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Barbara Paoletti, Leonardo Della Salda, Angela Di Cesare, Raffaella Iorio, Alberto Vergara, Camilla Fava, Alberto Olivastri, Giorgia Dessì, Antonio Scala, Antonio Varcasia
Despite the wide distribution of wild boar populations in Italy and the increase of its diffusion in urbanized areas, only one case report has described the occurrence of Echinococcus granulosus s.l. in a wild boar from Marche (Central Italy). The present study investigated the presence of E. granulosus sensu lato with an epidemiological survey on wild boars from central Italy that had been killed during hunting season. Seven hundred sixty-five (765) adult wild boars were examined during the 2016-2017 hunting season...
October 12, 2018: Parasitology Research
Qian Zhao, Ling Chen, Kun Dong, Yan Dong, Jingxiu Xiao
To ascertain the role and mechanism of cinnamic acid in the process of soil-borne Fusarium wilt infection with fava bean, we studied the effect of cinnamic acid on the faba bean and Fusarium oxysporum f. fabae (FOF). Our results showed that cinnamic acid treatment affected the physiological resistance of faba bean to FOF after inoculation with the pathogen and enhanced the pathogenicity of the pathogen, which may have led to aggravation of infection by the pathogen and increases in the incidence rates of Fusarium wilt and disease...
October 11, 2018: Plants (Basel, Switzerland)
Maria Pia Pistillo, Vincenzo Fontana, Anna Morabito, Beatrice Dozin, Stefania Laurent, Roberta Carosio, Barbara Banelli, Francesca Ferrero, Laura Spano, Enrica Tanda, Pier Francesco Ferrucci, Chiara Martinoli, Emilia Cocorocchio, Michele Guida, Stefania Tommasi, Federica De Galitiis, Elena Pagani, Gian Carlo Antonini Cappellini, Paolo Marchetti, Pietro Quaglino, Paolo Fava, Simona Osella-Abate, Paolo Antonio Ascierto, Mariaelena Capone, Ester Simeone, Massimo Romani, Francesco Spagnolo, Paola Queirolo
CTLA-4 blockade by means of ipilimumab (IPI) potentiates the immune response and improves overall survival (OS) in a minority of metastatic melanoma (MM) patients. We investigated the role of soluble CTLA-4 (sCTLA-4) as a possible biomarker for identifying this subset of patients. sCTLA-4 levels were analyzed at baseline in sera from 113 IPI-treated MM patients by ELISA, and the median value (200 pg/ml) was used to create two equally sized subgroups. Associations of sCTLA-4 with best overall response (BOR) to IPI and immune-related adverse events (irAEs) were evaluated through logistic regression...
October 11, 2018: Cancer Immunology, Immunotherapy: CII
Cristiano Fava, Sara Bonafini
Metabolites of arachidonic acid via CYP450 such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), have vasoactive and natriuretic properties and have been implicated in BP homeostasis and the incidence of cardio- and cerebrovascular diseases in animal studies. In humans, genetic studies considering genes implicated in arachidonic acids metabolism (CYP4F2, CYP4A11, CYP2J2, CYP2C8, CYP2C9, CYP2A1/2, EPHX2) can offer a hint to understand their role, if any, in hypertension development and its deleterious cardiovascular effects...
October 5, 2018: Prostaglandins & Other Lipid Mediators
Beth C Bock, Shira I Dunsiger, Rochelle K Rosen, Herpreet Thind, Ernestine Jennings, Joseph L Fava, Bruce M Becker, James Carmody, Bess H Marcus
Introduction: There is evidence that yoga may be helpful as an aid for smoking cessation. Yoga has been shown to reduce stress and negative mood and may aid weight control, all of which have proven to be barriers to quitting smoking. This study is the first rigorous, randomized clinical trial of yoga as a complementary therapy for smokers attempting to quit. Methods: Adult smokers (n=227; 55% women) were randomized to an 8-week program of cognitive-behavioral smoking cessation and either twice-weekly Iyengar Yoga, or general Wellness classes (control)...
October 6, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Paolo Fava, Chiara Astrua, Matteo Brizio, Giovanni Cavaliere, Rebecca Senetta, Maria Teresa Fierro, Pietro Quaglino
No abstract text is available yet for this article.
October 3, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Zhao Wang, Si-Han Liu, Li-Jin Bo, Yi-Zhou Zheng, Jun Shi, Yan Xu, Xue Sun, Yu-Ping Zhao
OBJECTIVE: To explore clinical features and laboratory data of glucose-6-phosphate dehydrogenase(G6PD)deficiency and to investigate the relationship between them. METHODS: Clinical data of 43 patients with G6PD deficiency was analyzed, the statistical method was applied to investigate the relationship between clinical features and laboratory data. RESULTS: Among 43 patients,neonatal jaundice occurred as the first symptom in 10 cases,while acute hemolytic anemia occurred as the first symptom in 23 cases...
October 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
Dawn F Ionescu, Kate H Bentley, Matthias Eikermann, Norman Taylor, Oluwaseun Johnson-Akeju, Michaela B Swee, Kara J Pavone, Samuel R Petrie, Christina Dording, David Mischoulon, Jonathan E Alpert, Emery N Brown, Lee Baer, Matthew K Nock, Maurizio Fava, Cristina Cusin
BACKGROUND: Several studies indicate that ketamine has rapid antidepressant effects in patients with treatment-resistant depression (TRD). The extent to which repeated doses of ketamine (versus placebo) reduce depression in the short and long term among outpatients with TRD and chronic, current suicidal ideation remains unknown. METHODS: Twenty-six medicated outpatients with severe major depressive disorder with current, chronic suicidal ideation were randomized in a double-blind fashion to six ketamine infusions (0...
January 15, 2019: Journal of Affective Disorders
Maurizio Fava, Marlene P Freeman, Martina Flynn, Heidi Judge, Bettina B Hoeppner, Cristina Cusin, Dawn F Ionescu, Sanjay J Mathew, Lee C Chang, Dan V Iosifescu, James Murrough, Charles Debattista, Alan F Schatzberg, Madhukar H Trivedi, Manish K Jha, Gerard Sanacora, Samuel T Wilkinson, George I Papakostas
Numerous placebo-controlled studies have demonstrated the ability of ketamine, an NMDA receptor antagonist, to induce rapid (within hours), transient antidepressant effects when administered intravenously (IV) at subanesthetic doses (0.5 mg/kg over 40 min). However, the optimal antidepressant dose remains unknown. We aimed to compare to active placebo the rapid acting antidepressant properties of a broad range of subanesthetic doses of IV ketamine among outpatients with treatment-resistant depression (TRD)...
October 3, 2018: Molecular Psychiatry
Hyewon Kim, Kwan Woo Choi, Eun Jin Na, Jin Pyo Hong, Maurizio Fava, David Mischoulon, Hana Cho, Hong Jin Jeon
Regardless of categorical diagnosis, many psychiatric patients suffer from sudden attack of fear or intense anxiety. In this study, we defined anxiety attacks to refer to these phenomena and investigated their association with depression and suicide attempts. A total of 12,532 adults randomly selected population through the one-person-per-household method completed a face-to-face interview using the Korean version of Composite International Diagnostic Interview (K-CIDI). A total of 5.88% reported to have experienced anxiety attacks...
September 21, 2018: Psychiatry Research
Giovanni A Fava, Danilo Carrozzino, Lone Lindberg, Elena Tomba
No abstract text is available yet for this article.
September 28, 2018: Psychotherapy and Psychosomatics
Kwan Woo Choi, Eun Jin Na, Maurizio Fava, David Mischoulon, Hana Cho, Hong Jin Jeon
Previous studies have reported dysfunction in the hypothalamic-pituitary-adrenal (HPA) axis in patients with major depressive disorder (MDD). Outpatients diagnosed with MDD (n = 199) underwent psychological evaluation, and were followed up with a phone interview after 6 months, using the Patient Health Questionnaire (PHQ-9). At 6-month follow-up, 59 out of 199 patients with MDD were still depressed (29.5%), as shown by scores ≥ 10 on the PHQ-9. The depressed group at follow-up showed significantly higher anxiety and suicidality levels at baseline than the non-depressed group at follow-up...
September 21, 2018: Psychiatry Research
Alexia G Abela, Stephen Fava
BACKGROUND: Environmental factors play an increasingly important role in the aetiology of type 1 diabetes. One geographical feature which exerts a major effect on climate but whose relationship to the incidence of type 1 diabetes has not been studied is distance from the sea. The aim of this study was therefore to investigate any possible relationship between distance from the sea and incidence of type 1 diabetes. METHODS: Spearman correlation between incidence of type 1 diabetes and distance from the sea...
September 28, 2018: Journal of Diabetes
Ronaldo de Carvalho Neiva, Carlos Eduardo Garcia Westin, José Germano Ferraz de Arruda, Pedro Francisco Ferraz de Arruda, Marcio Gatti, Ana Paula Bogdan, Thiago Antoniassi, Luis Cesar Fava Spessoto, Fernando Nestor Facio Junior
Inguinal hernias are a common disease in adults, but involvement of extraperitoneal structures is rare. This condition is usually asymptomatic and an incidental finding during the surgical correction of inguinal hernias, often resulting in iatrogenic damage. We present a rare case of left renal agenesis and right inguinal hernia, with the ureter being the only organ protruding as an inguinal hernia, diagnosed in the preoperative period.
2018: AME case reports
Hideyuki Akaza, Giuseppe Procopio, Choosak Pripatnanont, Gaetano Facchini, Sergio Fava, Duncan Wheatley, Kwong Chuen Leung, Mohammad Butt, Alberto Silva, Liliana Castillo, Vasilios Karavasilis, Ayse Ӧzatılgan, Simon Hitier, Evelyne B Ecstein-Fraisse, Mustafa Ӧzgüroḡlu
PURPOSE: There is a major clinical need to devise an optimal treatment sequence for the multiple therapy options available for patients with metastatic castration-resistant prostate cancer (mCRPC). In the absence of prospective clinical trials, sequencing information can be derived from large, real-world registry studies. PATIENTS AND METHODS: PROXIMA (Treatment Patterns in Patients With Metastatic Castration-Resistant Prostate Cancer Previously Treated With Docetaxel-Based Chemotherapy) is a large, global, prospective registry study evaluating real-world treatment patterns of patients with mCRPC who experience disease progression during or after docetaxel therapy...
September 2018: Journal of Global Oncology
Massimiliano Bergallo, Valentina Daprà, Renata Ponti, Pietro Quaglino, Mauro Novelli, Paolo Fava, Paola Montanari, Cristina Calvi, Ilaria Galliano, Mariateresa Fierro
BACKGROUND: Psoriasis is a common inflammatory skin disease characterized by uncontrolled proliferation of keratinocytes and recruitment of T lymphocytes into the skin. Possible triggers for psoriasis have been attributed to drugs or pathogens such as bacteria and possibly virus. Human endogenous retroviruses (HERVs) might play a role in triggering these anti-viral immune responses, since the role of HERVs in the pathogenesis of autoimmune diseases has generated considerable interest...
September 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Johannes A C Laferton, Sagar Vijapura, Lee Baer, Alisabet J Clain, Abigail Cooper, George Papakostas, Lawrence H Price, Linda L Carpenter, Audrey R Tyrka, Maurizio Fava, David Mischoulon
Objective: It has been suggested that patients' perception of treatment assignment might serve to bias results of double blind randomized controlled trials (RCT). Most previous evidence on the effects of patients' perceptions and the mechanisms influencing these perceptions relies on cross-sectional associations. This re-analysis of a double blind, placebo controlled RCT of pharmacological treatment of major depression set out to gather longitudinal evidence on the mechanism and effects of patients' perceived treatment assignment in the pharmacological treatment of major depression...
2018: Frontiers in Psychiatry
Holly Turula, Juliana Bragazzi Cunha, Bernardo A Mainou, Sadeesh K Ramakrishnan, Carol A Wilke, Mariam B Gonzalez-Hernandez, Alexandra Pry, Julianne Fava, Christine M Bassis, Jacob Edelman, Yatrik M Shah, Blaise Corthesy, Bethany B Moore, Christiane E Wobus
Noroviruses are enteric pathogens causing significant morbidity, mortality and economic losses worldwide. Secretory immunoglobulins (SIg) are a first line of mucosal defense against enteric pathogens. They are secreted into the intestinal lumen via the polymeric immunoglobulin receptor (pIgR), where they bind to antigens. However, whether natural SIg protect against norovirus infection remains unknown. To determine if natural SIg alter murine norovirus (MNV) pathogenesis, we infected pIgR knockout (KO) mice, which lack SIg in mucosal secretions...
September 19, 2018: Journal of Virology
Andrea Dalbeni, Davide Treggiari, Angela Tagetti, Michele Bevilaqua, Sara Bonafini, Martina Montagnana, Giuliana Scaturro, Pietro Minuz, Cristiano Fava
Tomato consumption has been recently associated with a reduced incidence of cardiovascular disease (CVD). The aim of this study was to test whether a seven-day period of tomato paste purèe (tomato paste, TP) supplementation could improve some haemodynamic parameters in healthy volunteers before and after a standardized fat meal (FM). METHODS AND RESULTS: Nineteen healthy male volunteers participated in a randomized, single-blind (operator) crossover study. Participants maintained low fiber diets (LFD) during the study periods...
September 15, 2018: Nutrients
Paolo Cassano, Christina Dording, Garrett Thomas, Simmie Foster, Albert Yeung, Mai Uchida, Michael R Hamblin, Eric Bui, Maurizio Fava, David Mischoulon, Dan V Iosifescu
OBJECTIVES: Transcranial photobiomodulation (t-PBM) consists of the delivery of near-infrared (NIR) or red light to the scalp designed to penetrate to subjacent cortical areas of the brain. NIR t-PBM has recently emerged as a potential therapy for brain disorders. This study assessed the efficacy of repeated sessions of NIR t-PBM on sexual dysfunction. METHODS: We performed a secondary analysis of a double-blind clinical trial on t-PBM for major depressive disorder (MDD)...
September 17, 2018: Lasers in Surgery and Medicine
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