, Juan Manuel Ruiz-Lozano, Ricardo Aroca
Rhizobial symbiosis improved the water status of bean plants under salinity-stress conditions, in part by increasing their osmotic root water flow. One of the main problems for agriculture worldwide is the increasing salinization of farming lands. The use of soil beneficial microorganisms stands up as a way to tackle this problem. One approach is the use of rhizobial N2 -fixing, nodule-forming bacteria. Salinity-stress causes leaf dehydration due to an imbalance between water lost through stomata and water absorbed by roots...
January 2, 2019: Planta
Junxiang Zuo, Qixin Chen, Xixi Hu, Hua Guo, Daiqian Xie
The O(3P) + C2H2 reaction is the first step in acetylene oxidation. The accurate kinetic data and the understanding of the reaction dynamics is of great importance. To this end, a full-dimensional global potential energy surface (PES) for the ground triplet state of the O(3P) + C2H2 reaction is constructed based on approximately 85 000 ab initio points calculated at the level of explicitly correlated unrestricted coupled cluster single, double, and perturbative triple excitations with the explicitly correlated polarized valence triple zeta basis set (UCCSD(T)-F12b/VTZ-F12)...
January 2, 2019: Physical Chemistry Chemical Physics: PCCP
Nathanya Baez Hernandez, Abdulhamid Milad, Yi Li, Andrew H Van Bergen
We assessed the feasibility and the impact of NAVA compared to conventional modes of mechanical ventilation in ventilatory and gas exchange parameters in post-operative children with congenital heart disease. Infants and children (age < 18 years) that underwent congenital heart surgery were enrolled. Patients were ventilated with conventional synchronized intermittent mechanical ventilation (SIMV) and subsequently transitioned to NAVA during their cardiovascular intensive care unit (CVICU) stay. The ventilatory and gas exchange parameters for the 24 h pre- and post-transition to NAVA were compared...
January 2, 2019: Pediatric Cardiology
Mohamed Zarzoura, Pablo Del Moral, Mohammed I Awad, Farid A Tolbah
Underactuation is widely used when designing anthropomorphic hand, which involves fewer degrees of actuation than degrees of freedom. However, the similarities between coordinated joint movements and movement variances across different grasp tasks have not been suitably examined. This work suggests a systematic approach to identify the actuation strategy with the minimum number for degrees of actuation for anthropomorphic hands. This work evaluates the correlations of coordinated movements in human hands during 23 grasp tasks to suggest actuation strategies for anthropomorphic hands...
January 1, 2019: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
Akasbi Nessrine, Driouach Siham, Baya Meryem, El Fakir Samira, Harzy Taoufik
INTRODUCTION: The definition of remission in rheumatoid arthritis (RA) is still difficult to determine. An ultrasound of the hands may be important in helping to confirm clinical remission. This study's aim was to evaluate the interest in using an ultrasound of the hands to confirm clinical remission, as well as comparing the various remission scores (DAS 28 VS, DAS 28 CRP, and SDAI) and the ultrasound data, in order to deduce the most accurate score to confirm this remission. METHODS: In this prospective monocentric study, we studied patients with rheumatoid arthritis in clinical remission, according to DAS 28 VS, for at least 3 months without corticosteroid therapy...
December 30, 2018: Current Rheumatology Reviews
Sang Won Yoon, Hyun Kang, Geun Joo Choi, Choongun Ryu, Yong Hee Park, Chong Wha Baek, Yong Hun Jung, Young Cheol Woo
STUDY OBJECTIVE: To review all randomized controlled trials (RCTs) on supraglottic airway devices (SADs) used in laparoscopy and compare their oropharyngeal leak pressure (OLP) and peak inspiratory pressure (PIP) before and after pneumoperitoneum, and success rate of gastric tube insertion rate. DESIGN: Systematic review and network meta-analysis of RCTs. SETTING: Laparoscopic surgeries using SADs. PATIENTS: We searched MEDLINE, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, and Google Scholar databases to detect all relevant RCTs on SADs for laparoscopic surgery published until March 2018...
December 28, 2018: Journal of Clinical Anesthesia
Florence Labrell, Hugo Câmara-Costa, Christelle Dufour, Jacques Grill, Mathilde Chevignard
BACKGROUND: Despite evidence that pediatric cancer induces a trajectory of parental stress, studies including mothers of children with malignant brain tumors remain scarce. The present work aims to add to the scientific literature by evaluating maternal stress with a French translation of the Pediatric Inventory for Parents (PIP) in a population of mothers whose children have been diagnosed with a brain tumor. PROCEDURE: The mothers of 35 children with malignant brain tumors completed the Pediatric Inventory for Parents (PIP), the State-Trait Anxiety Inventory (STAI) and the Family Assessment Device (FAD) at a mean time since diagnosis of 2...
December 28, 2018: Journal of Psychosocial Oncology
Mirco Michel, David Menéndez Hurtado, Arne Elofsson
Motivation: Residue contact prediction was revolutionized recently by the introduction of direct coupling analysis (DCA). Further improvements, in particular for small families, have been obtained by the combination of DCA and deep learning methods. However, existing deep learning contact prediction methods often rely on a number of external programs and are therefore computationally expensive. Results: Here, we introduce a novel contact predictor, PconsC4, which performs on par with state of the art methods...
December 24, 2018: Bioinformatics
Annika Koponen, Amita Arora, Kohta Takahashi, Henriikka Kentala, Annukka Kivelä, Eeva Jääskeläinen, Johan Peränen, Pentti Somerharju, Elina Ikonen, Tapani Viitala, Vesa M Olkkonen
ORP2 is a sterol-binding protein with documented functions in lipid and glucose metabolism, Akt signaling, steroidogenesis, cell adhesion, migration and proliferation. Here we investigate the interactions of ORP2 with phosphoinositides (PIPs) by surface plasmon resonance (SPR), its affinity for cholesterol with a pull-down assay, and its capacity to transfer sterol in vitro. Moreover, we determine the effects of wild-type (wt) ORP2 and a mutant with attenuated PIP binding, ORP2(mHHK), on the subcellular distribution of cholesterol, and analyze the interaction of ORP2 with the related cholesterol transporter ORP1L...
December 24, 2018: Biochimie
Ilhan Kilic, Kultural Gungor, Ilhan Kurultak, Sedat Ustundag
Serratia marcescens (SM) is an opportunistic Gram-negative bacterium. It can cause technique failure or severe sepsis despite being a rare agent causing peritonitis. We present a case of a 40-year-old woman with end-stage renal disease secondary to chronic glomerulo-nephritis on continuous ambulatory peritoneal dialysis (PD). She presented with severe abdominal pain and a cloudy peritoneal fluid. The fluid was cultured according to our unit protocol. The organism isolated was identified as SM; this was after the patient was treated for SM peritonitis one week earlier...
November 2018: Saudi Journal of Kidney Diseases and Transplantation
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