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https://www.readbyqxmd.com/read/30091812/assessing-recrudescence-of-photoregressed-siberian-hamster-ovaries-using-in-vitro-whole-ovary-culture
#1
Asha Shahed, Kelly A Young
In vitro culture has been used to study different aspects of ovarian function; however, this technique has not been applied to study recrudescence, or the return of ovarian function in seasonally breeding species. In Siberian hamsters, exposure to inhibitory photoperiods induces declines in ovarian function which are restored with photostimulation. Because these changes are mediated by changes in systemic gonadotropin (GT) secretion, we hypothesized that culturing photoregressed ovaries with GT would restore aspects of function and induce expression of key folliculogenic factors...
August 9, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/30039232/gdf-9-and-bmp-15-direct-the-follicle-symphony
#2
REVIEW
Alexandra Sanfins, Patrícia Rodrigues, David F Albertini
Understanding the physiology underlying the complex dialog between the oocyte and its surrounding somatic cells within the ovarian follicle has been crucial in defining optimal procedures for the development of clinical approaches in ART for women suffering from infertility and ovarian dysfunction. Recent studies have implicated oocyte-secreted factors like growth differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15), members of the transforming growth factor-beta (TGFβ) superfamily, as potent regulators of folliculogenesis and ovulation...
July 23, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/30013422/modulation-of-bone-morphogenetic-protein-activity-by-melatonin-in-ovarian-steroidogenesis
#3
REVIEW
Fumio Otsuka
Background: Melatonin regulates circadian and seasonal rhythms and the activities of hormones and cytokines that are expressed in various tissues, including the ovary, in which melatonin receptors are expressed. In the ovary, follicular growth occurs as a result of complex interactions between pituitary gonadotropins and autocrine and paracrine factors, including bone morphogenetic proteins (BMPs) that are expressed in the ovary. Methods: The effects of melatonin and BMPs on steroidogenesis were examined by using the primary cultures of rat granulosa cells...
July 2018: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29963719/fam83g-fam83g-genetic-variants-affect-canine-and-murine-hair-formation
#4
Pierre Balmer, Auxanne K Fellay, Beyza S Sayar, William V J Hariton, Dominique J Wiener, Arnaud Galichet, Eliane J Müller, Petra J Roosje
FAM83G/Fam83g genetic variants have been described in dogs, mice and recently also in humans. They are associated with palmoplantar keratoderma and altered hair or coat phenotype, reported as wooly phenotype in mice. FAM83G/Fam83g is an unexplored effector of temporally and spatially coordinated Wnt and BMP signalling which are key pathways in pre- and postnatal hair follicle morphogenesis and differentiation. The aim of this study was to unravel phenotypic consequences of FAM83G/Fam83g variants on hair coat formation in dogs and mice...
July 2, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29958887/interfering-effects-of-bisphenol-a-on-in-vitro-growth-of-preantral-follicles-and-maturation-of-oocyes
#5
Xiyan Wang, Shi-Wen Jiang, Liguo Wang, Yanmei Sun, Fangyan Xu, Hai He, Shuo Wang, Zhenghong Zhang, Xiaoyan Pan
AIMS: In order to investigate the effects and mechanism of Bisphenol A (BPA) on the growth of preantral follicles and the maturation of oocytes in vitro, preantral follicles were harvested from mouse ovaries and in vitro cultured for 11 days with different concentrations of BPA (0, 4.5 and 45 μM) for calculating the percentages of antral follicles, denuded oocytes, degenerative oocytes and the maturation rate of oocytes, besides measuring the diameter of follicles and the thickness of cumulus cell layers...
June 27, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29867522/transcriptome-reveals-long-non-coding-rnas-and-mrnas-involved-in-primary-wool-follicle-induction-in-carpet-sheep-fetal-skin
#6
Yangfan Nie, Shaomei Li, XinTing Zheng, Wenshuo Chen, Xueer Li, Zhiwei Liu, Yong Hu, Haisheng Qiao, Quanqing Qi, Quanbang Pei, Danzhuoma Cai, Mei Yu, Chunyan Mou
Murine primary hair follicle induction is driven by the communication between the mesenchyme and epithelium and mostly governed by signaling pathways including wingless-related integration site (WNT), ectodysplasin A receptor (EDAR), bone morphogenetic protein (BMP), and fibroblast growth factor (FGF), as observed in genetically modified mouse models. Sheep skin may serve as a valuable system for hair research owing to the co-existence of sweat glands with wool follicles in trunk skin and asynchronized wool follicle growth pattern similar to that of human head hair follicles...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29804175/cryopreservation-of-ovarian-tissue-may-be-considered-in-young-girls-with-galactosemia
#7
Linn Salto Mamsen, Thomas W Kelsey, Erik Ernst, Kirsten Tryde Macklon, Allan Meldgaard Lund, Claus Yding Andersen
PURPOSE: The aim was to describe the first experience with fertility preservation by cryopreservation of ovarian tissue (OTC) in pre-pubertal girls with galactosemia and further to characterize ovarian follicular morphology and expression of proteins important for ovarian function. METHODS: Retrospectively, follicle density was estimated in ovarian cortical tissues from 6 pre-pubertal girls below the age of 12 years diagnosed with galactosemia and from 31 girls below the age of 18 years who had one ovary removed for fertility preservation for other reasons prior to gonadotoxic treatment...
July 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29793441/dynamic-transcriptome-profiling-towards-understanding-the-morphogenesis-and-development-of-diverse-feather-in-domestic-duck
#8
Jing Yang, Yanhua Qu, Yuan Huang, Fumin Lei
BACKGROUND: Feathers with complex and fine structure are hallmark avian integument appendages, which have contributed significantly to the survival and breeding for birds. Here, we aimed to explore the differentiation, morphogenesis and development of diverse feathers in the domestic duck. RESULTS: Transcriptome profiles of skin owing feather follicle from two body parts at three physiological stages were constructed to understand the molecular network and excavate the candidate genes associated with the development of plumulaceous and flight feather structures...
May 24, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29771334/%C3%AE-catenin-activation-in-hair-follicle-dermal-stem-cells-induces-ectopic-hair-outgrowth-and-skin-fibrosis
#9
Yixin Tao, Qingchun Yang, Lei Wang, Jie Zhang, Xuming Zhu, Qianqian Sun, Yunbin Han, Qian Luo, Yushu Wang, Xizhi Guo, Ji Wu, Baojie Li, Xiao Yang, Lin He, Gang Ma
Hair follicle dermal sheath (DS) harbors hair follicle dermal stem cells (hfDSCs), which can be recruited to replenish DS and dermal papilla (DP). Cultured DS cells can differentiate into various cell lineages in vitro. However, it is unclear how its plasticity is modulated in vivo. Wnt/β-catenin signaling plays an important role in maintaining stem cells of various lineages and is required for HF development and regeneration. Here we report that activation of β-catenin in DS generates ectopic HF outgrowth (EF) by reprogramming HF epidermal cells and DS cells themselves, and endows DS cells with hair inducing ability...
May 16, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29691589/gene-expression-profiling-of-the-intact-dermal-sheath-cup-of-human-hair-follicles
#10
Shiro Niiyama, Yumiko Ishimatsu-Tsuji, Yosuke Nakazawa, Yuzo Yoshida, Tsutomu Soma, Ritsuro Ideta, Hideki Mukai, Jiro Kishimoto
Cells that constitute the dermal papillae of hair follicles might be derived from the dermal sheath, the peribulbar component of which is the dermal sheath cup. The dermal sheath cup is thought to include the progenitor cells of the dermal papillae and possesses hair inductive potential; however, it has not yet been well characterized. This study investigated the gene expression profile of the intact dermal sheath cup, and identified dermal sheath cup signature genes, including extracellular matrix components and bone morphogenetic protein-binding molecules, as well as transforming frowth factor beta 1 as an upstream regulator...
July 11, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29684814/transcriptional-and-translational-abundance-of-bone-morphogenetic-protein-bmp-2-4-6-7-and-their-receptors-bmpr1a-1b-and-bmpr2-in-buffalo-ovarian-follicle-and-the-role-of-bmp4-and-bmp7-on-estrogen-production-and-survival-of-cultured-granulosa-cells
#11
G Rajesh, S R Mishra, A Paul, M Punetha, G M Vidyalakshmi, K Narayanan, S Bag, S K Bhure, V Singh Chouhan, V P Maurya, G Singh, Mihir Sarkar
BMPs and their receptors modulate the granulosa cell (GC) function in the follicle of domestic animals. Since little is known on BMPs in the buffalo, the present study was aimed to investigate the expression of BMP2, 4, 6, 7 and their receptors BMPR1A, BMPR1B, BMPR2 in the GC and theca cells (TC) of ovarian follicles and the role of BMP4 and BMP7 on buffalo GC. Follicles were classified into four groups based on size and E2 level in the follicular fluid as follows: (i) Group1(4-6 mm; <0.5 ng/mL) (ii) Group 2 (7-9 mm; 0...
June 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29594991/-neurotrophin-3-promotes-osteogenic-differentiation-of-human-dental-follicle-cells
#12
Lei Wei, Ma Yue, Ren Aishu
OBJECTIVE: This study aims to investigate the effect of neurotrophin 3 (NT-3) on the osteogenic differentiation of human dental follicle cells (hDFCs). METHODS: hDFCs were isolated and cultured in vitro. Immunocytochemical staining was used to identify the origin of hDFCs. The effects of different NT-3 concentrations on hDFCs proliferation were detected by using CCK-8 assay. The alkaline phosphatase (ALP) activities and mRNA expression levels of bone morphogenetic protein-2 (BMP-2) and osteocalcin (OCN) were determined to investigate the effects of NT-3 on hDFCs osteogenesis...
February 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29577917/msx2-supports-epidermal-competency-during-wound-induced-hair-follicle-neogenesis
#13
Michael W Hughes, Ting-Xin Jiang, Maksim V Plikus, Christian Fernando Guerrero-Juarez, Chien-Hong Lin, Christopher Schafer, Robert Maxson, Randall B Widelitz, Cheng-Ming Chuong
Cutaneous wounds in adult mammals typically heal by scarring. However, large full-thickness wounds undergo wound-induced hair follicle neogenesis (WIHN), a form of regeneration. Here, we show that WIHN requires transient expression of epidermal Msx2 in two phases: the wound margin early and the wound center late. Msx2 expression is present in the migrating epithelium during early wound healing and then presents in the epithelium and mesenchyme later in the wound center. WIHN is abrogated in germline and epithelial-specific Msx2 mutant mice...
March 23, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29544632/involvement-of-bone-morphogenetic-proteins-bmp-in-the-regulation-of-ovarian-function
#14
Sheena L P Regan, Phil G Knight, John L Yovich, Yee Leung, Frank Arfuso, Arun Dharmarajan
Primordial germ cells migrate to the fetal gonads and proliferate during gestation to generate a fixed complement of primordial follicles, the so-called ovarian reserve. Primordial follicles comprise an oocyte arrested at the diplotene stage of meiosis, surrounded by a layer of pregranulosa cells. Activation of primordial follicles to grow beyond this arrested stage is of particular interest because, once activated, they are subjected to regulatory mechanisms involved in growth, selection, maturation, and ultimately, ovulation or atresia...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29544628/interaction-of-melatonin-and-bmp-6-in-ovarian-steroidogenesis
#15
Fumio Otsuka
The bone morphogenetic protein (BMP) system in the ovary plays a physiological role as a luteinization inhibitor in growing follicles. BMP-6 secreted from oocytes and granulosa cells can exert an inhibitory effect on follicle-stimulating hormone (FSH) actions by suppressing adenylate cyclase activity downstream of the FSH receptor. The inhibition of FSH-induced progesterone production by BMP-6 is impaired by melatonin treatment in granulosa cells. Intracellular Smad signaling induced by BMP-6 is suppressed by melatonin, suggesting that melatonin has a regulatory role in BMP receptor signaling in granulosa cells...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29534827/effects-of-immunization-against-bone-morphogenetic-protein-15-and-growth-differentiation-factor-9-on-ovarian-function-in-mares
#16
Kelli A Davis, Kristin M Klohonatz, Darcy S O Mora, Hannah M Twenter, Peter E Graham, Pablo Pinedo, Douglas C Eckery, Jason E Bruemmer
Currently there is no contraceptive vaccine that can cause permanent sterility in mares. This study investigates the effect of vaccination against oocyte-specific growth factors, Bone Morphogenetic Protein 15 (BMP-15) and Growth Differentiation Factor 9 (GDF-9), on ovarian function of mares. It was hypothesized that immunization against these growth factors would prevent ovulation and/or accelerate depletion of the oocyte reserve. For this study, 30 mares were randomly assigned to three groups (n = 10/group) and vaccinated with BMP-15 or GDF-9 peptides conjugated to KLH and adjuvant, or a control of phosphate buffered saline and adjuvant...
May 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29521016/dullard-deficiency-causes-hemorrhage-in-the-adult-ovarian-follicles
#17
Tadayoshi Hayata, Masahiko Chiga, Yoichi Ezura, Makoto Asashima, Hidetaka Katabuchi, Ryuichi Nishinakamura, Masaki Noda
In mammals, the ovarian follicles are regulated at least in part by bone morphogenetic protein (BMP) family members. Dullard (also known as Ctdnep1) gene encodes a phosphatase that suppresses BMP signaling by inactivating or degrading BMP receptors. Here we report that the Col1a1-Cre-induced Dullard mutant mice displayed hemorrhagic ovarian cysts, with red blood cells accumulated in the follicles, resulting in infertility. Cells expressing Cre driven by Col1a1 2.3-kb promoter and their descendants were found in granulosa cells in the ovary and in Sertoli cells in the testis...
May 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/29514440/cashmere-growth-control-in-liaoning-cashmere-goat-by-ovarian-carcinoma-immunoreactive-antigen-like-protein-2-and-decorin-genes
#18
Mei Jin, Jun-Yan Zhang, Ming-Xing Chu, Jun Piao, Jing-Ai Piao, Feng-Qin Zhao
OBJECTIVE: The study investigated the biological functions and mechanisms for controlling cashmere growth of Liaoning cashmere goat by ovarian carcinoma immunoreactive antigen-like protein 2 ( OCIAD2 ) and decorin ( DCN ) genes. METHODS: cDNA library of Liaoning cashmere goat was constructed in early stages. OCIAD2 and DCN genes related to cashmere growth were identified by homology analysis comparison. The expression location of OCIAD2 and DCN genes in primary and secondary hair follicles (SF) was performed using in situ hybridization...
May 2018: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29375042/effect-of-bone-morphogenetic-protein-15-on-gonadotropin-stimulated-synthesis-of-hyaluronan-and-progesterone-in-porcine-ovarian-follicle
#19
E Nagyova, L Nemcova, A Bujnakova Mlynarcikova, M Blaha, R Prochazka, S Scsukova
Bone morphogenetic protein-15 (BMP-15), an oocyte-derived growth factor, has been shown to play integral roles in regulation of ovarian follicular function in mammals. Despite the recognition of the physiological importance of the BMP system in regulation of gonadotropin action in the ovary, molecular mechanisms of BMP-15 effect on oocyte and somatic follicular cell functions remain poorly understood. The objective of this study was to determine the effect of BMP-15 on the FSH/LH-stimulated synthesis of hyaluronan (HA) by oocyte cumulus complexes (OCC) and progesterone by OCC and granulosa cells (GC) in the presence or absence of serum using primary porcine cultures...
October 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29337183/temporal-layering-of-signaling-effectors-drives-chromatin-remodeling-during-hair-follicle-stem-cell-lineage-progression
#20
Rene C Adam, Hanseul Yang, Yejing Ge, Wen-Hui Lien, Ping Wang, Yilin Zhao, Lisa Polak, John Levorse, Sanjeethan C Baksh, Deyou Zheng, Elaine Fuchs
Tissue regeneration relies on resident stem cells (SCs), whose activity and lineage choices are influenced by the microenvironment. Exploiting the synchronized, cyclical bouts of tissue regeneration in hair follicles (HFs), we investigate how microenvironment dynamics shape the emergence of stem cell lineages. Employing epigenetic and ChIP-seq profiling, we uncover how signal-dependent transcription factors couple spatiotemporal cues to chromatin dynamics, thereby choreographing stem cell lineages. Using enhancer-driven reporters, mutagenesis, and genetics, we show that simultaneous BMP-inhibitory and WNT signals set the stage for lineage choices by establishing chromatin platforms permissive for diversification...
March 1, 2018: Cell Stem Cell
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