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https://www.readbyqxmd.com/read/30549413/a-novel-autosomal-dominant-mutation-in-sox18-resulting-in-a-fatal-case-of-hypotrichosis-lymphedema-telangiectasia-syndrome
#1
Hannah Wangberg, Kristen Wigby, Marilyn C Jones
Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS) is a rare disorder caused by autosomal recessive and autosomal dominant mutations in SOX18. This gene encodes a transcription factor involved in the regulation and development of the human vasculature, lymphatic, and integumentary systems. Individuals with HLTS develop varying degrees of hypotrichosis, lymphedema, and telangiectasias. Other complications, such as renal failure and aortic dilation, have also been observed. Here, we report a neonate with a novel mutation in SOX18 (c...
December 14, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/30549404/comparison-of-two-different-radiofrequency-ablation-systems-for-renal-artery-denervation-evaluation-of-short-term-and-long-term-follow-up
#2
Sara I Al Raisi, Jim Pouliopoulos, Pierre Qian, Patricia King, Karen Byth, Michael T Barry, John Swinnen, Aravinda Thiagalingam, Pramesh Kovoor
OBJECTIVES: To assess the clinical efficacy of renal artery denervation (RAD) in our center and to compare the efficacy of two different radiofrequency (RF) systems. BACKGROUND: Several systems are available for RF renal denervation. Whether there is a difference in clinical efficacy among various systems remains unknown. METHODS: Renal artery denervation was performed on 43 patients with resistant hypertension using either the single electrode Symplicity Flex (n = 20) or the multi-electrode EnligHTN system (n = 23)...
December 14, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/30547127/utility-of-the-claw-sign-in-spine-magnetic-nuclear-resonance-with-diffusion-to-differentiate-modic-type-i-changes-for-degenerative-disease-versus-infection
#3
Juan Esteban Muñoz Montoya, Carlos Pérez Cataño, Angela María Tapicha Cuellar, Maria Paula Vargas Osorio, Jimar Rivero Cano, Juan Carlos Luque Suarez, Marco Luciano Charry Lopez
Background: In 1988, Modic and his colleagues described changes in the subchondral bone marrow of the vertebral plates in patients with degenerative disease or other pathologies, which were observed in the nuclear magnetic resonance (NMR) of the spine and were subdivided into three patterns of signal changes, called Modic type I, Modic type II and Modic type III. The main differential diagnosis of the Modic I changes of the vertebral plates due to degenerative disease in spine NMR, is infection in its early stages...
September 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/30544382/the-impact-of-abdominal-fat-on-abdominal-aorta-calcification-measured-on-non-enhanced-ct
#4
Limor Goldenberg, Walid Saliba, Hashem Hayeq, Rabea Hasadia, Abdel-Rauf Zeina
Cardiovascular (CV) morbidity, atherosclerosis, and obesity are all targets of clinical concern and vast research, as is the association between them. Aim of this study is to assess the impact of adipose tissue (including visceral and subcutaneous fat) on abdominal aorta calcification measured on non-enhanced computed tomography (CT). We retrospectively included 492 patients who underwent non-enhanced CT scans during workup for clinically suspected renal colic. All scans were reviewed for abdominal aorta calcification, liver attenuation, and thickness of visceral and subcutaneous fat...
December 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30544108/echocardiographic-and-hemodynamic-parameters-associated-with-diminishing-renal-filtration-among-patients-with-heart-failure-with-preserved-ejection-fraction
#5
Kevin Bryan Lo, Kene Mezue, Pradhum Ram, Abhinav Goyal, Mahek Shah, Parasuram Krishnamoorthy, Shuchita Gupta, Gregg S Pressman, Janani Rangaswami
BACKGROUND: Renal dysfunction is an important predictor of poor outcomes in patients with heart failure with preserved ejection fraction (HFpEF). Right ventricular (RV) dysfunction is implicated as one of the explanations for worsening renal function in cardiorenal syndrome. Novel right heart catheterization (RHC) parameters such as pulmonary artery pulsatility index (PAPi) and right atrial to pulmonary capillary wedge pressure ratio (RA:PCWP) have been found as predictors of RV dysfunction...
December 13, 2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/30544040/total-arch-replacement-for-aortic-arch-aneurysm-with-coexisting-middle-aortic-syndrome
#6
Zaiqiang Yu, Masahito Minakawa, Norihiro Kondo, Kazuyuki Daitoku, Ikuo Fukuda
INTRODUCTION: Middle aortic syndrome (MAS) combined with thoracic aortic aneurysm (TAA) is a rare vascular disease. One stage open surgery to treat this condition, becomes a challenge for our cardiovascular surgery. PRESENTATION OF CASE: A 69-year-old man presented with a saccular type aortic arch aneurysm, shaggy aorta and severe atherosclerotic stenosis of the thoracoabdominal aorta with middle aortic syndrome and aberrant right subclavian artery, renovascular hypertension, renal dysfunction, and intermittent claudication of both legs...
November 24, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30543742/-a-case-report-fdg-uptake-to-brown-adipose-tissue-activated-by-elevated-serum-catecholamine-in-a-patient-with-pheochromocytoma
#7
Yoko Koh, Toshihisa Asakura, Kinzo Katayama, Norihide Tei, Yasunori Harada, Kensaku Nishimura
A 69-year-old woman was admitted to the previous hospital because of a right adrenal tumor detected by a medical checkup. Although the tumor was diagnosed as non-functional adrenal adenoma, abdominal computed tomography (CT) revealed a left renal mass which was suspected to be renal cell carcinoma. Chest CT seeking for metastatic lesions revealed lung cancer of the left lung. First, laparoscopic radical nephrectomy was performed. After the surgery, 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) CT performed for staging of the lung cancer demonstrated FDG uptake to the left lung mass, the heart, the right adrenal mass and perirenal regions of the right kidney...
November 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/30542527/immunosuppression-associated-posterior-reversible-encephalopathy-syndrome-in-an-acute-leukemia-case
#8
Umit Y Malkan, Gursel Gunes, Haluk Demiroglu, Hakan Goker
Posterior reversible encephalopathy syndrome (PRES) was described in 1996. Herein, we aimed to report an immunosuppression- related PRES case. A 34-year-old woman was diagnosed as t-cell acute lymphoblastic leukemia and allogeneic hematopoietic stem cell transplantation (HSCT) was performed. Cyclosporine was given for GVHD prophylaxis in addition to the other routine medications of HSCT. She was hospitalized for acute renal failure and due to the possible contribution of acute renal failure cyclosporine was stopped...
November 6, 2018: Hematology Reports
https://www.readbyqxmd.com/read/30541108/educational-level-and-risk-of-chronic-kidney-disease-longitudinal-data-from-the-prevend-study
#9
Chris H L Thio, Priya Vart, Lyanne M Kieneker, Harold Snieder, Ron T Gansevoort, Ute Bültmann
Background: The longitudinal association between low education and chronic kidney disease (CKD) and its underlying mechanisms is poorly characterized. We therefore examined the association of low education with incident CKD and change in kidney function, and explored potential mediators of this association. Methods: We analysed data on 6078 participants from the community-based Prevention of Renal and Vascular End-stage Disease study. Educational level was categorized into low, medium and high (< secondary, secondary/equivalent, > secondary schooling, respectively)...
December 12, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30541088/severe-vitamin-d-deficiency-is-a-risk-factor-for-renal-hyperfiltration
#10
Jong Hyun Jhee, Ki Heon Nam, Seong Yeong An, Min-Uk Cha, Misol Lee, Seohyun Park, Hyoungnae Kim, Hae-Ryong Yun, Youn Kyung Kee, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Tae-Hyun Yoo
Background: Vitamin D deficiency is associated with renal progression in chronic kidney disease. Moreover, improvement of clinical outcomes after vitamin D supplementation has been reported in the diabetic and chronic kidney disease population. Objective: We investigated the association between renal hyperfiltration (RHF) and vitamin D status in a relatively healthy population. Design: Data were retrieved from the Korean NHANES, a nationwide population-based cross-sectional study from 2008 to 2015...
December 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/30540575/complementary-and-integrative-medicine-in-kidney-transplantation
#11
Olta Tafaj-Reddy, Amarpali Brar, Mariana S Markell
PURPOSE OF REVIEW: Complementary and integrative medicine (CIM) use is widely prevalent in kidney transplant recipients but studies of efficacy or potential harm are sparse. This review examines prevalence of use of CIM and discusses potential beneficial and harmful aspects of CIM in renal transplant recipients. RECENT FINDINGS: The prevalence of CIM use in kidney transplant patients varies from 12 to 45%. There is a knowledge gap regarding CIM modalities among healthcare professionals that may contribute to reluctance to discuss CIM use with patients...
December 11, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/30539649/the-impact-of-obesity-as-an-independent-risk-factor-for-the-development-of-renal-injury-implications-from-rat-models-of-obesity
#12
Kasi C McPherson, Corbin A Shields, Bibek Poudel, Brianca Fizer, Alyssa Pennington, Ashley Szabo-Johnson, Willie L Thompson, Denise C Cornelius, Jan Michael Williams
Diabetes and hypertension are the major causes of chronic kidney disease (CKD). Epidemiological studies within the last few decades have revealed that obesity-associated renal disease is a emerging epidemic and that the increasing prevalence of obesity parallels the increased rate of CKD. This has led to the inclusion of obesity as an independent risk factor for CKD. A major complication when studying the relationship between obesity and renal injury is that cardiovascular and metabolic disorders that may result from obesity including hyperglycemia, hypertension, and dyslipidemia, or the cluster of these disorders (defined as the metabolic syndrome, MetS) also contribute to the development and progression of renal disease...
December 12, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/30538746/dental-care-for-patients-with-end-stage-renal-disease-and-undergoing-hemodialysis
#13
REVIEW
Fulvia Costantinides, Gaetano Castronovo, Erica Vettori, Costanza Frattini, Mary Louise Artero, Lorenzo Bevilacqua, Federico Berton, Vanessa Nicolin, Roberto Di Lenarda
Chronic renal failure is a progressive disease characterized by a gradual destruction of nephrons and a consequent reduction of kidney function. End-stage renal disease (ESRD) necessitates renal replacement therapy as peritoneal dialysis, hemodialysis, or transplantation. Patients affected by ESRD or in hemodialysis are at risk for developing a number of comorbidities including hypertension, anemia, risk of bleeding, susceptibility to infection, medication side effects, and oral manifestations associated with the disease itself and with hemodialysis treatment...
2018: International Journal of Dentistry
https://www.readbyqxmd.com/read/30537724/renal-functions-and-prognosis-stratification-in-chronic-heart-failure-patients-and-the-importance-of-neutrophil-gelatinase-associated-lipocalin
#14
Karel Lábr, Jindřich Špinar, Jiří Pařenica, Lenka Špinarová, Filip Málek, Monika Špinarová, Ondřej Ludka, Jiří Jarkovský, Klára Benešová, Monika Goldbergová-Pávková, Růžena Lábrová
BACKGROUND/AIMS: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients...
December 7, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/30537719/prediction-of-esrd-in-iga-nephropathy-patients-from-an-asian-cohort-a-random-forest-model
#15
Yexin Liu, Yan Zhang, Di Liu, Xia Tan, Xiaofang Tang, Fan Zhang, Ming Xia, Guochun Chen, Liyu He, Letian Zhou, Xuejing Zhu, Hong Liu
BACKGROUND/AIMS: There is an increasing risk of end-stage renal disease (ESRD) among Asian people with immunoglobulin A nephropathy (IgAN). A computer-aided system for ESRD prediction in Asian IgAN patients has not been well studied. METHODS: We retrospectively reviewed biopsy-proven IgAN patients treated at the Department of Nephrology of the Second Xiangya Hospital from January 2009 to November 2013. Demographic and clinicopathological data were obtained within 1 month of renal biopsy...
December 7, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/30537108/impaired-pressure-natriuresis-and-non-dipping-blood-pressure-in-rats-with-early-type-1-diabetes-mellitus
#16
Geoffrey J Culshaw, Hannah M Costello, David Binnie, Kevin R Stewart, Alicja Czopek, Neeraj Dhaun, Patrick W F Hadoke, David J Webb, Matthew A Bailey
KEY POINTS SUMMARY: Type 1 diabetes mellitus increases cardiovascular risk: hypertension amplifies this risk. Pressure natriuresis regulates long-term blood pressure. We induced type 1 diabetes in rats by streptozotocin injection and after three weeks demonstrated a substantial impairment of pressure natriuresis: acute increases in blood pressure did not increase renal medullary blood flow, and tubular sodium reabsorption was not downregulated. Proximal tubule sodium reabsorption, measured by lithium clearance, was unaffected...
December 7, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/30535994/pulmonary-hypertension-in-spanish-patients-with-systemic-sclerosis-data-from-the-rescle-registry
#17
Francisco J García-Hernández, María J Castillo-Palma, Carles Tolosa-Vilella, Alfredo Guillén-Del Castillo, Manuel Rubio-Rivas, Mayka Freire, José A Vargas-Hitos, José A Todolí-Parra, Mónica Rodríguez-Carballeira, Gerard Espinosa-Garriga, Dolores Colunga-Argüelles, Norberto Ortego-Centeno, Luis Trapiella-Martínez, María M Rodero-Roldán, Xavier Pla-Salas, Isabel Perales-Fraile, Isaac Pons-Martín Del Campo, Antonio J Chamorro, Rafael A Fernández-de la Puebla Giménez, Ana B Madroñero-Vuelta, Manuel Ruíz-Muñoz, Vicent Fonollosa-Pla, Carmen P Simeón-Aznar
INTRODUCTION: Our objective was to evaluate the pulmonary hypertension (PH) data for Spanish patients with systemic sclerosis (SSc), define the PH types and determine the associated factors. METHOD: Descriptive study of PH-related data from the multicentre RESCLE registry. Estimated systolic pulmonary artery pressure (esPAP), measured via echocardiogram was considered elevated if ≥ 35 mmHg. Left heart disease (LHD) and interstitial lung disease (ILD) were identified...
December 7, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30535798/hypertension-is-common-in-patients-with-newly-diagnosed-acromegaly-and-is-independently-associated-with-renal-resistive-index
#18
Hilmi Erdem Sumbul, Ayse Selcan Koc
INTRODUCTION: There are conflicting results regarding the frequency of hypertension (HT) and values of related parameters in patients with acromegaly. AIM: We aimed to determine the frequency of HT and values of its associated parameters in patients with acromegaly. METHODS: 57 patients with newly diagnosed acromegaly were included in this study. Renal ultrasonography (US) was performed in addition to routine evaluation of acromegaly. Renal resistive index (RRI), renal pulsatility index (RPI), and accelerated time were measured using Doppler US...
December 7, 2018: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/30535014/renal-nerve-ablation-for-hypertension-update-from-an-insider
#19
Murray Esler
No abstract text is available yet for this article.
December 7, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30535013/thomas-l%C3%A3-scher-on-the-revival-of-renal-nerve-ablation-for-hypertension
#20
Judy Ozkan
No abstract text is available yet for this article.
December 7, 2018: European Heart Journal
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