Yaoyang Liu, Chao Ma, Yingbo Li, Mengzhen Li, Tao Cui, Xueqi Zhao, Zhenli Li, Hongwei Jia, Hanxun Wang, Xiaomeng Xiu, Dexiang Hu, Ruiwen Zhang, Ningwei Wang, Peng Liu, Huali Yang, Maosheng Cheng
In this study, a series of carbamate derivatives incorporating multifunctional carrier scaffolds were designed, synthesized, and evaluated as potential therapeutic agents for Alzheimer's disease (AD). We used tacrine to modify the aliphatic substituent, and employed rivastigmine, indole and sibiriline fragments as carrier scaffolds. The majority of compounds exhibited good inhibitory activity for cholinesterase. Notably, compound C7 with sibiriline fragment exhibited potent inhibitory activities against human acetylcholinesterase (hAChE, IC50 = 30...
December 21, 2023: European Journal of Medicinal Chemistry