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atrial fibrillation GERD

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https://www.readbyqxmd.com/read/30093055/immediate-post-procedural-12-lead-electrocardiography-as-predictor-of-late-conduction-defects-after-transcatheter-aortic-valve-replacement
#1
Troels H Jørgensen, Ole De Backer, Thomas A Gerds, Gintautas Bieliauskas, Jesper H Svendsen, Lars Søndergaard
OBJECTIVES: The aim of this study was to use a 12-lead electrocardiogram obtained immediately post-transcatheter aortic valve replacement (TAVR) to identify predictors of late high-degree conduction defect (HD-CD) within 30 days after TAVR. BACKGROUND: There are limited data on risk factors for the development of late HD-CD and the need to retain the temporary pacemaker after TAVR. METHODS: A single-center study was conducted including 467 consecutive patients, without pre-procedural pacemakers, undergoing TAVR...
August 13, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/30045389/thyroid-disorders-and-hemostasis
#2
Laura P B Elbers, Alessandro Squizzato, Victor E A Gerdes
Lower levels of free thyroxine (whether this is endogenous or exogenous) lead to a hypocoagulable state, and higher levels of free thyroxine lead to a hypercoagulable state. In this narrative review, the effects of different levels of thyroid hormones on clinical end points are described. Hypothyroidism is associated with an increased bleeding risk, whereas hyperthyroidism leads to an increased risk of venous thrombosis. Besides, effects of thyroid hormone on the heart may indirectly influence hemostasis. Hyperthyroidism leads to a higher incidence of atrial fibrillation and atrial flutter, and, at least partly by that mechanism, a higher risk of cerebral arterial thrombosis...
July 25, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29983251/differential-multivariable-risk-prediction-of-appropriate-shock-versus-competing-mortality-a-prospective-cohort-study-to-estimate-benefits-from-icd-therapy
#3
Leonard Bergau, Rik Willems, David J Sprenkeler, Thomas H Fischer, Panayota Flevari, Gerd Hasenfuß, Dimitrios Katsaras, Aleksandra Kirova, Stephan E Lehnart, Lars Lüthje, Christian Röver, Joachim Seegers, Samuel Sossalla, Albert Dunnink, Rajevaa Sritharan, Anton E Tuinenburg, Bert Vandenberk, Marc A Vos, Sofieke C Wijers, Tim Friede, Markus Zabel
BACKGROUND AND OBJECTIVE: We prospectively investigated combinations of risk stratifiers including multiple EP diagnostics in a cohort study of ICD patients. METHODS: For 672 enrolled patients, we collected history, LVEF, EP study and T-wave alternans testing, 24-h Holter, NT-proBNP, and the eGFR. All-cause mortality and first appropriate ICD shock were predefined endpoints. RESULTS: The 635 patients included in the final analyses were 63 ± 13 years old, 81% were male, LVEF averaged 40 ± 14%, 20% were inducible at EP study, 63% had a primary prophylactic ICD...
June 28, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29957227/risk-of-myocardial-infarction-in-anticoagulated-patients-with-atrial-fibrillation
#4
Christina Ji-Young Lee, Thomas Alexander Gerds, Nicholas Carlson, Anders Nissen Bonde, Gunnar Hilmar Gislason, Morten Lamberts, Jonas Bjerring Olesen, Jannik Langtved Pallisgaard, Morten Lock Hansen, Christian Torp-Pedersen
BACKGROUND: Evidence is conflicting as to the efficacy of direct oral anticoagulation (DOAC) and vitamin K antagonist (VKA) for prevention of myocardial infarction (MI). OBJECTIVES: This study aimed to investigate the risk of MI associated with the use of apixaban, dabigatran, rivaroxaban, and VKA in patients with atrial fibrillation. METHODS: Patients with atrial fibrillation were identified using Danish health care registers and stratified by initial oral anticoagulant treatment...
July 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29848496/risk-prediction-of-atrial-fibrillation-based-on-electrocardiographic-interatrial-block
#5
Morten W Skov, Jonas Ghouse, Jørgen T Kühl, Pyotr G Platonov, Claus Graff, Andreas Fuchs, Peter V Rasmussen, Adrian Pietersen, Børge G Nordestgaard, Christian Torp-Pedersen, Steen M Hansen, Morten S Olesen, Stig Haunsø, Lars Køber, Thomas A Gerds, Klaus F Kofoed, Jesper H Svendsen, Anders G Holst, Jonas B Nielsen
BACKGROUND: The electrocardiographic interatrial block (IAB) has been associated with atrial fibrillation (AF). We aimed to test whether IAB can improve risk prediction of AF for the individual person. METHODS AND RESULTS: Digital ECGs of 152 759 primary care patients aged 50 to 90 years were collected from 2001 to 2011. We identified individuals with P-wave ≥120 ms and the presence of none, 1, 2, or 3 biphasic P-waves in inferior leads. Data on comorbidity, medication, and outcomes were obtained from nationwide registries...
May 30, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29246425/fatal-attraction-a-brief-pathophysiology-of-the-interaction-between-atrial-fibrillation-and-myocardial-ischemia
#6
Helmut Lieder, Günter Breithardt, Gerd Heusch
Atrial fibrillation and coronary artery disease are highly prevalent diseases in an aging population. They share risk factors and are frequently associated. Beyond their mere association, they impact on each other. The positive feed-back between atrial fibrillation and acute myocardial ischemia involves sympathetic activation and may result in sudden death.
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29191055/recurrence-after-pulmonary-vein-isolation-is-associated-with-low-contact-force
#7
Bawer Jalal Tofig, Peter Lukac, Rune Borregaard, Jan Møller Nielsen, Henrik Kjærulf Jensen, Christian Gerdes, Jens Kristensen, Jens Cosedis Nielsen, Steen Buus Kristiansen
OBJECTIVES: Recurrent arrhythmia after pulmonary vein isolation (PVI) by radiofrequency (RF) ablation in patients with atrial fibrillation (AFIB) remains a significant challenge. Using contact force (CF) sensing ablation catheters, we aimed to identify procedure related parameters associated with recurrence after de-novo PVI in patients with AFIB. METHODS: Consecutive patients undergoing a de-novo PVI procedure (n = 120, 63% paroxysmal and 37% persistent AFIB) employing a force-sensing ablation catheter were included...
February 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29165556/resumption-of-oral-anticoagulation-following-traumatic-injury-and-risk-of-stroke-and-bleeding-in-patients-with-atrial-fibrillation-a-nationwide-cohort-study
#8
Laila Staerk, Emil Loldrup Fosbøl, Morten Lamberts, Anders Nissen Bonde, Kasper Gadsbøll, Caroline Sindet-Pedersen, Ellen A Holm, Thomas Alexander Gerds, Brice Ozenne, Gregory Y H Lip, Christian Torp-Pedersen, Gunnar Hilmar Gislason, Jonas Bjerring Olesen
Aims: We examined the risks of all-cause mortality, stroke, major bleeding, and recurrent traumatic injury associated with resumption of vitamin K antagonists (VKAs) and non-VKAs oral anticoagulants (NOACs) following traumatic injury in atrial fibrillation (AF) patients. Methods and results: This was a Danish nationwide registry-based study (2005-16), including 4541 oral anticoagulant (OAC)-treated AF patients experiencing traumatic injury (defined as traumatic brain injury, hip fracture, or traumatic torso or abdominal injury)...
May 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29134307/objective-evaluation-of-gastroesophageal-reflux-disease-in-patients-with-paroxysmal-atrial-fibrillation
#9
Enia Lucia Coutinho, Fernando A M Herbella, Carlos Alexandre Volponi Lovato, Marco G Patti, Francisco Schlottmann, Angelo Amato Vincenzo de Paola
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Some evidence shows that gastroesophageal reflux disease (GERD) may be a trigger for paroxysmal AF (PAF). Most of the previous studies that correlated GERD and AF used questionnaires to diagnose GERD, not an objective evaluation. This study aims to evaluate in patients with PAF: (a) accuracy of symptoms to diagnose GERD; (b) prevalence of GERD; and (c) temporal correlation between cardiac arrhythmia and reflux...
May 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29092916/use-of-oral-anticoagulants-in-combination-with-antiplatelet-s-in-atrial-fibrillation
#10
Caroline Sindet-Pedersen, Laila Staerk, Morten Lamberts, Thomas Alexander Gerds, Jeffrey S Berger, Anders Nissen Bonde, Jannik Langtved Pallisgaard, Morten Lock Hansen, Christian Torp-Pedersen, Gunnar H Gislason, Jonas Bjerring Olesen
OBJECTIVES: To investigate temporal trends in the use of non-vitamin K oral anticoagulants (NOACs) and vitamin K antagonists (VKAs) in combination with aspirin and/or clopidogrel in patients with atrial fibrillation (AF) following acute myocardial infarction (MI) and/or percutaneous coronary intervention (PCI). METHODS: Using Danish nationwide registries, all patients with AF who survived 30 days after discharge from MI and/or PCI between 22 August 2011 and 30 September 2016 were identified...
June 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28904084/relevance-of-supraventricular-runs-detected-after-cerebral-ischemia
#11
Mark Weber-Krüger, Constanze Lutz, Antonia Zapf, Raoul Stahrenberg, Joachim Seegers, Janin Witzenhausen, Katrin Wasser, Gerd Hasenfuß, Klaus Gröschel, Rolf Wachter
OBJECTIVE: Prolonged ECG monitoring after stroke frequently reveals short paroxysmal atrial fibrillation (pAF) and supraventricular (SV) runs. The minimal duration of atrial fibrillation (AF) required to induce cardioembolism, the relevance of SV runs, and whether short pAF results from cerebral damage itself are currently being debated. We aimed to study the relevance of SV runs and short pAF detected by prolonged Holter ECG after cerebral ischemia during long-term follow-up. METHODS: Analysis is from the prospective Find-AF trial (ISRCTN46104198)...
October 10, 2017: Neurology
https://www.readbyqxmd.com/read/28861925/standard-and-reduced-doses-of-dabigatran-rivaroxaban-and-apixaban-for-stroke-prevention-in-atrial-fibrillation-a-nationwide-cohort-study
#12
L Staerk, T A Gerds, G Y H Lip, B Ozenne, A N Bonde, M Lamberts, E L Fosbøl, C Torp-Pedersen, G H Gislason, J B Olesen
BACKGROUND: Comparative data of non-vitamin K antagonist oral anticoagulants (NOAC) are lacking in patients with atrial fibrillation (AF). OBJECTIVE: We compared effectiveness and safety of standard and reduced dose NOAC in AF patients. METHODS: Using Danish nationwide registries, we included all oral anticoagulant-naïve AF patients who initiated NOAC treatment (2012-2016). Outcome-specific and mortality-specific multiple Cox regressions were combined to compute average treatment effects as 1-year standardized differences in stroke and bleeding risks (g-formula)...
January 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28491580/relation-of-overweight-and-symptomatic-atrial-fibrillation-a-case-report
#13
Gijs E de Maat, Hendyke Z R Gerds-Ploeger, Massimo A Mariani, Isabelle C Van Gelder, Johan Brügemann, Michiel Rienstra
No abstract text is available yet for this article.
September 2015: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/28150508/is-the-knowledge-of-contact-force-beneficial-in-pulmonary-vein-antrum-isolation
#14
RANDOMIZED CONTROLLED TRIAL
Rune Borregaard, Henrik Kjærulf Jensen, Bawer Jalal Tofig, Samuel Alberg Thrysøe, Christian Gerdes, Jens Cosedis Nielsen, Peter Lukac
OBJECTIVE: To investigate the effect of the operator knowing the real-time contact force (CF) on the efficacy of pulmonary vein antrum isolation (PVAI). METHODS: Fifty patients with paroxysmal atrial fibrillation (AF) or short lasting persistent AF were randomized to CF guided PVAI (n = 25) or conventional PVAI (n = 25). In the CF guided group, CF between 10 and 40 g was aimed at. Efficacy of PVAI was measured as reduction in AF burden (AFB) and time to AF recurrence detected by implantable cardiac monitor (ICM), inserted three months before PVAI...
June 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/28134128/atrial-fibrillation-and-sympathovagal-balance-in-patients-with-gastroesophageal-reflux-disease
#15
Mariana Floria, Oana Bărboi, Mihaela Grecu, Cristina Cijevschi Prelipcean, Gheorghe Balan, Vasile Liviu Drug
BACKGROUND/AIMS: Similar autonomic innervation of the esophagus and left atrium with sympathovagal imbalance seems to explain the association between non-valvular atrial fibrillation (AF) and gastroesophageal reflux disease (GERD). We aimed to assess this association via parameters of heart rate variability in time (SDNN) and frequency (low-frequency (LF)/high-frequency (HF) ratio) domains by 24-hour electrocardiographic (ECG) Holter monitoring. MATERIALS AND METHODS: One hundred thirty-five patients were prospectively included by a joint team consisting of a gastroenterologist and a cardiologist on the basis of the patients' complaints...
March 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28028458/risk-of-lung-cancer-in-patients-with-gastro-esophageal-reflux-disease-a-population-based-cohort-study
#16
Chi-Kuei Hsu, Chih-Cheng Lai, Kun Wang, Likwang Chen
This large-scale, controlled cohort study estimated the risks of lung cancer in patients with gastro-esophageal reflux disease (GERD) in Taiwan. We conducted this population-based study using data from the National Health Insurance Research Database of Taiwan during the period from 1997 to 2010. Patients with GERD were diagnosed using endoscopy, and controls were matched to patients with GERD at a ratio of 1:4. We identified 15,412 patients with GERD and 60,957 controls. Compared with the controls, the patients with GERD had higher rates of osteoporosis, diabetes mellitus, asthma, chronic obstructive pulmonary disease, pneumonia, bronchiectasis, depression, anxiety, hypertension, dyslipidemia, chronic liver disease, congestive heart failure, atrial fibrillation, stroke, chronic kidney disease, and coronary artery disease (all P  < ...
2016: PeerJ
https://www.readbyqxmd.com/read/27742807/ischaemic-and-haemorrhagic-stroke-associated-with-non-vitamin-k-antagonist-oral-anticoagulants-and-warfarin-use-in-patients-with-atrial-fibrillation-a-nationwide-cohort-study
#17
MULTICENTER STUDY
Laila Staerk, Emil Loldrup Fosbøl, Gregory Y H Lip, Morten Lamberts, Anders Nissen Bonde, Christian Torp-Pedersen, Brice Ozenne, Thomas Alexander Gerds, Gunnar Hilmar Gislason, Jonas Bjerring Olesen
Background: Non-vitamin K antagonist (VKA) oral anticoagulants (NOACs) are widely used as stroke prophylaxis in non-valvular atrial fibrillation (AF), but comparative data are sparse. Purpose: To compare dabigatran, rivaroxaban, and apixaban vs. VKA and the risk of stroke/thromboembolism (TE) and intracranial bleeding in AF. Methods: Using Danish nationwide registries (2011-15), anticoagulant-naïve AF patients were identified when initiating VKA or an NOAC...
March 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/27650424/antiarrhythmic-effects-of-dantrolene-in-human-diseased-cardiomyocytes
#18
Nico Hartmann, Steffen Pabel, Jonas Herting, Felix Schatter, André Renner, Jan Gummert, Hanna Schotola, Bernhard C Danner, Lars S Maier, Norbert Frey, Gerd Hasenfuss, Thomas H Fischer, Samuel Sossalla
BACKGROUND: Cardiac type 2 ryanodine receptors (RyR2 s) play a pivotal role in cellular electrophysiology and contractility. Increased RyR2 -mediated diastolic sarcoplasmic reticulum (SR) Ca2+ release is linked to heart failure (HF) and arrhythmias. Dantrolene, a drug used for the treatment of malignant hyperthermia, is known to stabilize RyRs in skeletal muscle. OBJECTIVE: The purpose of this study was to investigate the effects of dantrolene on arrhythmogenic triggers and contractile function in human atrial fibrillation (AF) and HF cardiomyocytes (CM)...
March 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27394409/association-between-heart-rate-at-rest-and-incident-atrial-fibrillation-from-the-copenhagen-electrocardiographic-study
#19
Morten W Skov, Troels N Bachmann, Peter V Rasmussen, Morten S Olesen, Adrian Pietersen, Claus Graff, Bent Lind, Johannes J Struijk, Lars Køber, Stig Haunsø, Jesper H Svendsen, Thomas A Gerds, Anders G Holst, Jonas B Nielsen
Heart rate (HR) at rest is a well-known marker of cardiovascular morbidity and mortality. Results on the association between HR and incident atrial fibrillation (AF) have, however, been conflicting. Using digital electrocardiograms from 281,451 primary care patients, we aimed to describe the association between HR at rest and the hazards of incident AF. Secondary end points were death from all causes and pacemaker implantation. Data on drug use, co-morbidity, and outcomes were collected from nationwide administrative health care registries...
September 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27247004/atrial-fibrillation-and-gastroesophageal-reflux-disease-the-cardiogastric-interaction
#20
REVIEW
Dominik Linz, Mathias Hohl, Johanna Vollmar, Christian Ukena, Felix Mahfoud, Michael Böhm
Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with significant morbidity and mortality. Multiple conditions like hypertension, heart failure, diabetes, sleep apnoea, and obesity play a role for the initiation and perpetuation of AF. Recently, a potential association between gastroesophageal reflux disease (GERD) and AF development has been proposed due to the close anatomic vicinity of the oesophagus and the left atrium. As an understanding of the association between acid reflux disease and AF may be important in the global multimodal treatment strategy to further improve outcomes in a subset of patients with AF, we discuss potential atrial arrhythmogenic mechanisms in patients with GERD, such as gastric and subsequent systemic inflammation, impaired autonomic stimulation, mechanical irritation due to anatomical proximity of the left atrium and the oesophagus, as well as common comorbidities like obesity and sleep-disordered breathing...
January 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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