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Survivorship pediatric cancer

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https://www.readbyqxmd.com/read/30489397/understanding-the-role-of-advanced-practice-providers-in-oncology-in-the-united-states
#1
Suanna S Bruinooge, Todd A Pickard, Wendy Vogel, Amy Hanley, Caroline Schenkel, Elizabeth Garrett-Mayer, Eric Tetzlaff, Margaret Rosenzweig, Heather Hylton, Shannon N Westin, Noël Smith, Conor Lynch, Michael P Kosty, Stephanie F Williams
PURPOSE: Advanced practice providers (APPs, which include NPs and physician assistants [PAs]) are integral members of oncology teams. This study aims first to identify all APPs in oncology and, second, to understand personal and practice characteristics (including compensation) of those APPs. METHODS: We identified APPs who practice oncology from membership and claims data. We surveyed 3,055 APPs about their roles in clinical care. RESULTS: We identified at least 5,350 APPs in oncology and an additional 5,400 who might practice oncology...
December 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/30467017/cancer-screening-in-the-pediatric-cancer-patient-a-focus-on-genitourinary-malignancies-and-why-does-a-urologist-need-to-know-about-this
#2
REVIEW
D A Husmann
INTRODUCTION: The long-term survival of a patient with childhood cancer now exceeds 80%. Unfortunately, as survivorship improves, the long-term consequences of the treatments used have become manifest. Specifically, the finding that development of a subsequent malignant neoplasm (SMN) is the leading cause of late mortality is concerning. In cancer survivors who are at high risk for developing an SMN, cancer screening protocols have well-documented survivorship benefits. Regrettably, 50% of these high-risk patients are non-compliant with these protocols, with studies revealing that inadequate patient compliance is in part because of insufficient knowledge of the physician regarding its need...
October 24, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/30426816/the-children-s-oncology-group-organizational-structure-membership-and-institutional-characteristics
#3
Janice S Withycombe, Todd A Alonzo, Michele A Wilkins-Sanchez, Maxine Hetherington, Peter C Adamson, Wendy Landier
BACKGROUND: The Children's Oncology Group (COG) is the only organization within the National Cancer Institute's National Clinical Trials Network dedicated exclusively to pediatric cancer research. The purpose of this article is to provide an overview of COG's organizational structure, to characterize its institutional and individual membership, and to summarize enrollments onto COG clinical trials. METHOD: Data from 2013 to 2015 were compiled from sources internal (Network Operations, Statistics and Data Center, Chair's Office) and external (American Hospital Association, American Nurses Credentialing Center) to COG, to present a comprehensive overview of COG's structure, individual and institutional membership, and group operations...
November 14, 2018: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/30426663/social-adjustment-of-adolescent-cancer-patients-transitioning-off-active-treatment-a-short-term-prospective-mixed-methods-study
#4
Sherilynn F Chan, Jennifer A Hoag, Jeffrey S Karst, Kristin M Bingen
BACKGROUND: Psychosocial follow-up in survivorship is a standard of care in pediatric oncology; however, little is known about patients' psychosocial functioning during the transition off active treatment, a unique time in the cancer journey. This study examined the social adjustment of adolescent cancer patients during this transition period, which has been understudied to date. PROCEDURE: Participants were 21 patients (ages 12-18 years; age M = 14.71 years; 62% female, 81% White) with various cancer diagnoses...
November 14, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30348991/bmi1-is-a-therapeutic-target-in-recurrent-medulloblastoma
#5
David Bakhshinyan, Chitra Venugopal, Ashley A Adile, Neha Garg, Branavan Manoranjan, Robin Hallett, Xin Wang, Sujeivan Mahendram, Parvez Vora, Thusyanth Vijayakumar, Minomi Subapanditha, Mohini Singh, Michelle Masayo Kameda-Smith, Maleeha Qazi, Nicole McFarlane, Aneet Mann, Olufemi A Ajani, Blake Yarascavitch, Vijay Ramaswamy, Hamza Farooq, Sorana Morrissy, Liangxian Cao, Nadiya Sydorenko, Ramil Baiazitov, Wu Du, Josephine Sheedy, Marla Weetall, Young-Choon Moon, Chang-Sun Lee, Jacek M Kwiecien, Kathleen H Delaney, Brad Doble, Yoon-Jae Cho, Siddhartha Mitra, David Kaplan, Michael D Taylor, Thomas W Davis, Sheila K Singh
Medulloblastoma (MB) is the most frequent malignant pediatric brain tumor, representing 20% of newly diagnosed childhood central nervous system malignancies. Although advances in multimodal therapy yielded a 5-year survivorship of 80%, MB still accounts for the leading cause of childhood cancer mortality. In this work, we describe the epigenetic regulator BMI1 as a novel therapeutic target for the treatment of recurrent human Group 3 MB, a childhood brain tumor for which there is virtually no treatment option beyond palliation...
October 22, 2018: Oncogene
https://www.readbyqxmd.com/read/30345652/utilization-of-integrated-psychosocial-care-in-a-pediatric-cancer-survivorship-clinic-a-retrospective-medical-record-review
#6
Clara Hungr, Christopher J Recklitis
No abstract text is available yet for this article.
October 22, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/30339144/understanding-the-role-of-advanced-practice-providers-in-oncology-in-the-united-states
#7
Suanna Bruinooge, Todd A Pickard, Wendy Vogel, Amy Hanley, Caroline Schenkel, Elizabeth Garrett-Mayer, Eric Tetzlaff, Margaret Rosenzweig, Heather Hylton, Shannon N Westin, Noel Smith, Conor Lynch, Michael P Kosty, Stephanie F Williams
PURPOSE: Advanced practice providers (APPs, which include nurse practitioners [NPs] and physician assistants [PAs]) are integral members of oncology teams. This study aims to identify all oncology APPs and to understand personal and practice characteristics (including compensation) of those APPs. METHODS: We identified APPs who practice oncology from membership and claims data. We surveyed 3,055 APPs about their roles in clinical care. RESULTS: We identified at least 5,350 APPs in oncology and an additional 5,400 who might practice oncology...
November 1, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/30324284/taste-changes-in-children-with-cancer-and-hematopoietic-stem-cell-transplant-recipients
#8
Robyn Loves, Deborah Tomlinson, Christina Baggott, David Dix, Paul Gibson, Shannon Hyslop, Donna L Johnston, Andrea D Orsey, Carol Portwine, Victoria Price, Tal Schechter, Magimairajan Vanan, Susan Kuczynski, Brenda Spiegler, George A Tomlinson, L Lee Dupuis, Lillian Sung
BACKGROUND: Objectives were to describe bothersome self-reported changes in taste in pediatric oncology and hematopoietic stem cell (HSCT) patients and to identify patient and treatment-related factors associated with bothersome taste changes. METHODS: We prospectively enrolled children and adolescents with cancer or pediatric HSCT recipients 8-18 years of age from three groups: inpatients receiving cancer treatments; outpatients in maintenance therapy for acute lymphoblastic leukemia (ALL); and outpatients in survivorship...
October 15, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/30229367/-late-effects-following-childhood-cancer-treatment-a-special-challenge-for-transition-medicine
#9
REVIEW
J Gebauer, H Lehnert, S M Schmid, C Spix, A Stein, T Langer
BACKGROUND: Childhood cancer survivors are at risk of cancer- and treatment-related chronic health conditions. Since these sequelae may occur years after the end of treatment, many patients are already adults and have completed pediatric oncological care. Thus, successful transition is essential in order to ensure long-term surveillance. OBJECTIVES: The present review outlines the most frequent late effects of childhood cancer treatment. Moreover, difficulties in transition of these patients are discussed and interdisciplinary models of care are presented...
November 2018: Der Internist
https://www.readbyqxmd.com/read/30133346/understanding-the-role-of-advanced-practice-providers-in-oncology-in-the-united-states
#10
Suanna S Bruinooge, Todd A Pickard, Wendy Vogel, Amy Hanley, Caroline Schenkel, Elizabeth Garrett-Mayer, Eric Tetzlaff, Margaret Rosenzweig, Heather Hylton, Shannon N Westin, Noël Smith, Conor Lynch, Michael P Kosty, Stephanie F Williams
PURPOSE: Advanced practice providers (APPs, which include nurse practitioners [NPs] and physician assistants [PAs]) are integral members of oncology teams. This study aims first to identify all oncology APPs and, second, to understand personal and practice characteristics (including compensation) of those APPs. METHODS: We identified APPs who practice oncology from membership and claims data. We surveyed 3,055 APPs about their roles in clinical care. RESULTS: We identified at least 5,350 APPs in oncology and an additional 5,400 who might practice oncology...
September 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/30126755/neurological-complications-of-the-treatment-of-pediatric-neoplastic-disorders
#11
REVIEW
Lisa R Sun, Stacy Cooper
Neurological complications resulting from childhood cancer treatments are common. Treatment for childhood neoplastic disorders is often multimodal and may include procedures, cranial irradiation, chemotherapy, transplant, and immunotherapy, each of which carries distinct neurological risks. Procedures, such as lumbar punctures, are commonly used in this population for diagnostic purposes as well as intrathecal medication administration. Surgery is associated with an array of potential neurological complications, with posterior fossa syndrome being a common cause of morbidity in pediatric brain tumor patients after neurosurgical resection...
August 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/30024087/parental-perception-of-child-vulnerability-in-childhood-cancer-survivors
#12
Mary-Jane Staba Hogan, Wilhelmenia L Ross, Lyn Balsamo, Hannah-Rose Mitchell, Nina S Kadan-Lottick
BACKGROUND: Parents' perception of their children's vulnerability to illness following cancer treatment is largely unknown, but is important to understand given known challenges of transitioning survivors to postcancer care. We investigated the frequency of and factors associated with perceived vulnerability by parents of childhood cancer survivors attending a regional survivorship clinic. PROCEDURE: This cohort study was offered to all parents of pediatric patients (currently ≤18 years) attending the Yale childhood cancer survivorship clinic January 2010 to October 2016 who were ≥1 year postcurative cancer therapy...
July 19, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29938339/creation-and-evaluation-of-a-cancer-survivorship-curriculum-for-pediatric-resident-physicians
#13
Lindsay F Schwartz, Clarence H Braddock, Roy L Kao, Myung-Shin Sim, Jacqueline N Casillas
PURPOSE: There is a paucity of formal clinician education concerning cancer survivorship care, which produces care barriers and poorer outcomes for survivors of childhood cancer. To address this, we implemented a curriculum in childhood cancer survivorship care for pediatric residents at the University of California, Los Angeles (UCLA). We examined the efficacy of this curriculum following program completion. METHODS: A case-based curriculum was created and integrated within existing educational structures using Kern's model...
June 25, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29880581/president-signs-star-act-for-kids-cancers
#14
(no author information available yet)
On June 5, President Donald Trump signed the Childhood Cancer Survivorship, Treatment, Access and Research Act, which aims to support pediatric cancer research by expanding the collection of patient biospecimens and records, improving surveillance, and investigating pediatric survivorship.
July 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29874142/new-agents-emerging-late-effects-and-the-development-of-precision-survivorship
#15
Eric J Chow, Zoltan Antal, Louis S Constine, Rebecca Gardner, W Hamish Wallace, Brent R Weil, Jennifer M Yeh, Elizabeth Fox
Incremental improvements in the treatment of children and adolescents with cancer have led to 5-year survival rates reaching nearly 85%. In the past decade, impressive progress has been made in understanding the biology of many pediatric cancers. With that understanding, multiple new agents have become available that offer the promise of more-effective and less-toxic treatment. These include agents that target various cell surface antigens and engage the adaptive immune system, as well as those that interfere with key signaling pathways involved in tumor development and growth...
July 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29874138/models-of-care-for-survivors-of-childhood-cancer-from-across-the-globe-advancing-survivorship-care-in-the-next-decade
#16
Emily S Tonorezos, Dana Barnea, Richard J Cohn, Monica S Cypriano, Brice C Fresneau, Riccardo Haupt, Lars Hjorth, Yasushi Ishida, Jarmila Kruseova, Claudia E Kuehni, Purna A Kurkure, Thorsten Langer, Paul C Nathan, Jane E Skeen, Roderick Skinner, Nurdan Tacyildiz, Marry M van den Heuvel-Eibrink, Jeanette F Winther, Melissa M Hudson, Kevin C Oeffinger
With improvements in cancer treatment and supportive care, a growing population of survivors of childhood cancer at risk for significant and potentially life-threatening late effects has been identified. To provide a current snapshot of the models of care from countries with varying levels of resources and health care systems, stakeholders in childhood cancer survivorship clinical care and research were identified from 18 countries across five continents. Stakeholders responded to a survey and provided a brief narrative regarding the current state of survivorship care...
July 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29799906/chemotherapy-induced-peripheral-neuropathy-in-long-term-survivors-of-childhood-cancer-clinical-neurophysiological-functional-and-patient-reported-outcomes
#17
Tejaswi Kandula, Michelle Anne Farrar, Richard J Cohn, David Mizrahi, Kate Carey, Karen Johnston, Matthew C Kiernan, Arun V Krishnan, Susanna B Park
Importance: In light of the excellent long-term survival of childhood cancer patients, it is imperative to screen for factors affecting health, function, and quality of life in long-term survivors. Objective: To comprehensively assess chemotherapy-induced peripheral neuropathy in childhood cancer survivors to define disease burden and functional effect and to inform screening recommendations. Design, Setting, and Participants: In this cross-sectional observational study, cancer survivors who were treated with chemotherapy for extracranial malignancy before age 17 years were recruited consecutively between April 2015 and December 2016 from a single tertiary hospital-based comprehensive cancer survivorship clinic and compared with healthy age-matched controls...
August 1, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29740904/falling-through-the-cracks-a-thematic-evaluation-of-unmet-needs-of-adult-survivors-of-childhood-cancers
#18
Jennifer White, Joanne Park, K Brooke Russell, K A Reynolds, A Madani, Linda E Carlson, Janine Giese-Davis
OBJECTIVE: The population of adult survivors of childhood cancers (ASCCs) is growing, resulting in unique long-term challenges. This study explored experiences of perceived unmet ASCC survivorship needs. METHODS: We invited ASCCs to complete surveys sent through the cancer registry. Four open-ended questions allowed participants to write in comments. We analyzed responses to these open-ended questions thematically, employing a process of constant comparison. RESULTS: Our sample included 94 ASCCs who completed open-ended questions (61 female; aged 20-78 years, mean age = 34...
August 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29671249/importance-ratings-on-patient-reported-outcome-items-for-survivorship-care-comparison-between-pediatric-cancer-survivors-parents-and-clinicians
#19
Conor M Jones, Justin N Baker, Rachel M Keesey, Ruth J Eliason, Jennifer Q Lanctot, Jennifer L Clegg, Belinda N Mandrell, Kirsten K Ness, Kevin R Krull, Deokumar Srivastava, Christopher B Forrest, Melissa M Hudson, Leslie L Robison, I-Chan Huang
PURPOSE: To compare importance ratings of patient-reported outcomes (PROs) items from the viewpoints of childhood cancer survivors, parents, and clinicians for further developing short-forms to use in survivorship care. METHODS: 101 cancer survivors, 101 their parents, and 36 clinicians were recruited from St. Jude Children's Research Hospital. Participants were asked to select eight items that they deemed useful for clinical decision making from each of the four Patient-Reported Outcomes Measurement Information System Pediatric item banks...
July 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29582194/clinical-practice-guidelines-for-fertility-preservation-in-pediatric-adolescent-and-young-adults-with-cancer
#20
REVIEW
Nao Suzuki
In recent years, more cancer patients are achieving long-term survival owing to advances in treatment. However, cancer treatment can cause gonadal dysfunction that leads to loss of fertility. Thus, it is important for clinical oncologists to consider fertility preservation in children, adolescents, and young adults with cancer who are expected to have a favorable outcome and may wish to have children in the future. Sometimes, fertility preservation has to be abandoned depending on the stage of the cancer and the general condition of the patient, because fertility preservation procedures may unacceptably delay cancer treatment or be too risky for the patient...
March 26, 2018: International Journal of Clinical Oncology
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