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https://www.readbyqxmd.com/read/29239495/comparisons-between-traditional-medicines-and-pharmacotherapies-for-alzheimer-disease-a-systematic-review-and-meta-analysis-of-cognitive-outcomes
#1
REVIEW
Brian H May, Mei Feng, Anna J Hyde, Helmut Hügel, Su-Yueh Chang, Lin Dong, Xinfeng Guo, Anthony L Zhang, Chuanjian Lu, Charlie C Xue
OBJECTIVES: To evaluate the clinical evidence for traditional medicines (TMs) used in East Asia on measures of cognition in Alzheimer disease, determine the effect sizes at different time points for the TMs and pharmacotherapies, and assess the tolerability of the TMs. METHODS: We searched 12 databases in English, Chinese, and Japanese for eligible randomised controlled trials that compared orally administered TMs with pharmacotherapy and reported cognitive outcomes...
December 14, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29237450/adding-chinese-herbal-medicine-to-conventional-therapy-brings-cognitive-benefits-to-patients-with-alzheimer-s-disease-a-retrospective-analysis
#2
Jing Shi, Jingnian Ni, Tao Lu, Xuekai Zhang, Mingqing Wei, Ting Li, Weiwei Liu, Yongyan Wang, Yuanyuan Shi, Jinzhou Tian
BACKGROUND: Conventional therapy (CT) such as donepezil and memantine are well-known short-term treatments for the symptoms of Alzheimer's disease (AD). The efficacy of them, however, drops below baseline level after 9 months. In China, herbal therapy as a complementary therapy is very popular. Should conventional therapy combined with herbal therapy (CT + H) make add-on benefit? METHODS: In this retrospective cohort study, 344 outpatients diagnosed as probable dementia due to AD were collected, with the treatment of either CT + H or CT alone in clinical settings...
December 13, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29215907/chemotherapy-and-cognitive-impairment-an-animal-model-approach
#3
Gordon Winocur
A substantial number of cancer survivors who undergo chemotherapy report cognitive disturbances that severely limit daily function (chemobrain). Despite supportive neuropsychological evidence, there is controversy over whether cognitive impairment is caused by the chemotherapy or is the result of potentially confounding factors that include the disease itself, age, and psychological stress. Our research program, conducted on rodents, has confirmed that a range of cognitive processes, mediated in particular by hippocampal and prefrontal brain regions, are affected by anticancer drugs in combination with tumor development and that many of the effects are long lasting...
December 2017: Canadian Journal of Experimental Psychology, Revue Canadienne de Psychologie Expérimentale
https://www.readbyqxmd.com/read/29211061/erratum-to-prediction-of-treatment-response-to-donepezil-using-automated-hippocampal-subfields-volumes-segmentation-in-patients-with-mild-alzheimer-s-disease
#4
Yoo Hyun Um, Tae-Won Kim, Jong-Hyun Jeong, Ho-Jun Seo, Jin-Hee Han, Seung-Chul Hong, Chang-Uk Lee, Hyun Kook Lim
[This corrects the article on p. 698 in vol. 14.].
November 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29195794/design-synthesis-and-pharmacological-evaluation-of-some-novel-indanone-derivatives-as-acetylcholinesterase-inhibitors-for-the-management-of-cognitive-dysfunction
#5
Poonam Piplani, Ankit Jain, Dhiksha Devi, Anjali, Anuradha Sharma, Pragati Silakari
The present study reports the effect of indanone derivatives on scopolamine induced deficit cholinergic neurotransmission serving as promising leads for the therapeutics of cognitive dysfunction. Eleven compounds 54-64 have been designed, synthesised and evaluated against behavioural alterations using step down passive avoidance protocol at a dose of 0.5 mg/kg with Donepezil (1) as the reference standard. All the synthesised compounds were evaluated for their in vitro acetylcholinesterase (AChE) inhibition at five different concentrations using mice brain homogenate as the source of the enzyme...
November 22, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29190477/synthesis-and-biological-evaluation-of-new-oxopyrrolidine-derivatives-as-inhibitors-of-acetyl-cholinesterase-and-%C3%AE-amyloid-protein-as-anti-alzheimer-s-agents
#6
Lamia W Mohamed, Suzan M Abuel-Maaty, Waleed A Mohammed, May A Galal
A new series of oxopyrrolidines was synthesized and evaluated for their effect on Alzheimer's disease by measuring their inhibitory activity against acetyl cholinesterase enzyme and amyloid β 42 protein. Most of the compounds showed good inhibitory activity with ethyl 2-(2-(2, 6-dimethylphenylcarbamoyl)- 5-oxopyrrolidin-1-yl) acetate (V) having the highest activity against acetyl cholinesterase with IC50 value 1.84 ng/g tissue compared to standard donepezil 3.34 ng/g tissue. Furthermore, compound 1-((4-(4-chlorophenyl) piperazin-1-yl) methyl)-N-(2,6-dimethylphenyl)-5- oxopyrrolidine- 2-carboxamide (IIIe) displayed the highest activity against β 42 protein with IC50 value of 11...
November 15, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29182921/hydroxypyridinone-benzofuran-hybrids-with-potential-protective-roles-for-alzheimer%C3%A2-s-disease-therapy
#7
Asha Hiremathad, Karam Chand, Lori Tolayan, Rajeshwari, Rangappa S Keri, A Raquel Esteves, Sandra M Cardoso, Sílvia Chaves, M Amélia Santos
A series of (3-hydroxy-4-pyridinone)-benzofuran hybrids have been developed and studied as potential multitargeting drugs for Alzheimer's disease (AD). Their design envisaged mainly to mimic the donepezil drug, a marketed inhibitor of acetylcholinesterase (AChE), and to endow the conjugate molecules with extra-properties such as metal chelation, radical scavenging and inhibition of amyloid peptide (Aβ) aggregation. Thus, a set of eleven new hybrid compounds was developed and evaluated for chemical and biological properties, in solution and in neuronal cell environment...
November 21, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29174946/fluoxetine-not-donepezil-reverses-anhedonia-cognitive-dysfunctions-and-hippocampal-proteome-changes-during-repeated-social-defeat-exposure
#8
M G Gottschalk, P Mortas, M Haman, S Ozcan, B Biemans, S Bahn
While anhedonia is considered a core symptom of major depressive disorder (MDD), less attention has been paid to cognitive dysfunctions. We evaluated the behavioural and molecular effects of a selective serotonin re-uptake inhibitor (SSRI, fluoxetine) and an acetylcholinesterase inhibitor (AChEI, donepezil) on emotional-cognitive endophenotypes of depression and the hippocampal proteome. A chronic social defeat (SD) procedure was followed up by "reminder" sessions of direct and indirect SD. Anhedonia-related behaviour was assessed longitudinally by intracranial self-stimulation (ICSS)...
November 23, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29170853/brain-networks-are-independently-modulated-by-donepezil-sleep-and-sleep-deprivation
#9
Jonathan Wirsich, Marc Rey, Maxime Guye, Christian Bénar, Laura Lanteaume, Ben Ridley, Sylviane Confort-Gouny, Catherine Cassé-Perrot, Elisabeth Soulier, Patrick Viout, Franck Rouby, Marie-Noëlle Lefebvre, Christine Audebert, Romain Truillet, Elisabeth Jouve, Pierre Payoux, David Bartrés-Faz, Régis Bordet, Jill C Richardson, Claudio Babiloni, Paolo Maria Rossini, Joelle Micallef, Olivier Blin, Jean-Philippe Ranjeva
Resting-state connectivity has been widely studied in the healthy and pathological brain. Less well-characterized are the brain networks altered during pharmacological interventions and their possible interaction with vigilance. In the hopes of finding new biomarkers which can be used to identify cortical activity and cognitive processes linked to the effects of drugs to treat neurodegenerative diseases such as Alzheimer's disease, the analysis of networks altered by medication would be particularly interesting...
November 23, 2017: Brain Topography
https://www.readbyqxmd.com/read/29167913/synergistic-enhancing-memory-effect-of-donepezil-and-s-47445-an-ampa-positive-allosteric-modulator-in-middle-aged-and-aged-mice
#10
S Bretin, A Krazem, N Henkous, C Froger-Colleaux, E Mocaer, C Louis, N Perdaems, A Marighetto, D Beracochea
Positive allosteric modulators of AMPA receptors (AMPA-PAMs) are described to facilitate cognitive processes in different memory-based models. Among them, S 47445 is a novel potent and selective AMPA-PAM. In order to assess its efficacy after repeated administration, S 47445 effect was evaluated in two aging-induced memory dysfunction tasks in old mice, one short-term working memory model evaluated in a radial maze task and one assessing contextual memory performance. S 47445 was shown to improve cognition in both models sensitive to aging...
November 22, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29159197/donepezil-enhances-understanding-of-degraded-speech-in-alzheimer-s-disease
#11
Chris J D Hardy, Yun T Hwang, Rebecca L Bond, Charles R Marshall, Basil H Ridha, Sebastian J Crutch, Martin N Rossor, Jason D Warren
Auditory dysfunction under complex, dynamic listening conditions is a clinical hallmark of Alzheimer's disease (AD) but challenging to measure and manage. Here, we assessed understanding of sinewave speech (a paradigm of degraded speech perception) and general cognitive abilities in 17 AD patients, before and following a 10 mg dose of donepezil. Relative to healthy older individuals, patients had impaired sinewave speech comprehension that was selectively ameliorated by donepezil. Our findings demonstrate impaired perception of degraded speech in AD but retained perceptual learning capacity that can be harnessed by acetylcholinesterase inhibition, with implications for designing communication interventions and acoustic environments in dementia...
November 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29154400/a-chiral-enantioseparation-generic-strategy-for-anti-alzheimer-and-antifungal-drugs-by-short-end-injection-capillary-electrophoresis-using-an-experimental-design-approach
#12
Ahmed M Abdel-Megied, Rasha S Hanafi, Hassan Y Aboul-Enein
The present study describes a generic strategy using capillary electrophoretic (CE) method for chiral enantioseparation of anti-Alzheimer drugs, namely, donepezil (DON), rivastigmine (RIV), and antifungal drugs, namely, ketoconazole (KET), Itraconazole (ITR), fluconazole (FLU), and sertaconazole (SRT) in which these drugs have different basic and acidic properties. Several modified cyclodextrins (CDs) were applied for enantioseparation of racemates such as highly sulfated α, γ CDs, hydroxyl propyl-β-CD, and Sulfobutyl ether-β-CD...
November 20, 2017: Chirality
https://www.readbyqxmd.com/read/29143695/an-overview-of-systematic-reviews-of-pharmacological-and-non-pharmacological-interventions-for-the-treatment-of-behavioral-and-psychological-symptoms-of-dementia
#13
Suzanne M Dyer, Stephanie L Harrison, Kate Laver, Craig Whitehead, Maria Crotty
BACKGROUND: This systematic overview reports findings from systematic reviews of randomized controlled trials of pharmacological and non-pharmacological interventions for behavioural and psychological symptoms of dementia (BPSD). METHODS: The Cochrane Database of Systematic Reviews, DARE, Medline, EMBASE, and PsycINFO were searched to September 2015. RESULTS: Fifteen systematic reviews of eighteen different interventions were included. A significant improvement in BPSD was seen with: functional analysis-based interventions (GRADE quality of evidence moderate; standardized mean difference (SMD) -0...
November 16, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29142396/antioxidant-and-cholinesterase-inhibitory-activities-of-ethyl-acetate-extract-of-terminalia-chebula-cell-free-in-vitro-and-in-silico-studies
#14
Mohamed Asik Rajmohamed, Suganthy Natarajan, Premkumar Palanisamy, Akbarsha Mohammad Abdulkader, Archunan Govindaraju
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder clinically characterized by memory loss and impaired cognitive function. Cholinergic enzyme deficiency and oxidative stress are the two major factors implicated in the pathogenesis of AD. The symptomatic treatment, as of now, is the use of cholinesterase inhibitors toward cholinergic "downturn." Therefore, there is a search for compounds that will be useful in focused therapies. There has been suggestion that Terminalia chebula fruit would be a potential source...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29139192/donepezil-is-associated-with-decreased-in-hospital-mortality-as-a-result-of-pneumonia-among-older-patients-with-dementia-a-retrospective-cohort-study
#15
Yasuko Abe, Kentaro Shimokado, Kiyohide Fushimi
AIM: Pneumonia is one of the major causes of mortality in older adults. As the average lifespan has extended and new modalities to prevent or treat pneumonia are developed, the factors that affect the length of hospital stay (LHS) and in-hospital mortality of older patients with pneumonia have changed. The object of the present study was to determine the factors associated with LHS and mortality as a result of pneumonia among older patients with dementia. METHODS: With a retrospective cohort study design, we used the data derived from the Japanese Administrative Database and diagnosis procedure combination/per diem payment system (DPC/PDPS) database...
November 15, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29133030/20-s-protopanaxadiol-ppd-alleviates-scopolamine-induced-memory-impairment-via-regulation-of-cholinergic-and-antioxidant-systems-and-expression-of-egr-1-c-fos-and-c-jun-in-mice
#16
Cong Lu, Liming Dong, Jingwei Lv, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Liu
20(S)-protopanaxadiol (PPD) possesses various biological properties, including anti-inflammatory, antitumor and anti-fatigue properties. Recent studies found that PPD functioned as a neurotrophic agent to ameliorate the sensory deficit caused by glutamate-induced excitotoxicity through its antioxidant effects and exhibited strong antidepressant-like effects in vivo. The objective of the present study was first to investigate the effect of PPD in scopolamine (SCOP)-induced memory deficit in mice and the potential mechanisms involved...
November 10, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29132093/a-benzothiazole-piperazine-derivative-with-acetylcholinesterase-inhibitory-activity-improvement-in-streptozotocin-induced-cognitive-deficits-in-rats
#17
Ümide Demir Özkay, Özgür Devrim Can, Begüm Nurpelin Sağlık, Nazlı Turan
BACKGROUND: Acetylcholinesterase (AChE) inhibitors are frequently prescribed to mitigate the cognitive decline in Alzheimer's disease. Thus, we investigated the possible efficacy of the AChE inhibitor 2-[(6-Nitro-2-benzothiazolyl)amino]-2-oxoethyl4-[2-(N,N-dimethylamino)ethyl] piperazine-1 carbodithioate (BPCT) in a streptozotocin (STZ)-induced Alzheimer's disease model (SADM). METHODS: First, we analyzed the molecular interaction of BPCT with AChE via a docking study...
June 30, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29131306/comparative-effectiveness-and-safety-of-cognitive-enhancers-for-treating-alzheimer-s-disease-systematic-review-and-network-metaanalysis
#18
Andrea C Tricco, Huda M Ashoor, Charlene Soobiah, Patricia Rios, Areti Angeliki Veroniki, Jemila S Hamid, John D Ivory, Paul A Khan, Fatemeh Yazdi, Marco Ghassemi, Erik Blondal, Joanne M Ho, Carmen H Ng, Brenda Hemmelgarn, Sumit R Majumdar, Laure Perrier, Sharon E Straus
BACKGROUND/OBJECTIVES: To examine the comparative effectiveness and safety of cognitive enhancers for Alzheimer's disease (AD). DESIGN: Systematic review and Bayesian network metaanalysis (NMA). SETTING: MEDLINE, EMBASE, Cochrane Library, CINAHL, Ageline (inception-March 2016). PARTICIPANTS: Individuals with AD in randomized controlled trials (RCTs), quasi-RCTs, and nonrandomized studies. INTERVENTION: Any combination of donepezil, rivastigmine, galantamine, or memantine...
September 29, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29127580/sigma-1-receptor-agonists-induce-oxidative-stress-in-mitochondria-and-enhance-complex-i-activity-in-physiological-condition-but-protect-against-pathological-oxidative-stress
#19
Nino Goguadze, Elene Zhuravliova, Didier Morin, Davit Mikeladze, Tangui Maurice
The sigma1 receptor (σ1R) is a chaperone protein residing at mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), where it modulates Ca(2+) exchange between the ER and mitochondria by interacting with inositol-1,4,5 trisphosphate receptors (IP3Rs). The σ1R is highly expressed in the central nervous system and its activation stimulates neuromodulation and neuroprotection, for instance in Alzheimer's disease (AD) models in vitro and in vivo. σ1R effects on mitochondria pathophysiology and the downstream signaling are still not fully understood...
November 10, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/29126976/involvement-of-glucose-related-energy-crisis-and-endoplasmic-reticulum-stress-insinuation-of-streptozotocin-induced-alzheimer-s-like-pathology
#20
Joyshree Biswas, Sonam Gupta, Dinesh Kumar Verma, Parul Gupta, Abhishek Singh, Shubhangini Tiwari, Poonam Goswami, Sharad Sharma, Sarika Singh
The present study was conducted to correlate the cellular and molecular alterations in Alzheimer's pathology employing streptozotocin (STZ) induced experimental rat model. The STZ was administered in rat brain bilaterally by intracerebroventricular route using stereotaxic surgery followed by donepezil dosing. The Alzheimer's related pathological marker like acetylcholinesterase (AChE) activity, tau phosphorylation and amyloid aggregation were observed after STZ administration. STZ treatment showed decreased glucose and glucose transporters (GLUT) level along with augmented level of calcium in both cortical and hippocampal regions of rat brain...
November 7, 2017: Cellular Signalling
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