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Pia Löwhagen Hendén, Alexandros Rentzos, Jan-Erik Karlsson, Lars Rosengren, Jonatan Oras, Sven-Erik Ricksten
BACKGROUND AND PURPOSE: In the new era of endovascular treatment for acute ischemic stroke, one of the main predictors of good neurological outcome is a short time interval from stroke onset to recanalization of the occluded vessel. In this study, we examined the effect of on-hour vs off-hour admittance on the time intervals from stroke onset to recanalization in patients with acute ischemic stroke (AIS) undergoing endovascular treatment (EVT). METHODS: One-hundred-ninety-eight patients receiving EVT for anterior AIS between 2007 and 2016 were included...
August 16, 2018: Acta Anaesthesiologica Scandinavica
Angela Pia Cazzolla, Graziano Montaruli, Nunzio Francesco Testa, Gianfranco Favia, Maria Grazia Lacaita, Lorenzo Lo Muzio, Domenico Ciavarella
Background: Mandibular condylar fractures commonly occur after trauma and account for 25 to 35% of all mandibular fractures; its appropriate therapy still remains a point of controversy in children. The purpose of this paper is to describe the treatment of an 11-years-old male patient affected by neck-condylar fracture as result of trauma in evolutive age. Methods: No surgical treatment was performed. A functional therapy was applied with a jaw splint. A closed treatment for mandibular condyle fractures was preferred because the amount of condylar displacement wasn't considerable...
April 2018: Journal of Oral & Maxillofacial Research
Ernesto Guerra, Pia Knoeferle
[This corrects the article DOI: 10.3389/fpsyg.2018.00718.].
2018: Frontiers in Psychology
Iuliana Vaxman, Daniel Shepshelovich, Lucille Hayman, Pia Raanani, Meir Lahav
Currently, there are only 2 case reports of Waldenström macroglobulinemia (WM) associated with severe neutropenia. This is a case report of a woman with a past medical history of WM who presented with neutropenic fever. The patient's febrile neutropenia resolved after RCD chemotherapy (cyclophosphamide 750 mg/m2, dexamethasone 20 mg, and rituximab 375 mg/m2). Fourteen days after administration, the neutrophil level had started to rise and normalized after 6 days. To the best of our knowledge, this is the 3rd reported case of agranulocytosis due to WM...
August 16, 2018: Acta Haematologica
Jaime-Jürgen Eulert-Grehn, Pia Lanmüller, Felix Schönrath, Natalia Solowjowa, Marcus Müller, Johanna Mulzer, Friedrich Kaufmann, Christoph Starck, Thomas Krabatsch, Volkmar Falk, Evgenij Potapov
OBJECTIVES: No continuous-flow right ventricular assist device for long-term support is available at the moment. Two continuous-flow ventricular assist devices used in a continuous-flow biventricular assist device configuration is an emerging option which has proven its feasibility but still is not approved for routine use. We present our technique and results of modifying the left ventricular assist device and making it suitable for right ventricular support. METHODS: Between September 2009 and October 2017, 39 patients received implantation of a continuous-flow ventricular assist device for right ventricular support in a continuous-flow biventricular assist device configuration...
August 2, 2018: Interactive Cardiovascular and Thoracic Surgery
Inga C Teller, Heike Hoyer-Kuhn, Hella Brönneke, Pia Nosthoff-Horstmann, Annemarie Oosting, Gregor Lippach, Maria Wohlfarth, Manfred Rauh, Eline M van der Beek, Jörg Dötsch, Kai D Nüsken
Intra-uterine growth restriction (IUGR) is associated with adverse metabolic outcome later in life. Healthy mice challenged with a Western-style diet (WSD) accumulated less body fat when previously fed a diet containing large lipid globules (complex lipid matrix (CLM)). This study was designed to clarify whether an early-life CLM diet mitigates 'programmed' visceral adiposity and associated metabolic sequelae after IUGR. In rats, IUGR was induced either by bilateral uterine vessel ligation (LIG) or sham operation (i...
August 15, 2018: British Journal of Nutrition
Anders Emanuelsen, Michael Voigt, Pascal Madeleine, Pia Kjær, Sebastian Dam, Nikolaj Koefoed, Ernst A Hansen
Voluntary rhythmic movements, such as, for example, locomotion and other cyclic tasks, are fundamental during everyday life. Patients with impaired neural or motor function often take part in rehabilitation programs, which include rhythmic movements. Therefore, it is imperative to have the best possible understanding of control and behaviour of human voluntary rhythmic movements. A behavioural phenomenon termed repeated bout rate enhancement has been established as an increase of the freely chosen index finger tapping frequency during the second of two consecutive tapping bouts...
2018: Frontiers in Neuroscience
Johanna Kondelin, Kari Salokas, Lilli Saarinen, Kristian Ovaska, Heli Rauanheimo, Roosa-Maria Plaketti, Jiri Hamberg, Xiaonan Liu, Leena Yadav, Alexandra E Gylfe, Tatiana Cajuso, Ulrika A Hänninen, Kimmo Palin, Heikki Ristolainen, Riku Katainen, Eevi Kaasinen, Tomas Tanskanen, Mervi Aavikko, Minna Taipale, Jussi Taipale, Laura Renkonen-Sinisalo, Anna Lepistö, Selja Koskensalo, Jan Böhm, Jukka-Pekka Mecklin, Halit Ongen, Emmanouil T Dermitzakis, Outi Kilpivaara, Pia Vahteristo, Mikko Turunen, Sampsa Hautaniemi, Sari Tuupanen, Auli Karhu, Niko Välimäki, Markku Varjosalo, Esa Pitkänen, Lauri A Aaltonen
Microsatellite instability (MSI) leads to accumulation of an excessive number of mutations in the genome, mostly small insertions and deletions. MSI colorectal cancers (CRCs), however, also contain more point mutations than microsatellite-stable (MSS) tumors, yet they have not been as comprehensively studied. To identify candidate driver genes affected by point mutations in MSI CRC, we ranked genes based on mutation significance while correcting for replication timing and gene expression utilizing an algorithm, MutSigCV Somatic point mutation data from the exome kit-targeted area from 24 exome-sequenced sporadic MSI CRCs and respective normals, and 12 whole-genome-sequenced sporadic MSI CRCs and respective normals were utilized...
August 14, 2018: EMBO Molecular Medicine
Antal Martinecz, Pia Abel Zur Wiesch
Treatment of infectious diseases is often long and requires patients to take drugs even after they have seemingly recovered. This is because of a phenomenon called persistence, which allows small fractions of the bacterial population to survive treatment despite being genetically susceptible. The surviving subpopulation is often below detection limit and therefore is empirically inaccessible but can cause treatment failure when treatment is terminated prematurely. Mathematical models could aid in predicting bacterial survival and thereby determine sufficient treatment length...
August 9, 2018: Pathogens and Disease
Martina Pesaresi, Ruben Sebastian-Perez, Maria Pia Cosma
Regenerative capacities vary enormously across the animal kingdom. In contrast to most cold-blooded vertebrates, mammals, including humans, have very limited regenerative capacity when it comes to repairing damaged or degenerating tissues. Here, we review the main mechanisms of tissue regeneration, underlying the importance of cell dedifferentiation and reprogramming. We discuss the significance of cell fate and identity changes in the context of regenerative medicine, with a particular focus on strategies aiming at the promotion of the body's self-repairing mechanisms...
August 13, 2018: FEBS Journal
Pia M Mauro, Julian Santaella-Tenorio, Alexander S Perlmutter, Deborah S Hasin, Christine M Mauro, Silvia S Martins
BACKGROUND: Studies have found age-specific effects of medical cannabis laws (MCLs), particularly affecting adult cannabis use but not adolescent use. We examined whether age differences in MCL knowledge are in accordance with age differences in MCL effects on cannabis use. METHODS: Data from the 2004-2013 repeated cross-sectional National Surveys on Drug Use and Health included people ages 12 and older in the United States. State-aggregated MCL knowledge was the proportion of people that correctly identified living in a state that did not allow medical cannabis prior to MCL enactment, or that allowed medical cannabis after MCL enactment...
July 30, 2018: Addictive Behaviors
Elena Sticchi, Betti Giusti, Antonella Cordisco, Anna Maria Gori, Alice Sereni, Francesco Sofi, Fabio Mori, Stefania Colonna, Maria Pia Fugazzaro, Guglielmina Pepe, Stefano Nistri, Rossella Marcucci
Hemodynamic valvular impairment is a frequent determinant of the natural history of bicuspid aortic valve (BAV). The role of elevated Lp(a) levels and LPA Kringle IV type 2 (KIV-2) size polymorphism in influencing aortic valve calcification and stenosis development in patients with tricuspid aortic valve was recognized. In this study, we investigate the association between Lp(a) and LPA KIV-2 repeat number, and the presence of calcification and stenosis in BAV patients. Sixty-nine patients [79.7% males; median age 45(30-53) yrs], consecutively referred to Center for Cardiovascular Diagnosis or Referral Center for Marfan syndrome or related disorders, AOU Careggi, from June to November 2014, were investigated...
August 11, 2018: Internal and Emergency Medicine
Min Ju Park, Hailian Shen, Nam Hee Kim, Fangjian Gao, Courtney Failor, Jennifer F Knudtson, Jessica McLaughlin, Sunil K Halder, Tuomas A Heikkinen, Pia Vahteristo, Ayman Al-Hendy, Robert S Schenken, Thomas G Boyer
Context: Mutations in the gene encoding Mediator complex subunit MED12 are dominant drivers of uterine fibroids (UFs) in women of diverse racial and ethnic origins. Previously, we showed that UF-linked mutations in MED12 disrupt its ability to activate Cyclin C-CDK8/19 in Mediator. However, validation of Mediator kinase disruption in the clinically relevant setting of MED12-mutant UFs is currently lacking. Objective: The objective of this study was two-fold. First, to extend the ethnic distribution profile of MED12 mutations by establishing their frequency in UFs from Hispanic women of South Texas...
August 6, 2018: Journal of Clinical Endocrinology and Metabolism
Jeff Ollerton, Sigrid Liede-Schumann, Mary E Endress, Ulrich Meve, André Rodrigo Rech, Adam Shuttleworth, Héctor A Keller, Mark Fishbein, Leonardo O Alvarado-Cárdenas, Felipe W Amorim, Peter Bernhardt, Ferhat Celep, Yolanda Chirango, Fidel Chiriboga-Arroyo, Laure Civeyrel, Andrea Cocucci, Louise Cranmer, Inara Carolina da Silva-Batista, Linde de Jager, Mariana Scaramussa Deprá, Arthur Domingos-Melo, Courtney Dvorsky, Kayna Agostini, Leandro Freitas, Maria Cristina Gaglianone, Leo Galetto, Mike Gilbert, Ixchel González-Ramírez, Pablo Gorostiague, David Goyder, Leandro Hachuy-Filho, Annemarie Heiduk, Aaron Howard, Gretchen Ionta, Sofia C Islas-Hernández, Steven D Johnson, Lize Joubert, Christopher N Kaiser-Bunbury, Susan Kephart, Aroonrat Kidyoo, Suzanne Koptur, Cristiana Koschnitzke, Ellen Lamborn, Tatyana Livshultz, Isabel Cristina Machado, Salvador Marino, Lumi Mema, Ko Mochizuki, Leonor Patrícia Cerdeira Morellato, Chediel K Mrisha, Evalyne W Muiruri, Naoyuki Nakahama, Viviany Teixeira Nascimento, Clive Nuttman, Paulo Eugenio Oliveira, Craig I Peter, Sachin Punekar, Nicole Rafferty, Alessandro Rapini, Zong-Xin Ren, Claudia I Rodríguez-Flores, Liliana Rosero, Shoko Sakai, Marlies Sazima, Sandy-Lynn Steenhuisen, Ching-Wen Tan, Carolina Torres, Kristian Trøjelsgaard, Atushi Ushimaru, Milene Faria Vieira, Ana Pía Wiemer, Tadashi Yamashiro, Tarcila Nadia, Joel Queiroz, Zelma Quirino
Background and Aims: Large clades of angiosperms are often characterized by diverse interactions with pollinators, but how these pollination systems are structured phylogenetically and biogeographically is still uncertain for most families. Apocynaceae is a clade of >5300 species with a worldwide distribution. A database representing >10 % of species in the family was used to explore the diversity of pollinators and evolutionary shifts in pollination systems across major clades and regions...
August 7, 2018: Annals of Botany
Ruth Elisa Eyl, Lena Koch-Gallenkamp, Lina Jansen, Viola Walter, Prudence Carr, Michael Hoffmeister, Jenny Chang-Claude, Hermann Brenner, Volker Arndt
PURPOSE: Since physical activity (PA) has been shown to be associated with better prognosis and quality of life (QOL) in colorectal cancer (CRC) patients, this study focuses on the barriers of PA among CRC survivors. METHODS: This study is based on a population-based study from Germany of 1343 women and men, diagnosed with CRC between 2003 and 2008 and being alive five years later. Multivariable logistic regression was used to explore associations between baseline as well as five-year follow-up (5YFU) characteristics and physical inactivity (PIA) at 5YFU...
August 10, 2018: Journal of Cancer Survivorship: Research and Practice
Ana Díez-Izquierdo, Pia Cassanello-Peñarroya, Cristina Lidón-Moyano, Nuria Matilla-Santander, Albert Balaguer, Jose M Martínez-Sánchez
OBJECTIVE: The objective of this study is to perform a comprehensive review of the literature about thirdhand smoke (THS). METHODS: Systematic review of all aspects of THS. Standard methodological procedures were used to search the following databases through April 2018: MEDLINE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science (WOS) in Indo-European languages. To identify published grey literature, the first 200 hits from Google Scholar™ were evaluated...
July 11, 2018: Environmental Research
Pia Sander, Aleksandra Markovic, Marc Schmidtmann, Oliver Janka, Gunther Wittstock, Rüdiger Beckhaus
Trinuclear titanium complexes coordinated by one ligand with three coordination sites have shown properties of mixed valency and a high number of reversible redox steps. Herein we report on the hexaphenyl-substituted derivative (Cp2 Ti)3 (μ3 -HATNPh6 ) (2). On reaction of 2 with the ferrocenium salt [Cp2 Fe]BF4 , the cationic complexes [(Cp2 Ti)3 (μ3 -HATNPh6 )] n+ ( n = 1-3; 3-5) become available in a selective way. Cyclic voltammograms show 10 reversible redox states of the trinuclear species 2 without decomposition...
August 10, 2018: Inorganic Chemistry
Jens R Eriksen, Pia Munk-Madsen, Henrik Kehlet, Ismail Gögenur
BACKGROUND: Orthostatic hypotension (OH) and intolerance (OI) are common findings in the early postoperative period after major surgery and may delay early mobilization. The mechanism of impaired orthostatic competence and OI symptoms is not fully understood, and specific data after colorectal surgery with well-defined perioperative care regimens and mobilization protocols are lacking. The aim of this study was to investigate the prevalence, possible risk factors and the impact of OI in patients undergoing elective minimal invasive colorectal cancer resection...
August 10, 2018: Acta Anaesthesiologica Scandinavica
Sebastiano Laquale, Pinarosa Avato, Maria Pia Argentieri, Vincenzo Candido, Michele Perniola, Trifone D'Addabbo
This study was aimed to investigate the activity of the Asteraceae species Taraxacum officinale against the root-knot nematode Meloidogyne incognita. Leaf and root extracts of T. officinale were tested in vitro at a range of 62.5-1000 and 250-1000 μg mL-1 concentrations on nematode juveniles and eggs, respectively, whereas treatments with 10-40 g kg-1 soil rates of dry leaf and root T. officinale biomass were applied to soil infested by M. incognita in greenhouse experiments on potted tomato. Peak 36 and 50% juvenile mortality and 14...
August 9, 2018: Environmental Science and Pollution Research International
Premashis Manna, Sheng-Ting Hung, Srijit Mukherjee, Pia Friis, David M Simpson, Maria N Lo, Amy E Palmer, Ralph Jimenez
Green fluorescent proteins (GFP) and their blue, cyan and red counterparts offer unprecedented advantages as biological markers owing to their genetic encodability and straightforward expression in different organisms. Although significant advancements have been made towards engineering the key photo-physical properties of red fluorescent proteins (RFPs), they continue to perform sub-optimally relative to GFP variants. Advanced engineering strategies are needed for further evolution of RFPs in the pursuit of improving their photo-physics...
August 10, 2018: Integrative Biology: Quantitative Biosciences From Nano to Macro
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