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Dysfunctional hdl and atherosclerosis cardiovascular

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https://www.readbyqxmd.com/read/29992715/adverse-effects-on-macrophage-lipid-transport-and-survival-by-high-density-lipoprotein-from-patients-with-coronary-heart-disease
#1
S Sini, D Deepa, S Harikrishnan, N Jayakumari
High density lipoprotein (HDL)-macrophage interactions have the potential to modulate macrophage function in a beneficial way to prevent the development of lipid-loaded foam cell formation in atherosclerosis. Although HDL is atheroprotective, it can become dysfunctional in chronic inflammatory conditions and increase cardiovascular risk. Here, we examined the effect of dysfunctional-HDL from patients with coronary artery disease, on macrophage function in comparison to functional-HDL from controls. Exposure of macrophages to dysfunctional-HDL for 24 h resulted significant increase in cellular oxidative stress, cholesterol, and cytotoxicity...
July 10, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29901625/high-density-lipoprotein-cholesterol-functionality-and-metabolic-syndrome-protocol-for-review-and-meta-analysis
#2
REVIEW
Leonardo Roever, Elmiro Santos Resende, Angélica Lemos Debs Diniz, Nilson Penha-Silva, João Lucas O'Connell, Paulo Fernando Silva Gomes, Hugo Ribeiro Zanetti, Anaisa Silva Roerver-Borges, Fernando César Veloso, Fernanda Rodrigues de Souza, Poliana Rodrigues Alves Duarte, Thiago Montes Fidale, Antonio Casella-Filho, Paulo Magno Martins Dourado, Antonio Carlos Palandri Chagas, Sadeq Ali-Hasan-Al-Saegh, Paulo Eduardo Ocke Reis, Rogério de Melo Costa Pinto, Gustavo B F Oliveira, Álvaro Avezum, Mansueto Neto, André Rodrigues Durães, Rose Mary Ferreira Lisboa da Silva, Antonio José Grande, Celise Denardi, Renato Delascio Lopes, Nitesh Nerlekar, Shahab Alizadeh, Adrian V Hernandez, Maria Inês da Rosa, Giuseppe Biondi-Zoccai
INTRODUCTION: The prevalence of metabolic syndrome (MetS) and MetS-related stroke is set to increase dramatically in coming decades. MetS is a complex disease that includes endothelial dysfunction, insulin resistance, diabetes, hypertension, ectopic obesity, and dyslipidaemia and an increased risk of cardiovascular events. One function of high-density lipoprotein (HDL) cholesterol (HDL-C) is the cholesterol-efflux pathway, which is the pathway where cholesterol is removed from macrophages within the arterial walls back into the bloodstream and out to the liver...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29874886/the-role-of-high-density-lipoproteins-in-diabetes-and-its-vascular-complications
#3
REVIEW
Nathan K P Wong, Stephen J Nicholls, Joanne T M Tan, Christina A Bursill
Almost 600 million people are predicted to have diabetes mellitus (DM) by 2035. Diabetic patients suffer from increased rates of microvascular and macrovascular complications, associated with dyslipidaemia, impaired angiogenic responses to ischaemia, accelerated atherosclerosis, and inflammation. Despite recent treatment advances, many diabetic patients remain refractory to current approaches, highlighting the need for alternative agents. There is emerging evidence that high-density lipoproteins (HDL) are able to rescue diabetes-related vascular complications through diverse mechanisms...
June 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29870498/cardiovascular-disease-in-systemic-lupus-erythematosus-an-update
#4
Yudong Liu, Mariana J Kaplan
PURPOSE OF REVIEW: The mechanisms leading to the development of premature atherosclerosis and vascular injury in systemic lupus erythematosus (SLE) remain to be fully elucidated. This is a comprehensive review of recent research developments related to the understanding of cardiovascular disease (CVD) in lupus. RECENT FINDINGS: SLE patients with lupus nephritis display significantly increased risk of myocardial infarction and CVD mortality than SLE patients without lupus nephritis...
September 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29869756/molecular-mechanisms-underlying-uremic-toxin-related-systemic-disorders-in-chronic-kidney-disease-focused-on-%C3%AE-2-microglobulin-related-amyloidosis-and-indoxyl-sulfate-induced-atherosclerosis-oshima-award-address-2016
#5
REVIEW
Suguru Yamamoto
Uremic toxins are linked to chronic kidney disease (CKD)-related systemic diseases. β2 -Microglobulin (β2 -m), a water-soluble, middle-sized molecule, is associated with mortality and dialysis-related amyloidosis (DRA). DRA occurs in long-term dialysis patients, with β2 -m amyloid deposited mainly in osteoarticular tissues. We investigated a model of β2 -m amyloid fibril extension at neutral pH in the presence of trifluoroethanol or sodium dodecyl sulfate. Using this model, some biological molecules, including glycosaminoglycans and lysophospholipids, were found to be chaperones for β2 -m amyloid fibril extension...
June 5, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29848265/biological-consequences-of-dysfunctional-hdl
#6
Angela Pirillo, Alberico Luigi Catapano, Giuseppe Danilo Norata
Epidemiological studies have suggested an inverse correlation between high density lipoprotein (HDL) cholesterol levels and the risk of cardiovascular disease. HDLs promote reverse cholesterol transport (RCT) and possess several putative atheroprotective functions, associated to the anti-inflammatory, anti-thrombotic and anti-oxidant properties as well as to the ability to support endothelial physiology. The assumption that increasing HDL-C levels would be beneficial on cardiovascular disease (CVD), however, has been questioned as, in most clinical trials, HDL-C-raising therapies did not result in improved cardiovascular outcomes...
May 29, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29793333/oleanolic-acid-protects-against-pathogenesis-of-atherosclerosis-possibly-via-fxr-mediated-angiotensin-ang-1-7-upregulation
#7
Yunyun Pan, Fenghua Zhou, Zhenhua Song, Huiping Huang, Yong Chen, Yonggang Shen, Yuhua Jia, Jisheng Chen
Atherosclerosis, the leading cause of cardiovascular diseases in the world, is a chronic inflammatory disorder characterized by the dysfunction of arteries. Oleanolic acid (OA) is a bioactive nature product which exists in various plants and herbs. Previous studies have demonstrated that OA was involved in numerous of biological processes, including atherosclerosis. However, the exact mechanisms of the anti-atherosclerosis effects of OA remain unknown. Here, in our study, we analyzed the effects and possible underlying mechanisms of OA in atherosclerosis depending a cell model and an animal model of atherosclerosis...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29731282/rethinking-reverse-cholesterol-transport-and-dysfunctional-high-density-lipoproteins
#8
REVIEW
Baiba K Gillard, Corina Rosales, Bingqing Xu, Antonio M Gotto, Henry J Pownall
Human plasma high-density lipoprotein cholesterol concentrations are a negative risk factor for atherosclerosis-linked cardiovascular disease. Pharmacological attempts to reduce atherosclerotic cardiovascular disease by increasing plasma high-density lipoprotein cholesterol have been disappointing so that recent research has shifted from HDL quantity to HDL quality, that is, functional vs dysfunctional HDL. HDL has varying degrees of dysfunction reflected in impaired reverse cholesterol transport (RCT). In the context of atheroprotection, RCT occurs by 2 mechanisms: one is the well-known trans-hepatic pathway comprising macrophage free cholesterol (FC) efflux, which produces early forms of FC-rich nascent HDL (nHDL)...
April 12, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29669944/neutrophil-subsets-and-their-gene-signature-associate-with-vascular-inflammation-and-coronary-atherosclerosis-in-lupus
#9
Philip M Carlucci, Monica M Purmalek, Amit K Dey, Yenealem Temesgen-Oyelakin, Simantini Sakhardande, Aditya A Joshi, Joseph B Lerman, Alice Fike, Michael Davis, Jonathan H Chung, Martin P Playford, Mohammad Naqi, Pragnesh Mistry, Gustavo Gutierrez-Cruz, Stefania Dell'Orso, Faiza Naz, Taufiq Salahuddin, Balaji Natarajan, Zerai Manna, Wanxia L Tsai, Sarthak Gupta, Peter Grayson, Heather Teague, Marcus Y Chen, Hong-Wei Sun, Sarfaraz Hasni, Nehal N Mehta, Mariana J Kaplan
BACKGROUND: Systemic lupus erythematosus (SLE) is associated with enhanced risk of atherosclerotic cardiovascular disease not explained by Framingham risk score (FRS). Immune dysregulation associated to a distinct subset of lupus proinflammatory neutrophils (low density granulocytes; LDGs) may play key roles in conferring enhanced CV risk. This study assessed if lupus LDGs are associated with in vivo vascular dysfunction and inflammation and coronary plaque. METHODS: SLE subjects and healthy controls underwent multimodal phenotyping of vascular disease by quantifying vascular inflammation (18F-fluorodeoxyglucose-PET/CT [18F-FDG-PET/CT]), arterial dysfunction (EndoPAT and cardio-ankle vascular index), and coronary plaque burden (coronary CT angiography)...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29663823/would-janus-view-on-hdl-be-useful
#10
M Kasko, V Kasko, S Oravec
Low-density lipoprotein cholesterol (LDL-C) is generally considered to be pro-atherogenic and high-density lipoprotein cholesterol (HDL-C) to be anti-atherogenic. The clinical approach to the diagnostics and treatment of clinical manifestations of atherosclerosis is the examination of the lipid spectrum. In routine clinical practice, the effects of the HDL class are measured only by determining the concentration of HDL cholesterol. It is questionable whether this clinical approach provides sufficient information to evaluate both the overall cardiovascular risk and the effect of hypolipidemic therapy...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29588416/programmed-cell-death-5-suppresses-akt-mediated-cytoprotection-of-endothelium
#11
Seung-Hyun Lee, Jaesung Seo, Soo-Yeon Park, Mi-Hyeon Jeong, Hyo-Kyoung Choi, Chan Joo Lee, Mi Jeong Kim, Garam Guk, SooYeon Lee, Hyewon Park, Jae-Wook Jeong, Chang Hoon Ha, Sungha Park, Ho-Geun Yoon
Programmed cell death 5 (PDCD5) has been associated with human cancers as a regulator of cell death; however, the role of PDCD5 in the endothelium has not been revealed. Thus, we investigated whether PDCD5 regulates protein kinase B (PKB/AKT)-endothelial nitric oxide synthase (eNOS)-dependent signal transduction in the endothelium and affects atherosclerosis. Endothelial-specific PDCD5 knockout mice showed significantly reduced vascular remodeling compared with wild-type (WT) mice after partial carotid ligation...
May 1, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29546829/dysfunctional-hdl-as-a-therapeutic-target-for-atherosclerosis-prevention
#12
Alice Ossoli, Chiara Pavanello, Eleonora Giorgio, Laura Calabresi, Monica Gomaraschi
Hypercholesterolemia is one of the main risk factors for the development of atherosclerosis. Among the various lipoprotein classes, however, high density lipoproteins (HDL) are inversely associated with the incidence of atherosclerosis, since they are able to exert a series of atheroprotective functions. The central role of HDL within the reverse cholesterol transport, their antioxidant and anti-inflammatory properties and their ability to preserve endothelial homeostasis are likely responsible for HDL-mediated atheroprotection...
March 15, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29537350/association-of-obstructive-sleep-apnea-with-microvascular-endothelial-dysfunction-and-subclinical-coronary-artery-disease-in-a-community-based-population
#13
Daniel Shpilsky, Sebhat Erqou, Sanjay R Patel, Kevin E Kip, Oluremi Ajala, Aryan Aiyer, Patrick J Strollo, Steven E Reis, Oladipupo Olafiranye
Studies have reported an association between obstructive sleep apnea (OSA) and cardiovascular disease (CVD) morbidity and mortality. Proposed mechanisms include endothelial dysfunction and atherosclerosis. We aimed to investigate the associations of OSA with endothelial dysfunction and subclinical atherosclerotic coronary artery disease (CAD), and assess the impact of race on these associations. We used data from the Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) study, a community-based prospective cohort with approximately equal representation of black and white participants...
August 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29423541/autoantibody-to-apolipoprotein-a-1-in-hepatitis-c-virus-infection-a-role-in-atherosclerosis
#14
Simon H Bridge, Sabrina Pagano, Meleri Jones, Graham R Foster, Dermot Neely, Nicolas Vuilleumier, Margaret F Bassendine
BACKGROUND/PURPOSE: One to three per cent of the world's population has hepatitis C virus (HCV) infection, which is not only a major cause of liver disease and cancer but also associated with an increased risk of atherosclerosis, despite an ostensibly favourable lipid profile. Autoantibodies are frequent in HCV infection and emerging evidence shows that autoantibodies could be valuable for cardiovascular disease (CVD) risk stratification. This study investigated a novel independent biomarker of CVD, autoantibodies to apolipoprotein A-1 (anti-apoA-1 IgG) and lipids in patients with chronic HCV before, during and after direct-acting anti-viral (DAA) therapy...
January 2018: Hepatology International
https://www.readbyqxmd.com/read/29368426/serum-endocan-levels-are-associated-with-paraoxonase-1-concentration-in-patients-with-chronic-kidney-disease
#15
Elisabeth Samouilidou, Eirini Bountou, Fotini Papandroulaki, Manolis Papamanolis, Dimitris Papakostas, Eirini Grapsa
Endocan is a soluble proteoglycan released by the vascular endothelium. The increase of its serum levels is associated with inflammation, endothelial dysfunction and cardiovascular events in patients with chronic kidney disease (CKD). We studied the association of serum endocan with the lipid profile of 105 CKD patients with dyslipidemia, divided in two groups, non-dialyzed (CKD, N = 57) and hemodialysis (HD, N = 48) in comparison with 30 normal controls (NC). We also analyzed endocan in relation with the concentration of two serum HDL-linked members of the paraoxonase (PON) family, PON1 and PON3, which have been previously found to have antiatherogenic properties...
January 25, 2018: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29363163/lncrna-rp11-714g18-1-suppresses-vascular-cell-migration-via-directly-targeting-lrp2bp
#16
Yuan Zhang, Lei Zheng, Bang-Ming Xu, Wai-Ho Tang, Zhi-Dong Ye, Chuan Huang, Xin Ma, Jing-Jing Zhao, Feng-Xia Guo, Chun-Min Kang, Jing-Bo Lu, Jian-Cheng Xiu, Pan Li, Yuan-Jun Xu, Lei Xiao, Qian Wu, Yan-Wei Hu, Qian Wang
Atherosclerotic cardiovascular disease is considered as the leading cause of mortality and morbidity worldwide. Accumulating evidence supports an important role for long noncoding RNA (lncRNA) in the pathogenesis of atherosclerosis. Nevertheless, the role of lncRNA in atherosclerosis-associated vascular dysfunction and the underlying mechanism remain elusive. Here, using microarray analysis, we identified a novel lncRNA RP11-714G18.1 with significant reduced expression in human advanced atherosclerotic plaque tissues...
February 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29358116/cadmium-and-atherosclerosis-a-review-of-toxicological-mechanisms-and-a-meta-analysis-of-epidemiologic-studies
#17
REVIEW
Alexey A Tinkov, Tommaso Filippini, Olga P Ajsuvakova, Margarita G Skalnaya, Jan Aaseth, Geir Bjørklund, Eugenia R Gatiatulina, Elizaveta V Popova, Olga N Nemereshina, Pai-Tsang Huang, Marco Vinceti, Anatoly V Skalny
Cadmium has been proposed to be the one of the factors of atherosclerosis development, although the existing data are still controversial. The primary objective of the present study is the review and the meta-analysis of studies demonstrating the association between Cd exposure and atherosclerosis as well as review of the potential mechanisms of such association. We performed a systematic search in the PubMed-Medline database using the MeSH terms cadmium, cardiovascular disease, atherosclerosis, coronary artery disease, myocardial infarction, stroke, mortality and humans up through December 20, 2017...
April 2018: Environmental Research
https://www.readbyqxmd.com/read/29224678/atherosclerosis-in-systemic-lupus-erythematosus
#18
REVIEW
Sara Croca, Anisur Rahman
Cardiovascular disease (CVD), comprising coronary heart disease and stroke, is one of the most important causes of death in patients with systemic lupus erythematosus (SLE). The risks of developing both clinical CVD and sub-clinical atherosclerosis are increased in patients with SLE. This increase is not fully explained by traditional cardiovascular risk factors such as smoking, hypertension and elevated cholesterol, and it is believed that immune dysfunction also contributes to CVD risk in SLE. In particular, recent studies have shown that abnormalities in both serum lipid profile and the autoantibody and T lymphocyte response to lipids may play a role in development of atherosclerosis...
June 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29084567/the-role-and-function-of-hdl-in-patients-with-diabetes-mellitus-and-the-related-cardiovascular-risk
#19
REVIEW
Marek Femlak, Anna Gluba-Brzózka, Aleksandra Ciałkowska-Rysz, Jacek Rysz
BACKGROUND: Diabetes mellitus (DM) is a major public health problem which prevalence is constantly raising, particularly in low- and middle-income countries. Both diabetes mellitus types (DMT1 and DMT2) are associated with high risk of developing chronic complications, such as retinopathy, nephropathy, neuropathy, endothelial dysfunction, and atherosclerosis. METHODS: This is a review of available articles concerning HDL subfractions profile in diabetes mellitus and the related cardiovascular risk...
October 30, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28954528/recombinant-human-cytoglobin-prevents-atherosclerosis-by-regulating-lipid-metabolism-and-oxidative-stress
#20
Lingling Ou, Xin Li, Baihong Chen, Zhenhuang Ge, Junyi Zhang, Ye Zhang, Gaotai Cai, Zhen Li, Ping Wang, Wenqi Dong
Atherosclerosis is a chronic inflammatory vascular disease characterized by lipid accumulation and endothelial dysfunction. Cytoglobin has been shown to exert protective effects under oxidative stress conditions. The aim of this study was to determine whether recombinant human cytoglobin (rhCYGB) has protective effects against atherosclerosis. We intraperitoneally injected rhCYGB (0, 4, or 7 mg/kg BW) into the atherosclerotic rats daily for 60 days. The rhCYGB injections reduced low-density lipoprotein cholesterol (LDL-C) levels and increased high-density lipoprotein cholesterol levels in a dose-dependent manner, rhCYGB (7 mg/kg) significantly attenuated atherosclerosis...
March 2018: Journal of Cardiovascular Pharmacology and Therapeutics
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