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Late effects of childhood cancer

Myxuan Huynh, Loredana Gabriela Marcu, Eileen Giles, Michala Short, Donna Matthews, Eva Bezak
INTRODUCTION: The most common solid tumours that develop in children are cancers of the central nervous system. Due to the increased rate of survival over the past decades, greater focus has been placed on the minimisation of long term side effects. In childhood cancer survivors, over 60% report one or more radiation-related late toxicities while half of these adverse events are graded as life-threatening or severe. Proton therapy enables high conformity with the planning target volume and a reduction in dose to areas beyond the target...
October 9, 2018: Cancer Treatment Reviews
Julienne E Bower, Joshua Wiley, Laura Petersen, Michael R Irwin, Steve W Cole, Patricia A Ganz
OBJECTIVE: Fatigue is a common side effect of cancer treatment, but there is considerable variability in fatigue severity and persistence among survivors. This study aimed to characterize longitudinal trajectories of fatigue after breast cancer treatment and to identify predictors of varying fatigue trajectories. METHODS: Women (N = 191) from the Mind-Body Study completed assessments after primary treatment for early stage breast cancer and at regular follow-ups that occurred up to 6 years after treatment (M = 4...
November 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Annette Weiss, Grit Sommer, Christina Schindera, Laura Wengenroth, Axel Karow, Manuel Diezi, Gisela Michel, Claudia E Kuehni
PURPOSE: Hearing loss, a complication of cancer treatment, may reduce health-related quality of life (HRQoL), especially in childhood cancer survivors of central nervous system (CNS) tumours who often have multiple late effects. We examined the effect of hearing loss on HRQoL in young survivors of CNS and other childhood cancers. METHODS: Within the Swiss Childhood Cancer Survivor Study, we sent questionnaires about hearing loss and HRQoL (KIDSCREEN-27) to parents of survivors aged 8-15 years...
October 10, 2018: Quality of Life Research
Despoina-Rafailia Benetou, Evangelos Stergianos, Maria Geropeppa, Erato Ntinopoulou, Marina Tzanni, Apostolos Pourtsidis, Andreas C Petropoulos, Marios K Georgakis, Dimitrios Tousoulis, Eleni Th Petridou
PURPOSE: Medical advances in pediatric oncology have led to increases in survival but the long-term adverse effects of treatment in childhood cancer survivors have not yet been examined in depth. In this systematic review, we aimed to study the prevalence and risk factors of late-onset cardiomyopathy (LOCM) among survivors of childhood lymphoma treated with anthracyclines. METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines we searched Pubmed/Medline, abstracted data and rated studies on quality regarding late-onset (>1 year following treatment) cardiotoxicity of anthracyclines in survivors of childhood lymphoma...
September 28, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
Anne-Lotte L F van der Kooi, Eva Clemens, Linda Broer, Oliver Zolk, Julianne Byrne, Helen Campbell, Marleen van den Berg, Claire Berger, Gabriele Calaminus, Uta Dirksen, Jeanette Falck Winther, Sophie D Fosså, Desiree Grabow, Riccardo Haupt, Melanie Kaiser, Tomas Kepak, Leontien Kremer, Jarmila Kruseova, Dalit Modan-Moses, Andreas Ranft, Claudia Spix, Peter Kaatsch, Joop S E Laven, Eline van Dulmen-den Broeder, André G Uitterlinden, Marry M van den Heuvel-Eibrink
BACKGROUND: Improved risk stratification, more effective therapy and better supportive care have resulted in survival rates after childhood cancer of around 80% in developed countries. Treatment however can be harsh, and three in every four childhood cancer survivors (CCS) develop at least one late effect, such as gonadal impairment. Gonadal impairment can cause involuntary childlessness, with serious consequences for the well-being of CCS. In addition, early menopause increases the risk of comorbidities such as cardiovascular disease and osteoporosis...
September 26, 2018: BMC Cancer
J Gebauer, H Lehnert, S M Schmid, C Spix, A Stein, T Langer
BACKGROUND: Childhood cancer survivors are at risk of cancer- and treatment-related chronic health conditions. Since these sequelae may occur years after the end of treatment, many patients are already adults and have completed pediatric oncological care. Thus, successful transition is essential in order to ensure long-term surveillance. OBJECTIVES: The present review outlines the most frequent late effects of childhood cancer treatment. Moreover, difficulties in transition of these patients are discussed and interdisciplinary models of care are presented...
September 18, 2018: Der Internist
Thomas Wiebe, Lars Hjorth, Mercedes Marotta Kelly, Helena M Linge, Stanislaw Garwicz
A population based registry, with the acronym BORISS, was established. It contains all individuals (0-18 years of age at diagnosis) diagnosed with cancer from 1970-01-01 until 2016-12-31 in Southern Sweden. The treatment data has been entered into the registry after confirmation of the diagnosis by the Swedish national cancer registry and updates on vital status from the Swedish population registry. The number of individuals with a pediatric cancer diagnosed during these 46 years are 2928. Of these, 2065 are currently alive and 1882 individuals are 5-year survivors...
September 6, 2018: European Journal of Epidemiology
Catherine A Brown, Danny R Youlden, Joanne F Aitken, Andrew S Moore
BACKGROUND: Therapy-related acute myeloid leukemia (t-AML) is defined as AML that develops after exposure to cytotoxic chemotherapy and/or radiation therapy. There is a paucity of available literature, particularly in regard to t-AML following childhood cancer. Our aim was to describe the risk of t-AML among children treated for other cancers and their subsequent survival. PROCEDURE: We utilized data from the population-based Australian Childhood Cancer Registry to examine all childhood patients (<15 years at diagnosis) treated with chemotherapy and/or radiotherapy for cancers other than AML who received a subsequent diagnosis of AML between 1983 and 2014...
September 5, 2018: Pediatric Blood & Cancer
Christina Signorelli, Claire E Wakefield, Joanna E Fardell, Tali Foreman, Karen A Johnston, Jon Emery, Elysia Thornton-Benko, Afaf Girgis, Hanne C Lie, Richard J Cohn
BACKGROUND: Primary care physicians (PCPs) are well placed to provide holistic care to survivors of childhood cancer and may relieve growing pressures on specialist-led follow-up. We evaluated PCPs' role and confidence in providing follow-up care to survivors of childhood cancer. SUBJECTS, MATERIALS, AND METHODS: In Stage 1, survivors and parents (of young survivors) from 11 Australian and New Zealand hospitals completed interviews about their PCPs' role in their follow-up...
August 31, 2018: Oncologist
Claire Berger, Léonie Casagranda, Vincent Pichot, Béatrice Trombert-Paviot, Cécile Faure-Conter, Claire Freycon, Florentina Isfan, Isabelle Guichard, Isabelle Durieu, Arnauld Garcin, Fréderic Roche, Hugues Patural
PURPOSE: Survival rate of childhood cancers is now reaching 80% overall. However, early or late complications related to surgery, chemotherapy, and radiotherapy remain at a high rate and greatly increase the risk of late mortality. The objective of this study is to assess the autonomic nervous system (ANS) activity, measured through heart rate variability indices in childhood cancer survivors compared with healthy controls. METHODS: This prospective study included 51 long-term childhood cancer survivors diagnosed before 15 years of age between 1987 and 1992 and controlled for age and sex with healthy volunteers...
August 23, 2018: Journal of Adolescent and Young Adult Oncology
Lisa R Sun, Stacy Cooper
Neurological complications resulting from childhood cancer treatments are common. Treatment for childhood neoplastic disorders is often multimodal and may include procedures, cranial irradiation, chemotherapy, transplant, and immunotherapy, each of which carries distinct neurological risks. Procedures, such as lumbar punctures, are commonly used in this population for diagnostic purposes as well as intrathecal medication administration. Surgery is associated with an array of potential neurological complications, with posterior fossa syndrome being a common cause of morbidity in pediatric brain tumor patients after neurosurgical resection...
June 2, 2018: Pediatric Neurology
Ailin Song, Jonathan D Fish
PURPOSE OF REVIEW: Over 80% of children diagnosed with cancer are now cured. The burgeoning population of survivors of childhood cancer experiences high rates of morbidity and mortality due to 'late-effects' of treatment. These can be defined as any consequence of treatment that persists beyond or develops after the completion of cancer therapy. Awareness of late-effects is critically important for pediatricians and adult providers alike, as late-effects impact children in proximity to cancer treatment, as well as adults many decades removed...
August 16, 2018: Current Opinion in Pediatrics
Judith L Kok, Jop C Teepen, Flora E van Leeuwen, Wim J E Tissing, Sebastian J C M M Neggers, Helena J van der Pal, Jacqueline J Loonen, Dorine Bresters, Birgitta Versluys, Marry M van den Heuvel-Eibrink, Eline van Dulmen-den Broeder, Margriet van der Heiden-van der Loo, Berthe M P Aleman, Laurien A Daniels, Cornelis J A Haasbeek, Bianca Hoeben, Geert O Janssens, John H Maduro, Foppe Oldenburger, Caroline van Rij, Robbert J H A Tersteeg, Michael Hauptmann, Leontien C M Kremer, Cécile M Ronckers
Background: Pediatric cranial radiotherapy (CrRT) markedly increases risk of meningiomas. We studied meningioma risk factors with emphasis on independent and joint effects of CrRT dose, exposed cranial volume, exposure age, and chemotherapy. Methods: The DCOG-LATER cohort includes five-year childhood cancer survivors (CCSs) diagnosed 1963-2001. Histologically confirmed benign meningiomas were identified from the population-based Dutch Pathology Registry (PALGA; 1990-2015)...
August 7, 2018: Neuro-oncology
Line Elmerdahl Frederiksen, Luzius Mader, Maria Feychting, Hanna Mogensen, Laura Madanat-Harjuoja, Nea Malila, Anniina Tolkkinen, Henrik Hasle, Jeanette Falck Winther, Friederike Erdmann
Substantial improvements in childhood cancer survival have resulted in a steadily increasing population of childhood cancer survivors. Whereas somatic late effects have been assessed in many studies, less is known about the impact of childhood cancer on socioeconomic outcomes in survivors. The aim of this systematic review was to evaluate and summarise the evidence on the socioeconomic conditions of childhood cancer survivors and to identify survivors at particular risk of adverse socioeconomic outcomes. An extensive literature search of three electronic databases was conducted...
August 10, 2018: International Journal of Cancer. Journal International du Cancer
I-Chan Huang, Nickhill Bhakta, Tara M Brinkman, James L Klosky, Kevin R Krull, DeoKumar Srivastava, Melissa M Hudson, Leslie L Robison
Background: Financial hardship among survivors of pediatric cancer has been understudied. We investigated determinants and consequences of financial hardship among adult survivors of childhood cancer. Methods: Financial hardship, determinants, and consequences were examined in 2811 long-term survivors (mean age at evaluation = 31.8 years, years postdiagnosis = 23.6) through the baseline survey and clinical evaluation. Financial hardship was measured by material, psychological, and coping/behavioral domains...
August 1, 2018: Journal of the National Cancer Institute
Adel A Hagag, Walid A El Shehaby, Aml I El-Abasy, Maaly M Mabrouk
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer constituting about one third of pediatric malignancies. Doxorubicin is a well- established chemotherapeutic agent for treatment of childhood ALL, but its efficacy is often limited by its related cardiotoxicity. Cardioprotection against doxorubicin- induced cardiotoxicity can be of great value, especially for children. Silymarin (SM), an extract from the Silybum marianum (milk thistle) plant, has potent antioxidant properties that can be helpful in preventing cardiotoxicity...
August 3, 2018: Infectious Disorders Drug Targets
Yasushi Ishida, Miho Maeda, Souichi Adachi, Takeshi Rikiishi, Maho Sato, Hiroshi Kawaguchi, Atsushi Manabe, Mika Tokuyama, Hiroki Hori, Jun Okamura, Atsushi Ogawa, Hiroaki Goto, Ryoji Kobayashi, Shinji Yoshinaga, Junichiro Fujimoto, Tatsuo Kuroda
Background: Secondary cancer is the most life-threatening late effect of childhood cancer. We investigated the clinical features of secondary bone/soft tissue sarcoma among childhood cancer survivors (CCSs). Methods: We conducted a retrospective case-series study of 10 069 CCSs newly diagnosed with cancer between 1980 and 2009 across 15 Japanese hospitals. Twenty-one cases of pathologically diagnosed secondary bone/soft tissue sarcoma were selected, and the respective clinical courses were determined using additional questionnaires...
September 1, 2018: Japanese Journal of Clinical Oncology
Sarah S Kappa, Rebecca W Lewis, Ann C Mertens, Stephanie M Walsh, Karen Wasilewski-Masker, Lillian R Meacham
Using a survey, we assessed four health habits in 468 pediatric cancer survivors. Approximately 75% were at goal for ≥1 behavior-44% were active ≥1 hr per day, 40% engaged in ≤1 hr of screen time a day, 34% consumed sweetened beverages not often, and 4% ate >4 servings of fruits and vegetables per day. Survivors' age was associated with being active (P < 0.001) and limited screen time (P = 0.001). Males were more likely to be active (P = 0.003). The most common combination of goal behaviors was activity and screen time...
July 26, 2018: Pediatric Blood & Cancer
Jennifer L Harman, Andrew E Molnar, Lauren E Cox, Niki Jurbergs, Kathryn M Russell, Jillian Wise, Victoria W Willard
It is well known that children treated for cancer are at risk for cognitive and functional impairments. Such research is largely based on studies of late effects in school-aged or older children. However, far less is known about executive function weaknesses in preschool-aged children treated for cancer. Thus, the aim of this study was to examine executive functioning in a clinically referred sample of young oncology patients, and its association with broader domains of functioning. Data from 61 young children with cancer, who were referred for clinical cognitive evaluations, were abstracted and included in this study...
July 26, 2018: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
(no author information available yet)
The diagnosis of cancer in females younger than 20 years is rare, with the incidence of 17 cases per 100,000 individuals per year in the United States. Although advancements in cancer therapy have dramatically improved childhood cancer survival, gynecologists should be aware of the increased risk of adverse reproductive health effects from each type of therapy. Cancer and its treatment may have immediate or delayed adverse effects on reproductive health. Gynecologists may be consulted for the following issues: pubertal concerns; menstrual irregularities; heavy menstrual bleeding and anemia; sexuality; contraception; ovarian function, including fertility preservation; breast and cervical cancer screening; hormone therapy; and graft-versus-host disease...
August 2018: Obstetrics and Gynecology
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