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PIP—(Potentially Inappropriate Prescriptions)

Xu Xie, Jordan M Dennison, Jungwoo Shin, Zhu Diao, David G Cahill
We developed an optical pump-probe technique, frequency-domain probe beam deflection (FD-PBD) to measure the diffusion of water vapor in nanoscale polymer films with microsecond temporal resolution and micrometer spatial resolution. We describe the quantitative model of beam deflection for multilayer structures, the experimental approach, and the application of FD-PBD to measure the diffusivity ( D m ) of saturated water vapor in various glassy polymer films including polyimide (PI, D m = 7.0 × 10-13 m2 s-1 ), poly(methyl methacrylate) (PMMA, D m = 1...
October 2018: Review of Scientific Instruments
Marweh Schmitz, Dirk W Schubert, Joachim Kaschta, Jonas Daenicke, Bastian L Walter, Raymund E Horch
OBJECTIVES: Bacterial contamination of breast implants and biofilm formation has been discussed as a major reason for implant loss and capsular contraction. Intra- and perioperative treatment of breast implants with disinfectants to prevent bacterial contamination has been frequently reported. Given the increasing awareness of concerns about product liability the question of whether short-time irrigation of implants with antimicrobial substances during the operative procedure would potentially alter the integrity of the implant shell has attracted legal and medical interest...
October 15, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Pip C J Clark, Wendy R Flavell
Control of the surface and interface chemistry of colloidal quantum dots (CQDs) is critical to achieving a product with good air stability and high performing optoelectronic devices. Through various surface passivation treatments, vast improvements have been made in fields such as CQD photovoltaics; however devices have not currently reached commercial standards. We show how X-ray photoelectron spectroscopy (XPS) can provide a better understanding of exactly how surface treatments act on CQD surfaces, and the effect of surface composition on air stability and device performance...
November 2, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
Christoph A Umbricht, Martina Benešová, Roger Hasler, Roger Schibli, Nicholas P van der Meulen, Cristina Müller
Recently, we developed an albumin-binding radioligand (177 Lu-PSMA-ALB-56), which showed higher PSMA-specific tumor uptake in mice than the previously developed 177 Lu-PSMA-617 under the same experimental conditions. Such a radioligand may be of interest also for PET imaging, possibly enabling better visualization of even small metastases at late time-points after injection. The aim of this study was, therefore, to modify PSMA-ALB-56 by exchanging the DOTA chelator with a NODAGA chelator for stable coordination of 64 Cu ( T1/2 = 12...
October 30, 2018: Molecular Pharmaceutics
Jesper Nordenskjöld, Stina Brodén, Isam Atroshi
BACKGROUND: The most commonly reported outcome measure in Dupuytren disease is the extension deficit in finger joints. This study aimed to investigate the examiners' influence on the measured difference between active and passive extension deficit. METHODS: A prospective cohort study was conducted on 157 consecutive patients (81% men, mean age 70 years) scheduled for collagenase treatment for Dupuytren disease. Before injection, one of three experienced hand therapists measured active extension deficit (AED) and passive extension deficit (PED) in the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints of the affected fingers using a hand-held metal goniometer...
October 29, 2018: BMC Medical Research Methodology
Walter E Haefeli, Andreas D Meid
With advancing age there is an increase in the disease burden and thus in the number of drugs prescribed to this patient group. It is often assumed that an increase in pill count is associated per se with an increase in the number of medication errors (e.g., potentially inappropriate prescribing, PIP) and the frequency of adverse drug events (ADE). However, prescribing more drugs can also mean more successful treatment, making it important to critically assess the benefit/risk balance of the medications prescribed in each patient...
October 26, 2018: International Journal of Clinical Pharmacology and Therapeutics
Maiara de S Oliveira, Marília I F Barbosa, Thiago Belarmino de Souza, Diogo R M Moreira, Felipe Terra Martins, Wilmer Villarreal, Rafael P Machado, Antônio Carlos Doriguetto, Milena B P Soares, Daniel P Bezerra
Piplartine (piperlongumine) is a plant-derived compound found in some Piper species that became a novel potential antineoplastic agent. In the present study, we synthesized a novel platinum complex containing a piplartine derivative cis-[PtCl(PIP-OH)(PPh3 )2 ]PF6 (where, PIP-OH = piplartine demethylated derivative; and PPh3 = triphenylphosphine) with enhanced cytotoxicity in different cancer cells, and investigated its apoptotic action in human promyelocytic leukemia HL-60 cells. The structure of PIP-OH ligand was characterized by X-ray crystallographic analysis and the resulting platinum complex was characterized by infrared, molar conductance measurements, elemental analysis and NMR experiments...
October 12, 2018: Redox Biology
Pablo Cruces, Sebastián González-Dambrauskas, Federico Cristiani, Javier Martínez, Ronnie Henderson, Benjamin Erranz, Franco Díaz
BACKGROUND: Positive end-expiratory pressure (PEEP) has been demonstrated to decrease ventilator-induced lung injury in patients under mechanical ventilation (MV) for acute respiratory failure. Recently, some studies have proposed some beneficial effects of PEEP in ventilated patients without lung injury. The influence of PEEP on respiratory mechanics in children is not well known. Our aim was to determine the effects on respiratory mechanics of setting PEEP at 5 cmH2 O in anesthetized healthy children...
October 24, 2018: BMC Anesthesiology
Yagiz Ozbay, Ali Erdemir
To evaluate which laser system is more effective on smear layer removal when distilled water or combination of sodium hypochlorite (NaOCl) and ethylenediaminetetraacetic acid (EDTA) are used as irrigants. Ninety-six human mandibular premolar teeth were used. Standard access cavities were prepared and the root canals were enlarged using ProTaper system to size F4 and divided into two equal groups according to final irrigation solution. In Group 1, distilled water was used, whilst 2.5% NaOCI and 17% EDTA solutions were used in Group 2...
October 23, 2018: Microscopy Research and Technique
Margaret E Tome, Chelsea K Jarvis, Charles P Schaefer, Leigh M Jacobs, Joseph M Herndon, Kristen C Hunn, Nathan B Arkwright, Kathryn L Kellohen, Peyton C Mierau, Thomas P Davis
P-glycoprotein (PgP) is the major drug efflux pump in human cerebral microvessels. PgP prevents pathogens, toxins and therapeutic drugs from entering the CNS. Understanding the molecular regulation of PgP activity will suggest novel mechanisms to improve CNS drug delivery. Previously, we found that during peripheral inflammatory pain (PIP) (3 h after λ carrageenan injection in the rat paw), PgP traffics to the cortical microvessel endothelial cell plasma membrane concomitant with increased PgP activity. In the current study, we measured the changes in composition of PgP-containing protein complexes after PIP in rat microvessel isolates...
October 22, 2018: Journal of Cerebral Blood Flow and Metabolism
Shane D Rothermel, Umur Aydogan, Evan P Roush, Gregory S Lewis
BACKGROUND: Lesser toe proximal interphalangeal (PIP) joint arthrodesis is one of the most common foot and ankle elective procedures often using K-wires for fixation. K-wire associated complications led to development of intramedullary fixation devices. We hypothesized that X Fuse (Stryker) and Smart Toe (Stryker) would provide stronger and stiffer fixation than K-wire fixation. METHODS: 12 cadaveric second toe pairs were used. In one group, K-wires stabilized 6 PIP joints, and 6 contralateral PIP joints were fixed with X Fuse...
October 20, 2018: Foot & Ankle International
Maozhu Tang, Rong Zhang, Shiqi Li, Jian Zeng, Mingchao Luo, Yun-Xiang Xu, Guangsu Huang
Natural rubber is one of most famous self-reinforced rubbers thanks to the phenomenon of strain-induced crystallization. It is usually used in a vulcanized form to enhance the mechanical strength but this results in recycling issues. Herein a thermoplastic analogue of vulcanized natural rubber is obtained as a structural mimic. Terminally functionalized polyisoprene rubber B-4A-PIP was prepared by using tetra-analine as physical crosslinking units. The strong binding of tetra-analine groups gave B-4A-PIP a high tensile strength (15 MPa) and breaking strain of 890 %, which is much higher than those of undecorated copolymer B-OH-PIP...
October 21, 2018: Angewandte Chemie
Emma Barry, Frank Moriarty, Fiona Boland, Kathleen Bennett, Susan M Smith
OBJECTIVES: Evidence is limited regarding the quality of prescribing to children. The objective of this study was to apply a set of explicit prescribing indicators to a national pharmacy claims database (Primary Care Reimbursement Service) to determine the prevalence of potentially inappropriate prescribing in children (PIPc) in primary care. PRIMARY AND SECONDARY OUTCOMES MEASURES: To determine the overall prevalence of potentially inappropriate prescribing (PIP) in children in primary care...
October 21, 2018: BMJ Open
Christina Raae Hansen, Stephen Byrne, Denis O'Mahony, Patricia M Kearney, Laura J Sahm
PURPOSE: Older people are at risk of potentially inappropriate prescribing (PIP) due to polypharmacy arising from multi-morbidity. Despite available explicit criteria to reduce PIP, it is highly prevalent. Whilst community pharmacists have the required knowledge to help reduce PIP, they are not currently engaged with the problem. This study explores the views of community pharmacists on their potential involvement in reducing PIP and determines the challenges to its implementation. METHODS: Semi-structured interviews with pharmacists working in community pharmacies in Ireland...
October 20, 2018: European Journal of Clinical Pharmacology
Aoife M Fitzpatrick, Neil M Dundon, Kenneth F Valyear
The current study investigates a new neurobiological model of human hand choice: The Posterior Parietal Interhemispheric Competition (PPIC) model. The model specifies that neural populations in bilateral posterior intraparietal and superior parietal cortex (pIP-SPC) encode actions in hand-specific terms, and compete for selection across and within hemispheres. Actions with both hands are encoded bilaterally, but the contralateral hand is overrepresented. We use a novel fMRI paradigm to test the PPIC model. Participants reach to visible targets while in the scanner, and conditions involving free choice of which hand to use (Choice) are compared with when hand-use is instructed...
October 17, 2018: NeuroImage
G Dautel
Vascularized toe joint transfers are used for proximal interphalangeal (PIP) or metacarpophalangeal reconstruction of the fingers in children or young adults, as an alternative to joint arthroplasty. In children, this reconstruction aims to restore range of motion (ROM) and the growing capacities. The typical donor sites are the PIP or metatarsophalangeal joints of the second toe. These transfers are performed with short vascular pedicles in order to simplify the surgical technique and reduce the overall morbidity...
October 14, 2018: Hand Surgery and Rehabilitation
Changjian Xie, Xiaolei Zhu, David R Yarkony, Hua Guo
A machine learning method is proposed for representing the elements of diabatic potential energy matrices (PEMs) with high fidelity. This is an extension of the so-called permutation invariant polynomial-neural network (PIP-NN) method for representing adiabatic potential energy surfaces. While for one-dimensional irreducible representations the diagonal elements of a diabatic PEM are invariant under exchange of identical nuclei in a molecular system, the off-diagonal elements require special symmetry consideration, particularly in the presence of a conical intersection...
October 14, 2018: Journal of Chemical Physics
Rosy Southwell, Maria Chait
The brain draws on knowledge of statistical structure in the environment to facilitate detection of new events. Understanding the nature of this representation is a key challenge in sensory neuroscience. Specifically, it is unknown whether real-time perception of rapidly-unfolding sensory signals is driven by a coarse or detailed representation of the proximal stimulus history. We recorded electroencephalography brain responses to frequency outliers in regularly-patterned (REG) versus random (RAND) tone-pip sequences which were generated anew on each trial...
September 14, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Gary Eitzen, Cameron C Smithers, Allan Murray, Michael Overduin
FYVE domains are highly conserved protein modules that typically bind phosphatidylinositol 3-phosphate (PI3P) on the surface of early endosomes. Along with pleckstrin homology (PH) and phox homology (PX) domains, FYVE domains are the principal readers of the phosphoinositide (PI) code that mediate specific recognition of eukaryotic organelles. Of all the human FYVE domain-containing proteins, those within the Faciogenital dysplasia (Fgd) subfamily are particularly divergent, and couple with GTPases to exert unique cellular functions...
October 11, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
Michael J Gait, Andrey A Arzumanov, Graham McClorey, Caroline Godfrey, Corinne Betts, Suzan Hammond, Matthew J A Wood
The review starts with a historical perspective of the achievements of the Gait group in synthesis of oligonucleotides (ONs) and their peptide conjugates toward the award of the 2017 Oligonucleotide Therapeutic Society Lifetime Achievement Award. This acts as a prelude to the rewarding collaborative studies in the Gait and Wood research groups aimed toward the enhanced delivery of charge neutral ON drugs and the development of a series of Arg-rich cell-penetrating peptides called Pip (peptide nucleic acid/phosphorodiamidate morpholino oligonucleotide [PNA/PMO] internalization peptides) as conjugates of such ONs...
October 16, 2018: Nucleic Acid Therapeutics
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