Ye Zhang, Soumyabrata Munshi, Kaiping Burrows, Rayus Kuplicki, Leandra K Figueroa-Hall, Robin L Aupperle, Sahib S Khalsa, T Kent Teague, Taki Yasuyuki, Martin P Paulus, Jonathan Savitz, Haixia Zheng
BACKGROUND: Major Depressive Disorder (MDD) has a complex, bi-directional relationship with metabolic dysfunction, yet the neural correlates of this association are not well understood. METHOD: In this cross-sectional investigation, we employed a two-step 'discovery and confirmatory' strategy, utilizing two independent samples (Sample 1: 288 participants, Sample 2: 196 participants) to examine the association between circulating indicators of metabolic health (leptin and adiponectin) and brain structures in individuals with MDD...
April 15, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging