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Giovanna E Carpagnano, Giulia Scioscia, Donato Lacedonia, Piera Soccio, Giorgia Lepore, Marina Saetta, Maria Pia Foschino Barbaro, Peter J Barnes
BACKGROUND: Severe asthma is heterogeneous clinically and biologically and is often difficult to control. In particular, the type 2 (T2) immunity endotype of severe asthma is gaining increasing interest because it is susceptible to newly developed biologic treatments that can transform the quality of life of these patients. The aim of this study was to analyze periostin concentrations in the airways of patients with severe asthma, evaluating its role in clustering the T2 endotype. METHODS: We enrolled 40 consecutive patients with severe asthma (T2 endotype: n = 25; non-T2 endotype: n = 15), 21 patients with mild to moderate asthma, and 15 healthy control subjects...
October 8, 2018: Chest
Pia Raanani
No abstract text is available yet for this article.
October 18, 2018: Acta Haematologica
Eunice Ego Mgbeahuruike, Yvonne Holm, Heikki Vuorela, Chinyere Amandikwa, Pia Fyhrquist
ETHNOBOTANICAL RELEVANCE: Piper guineense occurs commonly in West Africa where it is used for fungal infections instead of the costly and not always accessible conventional antifungals. Fungal, yeast-based diseases are common in West-Africa especially among those living with HIV/ AIDS, and thus this study was performed in Imo state, South-Eastern Nigeria, where P. guineense is predominantly used for the treatment of fungal diseases, such as skin rashes, oral thrush and vaginosis. AIM OF STUDY: The scarce number of previous studies on the documentation of the traditional uses of P...
October 15, 2018: Journal of Ethnopharmacology
Pia Kontos, Alisa Grigorovich
Dance, as aesthetic self-expression, is a unique arts-based program that combines the physical benefits of exercise with psychosocial therapeutic benefits. While dance has also been shown to support empowerment, meaningful self-expression, and pleasurable experience, it is rarely adopted to support these aspects of engagement in the context of dementia care. The instrumental reduction of dance to its application as a therapeutic tool can be traced to the contemporary movement towards cognitive science with an emphasis on embodied cognition...
September 2018: Journal of Law, Medicine & Ethics: a Journal of the American Society of Law, Medicine & Ethics
Gustav Ahlberg, Lena Refsgaard, Pia R Lundegaard, Laura Andreasen, Mattis F Ranthe, Nora Linscheid, Jonas B Nielsen, Mads Melbye, Stig Haunsø, Ahmad Sajadieh, Lu Camp, Søren-Peter Olesen, Simon Rasmussen, Alicia Lundby, Patrick T Ellinor, Anders G Holst, Jesper H Svendsen, Morten S Olesen
A family history of atrial fibrillation constitutes a substantial risk of developing the disease, however, the pathogenesis of this complex disease is poorly understood. We perform whole-exome sequencing on 24 families with at least three family members diagnosed with atrial fibrillation (AF) and find that titin-truncating variants (TTNtv) are significantly enriched in these patients (P = 1.76 × 10-6 ). This finding is replicated in an independent cohort of early-onset lone AF patients (n = 399; odds ratio = 36...
October 17, 2018: Nature Communications
Masoumeh Abbasi, Soodeh Shahsavari, Pia Quitt, Sven Reese, Andrea Fischer, Simon Bertram, Clara Tauber, Lara Matiasek
No abstract text is available yet for this article.
October 18, 2018: Journal of Feline Medicine and Surgery
Anne D Lassen, Pia Knuthsen, Anette Bysted, Elisabeth W Andersen
Monitoring the nutritional environment is important to help inform future initiatives to improve access to healthy foods. The objective was to examine the nutritional quality of lunch meals eaten at 15 worksite canteens and then to compare with results from a study conducted 10 years before. The duplicate-portion-technique with subsequent chemical analysis was used to quantify 240 customers' lunch intake. Estimated mean energy intake was 2.1 MJ/meal (95% confidence interval (CI): 1.9 to 2.4 g/meal) and estimated energy density 599 kJ/100 g (95% CI 550 to 653 kJ/100 g)...
October 16, 2018: Nutrients
Lilian A Ghandour, Al Amira S Shehab, Pia Zeinoun, Lucy Tavitian, Fadi Halabi, Fadi T Maalouf
Recent epidemiological evidence for Lebanese adults along with the increased efforts for policy and service planning have demonstrated the importance of screening for rates of psychiatric disorders in the adolescent population. In response to this need, the Beirut Epidemiological Investigation of the Psychological Status of Youth was conducted in a community sample to estimate the prevalence of psychiatric disorders and their correlates among adolescents. The main aim of this report is to provide a synthesis of the research process and challenges faced in completing the first population-based mental health survey among children and adolescents in Lebanon...
October 10, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
Mattia Pia Arena, Vittorio Capozzi, Pasquale Russo, Djamel Drider, Giuseppe Spano, Daniela Fiocco
There is an error in the original publication of this paper. The incorrect author name was captured as "Djamel Dridier" instead of "Djamel Drider". The original article has been corrected.
October 17, 2018: Applied Microbiology and Biotechnology
Emma Rapposelli, Maria Pia Rigoldi, Daniela Satta, Donatella Delpiano, Sara Secci, Andrea Porceddu
BACKGROUND: Recent nutritional and medical studies have associated the regular consumption of almonds with a wide range of health benefits. As a consequence, kernel quality has become an important goal for breeding, considering not only the chemical composition conferring a specific organoleptic quality but also physical traits related to industrial processing. METHODS: We characterized an almond collection from Sardinia through analysis of 13 morpho-physiological traits and eight essential oil profiles...
October 15, 2018: Plants (Basel, Switzerland)
Ellinor Tengelin, Pia H Bülow, Ina Berndtsson, Elisabeth Dahlborg Lyckhage
The documents and literature that regulate nursing education are based on certain values and knowledge, and the underlying power in the curriculum raises the question of how health care professionals are molded during the course of their education. Norm criticism is a concept with its roots in critical pedagogy and gender and queer studies, emphasizing the origins as well as the consequences of marginalization, power, and knowledge of what is generally accepted as "normal" and "true." Norm criticism is used in this article to analyze the documents and literature underlying a nursing program in Sweden, which are shown to include a sometimes politically correct rhetoric, but one lacking a firm basis in social justice values...
October 13, 2018: ANS. Advances in Nursing Science
Claudia Maria Hattinger, Maria Pia Patrizio, Elisa Tavanti, Silvia Luppi, Federica Magagnoli, Piero Picci, Massimo Serra
Genetic characterization of osteosarcoma has evolved during the last decade, thanks to the integrated application of conventional and new candidate-driven and genome-wide technologies. Areas covered: This review provides an overview of the state of art in genetic testing applied to osteosarcoma, with particular regard to novel candidate genetic biomarkers that can be analyzed in tumor tissue and blood samples, which might be used to predict toxicity and prognosis, detect disease relapse, and improve patients' selection criteria for tailoring treatment...
October 16, 2018: Expert Review of Molecular Diagnostics
Pía Simonetti, Sandra Elizabeth Botté, Jorge Eduardo Marcovecchio
An extensive population of the burrowing crab, Neohelice granulata, inhabits the intertidal areas of the Bahía Blanca estuary, a moderately polluted temperate ecosystem located to the southwest of the province of Buenos Aires, Argentina. In order to determine the metal-accumulating ability of this species, concentrations of Cd, Cu, Pb, Ni, Zn, Mn, Cr, and Fe in soft tissues of adult specimens were measured. Subsequently, the bioconcentration factors (BCFs) of all heavy metals were determined using levels of concentrations previously obtained in intertidal sediments...
October 15, 2018: Environmental Science and Pollution Research International
Maria Pia Sormani, Nicola De Stefano, Gavin Giovannoni, Dawn Langdon, Daniela Piani-Meier, Dieter A Haering, Ludwig Kappos, Davorka Tomic
OBJECTIVE: To assess the prognostic value of practice effect on Paced Auditory Serial Addition Test (PASAT) in multiple sclerosis. METHODS: We compared screening (day -14) and baseline (day 0) PASAT scores of 1009 patients from the FTY720 Research Evaluating Effects of Daily Oral therapy in Multiple Sclerosis (FREEDOMS) trial. We grouped patients into high and low learners if their PASAT score change was above or below the median change in their screening PASAT quartile group...
October 15, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Andrea Gabusi, Davide Bartolomeo Gissi, Achille Tarsitano, Sofia Asioli, Claudio Marchetti, Lucio Montebugnoli, Maria Pia Foschini, Luca Morandi
PURPOSE: Improvements in sequencing technologies have shown that genetic differences among neoplastic cells can reflect clonal expansion. Intratumor heterogeneity (ITH) has been suggested to explain differences in prognosis and treatment response, indicating that personalized medicine is the goal of the future. This study evaluated ITH in 5 patients with recurrent metastatic oral squamous cell carcinoma (OSCC) and tracked the evolution from non-neoplastic tissue to neoplastic events developing after primary tumor formation...
September 20, 2018: Journal of Oral and Maxillofacial Surgery
Amy L Nelson, Lauren Bradley, Pia D M MacDonald
Globally, public health practitioners are called upon to respond quickly and capably to mitigate a variety of immediate and incipient threats to the health of their communities, which often requires additional training in new or updated methodologies or epidemiologic phenomena. Competing public health priorities and limited training resources can present challenges in developed and developing countries alike. Training provided to front-line public health workers by ministries of health, donors and/or partner organizations should be delivered in a way that is effective, adaptable to local conditions and culture, and should be an experience perceived as a job benefit...
2018: Frontiers in Public Health
Andrea Carolina Torres, Verónica Vannini, Graciela Font, Lucila Saavedra, María Pía Taranto
Vitamin B12 or cobalamin is an essential metabolite for humans, which makes it an interesting compound for many research groups that focus in different producer-strains synthesis pathways. In this work, we report the influence of key intermediaries for cobalamin synthesis added to the culture medium in two Lactobacillus ( L. ) strains, L. reuteri CRL 1098 and L. coryniformis CRL 1001. Here, we report that addition of Co2+ and 5,6-dimethylbenzimidazole increased the corrinoid compounds production in both strains while addition of L-threonine increased only the corrinoid compounds production by CRL 1001 strain...
2018: Frontiers in Microbiology
Sandra Kuehn, Wilhelm Meißner, Pia Grotegut, Carsten Theiss, H Burkhard Dick, Stephanie C Joachim
The glial protein S100B, which belongs to a calcium binding protein family, is up-regulated in neurological diseases, like multiple sclerosis or glaucoma. In previous studies, S100B immunization led to retinal ganglion cell (RGC) loss in an experimental autoimmune glaucoma (EAG) model. Now, the direct degenerative impact of S100B on the retina and optic nerve was evaluated. Therefore, 2 μl of S100B was intravitreally injected in two concentrations (0.2 and 0.5 μg/μl). At day 3, 14 and 21, retinal neurons, such as RGCs, amacrine and bipolar cells, as well as apoptotic mechanisms were analyzed...
2018: Frontiers in Cellular Neuroscience
Conrad S Brimacombe, Kevin L Kuykendall, Pia Nystrom
OBJECTIVES: Compared with frequent studies of skeletal development in chimpanzees, relatively little is known about bonobo skeletal development. This study seeks to explore the relationship between skeletal and dental development in both species of Pan. New data are presented for fusion sites not previously observed in bonobos. MATERIALS AND METHODS: In a sample of 34 Pan paniscus and 168 Pan troglodytes subadults, state of fusion was recorded for 30 epiphyseal fusion sites using a three-stage system of unfused, midfusion, and complete fusion based on Wintheiser, Clauser, and Tappen...
October 14, 2018: American Journal of Physical Anthropology
Aaydha C Vinayaka, Tien A Ngo, Krishna Kant, Pia Engelsmann, Vivek P Dave, Mohammad-Ali Shahbazi, Anders Wolff, Dang D Bang
Foodborne salmonellosis remains a major economic burden worldwide and particularly for food industries. The diverse and complexity of food matrices pose great challenges for rapid and ultra-sensitive detection of Salmonella in food samples. In this study, combination of pathogen pre-concentration with rapid molecular identification is presented to overcome these challenges. This combination enabled effective real-time PCR detection of low levels of Salmonella enterica serovar Typhimurium without culture enrichment...
September 26, 2018: Biosensors & Bioelectronics
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