Sheldon E Litwin, Jan Komtebedde, Mo Hu, Daniel Burkhoff, Gerd Hasenfuß, Barry A Borlaug, Scott D Solomon, Michael R Zile, Rajeev C Mohan, Rami Khawash, Aaron L Sverdlov, Peter Fail, Eugene S Chung, David M Kaye, John Blair, Jean-Christophe Eicher, Scott L Hummel, Andreas Zirlik, Ralf Westenfeld, Christopher Hayward, Thomas M Gorter, Catherine Demers, Ranjith Shetty, Gregory Lewis, Randall C Starling, Sanjay Patel, Deepak K Gupta, Hakim Morsli, Martin Penicka, Maja Cikes, Finn Gustafsson, Frank E Silvestry, Ethan J Rowin, Donald E Cutlip, Martin B Leon, Dalane W Kitzman, Franz X Kleber, Sanjiv J Shah
BACKGROUND: Many patients with heart failure and preserved ejection fraction have no overt volume overload and normal resting left atrial (LA) pressure. OBJECTIVES: This study sought to characterize patients with normal resting LA pressure (pulmonary capillary wedge pressure [PCWP] <15 mm Hg) but exercise-induced left atrial hypertension (EILAH). METHODS: The REDUCE LAP-HF II (A Study to Evaluate the Corvia Medical, Inc. IASD System II to Reduce Elevated Left Atrial Pressure in Patients With Heart Failure) trial randomized 626 patients with ejection fraction ≥40% and exercise PCWP ≥25 mm Hg to atrial shunt or sham procedure...
August 2023: JACC. Heart Failure