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Late effects of childhood cancer

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https://www.readbyqxmd.com/read/30099534/risk-of-benign-meningioma-after-childhood-cancer-in-the-dcog-later-cohort-contributions-of-radiation-dose-exposed-cranial-volume-and-age
#1
Judith L Kok, Jop C Teepen, Flora E van Leeuwen, Wim J E Tissing, Sebastian J C M M Neggers, Helena J van der Pal, Jacqueline J Loonen, Dorine Bresters, Birgitta Versluys, Marry M van den Heuvel-Eibrink, Eline van Dulmen-den Broeder, Margriet van der Heiden-van der Loo, Berthe M P Aleman, Laurien A Daniels, Cornelis J A Haasbeek, Bianca Hoeben, Geert O Janssens, John H Maduro, Foppe Oldenburger, Caroline van Rij, Robbert J H A Tersteeg, Michael Hauptmann, Leontien C M Kremer, Cécile M Ronckers
Background: Pediatric cranial radiotherapy (CrRT) markedly increases risk of meningiomas. We studied meningioma risk factors with emphasis on independent and joint effects of CrRT dose, exposed cranial volume, exposure age, and chemotherapy. Methods: The DCOG-LATER cohort includes five-year childhood cancer survivors (CCSs) diagnosed 1963-2001. Histologically confirmed benign meningiomas were identified from the population-based Dutch Pathology Registry (PALGA; 1990-2015)...
August 7, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/30098012/surviving-childhood-cancer-a-systematic-review-of-studies-on-risk-and-determinants-of-adverse-socioeconomic-outcomes
#2
Line Elmerdahl Frederiksen, Luzius Mader, Maria Feychting, Hanna Mogensen, Laura Madanat-Harjuoja, Nea Malila, Anniina Tolkkinen, Henrik Hasle, Jeanette Falck Winther, Friederike Erdmann
Substantial improvements in childhood cancer survival have resulted in a steadily increasing population of childhood cancer survivors. Whereas somatic late effects have been assessed in many studies, less is known about the impact of childhood cancer on socioeconomic outcomes in survivors. The aim of this systematic review was to evaluate and summarise the evidence on the socioeconomic conditions of childhood cancer survivors and to identify survivors at particular risk of adverse socioeconomic outcomes. An extensive literature search of three electronic databases was conducted...
August 10, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30085213/determinants-and-consequences-of-financial-hardship-among-adult-survivors-of-childhood-cancer-a-report-from-the-st-jude-lifetime-cohort-study
#3
I-Chan Huang, Nickhill Bhakta, Tara M Brinkman, James L Klosky, Kevin R Krull, DeoKumar Srivastava, Melissa M Hudson, Leslie L Robison
Background: Financial hardship among survivors of pediatric cancer has been understudied. We investigated determinants and consequences of financial hardship among adult survivors of childhood cancer. Methods: Financial hardship, determinants, and consequences were examined in 2811 long-term survivors (mean age at evaluation = 31.8 years, years postdiagnosis = 23.6) through the baseline survey and clinical evaluation. Financial hardship was measured by material, psychological, and coping/behavioral domains...
August 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30073931/protective-role-of-silymarin-in-early-doxorubicin-induced-cardiac-dysfunction-in-children-with-acute-lymphoblastic-leukemia
#4
Adel A Hagag, Walid A El Shehaby, Aml I El-Abasy, Maaly M Mabrouk
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer constituting about one third of pediatric malignancies. Doxorubicin is a well- established chemotherapeutic agent for treatment of childhood ALL, but its efficacy is often limited by its related cardiotoxicity. Cardioprotection against doxorubicin- induced cardiotoxicity can be of great value, especially for children. Silymarin (SM), an extract from the Silybum marianum (milk thistle) plant, has potent antioxidant properties that can be helpful in preventing cardiotoxicity...
August 3, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/30053029/secondary-bone-soft-tissue-sarcoma-in-childhood-cancer-survivors-a-nationwide-hospital-based-case-series-study-in-japan
#5
Yasushi Ishida, Miho Maeda, Souichi Adachi, Takeshi Rikiishi, Maho Sato, Hiroshi Kawaguchi, Atsushi Manabe, Mika Tokuyama, Hiroki Hori, Jun Okamura, Atsushi Ogawa, Hiroaki Goto, Ryoji Kobayashi, Shinji Yoshinaga, Junichiro Fujimoto, Tatsuo Kuroda
Background: Secondary cancer is the most life-threatening late effect of childhood cancer. We investigated the clinical features of secondary bone/soft tissue sarcoma among childhood cancer survivors (CCSs). Methods: We conducted a retrospective case-series study of 10 069 CCSs newly diagnosed with cancer between 1980 and 2009 across 15 Japanese hospitals. Twenty-one cases of pathologically diagnosed secondary bone/soft tissue sarcoma were selected, and the respective clinical courses were determined using additional questionnaires...
July 25, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30051591/a-brief-survey-of-health-habits-among-childhood-cancer-survivors
#6
Sarah S Kappa, Rebecca W Lewis, Ann C Mertens, Stephanie M Walsh, Karen Wasilewski-Masker, Lillian R Meacham
Using a survey, we assessed four health habits in 468 pediatric cancer survivors. Approximately 75% were at goal for ≥1 behavior-44% were active ≥1 hr per day, 40% engaged in ≤1 hr of screen time a day, 34% consumed sweetened beverages not often, and 4% ate >4 servings of fruits and vegetables per day. Survivors' age was associated with being active (P < 0.001) and limited screen time (P = 0.001). Males were more likely to be active (P = 0.003). The most common combination of goal behaviors was activity and screen time...
July 26, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30049262/parent-reported-executive-functioning-in-young-children-treated-for-cancer
#7
Jennifer L Harman, Andrew E Molnar, Lauren E Cox, Niki Jurbergs, Kathryn M Russell, Jillian Wise, Victoria W Willard
It is well known that children treated for cancer are at risk for cognitive and functional impairments. Such research is largely based on studies of late effects in school-aged or older children. However, far less is known about executive function weaknesses in preschool-aged children treated for cancer. Thus, the aim of this study was to examine executive functioning in a clinically referred sample of young oncology patients, and its association with broader domains of functioning. Data from 61 young children with cancer, who were referred for clinical cognitive evaluations, were abstracted and included in this study...
July 26, 2018: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/30045213/acog-committee-opinion-no-747-gynecologic-issues-in-children-and-adolescent-cancer-patients-and-survivors
#8
(no author information available yet)
The diagnosis of cancer in females younger than 20 years is rare, with the incidence of 17 cases per 100,000 individuals per year in the United States. Although advancements in cancer therapy have dramatically improved childhood cancer survival, gynecologists should be aware of the increased risk of adverse reproductive health effects from each type of therapy. Cancer and its treatment may have immediate or delayed adverse effects on reproductive health. Gynecologists may be consulted for the following issues: pubertal concerns; menstrual irregularities; heavy menstrual bleeding and anemia; sexuality; contraception; ovarian function, including fertility preservation; breast and cervical cancer screening; hormone therapy; and graft-versus-host disease...
August 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30045207/acog-committee-opinion-no-747-summary-gynecologic-issues-in-children-and-adolescent-cancer-patients-and-survivors
#9
(no author information available yet)
The diagnosis of cancer in females younger than 20 years is rare, with the incidence of 17 cases per 100,000 individuals per year in the United States. Although advancements in cancer therapy have dramatically improved childhood cancer survival, gynecologists should be aware of the increased risk of adverse reproductive health effects from each type of therapy. Cancer and its treatment may have immediate or delayed adverse effects on reproductive health. Gynecologists may be consulted for the following issues: pubertal concerns; menstrual irregularities; heavy menstrual bleeding and anemia; sexuality; contraception; ovarian function, including fertility preservation; breast and cervical cancer screening; hormone therapy; and graft-versus-host disease...
August 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30018516/is-carotid-stiffness-a-possible-surrogate-for-stroke-in-long-term-survivors-of-childhood-cancer-after-neck-radiotherapy
#10
Lorna Zadravec Zaletel, Matjaz Popit, Marjan Zaletel
Background: The risk for cerebrovascular late effects among childhood cancer survivors is considerable. According to recent studies it is not clear which marker could be reliable for the screening of cerebrovascular diseases among the long-term survivors of childhood cancer. The purpose of this study is to analyse arterial stiffness and intima-media thickness as possible early markers of later occurring stroke in long-term survivors of childhood cancer after neck radiotherapy. Patients and methods: Twenty-three patients, treated for Hodgkin disease (HD) in childhood, were included...
June 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29985720/-on-your-own-adolescent-and-young-adult-cancer-survivors-experience-of-managing-return-to-secondary-or-higher-education-in-denmark
#11
Abbey Elsbernd, Kaspar Jessen Pedersen, Kirsten Arntz Boisen, Julie Midtgaard, Hanne Bækgaard Larsen
PURPOSE: As a consequence of cancer treatment, many adolescents and young adults (AYA) patients are required to take leave or face setbacks from their education. While most AYA cancer survivors and survivors of childhood cancer are capable of successfully returning to the educational system, unsuccessful returns place AYA at an increased risk of social isolation, stigmatization, and financial burden. The perspective of AYA cancer survivors who have returned to education is valuable to understand the challenges faced and resources available throughout this transition...
July 9, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29982753/diagnosis-of-growth-hormone-deficiency-as-a-late-effect-of-radiotherapy-in-survivors-of-childhood-cancers
#12
Jad G Sfeir, Nana Esi Kittah, Shrikant U Tamhane, Sina Jasim, Wassim Chemaitilly, Laurie Cohen, M Hassan Murad
Background: Limited guidance exists for selecting a laboratory method for diagnosing growth hormone deficiency (GHD) when it occurs as a late effect of radiotherapy in childhood cancer survivors (CCS). Methods: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Database of Systematic Reviews, and Scopus for studies evaluating GHD using IGF-I and/or IGFBP-3 measurements compared to GH dynamic testing. Results: We included 15 studies [IGF-I (8) and IGFBP-3 (7)] enrolling 477 patients...
June 29, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29960606/second-malignancies-following-childhood-cancer-treatment-in-germany-from-1980-to-2014
#13
Peter Scholz-Kreisel, Peter Kaatsch, Claudia Spix, Heinz Schmidberger, Manuela Marron, Desiree Grabow, Cornelia Becker, Maria Blettner
BACKGROUND: Because of improvements in cancer treatment, more than 80% of all children with cancer now survive at least five years from the time of diagnosis. As a result, late sequelae of cancer and its treatment have become more common, particularly second malignancies. We studied the current incidence of second malignancies among childhood cancer survivors in Germany. METHODS: This study is based on the cohort of the German Childhood Cancer Registry (Deutsches Kinderkrebsregister, DKKR)...
June 8, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29937232/diabetes-risk-in-childhood-cancer-survivors-a-population-based-study
#14
Iliana C Lega, Jason D Pole, Peter C Austin, Cindy Lau, Paul C Nathan, Nancy N Baxter
OBJECTIVE: With continued improvements in survival following childhood cancer, the long-term health consequences of cancer treatments are receiving greater focus. Diabetes is emerging as a potential late effect of cancer therapy; however, the magnitude of risk has not been well established. The goal of our study was to evaluate the risk for diabetes in childhood cancer survivors in Ontario using validated population-based databases. METHODS: We used provincial administrative health databases to compare the rate of diabetes in childhood cancer survivors and controls from the general population...
January 31, 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29926896/somatic-late-effects-in-5-year-survivors-of-neuroblastoma-a-population-based-cohort-study-within-the-adult-life-after-childhood-cancer-in-scandinavia-aliccs-study
#15
Filippa Nyboe Norsker, Catherine Rechnitzer, Luise Cederkvist, Laufey Tryggvadottir, Laura-Maria Madanat-Harjuoja, Ingrid Øra, Halldora K Thorarinsdottir, Kim Vettenranta, Andrea Bautz, Henrik Schrøder, Henrik Hasle, Jeanette Falck Winther
Because of the rarity of neuroblastoma and poor survival until the 1990s, information on late effects in neuroblastoma survivors is sparse. We comprehensively reviewed the long-term risk for somatic disease in neuroblastoma survivors. We identified 721 5-year survivors of neuroblastoma in Nordic population-based cancer registries and identified late effects in national hospital registries covering the period 1977-2012. Detailed treatment information was available for 46% of the survivors. The disease-specific rates of hospitalization of survivors and of 152,231 randomly selected population comparisons were used to calculate standardized hospitalization rate ratios (SHRRs) and absolute excess risks (AERs)...
June 21, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29916842/understanding-survivors-needs-and-outcomes-the-role-of-routinely-collected-data
#16
Liya Lu, Jennifer Deane, Linda Sharp
PURPOSE OF REVIEW: The number of cancer survivors is growing due to population ageing, earlier detection and more effective therapies. Routinely collected data (RCD), generally cancer registry data, has been used to investigate survivors' needs and outcomes. We reviewed uses of RCD since 2017, identifying novel findings and research directions. RECENT FINDINGS: Survival is improving internationally but continues to vary between subgroups. Longitudinal survivor surveys suggest malignancy-specific temporal patterns in unmet needs and health-related quality-of-life (HRQoL)...
June 18, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29914775/buccal-micronucleus-cytome-assay-in-primary-school-children-a-descriptive-analysis-of-the-mapec_life-multicenter-cohort-study
#17
Milena Villarini, Sara Levorato, Tania Salvatori, Elisabetta Ceretti, Sara Bonetta, Annalaura Carducci, Tiziana Grassi, Samuele Vannini, Francesco Donato, Silvia Bonetta, Marco Verani, Antonella de Donno, Silvia Bonizzoni, Alberto Bonetti, Massimo Moretti, Umberto Gelatti
BACKGROUND: Recent data support the hypothesis that genetic damage occurring early in life during childhood can play an important role in the development of chronic diseases in adulthood, including cancer. OBJECTIVES: The objective of this paper, part of the MAPEC_LIFE project, is to describe the frequency of micronuclei and meta-nuclear alterations in exfoliated buccal cells of 6-8year-old Italian children recruited in five Italian towns (i.e., Brescia, Torino, Pisa, Perugia and Lecce) with different air pollution levels...
July 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29874139/surveillance-for-late-effects-in-childhood-cancer-survivors
#18
Wendy Landier, Roderick Skinner, W Hamish Wallace, Lars Hjorth, Renée L Mulder, F Lennie Wong, Yutaka Yasui, Nickhill Bhakta, Louis S Constine, Smita Bhatia, Leontien C Kremer, Melissa M Hudson
Many childhood cancer survivors carry a significant risk for late morbidity and mortality, a consequence of the numerous therapeutic exposures that contribute to their cure. Focused surveillance for late therapy-related complications provides opportunities for early detection and implementation of health-preserving interventions. The substantial body of research that links therapeutic exposures used during treatment of childhood cancer to adverse outcomes among survivors enables the characterization of groups at the highest risk for developing complications related to specific therapies; however, methods available to optimize screening strategies to detect these therapy-related complications are limited...
July 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29874138/models-of-care-for-survivors-of-childhood-cancer-from-across-the-globe-advancing-survivorship-care-in-the-next-decade
#19
Emily S Tonorezos, Dana Barnea, Richard J Cohn, Monica S Cypriano, Brice C Fresneau, Riccardo Haupt, Lars Hjorth, Yasushi Ishida, Jarmila Kruseova, Claudia E Kuehni, Purna A Kurkure, Thorsten Langer, Paul C Nathan, Jane E Skeen, Roderick Skinner, Nurdan Tacyildiz, Marry M van den Heuvel-Eibrink, Jeanette F Winther, Melissa M Hudson, Kevin C Oeffinger
With improvements in cancer treatment and supportive care, a growing population of survivors of childhood cancer at risk for significant and potentially life-threatening late effects has been identified. To provide a current snapshot of the models of care from countries with varying levels of resources and health care systems, stakeholders in childhood cancer survivorship clinical care and research were identified from 18 countries across five continents. Stakeholders responded to a survey and provided a brief narrative regarding the current state of survivorship care...
July 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29874137/neurocognitive-outcomes-and-interventions-in-long-term-survivors-of-childhood-cancer
#20
Kevin R Krull, Kristina K Hardy, Lisa S Kahalley, Ilse Schuitema, Shelli R Kesler
Recent research has demonstrated that survivors of childhood cancer are at risk for a myriad of late effects that affect physical and mental quality of life. We discuss the patterns and prevalence of neurocognitive problems commonly experienced by survivors of CNS tumors and acute lymphoblastic leukemia, the two most commonly researched cancer diagnoses. Research documenting the direct effects of tumor location and treatment type and intensity is presented, and patient characteristics that moderate outcomes (eg, age at diagnosis and sex) are discussed...
July 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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