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Renal hypertension

Ivo Petrov, Iveta Tasheva, Iskren Garvanski, Mihail Marzyanov, Gloria Adam
OBJECTIVE: To evaluate whether percutaneous recanalization and stenting of totally occluded renal arteries is feasible and might be justified as effective in reducing the blood pressure (BP) in some patients with preserved collateral renal flow. PATIENTS AND METHODS: Seven consecutive patients (3 women, 4 men) at average age of 42.8 years (range, 15-67 years) with resistant hypertension, high renin activity, renal artery occlusion and preserved subsegmental flow were included...
July 22, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Tufan Çınar, Ibrahim Rencüzoğulları, Yavuz Karabağ, Metin Çağdaş
BACKGROUND: Renal artery stenosis (RAS) is a leading cause of hypertension, renal failure, pulmonary edema, and loss of renal mass. Atherothrombotic renal disease is a well-described entity, known primarily for its high mortality rate. CASE: Here, we present a case of acute unrecognized atherothrombosis of RAS due to catheter-induced dissection in a patient with a limited functioning renal artery and solitary kidney. A fifty-two-year-old patient recently diagnosed with hypertension was admitted to our cardiology clinic showing symptoms of uncontrolled hypertension...
August 15, 2018: Heart & Lung: the Journal of Critical Care
Alfonso Eirin, Amir Lerman, Lilach O Lerman
PURPOSE OF REVIEW: This review summarizes literature pertaining to the dawning field of therapeutic targeting of mitochondria in hypertension and discusses the potential of these interventions to ameliorate hypertension-induced organ damage. RECENT FINDINGS: In recent years, mitochondrial dysfunction has been reported as an important contributor to the pathogenesis of hypertension-related renal, cardiac, and vascular disease. This in turn prompted development of novel mitochondria-targeted compounds, some of which have shown promising efficacy in experimental studies and safety in clinical trials...
August 17, 2018: Current Hypertension Reports
Hong Xue, Guangyuan Zhang, Aron M Geurts, Kristie Usa, David M Jensen, Yong Liu, Michael E Widlansky, Mingyu Liang
BACKGROUND: miR-29 is a master regulator of extracellular matrix genes, but conflicting data on its anti-fibrotic effect have been reported. miR-29 improves nitric oxide (NO) production in arterioles by targeting Lypla1. Mir29b1 targeted mutation exacerbates hypertension in a model derived from the Dahl salt-sensitive rat. We examined the effect of Mir29b1 mutation on tissue fibrosis and NO levels with a focus on kidney regions. METHODS: Mir29b1 targeted mutant rats on the genetic background of SS-Chr13BN rats were studied...
August 14, 2018: EBioMedicine
Salman Ahmed, Muhammad Mohtasheemul Hasan, Haroon Khan, Zafar Alam Mahmood, Seema Patel
About 12% of world population is affected by different forms of urolithiasis of which the recurrence rate in female is 47-60% and in male is 70-80%. Standard therapeutic agents (allopurinol, citrate, cystone and thiazide diuretics) are used to prevent and treat urolithiasis but these are not universally-effective due to common kidney stone relapse and other side effects. Surgical treatment causes long-term renal damage, hypertension and stone recurrence. Polyphenols, the plant-derived bioactive molecules, have showed protection against cancers, cardiovascular diseases, diabetes, osteoporosis and neurodegenerative diseases, among a number of other ailments...
July 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Eliane Campos Alves, Jacqueline de Almeida Gonçalves Sachett, Vanderson Souza Sampaio, José Diego de Brito Sousa, Sâmella Silva de Oliveira, Elizandra Freitas do Nascimento, Alessandra Dos Santos Santos, Iran Mendonça da Silva, Ana Maria Moura da Silva, Fan Hui Wen, Mônica Colombini, Marcus Vinicius Guimarães de Lacerda, Wuelton Marcelo Monteiro, Luiz Carlos de Lima Ferreira
Acute Kidney Injury (AKI) is the main systemic complication and cause of death in viperid envenomation. Although there are hypotheses for the development of AKI, the mechanisms involved are still not established. The aim of this study was to evaluate the clinical-laboratorial-epidemiological factors associated with AKI in victims of Bothrops sp envenomation. This is an observational study carried out at the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. AKI was defined according to the guidelines of the Acute Kidney Injury Network (AKIN)...
2018: PloS One
Christoffer V Madsen, Erik Ilsø Christensen, Rikke Nielsen, Helle Mogensen, Åse K Rasmussen, Ulla Feldt-Rasmussen
Fabry disease (FD) is an X-linked, lysosomal storage disease. Mutations in the gene coding for alpha-galactosidase A lead to globotriaosylceramide (Gb-3) accumulation in lysosomes and in placenta and umbilical cord. Impact of FD and treatment with enzyme replacement (ERT) on foetal development is undisclosed.A 38-year-old primigravida with FD (G85N) is reported. She has 50% reduced alpha-galactosidase A activity and elevated plasma and urine-Gb-3. She was severely affected with ischaemic stroke at age 23, hypertension, albuminuria and moderately reduced renal function...
August 17, 2018: JIMD Reports
María D Paredes, Paola Romecín, Noemí M Atucha, Francisco O'Valle, Julián Castillo, María Clara Ortiz, Joaquín García-Estañ
Many studies have shown that flavonoids are effective as antihypertensive drugs in arterial hypertension. In the present work, we have analyzed the effects of some flavonoid extracts in the spontaneous hypertensive rat model (SHR). An important feature of this study is that we have used a low dose, far from those that are usually applied in human therapy or experimental animals, a dose that responded to the criterion of a potential future commercial use in human subjects. Treatments were carried out for 6 and 12 weeks in two groups of SHR rats, which received apigenin, lemon extract, grapefruit + bitter orange (GBO) extracts, and cocoa extract...
August 16, 2018: Nutrients
Donata Ringaitiene, Lina Puodziukaite, Vaidas Vicka, Dalia Gineityte, Mindaugas Serpytis, Jurate Sipylaite
OBJECTIVE: To determine whether bioelectrical impedance-derived phase angle (PA) can be a predictor of red blood cell (RBC) transfusion in patients undergoing cardiac surgery. DESIGN: An observational retrospective study of prospectively collected data. SETTING: Single center, tertiary referral university hospital. PARTICIPANTS: The study sample comprised 642 adult patients undergoing elective cardiac surgery. INTERVENTIONS: Patient demographic and clinical variables were collected...
July 7, 2018: Journal of Cardiothoracic and Vascular Anesthesia
So-Ryoung Lee, Eue-Keun Choi, Kyung-Do Han, Jin-Hyung Jung, Seil Oh, Gregory Y H Lip
BACKGROUND: It is unclear whether edoxaban shows better risk reduction of ischemic stroke, bleeding, and all-cause mortality than warfarin in Asian patients with nonvalvular atrial fibrillation (AF). OBJECTIVES: This study compared the effectiveness and safety of edoxaban with those of warfarin in a Korean population with AF. METHODS: Using the Korean National Health Insurance Service database, we included new users of edoxaban and warfarin in patients with AF from January 2014 to December 2016 (n = 4,200 on edoxaban, and n = 31,565 on warfarin) and analyzed the risk of ischemic stroke, intracranial hemorrhage (ICH), hospitalization for gastrointestinal (GI) bleeding, hospitalization for major bleeding, and all-cause death...
August 21, 2018: Journal of the American College of Cardiology
T D Paula, B R Silva, M D Grando, H C D Souza, L M Bendhack
AIM: To investigate the molecular mechanisms and cellular signaling pathways involved in the activation of TP receptors and the consequent induction of contractile responses in coronary arteries of renal hypertensive (2K-1C) rats. METHODS AND RESULTS: The coronary perfusion pressure (CPP) was lower in 2K-1C rats during increased coronary flow as measured by the Langendorff technique. The coronary contraction and relaxation were evaluated by vascular reactivity studies, and the molecular mechanisms were investigated on the basis of the protein expression of TP receptors, Cav-1, eNOS, COX-1, and COX-2, as measured by Western blot...
August 13, 2018: Journal of Molecular and Cellular Cardiology
Türkan Acar, Yesim Güzey Aras, Sıdıka Sinem Gül, Atılgan Bilgehan Acar
Background and purpose: Uric acid is a molecule that is known to act as a natural antioxidant in acute oxidative stress conditions such as acute ischemic stroke (AIS). Although there are several studies on the prognostic value of serum uric acid (UA) level, especially the AIS, its importance in ischemic stroke is still controversial. Our aim in this study is to investigate whether the serum UA level is an indicative biomarker in the large-artery atherosclerosis in the AIS etiology. Methods: Of the patients admitted to Sakarya University Training and Research Hospital Department of Neurology between January 2017 and November 2017, 91 hospitalized patients, who had AIS diagnosis and had their uric acid levels measured, were analyzed retrospectively...
July 30, 2018: Ideggyógyászati Szemle
Pantelis A Sarafidis, Francesca Mallamaci, Charalampos Loutradis, Robert Ekart, Claudia Torino, Antonios Karpetas, Vasileios Raptis, Athanasios Bikos, Aikaterini Papagianni, Olga Balafa, Konstantinos Siamopoulos, Giovanni Pisani, Massimo Morosetti, Antonio Del Giudice, Filippo Aucella, Luca Di Lullo, Rocco Tripepi, Giovanni Tripepi, Kitty Jager, Friedo Dekker, Gerard London, Carmine Zoccali
No abstract text is available yet for this article.
August 2, 2018: Nephrology, Dialysis, Transplantation
Jacqueline Chua, Calvin Woon Loong Chin, Jimmy Hong, Miao Li Chee, Thu-Thao Le, Daniel Shu Wei Ting, Tien Yin Wong, Leopold Schmetterer
OBJECTIVE: Reduction in capillary density or rarefaction is a hallmark of essential hypertension. We measured the retinal capillary density using noninvasive optical coherence tomographic angiography (OCT-A) in adults with treated systemic hypertension and determined possible correlations with ambulatory blood pressure (BP) and renal parameters. METHODS: This observational cross-sectional study consisted of 153 normal eyes from 77 nondiabetic hypertensive adults [mean (SD) age, 58 (9) years; 49% women; 23% poorly controlled BP]...
August 14, 2018: Journal of Hypertension
Susanne Jung, Christian Ott, Marina V Karg, Agnes Bosch, Michael Schmid, Christian Schlundt, Stephan Achenbach, Roland E Schmieder
OBJECTIVE: In patients with resistant hypertension, percutaneous placement of an iliac arteriovenous coupler device leads to a reduction of blood pressure (BP) via decreased total vascular resistance and improved arterial compliance. However, long-term efficacy and safety need to be further explored. We report on the first case of 3.5-year follow-up in a patient who underwent implantation of an iliac arteriovenous coupler device. RESULTS: A patient with resistant hypertension was admitted to hospital...
August 14, 2018: Journal of Hypertension
Agustin J Ramirez, Maria J Sanchez, Ramiro A Sanchez
INTRODUCTION: Hypertension control reduces cardiovascular and renal risks in type 2 diabetes. Sodium-glucose cotransporter-2 inhibitors prevent renal glucose reabsorption and decrease glucose plasma levels, blood pressure (BP) and weight reduction. Treatment of hypertension and sodium-glucose cotransporter-2 are able to improve arterial stiffness. AIMS: To evaluate, in patients with type 2 diabetes and hypertension, the effects of 6 months treatment with canagliflozin, or perindopril, an angiotensin converting enzyme inhibitor, on central BP and carotid-femoral pulse wave velocity (cfPWV)...
August 14, 2018: Journal of Hypertension
Priyanka Nandakumar, Alanna C Morrison, Megan L Grove, Eric Boerwinkle, Aravinda Chakravarti
Rare variants, in particular renal salt handling genes, contribute to monogenic forms of hypertension and hypotension syndromes with electrolyte abnormalities. A study by Ji et al (2008) demonstrated this effect for rare loss-of-function coding variants in SLC12A3 (NCCT), SLC12A1 (NKCC2), and KCNJ1 (ROMK) that led to reduction of ∼6 mm Hg for SBP and ∼3 mm Hg for DBP among carriers in 2492 European ancestry Framingham Heart Study (FHS) subjects. These findings support a potentially large role for these variants in interindividual variation in systolic and diastolic blood pressure (SBP, DBP) in the population...
August 2018: Medicine (Baltimore)
Carina J Gronlund, Lianne Sheppard, Sara D Adar, Marie S O'Neill, Amy Auchincloss, Jaime Madrigano, Joel Kaufman, Ana V Diez Roux
BACKGROUND: With climate change, temperatures are increasing. Heat-associated health events disproportionately affect certain subpopulations. However, prior research has often lacked information on individual-level health and air conditioning and neighborhood stressors/protections. OBJECTIVES: To assess whether 1) heat (2-day mean temperature above local 75 percentiles) is associated with increased heart rate and decreased blood pressure, controlling for age, time, season, daily ozone, and daily particulate matter (PM2...
August 14, 2018: Epidemiology
Brian R Stotter, Michael A Ferguson
The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in a host of renal and cardiovascular functions. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), drugs that disrupt RAAS function, are effective in treating hypertension and offer other renoprotective effects independent of blood pressure (BP) reduction. As our understanding of RAAS physiology and the feedback mechanisms of ACE inhibition and angiotensin receptor blockade have improved, questions have been raised as to whether combination ACEI/ARB therapy is warranted in certain patients with incomplete angiotensin blockade on one agent...
August 15, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Andrew M South, Patricia A Nixon, Mark C Chappell, Debra I Diz, Gregory B Russell, Elizabeth T Jensen, Hossam A Shaltout, T Michael O'Shea, Lisa K Washburn
BACKGROUND: Preterm birth increases the risk of hypertension and kidney disease. However, it is unclear when changes in blood pressure (BP) and renal function become apparent and what role obesity and sex play. We hypothesized adolescents born preterm have higher BP and worse kidney function compared to term in an obesity- and sex-dependent manner. METHODS: Cross-sectional analysis of 14-year-olds born preterm with very low birth weight (n = 96) compared to term (n = 43)...
August 15, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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