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Pia Paffenholz, Katharina Grein, Isabel Heidegger, Tim Nestler, Markus Grabbert, Johannes Salem, Martin Hellmich, David Pfister, Axel Heidenreich
PURPOSE: To identify potential risk factors for the development of venous thromboembolic events in testicular cancer patients receiving platinum-based chemotherapy. METHODS: We performed a retrospective analysis including 255 patients with testicular germ cell tumors who received platinum-based chemotherapy from 2003 to 2018 as a multi-center observational cohort study. Patient and tumor characteristics of patients with and without a thromboembolic event were analyzed...
December 13, 2018: World Journal of Urology
Mohamad Nasser, Pia Chedid, Ali Salami, Mariam Khalifeh, Said El Shamieh, Wissam H Joumaa
Rapid growing of mobile phones users has raised about the possible effects of these electromagnetic waves (EMW) on human health. Many studies have examined the role of these EMW on biological systems, but the results are still contradictory and controversial. In addition to EMW, over-activation of angiotensin type 1 receptor (AT1R) has been associated with cognitive decline, incidence and progression of neurodegenerative diseases. Candesartan, an AT1R blocker, is well recognized for treatment of hypertension...
December 2018: Data in Brief
Adrian Schmalen, Julia Karius-Fischer, Pia Rauch, Christian Setz, Klaus Korn, Petra Henklein, Torgils Fossen, Ulrich Schubert
As part of the Pr55Gag polyprotein, p6 fulfills an essential role in the late steps of the replication cycle. However, almost nothing is known about the functions of the mature HIV-1 p6 protein. Recently, we showed that p6 is a bona fide substrate of the insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease. This phenomenon appears to be specific for HIV-1, since p6 homologs of HIV-2, SIV and EIAV were IDE-insensitive. Furthermore, abrogation of the IDE-mediated degradation of p6 reduces the replication capacity of HIV-1 in an Env-dependent manner...
December 12, 2018: Viruses
Paul Georg Werthmann, Pia Inter, Thilo Welsch, Anne-Kathrin Sturm, Robert Grützmann, Markus Debus, Martin-Günther Sterner, Gunver Sophia Kienle
RATIONALE: Metastatic pancreatic cancer has a dismal prognosis. Many patients seek integrative care as an add-on to their conventional cancer treatment. Viscum album extracts (VAE)-widely used as an adjunct to cancer treatment-have cytotoxic, apoptogenic, and immune stimulatory properties. A statistically significant survival benefit has been demonstrated for VAE in advanced pancreatic cancer. PATIENT CONCERNS AND DIAGNOSIS: A 28-year old patient presented with painless jaundice and was subsequently diagnosed as pancreatic adenocarcinoma with liver metastases...
December 2018: Medicine (Baltimore)
Pia M Jungmann, Alexandra S Gersing, Frederic Baumann, Christian Holwein, Sepp Braun, Jan Neumann, Julia Zarnowski, Felix C Hofmann, Andreas B Imhoff, Ernst J Rummeny, Thomas M Link
PURPOSE: To investigate, whether cartilage repair surgery for focal osteochondral defects at the knee results in less degenerative changes over 6 years in a MR imaging follow-up than morphologically initially identical defects in non-operated control subjects from the osteoarthritis initiative (OAI). METHODS: A total of 32 individuals received baseline and follow-up MRI. In n = 16 patients with cartilage repair [osteochondral autograft transfer system (OATS), n = 12; spongiosa-augmented matrix-associated autologous chondrocyte implantation (MACI), n = 4] MRI was performed preoperatively and after 5...
December 12, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Verônica O Alvarenga, Fernanda B Campagnollo, Arthur K R Pia, Deborah A Conceição, Yuri Abud, Celso Sant'Anna, Miriam D Hubinger, Anderson S Sant'Ana
[This corrects the article on p. 1113 in vol. 9, PMID: 29904375.].
2018: Frontiers in Microbiology
Charles J Ferro, Patrick B Mark, Mehmet Kanbay, Pantelis Sarafidis, Gunnar H Heine, Patrick Rossignol, Ziad A Massy, Francesca Mallamaci, Jose M Valdivielso, Jolanta Malyszko, Marianne C Verhaar, Robert Ekart, Raymond Vanholder, Gerard London, Alberto Ortiz, Carmine Zoccali
In the acknowledgements section of this article as originally published, information on the authors' roles as EURECAm members is missing. The correct acknowledgement is as follows: "This Review was planned as part of the activity of the European Renal and Cardiovascular Medicine working (EURECAm) group and all authors are EURECAm members. A.O.'s work was supported by Spanish Government ISCIII FEDER funds (PI16/02057, ISCIII-RETIC REDinREN RD16/0009) and Community of Madrid (B2017/BMD-3686 CIFRA2-CM). P...
December 11, 2018: Nature Reviews. Nephrology
Denny Vågerö, Pia R Pinger, Vanda Aronsson, Gerard J van den Berg
Studies of animals and plants suggest that nutritional conditions in one generation may affect phenotypic characteristics in subsequent generations. A small number of human studies claim to show that pre-pubertal nutritional experience trigger a sex-specific transgenerational response along the male line. A single historical dataset, the Överkalix cohorts in northern Sweden, is often quoted as evidence. To test this hypothesis on an almost 40 times larger dataset we collect harvest data during the pre-pubertal period of grandparents (G0, n = 9,039) to examine its potential association with mortality in children (G1, n = 7,280) and grandchildren (G2, n = 11,561) in the Uppsala Multigeneration Study...
December 11, 2018: Nature Communications
Chiara V Colombo, Luca Menin, Riccardo Ranieri, Diego Bonetti, Michela Clerici, Maria Pia Longhese
The Mre11-Rad50-Xrs2 (MRX) complex acts together with the Sae2 protein to initiate resection of DNA double-strand breaks (DSBs) and to regulate a checkpoint response that couples cell cycle progression with DSB repair. Sae2 supports resistance to DNA damage and downregulates the signalling activities of MRX, Tel1 and Rad53 checkpoint proteins at the sites of damage. How these functions are connected to each other is not known. Here, we describe the separation-of-function sae2-ms mutant that, similar to SAE2 deletion, upregulates MRX and Tel1 signalling activities at DSBs by reducing Mre11 endonuclease activity...
December 11, 2018: Genetics
Boris Zernikow, Katharina Szybalski, Bettina Hübner-Möhler, Julia Wager, Michael Paulussen, Lisa Lassay, Norbert Jorch, Carola Weber, Dominik T Schneider, Gisela Janßen, Prasad T Oommen, Michaela Kuhlen, Thomas Brune, Regina Wieland, Michael Schündeln, Bernhard Kremens, Alfred Längler, Aram Prokop, Rita Kiener, Tim Niehues, Martina Rose, Margit Baumann-Köhler, Monika Pöppelmann, Heike Thorer, Martin Irnich, Kumar Sinha, Joanne Wolfe, Pia Schmidt
BACKGROUND: About one quarter of children affected with cancer die. For children and their families, the end-of-life period is highly distressing. AIM: This study focused on how end-of-life care in pediatric cancer patients changed over a period of 10 years and if changes in pediatric palliative care structures were associated with quality of care. DESIGN: Over a 10-year period, all pediatric oncology departments in one German federal state were invited to participate in a repeated cross-sectional cohort study at three time-points (2005, 2010, 2015)...
December 12, 2018: Palliative Medicine
Regina Kropatsch, Helena M Schmidt, Pia Buttkereit, Jörg T Epplen, Sabine Hoffjan
No abstract text is available yet for this article.
December 7, 2018: Muscle & Nerve
Jeroen J Smits, Jaap Oostrik, Andy J Beynon, Sarina G Kant, Pia A M de Koning Gans, Liselotte J C Rotteveel, Jolien S Klein Wassink-Ruiter, Rolien H Free, Saskia M Maas, Jiddeke van de Kamp, Paul Merkus, Wouter Koole, Ilse Feenstra, Ronald J C Admiraal, Cornelis P Lanting, Margit Schraders, Helger G Yntema, Ronald J E Pennings, Hannie Kremer
ATP2B2 encodes the PMCA2 Ca2+ pump that plays an important role in maintaining ion homeostasis in hair cells among others by extrusion of Ca2+ from the stereocilia to the endolymph. Several mouse models have been described for this gene; mice heterozygous for loss-of-function defects display a rapidly progressive high-frequency hearing impairment. Up to now ATP2B2 has only been reported as a modifier, or in a digenic mechanism with CDH23 for hearing impairment in humans. Whole exome sequencing in hearing impaired index cases of Dutch and Polish origins revealed five novel heterozygous (predicted to be) loss-of-function variants of ATP2B2...
December 8, 2018: Human Genetics
Thomas M H Hope, Karl Friston, Cathy J Price, Alex P Leff, Pia Rotshtein, Howard Bowman
The proportional recovery rule asserts that most stroke survivors recover a fixed proportion of lost function. To the extent that this is true, recovery from stroke can be predicted accurately from baseline measures of acute post-stroke impairment alone. Reports that baseline scores explain more than 80%, and sometimes more than 90%, of the variance in the patients' recoveries, are rapidly accumulating. Here, we show that these headline effect sizes are likely inflated. The key effects in this literature are typically expressed as, or reducible to, correlation coefficients between baseline scores and recovery (outcome scores minus baseline scores)...
December 7, 2018: Brain: a Journal of Neurology
María Pía Martínez Marín, Ismael Gallardo Cuadra
Advances in cardiovascular diseases research have shown that there are differences in social groups, which have been solely explained by biomedical dimensions. Although there have been advances in the biological understanding of these diseases, they do not account for the complexity of the phenomenon. To address this, the introduction of psychosocial variables have shown that they may be useful to understand the manifestations and evolution of these conditions. Thus, gender gaps should not be studied exclusively from a biomedical perspective...
August 2018: Revista Médica de Chile
Sara Louise Dahl, Joshua S Woodworth, Christian Johann Lerche, Elisabeth Præstekjær Cramer, Pia Rude Nielsen, Claus Moser, Allan Randrup Thomsen, Niels Borregaard, Jack Bernard Cowland
Lipocalin-2 is a constituent of the neutrophil secondary granules and is expressed de novo by macrophages and epithelium in response to inflammation. Lipocalin-2 acts in a bacteriostatic fashion by binding iron-loaded siderophores required for bacterial growth. Mycobacterium tuberculosis (M.tb) produces siderophores that can be bound by lipocalin-2. The impact of lipocalin-2 in the innate immune response toward extracellular bacteria has been established whereas the effect on intracellular bacteria, such as M...
2018: Frontiers in Immunology
Pia Thisted Dinesen, Thomas Andersen Rix, Albert Marni Joensen, Christina Cathrine Dahm, Søren Lundbye-Christensen, Erik Berg Schmidt, Kim Overvad
Fatty acids in adipose tissue share dietary sources and metabolic pathways and therefore occur in patterns. The aim of the present study was to investigate the association between adipose tissue fatty acid patterns identified by the data-driven dimension-reducing method treelet transform and the risk of atrial fibrillation. A total of 57,053 Danish men and women aged 50-64 years participating in the Diet, Cancer and Health cohort had an adipose tissue biopsy taken at baseline. During a median follow-up of 14...
2018: PloS One
Brendan A Wintle, Heini Kujala, Amy Whitehead, Alison Cameron, Sam Veloz, Aija Kukkala, Atte Moilanen, Ascelin Gordon, Pia E Lentini, Natasha C R Cadenhead, Sarah A Bekessy
Island biogeography theory posits that species richness increases with island size and decreases with isolation. This logic underpins much conservation policy and regulation, with preference given to conserving large, highly connected areas, and relative ambivalence shown toward protecting small, isolated habitat patches. We undertook a global synthesis of the relationship between the conservation value of habitat patches and their size and isolation, based on 31 systematic conservation planning studies across four continents...
December 10, 2018: Proceedings of the National Academy of Sciences of the United States of America
Ian M Frayling, Victor-Felix Mautner, Rick van Minkelen, Roope A Kallionpaa, Safiye Aktaş, Diana Baralle, Shay Ben-Shachar, Alison Callaway, Harriet Cox, Diana M Eccles, Salah Ferkal, Holly LaDuca, Conxi Lázaro, Mark T Rogers, Aaron J Stuenkel, Pia Summerour, Ali Varan, Yoon Sim Yap, Ouidad Zehou, Juha Peltonen, Gareth D Evans, Pierre Wolkenstein, Meena Upadhyaya
BACKGROUND: Neurofibromatosis type 1 (NF1) predisposes to breast cancer (BC), but no genotype-phenotype correlations have been described. METHODS: Constitutional NF1 mutations in 78 patients with NF1 with BC (NF1-BC) were compared with the NF1 Leiden Open Variation Database (n=3432). RESULTS: No cases were observed with whole or partial gene deletions (HR 0.10; 95% CI 0.006 to 1.63; p=0.014, Fisher's exact test). There were no gross relationships with mutation position...
December 10, 2018: Journal of Medical Genetics
Alicia Alonso-Jimenez, Rosemarie H M J M Kroon, Aida Alejaldre-Monforte, Claudia Nuñez-Peralta, Corinne G C Horlings, Baziel G M van Engelen, Montse Olivé, Laura González, Enric Verges-Gil, Carmen Paradas, Celedonio Márquez, Matteo Garibaldi, Pía Gallano, Maria José Rodriguez, Lidia Gonzalez-Quereda, Cristina Dominguez Gonzalez, John Vissing, Freja Fornander, Anne-Sofie Vibæk Eisum, Tania García-Sobrino, Julio Pardo, Roberto García-Figueiras, Nuria Muelas, Juan Jesús Vilchez, Solange Kapetanovic, Giorgio Tasca, Mauro Monforte, Enzo Ricci, María Teresa Gomez, Jorge Alfredo Bevilacqua, Jorge Diaz-Jara, Ivonne Ingrid Zamorano, Robert Yves Carlier, Pascal Laforet, Ana Pelayo-Negro, Alba Ramos-Fransi, Amaia Martínez, Chiara Marini-Bettolo, Volker Straub, Gerardo Gutiérrez, María Asunción Martín, Germán Morís, Roberto Fernández-Torrón, Adolfo Lopez De Munaín, Elena Cortes-Vicente, Luis Querol, Ricardo Rojas-García, Isabel Illa, Jordi Diaz-Manera
BACKGROUND AND OBJECTIVE: Oculopharyngeal muscular dystrophy (OPMD) is a genetic disorder caused by an abnormal expansion of GCN triplets within the PABPN1 gene. Previous descriptions have focused on lower limb muscles in small cohorts of patients with OPMD, but larger imaging studies have not been performed. Previous imaging studies have been too small to be able to correlate imaging findings to genetic and clinical data. METHODS: We present cross-sectional, T1-weighted muscle MRI and CT-scan data from 168 patients with genetically confirmed OPMD...
December 8, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Katarzyna Polak-Kraśna, Sandra Robak-Nawrocka, Sylwia Szotek, Marcin Czyż, Daniel Gheek, Celina Pezowicz
BACKGROUND: Damage to the spinal cord is one of the most debilitating pathologies with considerable health, economic and social impact. Improved prevention, treatment and rehabilitation after spinal cord injury (SCI) requires the complex biomechanics of the spinal cord with all its structural elements and the injury mechanism to be understood. This comprehensive understanding will also allow development of models and tools enabling better diagnosis, surgical treatment with increased safety and efficacy and possible development of regenerative therapies...
November 20, 2018: Journal of the Mechanical Behavior of Biomedical Materials
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