Aleksander Turczynowicz, Piotr Jakubów, Karolina Niedźwiecka, Julia Kondracka, Weronika Pużyńska, Mariola Tałałaj, Tomasz Guszczyn, Paweł Grabala, Oksana Kowalczuk, Szymon Kocańda
Children constitute a special group in pain therapy. Single nucleotide polymorphisms that are associated with differences in postoperative, inflammatory pain perception and opioid requirement are the A118G SNP in the mu-opioid receptor 1 (OPRM1) gene and the rs1205 CRP. This study aimed to determine connection between OPRM1 and rs1205 CRP SNPs in pediatric patients postoperatively and pain intensity, the opioid dose needed to control pain after scoliosis correction, and other clinical aspects. Genotypes of rs1205 CRP and OPRM1 polymorphisms in a sample of 31 patients were specified, and statistical analysis was performed in terms of age, genotype frequency, pain assessment, sufentanil flow, post-anesthesia care unit stay, and the use of coanalgesics...
November 24, 2023: Brain Sciences