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Venus Leg Ulcer

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https://www.readbyqxmd.com/read/26260973/validation-of-the-veines-qol-quality-of-life-instrument-in-venous-leg-ulcers-repeatability-and-validity-study-embedded-in-a-randomised-clinical-trial
#1
RANDOMIZED CONTROLLED TRIAL
J Martin Bland, Jo C Dumville, Rebecca L Ashby, Rhian Gabe, Nikki Stubbs, Una Adderley, Arthur R Kang'ombe, Nicky A Cullum
BACKGROUND: VEINES-QOL/Sym is a disease-specific quality of life instrument for use in venous diseases of the leg. Its relative scoring system precludes comparisons between studies. There were very few venous leg ulcer patients in the validation samples. We report a validation study for venous leg ulcers and develop a scoring system which enables comparison between studies. METHODS: Four hundred fifty-one participants in the VenUS IV trial of the management of venous leg ulcers were asked to complete a VEINES-QOL questionnaire at recruitment, along with SF-12, pain, and other aspects of quality of life...
2015: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/25242076/venus-iv-venous-leg-ulcer-study-iv-compression-hosiery-compared-with-compression-bandaging-in-the-treatment-of-venous-leg-ulcers-a-randomised-controlled-trial-mixed-treatment-comparison-and-decision-analytic-model
#2
RANDOMIZED CONTROLLED TRIAL
Rebecca L Ashby, Rhian Gabe, Shehzad Ali, Pedro Saramago, Ling-Hsiang Chuang, Una Adderley, J Martin Bland, Nicky A Cullum, Jo C Dumville, Cynthia P Iglesias, Arthur R Kang'ombe, Marta O Soares, Nikki C Stubbs, David J Torgerson
BACKGROUND: Compression is an effective and recommended treatment for venous leg ulcers. Although the four-layer bandage (4LB) is regarded as the gold standard compression system, it is recognised that the amount of compression delivered might be compromised by poor application technique. Also the bulky nature of the bandages might reduce ankle or leg mobility and make the wearing of shoes difficult. Two-layer compression hosiery systems are now available for the treatment of venous leg ulcers...
September 2014: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/24315520/clinical-and-cost-effectiveness-of-compression-hosiery-versus-compression-bandages-in-treatment-of-venous-leg-ulcers-venous-leg-ulcer-study-iv-venus-iv-a-randomised-controlled-trial
#3
RANDOMIZED CONTROLLED TRIAL
Rebecca L Ashby, Rhian Gabe, Shehzad Ali, Una Adderley, J Martin Bland, Nicky A Cullum, Jo C Dumville, Cynthia P Iglesias, Arthur R Kang'ombe, Marta O Soares, Nikki C Stubbs, David J Torgerson
BACKGROUND: Drawbacks exist with the standard treatment (four-layer compression bandages) for venous leg ulcers. We have therefore compared the clinical effectiveness and cost-effectiveness of two-layer compression hosiery with the four-layer bandage for the treatment of such ulcers. METHODS: We undertook this pragmatic, open, randomised controlled trial with two parallel groups in 34 centres in England and Northern Ireland. The centres were community nurse teams or services, family doctor practices, leg ulcer clinics, tissue viability clinics or services, and wound clinics...
March 8, 2014: Lancet
https://www.readbyqxmd.com/read/23409783/patients-perceptions-and-experiences-of-venous-leg-ulceration-and-their-attitudes-to-larval-therapy-an-in-depth-qualitative-study
#4
Dorothy McCaughan, Nicky Cullum, Joanne Dumville
BACKGROUND: Venous leg ulcers are a common and distressing condition that can impair quality of life. Larval therapy has been widely promoted for the treatment of different types of chronic wounds, yet little is known about its acceptability to patients. OBJECTIVES: To explore patients' experiences of venous leg ulceration and of the acceptability of larval therapy as a treatment. DESIGN: Qualitative study, using semi-structured interviews alongside a randomized controlled trial...
August 2015: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/21509750/economic-evaluation-of-a-randomized-controlled-trial-of-ultrasound-therapy-for-hard-to-heal-venous-leg-ulcers
#5
RANDOMIZED CONTROLLED TRIAL
L-H Chuang, M O Soares, J M Watson, J M Bland, N Cullum, C Iglesias, A R Kang'ombe, D Torgerson, E A Nelson
BACKGROUND: A pragmatic, multicentre randomized controlled trial (VenUS III) was conducted to determine whether low-dose ultrasound therapy increased the healing rate of hard-to-heal leg ulcers. This study was a cost-effectiveness analysis of the trial data. METHODS: Cost-effectiveness and cost-utility analyses were conducted alongside the VenUS III trial, in which patients were randomly allocated to either ultrasound treatment administered weekly for 12 weeks along with standard care, or standard care alone...
August 2011: British Journal of Surgery
https://www.readbyqxmd.com/read/21385806/use-of-weekly-low-dose-high-frequency-ultrasound-for-hard-to-heal-venous-leg-ulcers-the-venus-iii-randomised-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
Judith M Watson, Arthur R Kang'ombe, Marta O Soares, Ling-Hsiang Chuang, Gill Worthy, J Martin Bland, Cynthia Iglesias, Nicky Cullum, David Torgerson, E Andrea Nelson
OBJECTIVE: To assess the clinical effectiveness of weekly delivery of low dose, high frequency therapeutic ultrasound in conjunction with standard care for hard to heal venous leg ulcers. DESIGN: Multicentre, pragmatic, two arm randomised controlled trial. SETTING: Community and district nurse led services, community leg ulcer clinics, and hospital outpatient leg ulcer clinics in 12 urban and rural settings (11 in the United Kingdom and one in the Republic of Ireland)...
March 8, 2011: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/21375959/venus-iii-a-randomised-controlled-trial-of-therapeutic-ultrasound-in-the-management-of-venous-leg-ulcers
#7
RANDOMIZED CONTROLLED TRIAL
J M Watson, A R Kang'ombe, M O Soares, L-H Chuang, G Worthy, J M Bland, C Iglesias, N Cullum, D Torgerson, E A Nelson
OBJECTIVES: To compare the clinical effectiveness and cost-effectiveness of low-dose ultrasound delivered in conjunction with standard care against standard care alone in the treatment of hard-to-heal venous ulcers. DESIGN: A multicentre, pragmatic, two-armed randomised controlled trial with an economic evaluation. SETTING: Community nurse services; community leg ulcer clinics; hospital outpatient leg ulcer clinics, among both urban and rural settings in England, Scotland, Northern Ireland and Ireland...
March 2011: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/20309947/value-of-a-modified-clinical-signs-and-symptoms-of-infection-checklist-for-leg-ulcer-management
#8
RANDOMIZED CONTROLLED TRIAL
L A Dennis, J C Dumville, N Cullum, J M Bland
BACKGROUND: The aim of this study was to analyse the validity of a modified Clinical Signs and Symptoms Checklist used to measure infection in a sample of patients with a leg ulcer. METHODS: Data from patients recruited to a randomized controlled trial evaluating larval therapy (VenUS II) were analysed using factor analysis to identify the underlying checklist structure. Linear regression analysis identified whether checklist items, patient characteristics and subjective judgement of infection could predict bacterial load...
May 2010: British Journal of Surgery
https://www.readbyqxmd.com/read/19925723/venus-ii-a-randomised-controlled-trial-of-larval-therapy-in-the-management-of-leg-ulcers
#9
RANDOMIZED CONTROLLED TRIAL
J C Dumville, G Worthy, M O Soares, J M Bland, N Cullum, C Dowson, C Iglesias, D McCaughan, J L Mitchell, E A Nelson, D J Torgerson
OBJECTIVES: To compare the clinical effectiveness and cost-effectiveness of larval therapy with a standard debridement technique (hydrogel). DESIGN: A pragmatic, three-arm, randomised controlled trial with an economic evaluation. SETTING: Community nursing services, community leg ulcer clinics and hospital outpatient leg ulcer clinics. A range of urban and rural settings. PARTICIPANTS: Patients with venous or mixed venous/arterial ulcers (minimum ankle brachial pressure index of 0...
November 2009: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/19304578/cost-effectiveness-analysis-of-larval-therapy-for-leg-ulcers
#10
RANDOMIZED CONTROLLED TRIAL
Marta O Soares, Cynthia P Iglesias, J Martin Bland, Nicky Cullum, Jo C Dumville, E Andrea Nelson, David J Torgerson, Gill Worthy
OBJECTIVE: To assess the cost effectiveness of larval therapy compared with hydrogel in the management of leg ulcers. DESIGN: Cost effectiveness and cost utility analyses carried out alongside a pragmatic multicentre, randomised, open trial with equal randomisation. Population Intention to treat population comprising 267 patients with a venous or mixed venous and arterial ulcers with at least 25% coverage of slough or necrotic tissue. INTERVENTIONS: Patients were randomly allocated to debridement with bagged larvae, loose larvae, or hydrogel...
2009: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/19304577/larval-therapy-for-leg-ulcers-venus-ii-randomised-controlled-trial
#11
RANDOMIZED CONTROLLED TRIAL
Jo C Dumville, Gill Worthy, J Martin Bland, Nicky Cullum, Christopher Dowson, Cynthia Iglesias, Joanne L Mitchell, E Andrea Nelson, Marta O Soares, David J Torgerson
OBJECTIVE: To compare the clinical effectiveness of larval therapy with a standard debridement technique (hydrogel) for sloughy or necrotic leg ulcers. DESIGN: Pragmatic, three armed randomised controlled trial. SETTING: Community nurse led services, hospital wards, and hospital outpatient leg ulcer clinics in urban and rural settings, United Kingdom. PARTICIPANTS: 267 patients with at least one venous or mixed venous and arterial ulcer with at least 25% coverage of slough or necrotic tissue, and an ankle brachial pressure index of 0...
March 19, 2009: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/16119182/quality-of-life-of-people-with-venous-leg-ulcers-a-comparison-of-the-discriminative-and-responsive-characteristics-of-two-generic-and-a-disease-specific-instruments
#12
COMPARATIVE STUDY
Cynthia P Iglesias, Yvonne Birks, Elizabeth A Nelson, Elizabeth Scanlon, Nicky A Cullum
BACKGROUND: Venous leg ulcers are an important source of morbidity in society. Measuring the impact of leg ulcers on quality of life is important within clinical and economic evaluations. In this study we report a validation study of the leg ulcer disease specific Hyland questionnaire and compare its discriminative and responsive characteristics to general health quality of life measures: the SF-12 and EQ-5D. METHODS: HRQoL of venous leg ulcer patients from 9 UK regions was measured using SF-12, EQ-5D and Hyland, at baseline and every three months for 1 year...
September 2005: Quality of Life Research
https://www.readbyqxmd.com/read/15886669/effectiveness-of-an-extracellular-matrix-graft-oasis-wound-matrix-in-the-treatment-of-chronic-leg-ulcers-a-randomized-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Eliot N Mostow, G Davin Haraway, Michael Dalsing, Jason P Hodde, Dennis King
BACKGROUND: Venous leg ulcers are a major cause of morbidity, economic loss, and decreased quality of life in affected patients. Recently, biomaterials derived from natural tissue sources have been used to stimulate wound closure. One such biomaterial obtained from porcine small-intestine submucosa (SIS) has shown promise as an effective treatment to manage full-thickness wounds. Our objective was to compare the effectiveness of SIS wound matrix with compression vs compression alone in healing chronic leg ulcers within 12 weeks...
May 2005: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/15709358/a-new-clinical-trial-of-the-effect-of-larval-therapy
#14
RANDOMIZED CONTROLLED TRIAL
Pauline Raynor, Jo Dumville, Nicky Cullum
The VenUS II trial is the first large, prospective clinical study to investigate the effect of larval therapy and hydrogel on both the bacteriology and healing of leg ulcers. This trial will compare the clinical and cost effectiveness of two types of larval therapy (loose and bagged) with a standard debridement intervention (hydrogel) in terms of effects on time to complete healing, time to debridement, wound microbiology, cost of treatment and health-related quality of life. This paper describes the aims and design of the trial, outlines the eligibility criteria for patients and discusses the nurses' role in the study...
July 2004: Journal of Tissue Viability
https://www.readbyqxmd.com/read/15382102/randomized-clinical-trial-of-four-layer-and-short-stretch-compression-bandages-for-venous-leg-ulcers-venus-i
#15
RANDOMIZED CONTROLLED TRIAL
E A Nelson, C P Iglesias, N Cullum, D J Torgerson et al.
BACKGROUND: A randomized clinical trial was undertaken to determine the relative effectiveness of four-layer and short-stretch bandaging for venous ulceration. METHODS: A total of 387 adults with a venous ulcer, who were receiving leg ulcer treatment either in primary care or as a hospital outpatient, were recruited to this parallel-group open study and randomized to either four-layer or short-stretch bandages. Follow-up continued until the patient's reference leg was ulcer free or for a minimum of 12 months...
October 2004: British Journal of Surgery
https://www.readbyqxmd.com/read/15382101/economic-analysis-of-venus-i-a-randomized-trial-of-two-bandages-for-treating-venous-leg-ulcers
#16
RANDOMIZED CONTROLLED TRIAL
C P Iglesias, E A Nelson, N Cullum, D J Torgerson et al.
BACKGROUND: The study investigated the cost-effectiveness of four-layer and short-stretch compression bandages for treating venous leg ulcers. METHODS: Cost-effectiveness and cost-utility analyses were performed using patient-level data collected alongside the VenUS I leg ulcer study. The perspective for the economic analysis was that of the UK National Health Service (NHS) and Personal Social Service. The time horizon for the analysis was 1 year after recruitment...
October 2004: British Journal of Surgery
https://www.readbyqxmd.com/read/15248939/venus-i-a-randomised-controlled-trial-of-two-types-of-bandage-for-treating-venous-leg-ulcers
#17
RANDOMIZED CONTROLLED TRIAL
C Iglesias, E A Nelson, N A Cullum, D J Torgerson
OBJECTIVES: To compare the clinical and cost-effectiveness of two different compression bandages for the healing of venous leg ulcers. DESIGN: A pragmatic, randomised controlled trial with an economic evaluation. SETTING: Community, district nurse-led services; community leg ulcer clinics; hospital leg ulcer clinics with community outreach. A range of urban and rural settings in England and Scotland. PARTICIPANTS: Patients with a venous leg ulcer of at least 1-week's duration, at least 1 cm in length or width and an ankle:brachial pressure index of at least 0...
July 2004: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/11144197/the-venus-bandage-trial-in-leg-ulcer-healing
#18
U Adderley, A Nelson
No abstract text is available yet for this article.
February 2000: Community Nurse
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