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https://www.readbyqxmd.com/read/30517395/the-waiting-room-potential-for-people-with-arterial-hypertension-to-learn
#1
Maria de Lourdes Barbosa Negrão, Patrícia Costa Dos Santos da Silva, Camila Maria Silva Paraizo, Roberta Garcia Gomes, Eliza Maria Rezende Dázio, Eliane Garcia Rezende, Zélia Marilda Rodrigues Resck, Silvana Maria Coelho Leite Fava
OBJECTIVE: To analyze the meanings assigned by people with systemic arterial hypertension to health education actions in the waiting room. METHOD: This is an analytical qualitative study, held in 2016 with 19 people with arterial hypertension from a health unit. The data were collected in households, through a semi-structured interview and field notes, recorded on audio, transcribed and organized by thematic analysis, being analyzed considering Vygostky's Cultural-Historical Learning Theory...
November 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/30517306/review-of-a-three-year-study-on-the-dental-care-of-onco-hematological-pediatric-patients
#2
Alexandre Viana Frascino, Marcelo Fava, Louise Cominato, Vicente Odone-Filho
The aim of this study was to provide an updated review of dental procedures undertaken at the dental unit of the Onco-hematology service of the Instituto da Criança at the Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (ICr/HC-FMUSP). We retrospectively reviewed 565 of 1902 medical and dental records of patients diagnosed with onco-hematological diseases who were seen in a 3-year study (January 2015 to December 2017). We assessed data regarding population characteristics, onco-hematological diagnosis and dental procedures performed...
December 3, 2018: Clinics
https://www.readbyqxmd.com/read/30510157/gwas-and-colocalization-analyses-implicate-carotid-intima-media-thickness-and-carotid-plaque-loci-in-cardiovascular-outcomes
#3
Nora Franceschini, Claudia Giambartolomei, Paul S de Vries, Chris Finan, Joshua C Bis, Rachael P Huntley, Ruth C Lovering, Salman M Tajuddin, Thomas W Winkler, Misa Graff, Maryam Kavousi, Caroline Dale, Albert V Smith, Edith Hofer, Elisabeth M van Leeuwen, Ilja M Nolte, Lingyi Lu, Markus Scholz, Muralidharan Sargurupremraj, Niina Pitkänen, Oscar Franzén, Peter K Joshi, Raymond Noordam, Riccardo E Marioni, Shih-Jen Hwang, Solomon K Musani, Ulf Schminke, Walter Palmas, Aaron Isaacs, Adolfo Correa, Alan B Zonderman, Albert Hofman, Alexander Teumer, Amanda J Cox, André G Uitterlinden, Andrew Wong, Andries J Smit, Anne B Newman, Annie Britton, Arno Ruusalepp, Bengt Sennblad, Bo Hedblad, Bogdan Pasaniuc, Brenda W Penninx, Carl D Langefeld, Christina L Wassel, Christophe Tzourio, Cristiano Fava, Damiano Baldassarre, Daniel H O'Leary, Daniel Teupser, Diana Kuh, Elena Tremoli, Elmo Mannarino, Enzo Grossi, Eric Boerwinkle, Eric E Schadt, Erik Ingelsson, Fabrizio Veglia, Fernando Rivadeneira, Frank Beutner, Ganesh Chauhan, Gerardo Heiss, Harold Snieder, Harry Campbell, Henry Völzke, Hugh S Markus, Ian J Deary, J Wouter Jukema, Jacqueline de Graaf, Jacqueline Price, Janne Pott, Jemma C Hopewell, Jingjing Liang, Joachim Thiery, Jorgen Engmann, Karl Gertow, Kenneth Rice, Kent D Taylor, Klodian Dhana, Lambertus A L M Kiemeney, Lars Lind, Laura M Raffield, Lenore J Launer, Lesca M Holdt, Marcus Dörr, Martin Dichgans, Matthew Traylor, Matthias Sitzer, Meena Kumari, Mika Kivimaki, Mike A Nalls, Olle Melander, Olli Raitakari, Oscar H Franco, Oscar L Rueda-Ochoa, Panos Roussos, Peter H Whincup, Philippe Amouyel, Philippe Giral, Pramod Anugu, Quenna Wong, Rainer Malik, Rainer Rauramaa, Ralph Burkhardt, Rebecca Hardy, Reinhold Schmidt, Renée de Mutsert, Richard W Morris, Rona J Strawbridge, S Goya Wannamethee, Sara Hägg, Sonia Shah, Stela McLachlan, Stella Trompet, Sudha Seshadri, Sudhir Kurl, Susan R Heckbert, Susan Ring, Tamara B Harris, Terho Lehtimäki, Tessel E Galesloot, Tina Shah, Ulf de Faire, Vincent Plagnol, Wayne D Rosamond, Wendy Post, Xiaofeng Zhu, Xiaoling Zhang, Xiuqing Guo, Yasaman Saba, Abbas Dehghan, Adrie Seldenrijk, Alanna C Morrison, Anders Hamsten, Bruce M Psaty, Cornelia M van Duijn, Deborah A Lawlor, Dennis O Mook-Kanamori, Donald W Bowden, Helena Schmidt, James F Wilson, James G Wilson, Jerome I Rotter, Joanna M Wardlaw, John Deanfield, Julian Halcox, Leo-Pekka Lyytikäinen, Markus Loeffler, Michele K Evans, Stéphanie Debette, Steve E Humphries, Uwe Völker, Vilmundur Gudnason, Aroon D Hingorani, Johan L M Björkegren, Juan P Casas, Christopher J O'Donnell
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4...
December 3, 2018: Nature Communications
https://www.readbyqxmd.com/read/30506689/the-effect-of-cyp4f2-vkorc1-and-cyp2c9-in-influencing-coumarin-dose-a-single-patient-data-meta-analysis-in-more-than-15-000-individuals
#4
Elisa Danese, Sara Raimondi, Martina Montagnana, Angela Tagetti, Taimour Langaee, Paola Borgiani, Cinzia Ciccacci, Antonio J Carcas, Alberto M Borobia, Hoi Y Tong, Cristina Dávila-Fajardo, Mariana Rodrigues Botton, Stephane Bourgeois, Panos Deloukas, Michael D Caldwell, Jim K Burmester, Richard L Berg, Larisa H Cavallari, Katarzyna Drozda, Min Huang, Li-Zi Zhao, Han-Jing Cen, Rocio Gonzalez-Conejero, Vanessa Roldan, Yusuke Nakamura, Taisei Mushiroda, Inna Y Gong, Richard B Kim, Keita Hirai, Kunihiko Itoh, Carlos Isaza, Leonardo Beltrán, Enrique Jiménez-Varo, Marisa Cañadas-Garre, Alice Giontella, Marianne Kristiansen Kringen, Kari Bente Foss Haug, Hye Sun Gwak, Kyung Eun Lee, Pietro Minuz, Ming Ta Michael Lee, Steven A Lubitz, Stuart Scott, Cristina Mazzaccara, Lucia Sacchetti, Ece Genç, Mahmut Özer, Anil Pathare, Rajagopal Krishnamoorthy, Andras Paldi, Virginie Siguret, Marie-Anne Loriot, Vijay Kumar Kutala, Guilherme Suarez-Kurtz, Jamila Perini, Josh C Denny, Andrea H Ramirez, Balraj Mittal, Saurabh Singh Rathore, Hersh Sagreiya, Russ Altman, Mohamed Hossam A Shahin, Sherief I Khalifa, Nita A Limdi, Charles Rivers, Aditi Shendre, Chrisly Dillon, Ivet M Suriapranata, Hong-Hao Zhou, Sheng-Lan Tan, Vacis Tatarunas, Vaiva Lesauskaite, Yumao Zhang, Anke H Maitland-van der Zee, Talitha I Verhoef, Anthonius de Boer, Monica Taljaard, Carlo Federico Zambon, Vittorio Pengo, Jieying Eunice Zhang, Munir Pirmohamed, Julie A Johnson, Cristiano Fava
The CYP4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at individual patients' level to capture the possible effect of ethnicity, gene-gene interaction or other drugs on the association and to verify if inclusion of CYP4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta-analysis (30 articles) and of 38 new articles retrieved by a systematic review to send us individual patients' data...
December 2, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/30471905/formulation-process-conditions-and-biological-evaluation-of-dairy-mixed-gels-containing-fava-bean-and-milk-proteins-effect-on-protein-retention-in-growing-young-rats
#5
I Berrazaga, J L Mession, K Laleg, J Salles, C Guillet, V Patrac, C Giraudet, O Le Bacquer, Y Boirie, V Micard, F Husson, R Saurel, S Walrand
Food formulation and process conditions can indirectly influence AA digestibility and bioavailability. Here we investigated the effects of formulation and process conditions used in the manufacture of novel blended dairy gels (called "mixed gels" here) containing fava bean (Vicia faba) globular proteins on both protein composition and metabolism when given to young rats. Three mixed dairy gels containing casein micelles and fava bean proteins were produced either by chemical acidification (A) with glucono-δ-lactone (GDL) or by lactic acid fermentation...
November 21, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/30457941/phylogeography-and-historical-biogeography-of-the-astyanax-bimaculatus-species-complex-teleostei-characidae-in-coastal-southeastern-south-america
#6
Marina S Cunha, Aline R Fregonezi, Lucioni Fava, Alexandre W S Hilsdorf, Lucio A O Campos, Jorge A Dergam
Astyanax bimaculatus, a ubiquitous species in many Neotropical basins, is characterized by a complex taxonomy and are currently considered a species complex. The goal of this study was to analyze 31 populations (N = 136) of this species from southeastern Brazil using cytogenetic techniques: conventional staining, nucleolar organizer region (Ag-NOR), C-banding, and 18S and 5S recombinant DNA fluorescent in situ hybridization (FISH) probes; and molecular techniques: S72, RAG2, and COI. All populations were 2n = 50 (6m + 20sm +18st +6a); Ag-NORs were predominantly simple, C-banding revealed high variation levels within and among basins, and the FISH probes 18S and 5S were restricted to chromosome pairs 14 and 7, respectively...
November 20, 2018: Zebrafish
https://www.readbyqxmd.com/read/30456405/influence-of-hydrocolloids-galactomannan-and-xanthan-gum-on-the-physicochemical-and-sensory-characteristics-of-gluten-free-cakes-based-on-fava-beans-phaseolus-lunatus
#7
F J E T Andrade, P B S Albuquerque, G M D Moraes, M D P Farias, D M A Teixeira-Sá, A A Vicente, M G Carneiro-da-Cunha
Most gluten-free bakery formulations have starch sources of low nutritional value. The objective of this work was to use fava beans (Phaseolus lunatus) for the production of gluten-free sponge cakes, in addition to evaluating the effects of the partial substitution of fava bean flour by galactomannan and xanthan gum, isolated or mixed at 0.5 and 1.0% proportions, compared with a commercial reference. The properties such as viscosity, specific gravity and microscopy of the air bubbles were evaluated in the raw cakes, while the cooked cakes were analyzed according to physicochemical (chemical composition, specific volume, texture and color) and sensorial properties...
November 20, 2018: Food & Function
https://www.readbyqxmd.com/read/30448290/systemic-lupus-erythematosus-diagnosis-and-clinical-management
#8
REVIEW
Andrea Fava, Michelle Petri
Systemic lupus erythematosus (SLE) is a worldwide chronic autoimmune disease which may affect every organ and tissue. Genetic predisposition, environmental triggers, and the hormonal milieu, interplay in disease development and activity. Clinical manifestations and the pattern of organ involvement are widely heterogenous, reflecting the complex mosaic of disrupted molecular pathways converging into the SLE clinical phenotype. The SLE complex pathogenesis involves multiple cellular components of the innate and immune systems, presence of autoantibodies and immunocomplexes, engagement of the complement system, dysregulation of several cytokines including type I interferons, and disruption of the clearance of nucleic acids after cell death...
November 15, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/30445901/the-clinical-role-of-well-being-therapy
#9
Jenny Guidi, Chiara Rafanelli, Giovanni A Fava
PURPOSE: There are several clinical areas where psychological well-being may play an important role: the assessment of the dynamic balance between ill-being and well-being; reduction of incidence, prevention of recurrence and achievement of full recovery in psychiatric disorders such as depression; patient's satisfaction and perceived change after treatment. The aim of this article is to discuss the clinical role of Well-Being Therapy (WBT). MATERIALS AND METHODS: A critical review of the literature concerned with psychological well-being and its treatment was performed...
November 16, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/30439676/tachyphylaxis-in-major-depressive-disorder-a-review-of-the-current-state-of-research
#10
Gustavo Kinrys, Alexandra K Gold, Vincent D Pisano, Marlene P Freeman, George I Papakostas, David Mischoulon, Andrew A Nierenberg, Maurizio Fava
BACKGROUND: Patients with major depressive disorder (MDD) often experience a re-emergence or worsening of symptoms despite ongoing treatment with previously effective antidepressant pharmacotherapy. This lost or reduced antidepressant response during maintenance, referred to as tachyphylaxis, negatively impacts treatment outcomes and quality of life for patients with MDD. This review assesses the prevalence of antidepressant tachyphylaxis as well as the evidence for interventions to manage it...
October 28, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/30429581/can-electronic-health-records-revive-central-nervous-system-clinical-trials
#11
Roy H Perlis, Maurizio Fava, Thomas H McCoy
No abstract text is available yet for this article.
November 14, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/30423470/understanding-the-effects-of-emotional-reactivity-on-depression-and-suicidal-thoughts-and-behaviors-moderating-effects-of-childhood-adversity-and-resilience
#12
Benjamin G Shapero, Amy Farabaugh, Olga Terechina, Stephanie DeCross, Joey C Cheung, Maurizio Fava, Daphne J Holt
BACKGROUND: Early adulthood is a period of increased risk for depression and suicide. Emotional reactivity (a tendency to react to stress with increases in negative affect and maladaptive interpretations of events) is an important risk factor for these outcomes that has been under-studied. We hypothesized that elevated emotional reactivity would be associated with higher levels of depressive symptoms and suicidal thoughts and behaviors. Further, we hypothesized that experiences of childhood maltreatment would amplify this relationship, whereas the presence of resilience would act as a buffer...
November 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/30417984/ultrasound-guided-fine-needle-aspiration-cytology-in-the-diagnosis-of-hepatic-and-pancreatic-perivascular-epithelioid-cell-tumors-a-case-series
#13
Valentina Sangiorgio, Lorenzo Daniele, Teresa Gallo, Rodolfo Rocca, Cristina Fava, Paola Campisi, Giovanni De Rosa
Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors that can affect any part of the body. They can be sporadic or arise in the setting of tuberous sclerosis (TSC). In this article, we report a series of three hepatic and two pancreatic PEComas diagnosed preoperatively with ultrasound-guided fine needle aspiration (FNA). All patients were female (age range 28-70), had no personal history of TSC and presented with a single, localized painless mass. Rapid on-site evaluation (ROSE) of cytologic samples was performed for all cases to evaluate for cellular content and adequacy of specimens...
November 12, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/30411926/measurement-of-the-branching-fraction-for-the-semileptonic-decay-d-0-%C3%A2-%C3%AF-0-%C3%AE-%C3%AE-_-%C3%AE-and-test-of-lepton-flavor-universality
#14
M Ablikim, M N Achasov, S Ahmed, M Albrecht, A Amoroso, F F An, Q An, J Z Bai, Y Bai, O Bakina, R Baldini Ferroli, Y Ban, D W Bennett, J V Bennett, N Berger, M Bertani, D Bettoni, J M Bian, F Bianchi, E Boger, I Boyko, R A Briere, H Cai, X Cai, O Cakir, A Calcaterra, G F Cao, S A Cetin, J Chai, J F Chang, G Chelkov, G Chen, H S Chen, J C Chen, M L Chen, P L Chen, S J Chen, X R Chen, Y B Chen, X K Chu, G Cibinetto, H L Dai, J P Dai, A Dbeyssi, D Dedovich, Z Y Deng, A Denig, I Denysenko, M Destefanis, F De Mori, Y Ding, C Dong, J Dong, L Y Dong, M Y Dong, Z L Dou, S X Du, P F Duan, J Fang, S S Fang, Y Fang, R Farinelli, L Fava, S Fegan, F Feldbauer, G Felici, C Q Feng, E Fioravanti, M Fritsch, C D Fu, Q Gao, X L Gao, Y Gao, Y G Gao, Z Gao, I Garzia, K Goetzen, L Gong, W X Gong, W Gradl, M Greco, M H Gu, Y T Gu, A Q Guo, R P Guo, Y P Guo, Z Haddadi, S Han, X Q Hao, F A Harris, K L He, X Q He, F H Heinsius, T Held, Y K Heng, T Holtmann, Z L Hou, H M Hu, T Hu, Y Hu, G S Huang, J S Huang, X T Huang, X Z Huang, Z L Huang, T Hussain, W Ikegami Andersson, Q Ji, Q P Ji, X B Ji, X L Ji, X S Jiang, X Y Jiang, J B Jiao, Z Jiao, D P Jin, S Jin, Y Jin, T Johansson, A Julin, N Kalantar-Nayestanaki, X L Kang, X S Kang, M Kavatsyuk, B C Ke, T Khan, A Khoukaz, P Kiese, R Kliemt, L Koch, O B Kolcu, B Kopf, M Kornicer, M Kuemmel, M Kuessner, M Kuhlmann, A Kupsc, W Kühn, J S Lange, M Lara, P Larin, L Lavezzi, H Leithoff, C Leng, C Li, Cheng Li, D M Li, F Li, F Y Li, G Li, H B Li, H J Li, J C Li, Jin Li, K J Li, Kang Li, Ke Li, Lei Li, P L Li, P R Li, Q Y Li, W D Li, W G Li, X L Li, X N Li, X Q Li, Z B Li, H Liang, Y F Liang, Y T Liang, G R Liao, D X Lin, B Liu, B J Liu, C X Liu, D Liu, F H Liu, Fang Liu, Feng Liu, H B Liu, H M Liu, Huanhuan Liu, Huihui Liu, J B Liu, J P Liu, J Y Liu, K Liu, K Y Liu, Ke Liu, L D Liu, P L Liu, Q Liu, S B Liu, X Liu, Y B Liu, Z A Liu, Zhiqing Liu, Y F Long, X C Lou, H J Lu, J G Lu, Y Lu, Y P Lu, C L Luo, M X Luo, X L Luo, X R Lyu, F C Ma, H L Ma, L L Ma, M M Ma, Q M Ma, T Ma, X N Ma, X Y Ma, Y M Ma, F E Maas, M Maggiora, Q A Malik, Y J Mao, Z P Mao, S Marcello, Z X Meng, J G Messchendorp, G Mezzadri, J Min, T J Min, R E Mitchell, X H Mo, Y J Mo, C Morales Morales, N Yu Muchnoi, H Muramatsu, P Musiol, A Mustafa, Y Nefedov, F Nerling, I B Nikolaev, Z Ning, S Nisar, S L Niu, X Y Niu, S L Olsen, Q Ouyang, S Pacetti, Y Pan, M Papenbrock, P Patteri, M Pelizaeus, J Pellegrino, H P Peng, K Peters, J Pettersson, J L Ping, R G Ping, A Pitka, R Poling, V Prasad, H R Qi, M Qi, S Qian, C F Qiao, N Qin, X S Qin, Z H Qin, J F Qiu, K H Rashid, C F Redmer, M Richter, M Ripka, M Rolo, G Rong, Ch Rosner, A Sarantsev, M Savrié, C Schnier, K Schoenning, W Shan, M Shao, C P Shen, P X Shen, X Y Shen, H Y Sheng, J J Song, W M Song, X Y Song, S Sosio, C Sowa, S Spataro, G X Sun, J F Sun, L Sun, S S Sun, X H Sun, Y J Sun, Y K Sun, Y Z Sun, Z J Sun, Z T Sun, C J Tang, G Y Tang, X Tang, I Tapan, M Tiemens, B Tsednee, I Uman, G S Varner, B Wang, B L Wang, D Wang, D Y Wang, Dan Wang, K Wang, L L Wang, L S Wang, M Wang, Meng Wang, P Wang, P L Wang, W P Wang, X F Wang, Y Wang, Y D Wang, Y F Wang, Y Q Wang, Z Wang, Z G Wang, Z Y Wang, Zongyuan Wang, T Weber, D H Wei, P Weidenkaff, S P Wen, U Wiedner, M Wolke, L H Wu, L J Wu, Z Wu, L Xia, Y Xia, D Xiao, H Xiao, Y J Xiao, Z J Xiao, Y G Xie, Y H Xie, X A Xiong, Q L Xiu, G F Xu, J J Xu, L Xu, Q J Xu, Q N Xu, X P Xu, L Yan, W B Yan, W C Yan, Y H Yan, H J Yang, H X Yang, L Yang, Y H Yang, Y X Yang, M Ye, M H Ye, J H Yin, Z Y You, B X Yu, C X Yu, J S Yu, C Z Yuan, Y Yuan, A Yuncu, A A Zafar, Y Zeng, Z Zeng, B X Zhang, B Y Zhang, C C Zhang, D H Zhang, H H Zhang, H Y Zhang, J Zhang, J L Zhang, J Q Zhang, J W Zhang, J Y Zhang, J Z Zhang, K Zhang, L Zhang, S Q Zhang, X Y Zhang, Y H Zhang, Y T Zhang, Yang Zhang, Yao Zhang, Yu Zhang, Z H Zhang, Z P Zhang, Z Y Zhang, G Zhao, J W Zhao, J Y Zhao, J Z Zhao, Lei Zhao, Ling Zhao, M G Zhao, Q Zhao, S J Zhao, T C Zhao, Y B Zhao, Z G Zhao, A Zhemchugov, B Zheng, J P Zheng, Y H Zheng, B Zhong, L Zhou, X Zhou, X K Zhou, X R Zhou, X Y Zhou, Y X Zhou, J Zhu, J Zhu, K Zhu, K J Zhu, S Zhu, S H Zhu, X L Zhu, Y C Zhu, Y S Zhu, Z A Zhu, J Zhuang, B S Zou, J H Zou
Using a data sample corresponding to an integrated luminosity of 2.93  fb^{-1} taken at a center-of-mass energy of 3.773 GeV with the BESIII detector operated at the BEPCII collider, we perform an analysis of the semileptonic decays D^{0(+)}→π^{-(0)}μ^{+}ν_{μ}. The branching fractions of D^{0}→π^{-}μ^{+}ν_{μ} and D^{+}→π^{0}μ^{+}ν_{μ} are measured to be (0.272±0.008_{stat}±0.006_{syst})% and (0.350±0.011_{stat}±0.010_{syst})%, respectively, where the former is of much improved precision compared to previous results and the latter is determined for the first time...
October 26, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30402402/food-consumption-and-the-risk-of-childhood-allergy
#15
Claudia Fsadni, Peter Fsadni, Stephen Montefort, Stephen Fava
Background: The prevalence of allergic conditions is increasing in most countries. One possible explanation may be childhood nutrition. Objective: The aim of the study was to investigate the relationship between consumption of pre-specified types of food in school-aged children and presence of respiratory and allergic symptoms. Methods: A total of 191 students aged 9-11 years were recruited from 5 schools to geographically cover all of Malta...
October 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/30400671/possible-role-of-cyp450-generated-omega-3-omega-6-pufa-metabolites-in-the-modulation-of-blood-pressure-and-vascular-function-in-obese-children
#16
Sara Bonafini, Alice Giontella, Angela Tagetti, Denise Marcon, Martina Montagnana, Marco Benati, Rossella Gaudino, Paolo Cavarzere, Mirjam Karber, Michael Rothe, Pietro Minuz, Franco Antonazzi, Claudio Maffeis, Wolf Hagen Schunck, Cristiano Fava
Obesity is often accompanied by metabolic and haemodynamic disorders such as hypertension, even during childhood. Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP450) enzymes to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), vasoactive and natriuretic metabolites that contribute to blood pressure (BP) regulation. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) omega-3 polyunsaturated fatty acids may compete with AA for CYP450-dependent bioactive lipid mediator formation...
November 5, 2018: Nutrients
https://www.readbyqxmd.com/read/30389749/glp-1-receptor-in-pancreatic-%C3%AE-cells-regulates-glucagon-secretion-in-a-glucose-dependent-bidirectional-manner
#17
Yanqing Zhang, Keshab R Parajuli, Genevieve E Fava, Rajesh Gupta, Weiwei Xu, Lauren U Nguyen, Anadil F Zakaria, Vivian A Fonseca, Hongjun Wang, Franck Mauvais-Jarvis, Kyle W Sloop, Hongju Wu
Glucagon-like peptide-1 (GLP-1) is known to suppress glucagon secretion, but the mechanism by which GLP-1 exerts this effect is unclear. In this study, we demonstrated GLP-1R expression in α cells using both antibody-dependent and -independent strategies. A novel α cell specific GLP-1R knockout (αGLP-1R-/- ) mouse model was then created and used to investigate its effects on glucagon secretion and glucose metabolism. Both male and female αGLP-1R-/- mice showed higher non-fasting glucagon levels than their wild-type littermates, whereas insulin and GLP-1 levels remained similar...
November 2, 2018: Diabetes
https://www.readbyqxmd.com/read/30389623/all-cause-mortality-in-patients-on-sulphonylurea-monotherapy-compared-to-metformin-monotherapy-in-a-nation-wide-cohort
#18
Sascha Reiff, Stephen Fava
BACKGROUND: Type 2 diabetes is associated with increased mortality. There is some data that sulphonylurea therapy may contribute to this. AIMS: To compare all-cause 3-year mortality of patients on sulphonylurea monotherapy with of patients on metformin monotherapy after adjusting for potential confounders. METHODS: We searched the Maltese national electronic database for diabetes treatment in April 2014. This is an electronic database of all treatment that patients are prescribed through the local National Health Service...
October 30, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/30388917/in-vitro-investigation-of-hypoglycemic-and-oxidative-stress-properties-of-fava-bean-vicia-faba-l-seed-extract-in-saccharomyces-cerevisiae-2376
#19
Dhiraj Kumar Choudhary, Abha Mishra
Imbalance of free radicals over antioxidants in human body may result in oxidative damage to biomolecules (lipids, proteins, DNA) that causes severe chronic diseases. The aim of this proposed research was to examine the hypoglycemic and oxidative stress potential of fava bean (Vicia faba L.) seed extract. Acetone extract showed a significant effect on glucose uptake rate (77.28 ± 2.42%) in yeast cells at 25 mM glucose concentration. Minimum glucose uptake rate was found to be 52.36 ± 2.06% % by chloroform seed extract...
November 2, 2018: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/30375215/lack-of-detection-of-cutavirus-dna-using-pcr-real-time-in-cutaneous-t-cell-lymphomas-ctcl
#20
Massimiliano Bergallo, Valentina Daprà, Paolo Fava, Renata Ponti, Cristina Calvi, Maria Teresa Fierro, Pietro Quaglino, Ilaria Galliano, Paola Montanari
BACKGROUND: A novel human protoparvovirus named cutavirus has been discovered. We investigated the presence of cutavirus in a sample of Cutaneous T-cell Lymphomas by using PCR real time taqman. METHODS: In total, 55 CTCL samples were analyzed using a Taqman Real time PCR on a 7500 ABI instrument. All of these shown internal control amplification. RESULTS: The presence of cutavirus DNA corresponding was examined. CuV DNA sequences were not detected in any skin specimen...
October 29, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
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