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https://www.readbyqxmd.com/read/29899403/fgf-signalling-controls-the-specification-of-hair-placode-derived-sox9-positive-progenitors-to-merkel-cells
#1
Minh Binh Nguyen, Idan Cohen, Vinod Kumar, Zijian Xu, Carmit Bar, Katherine L Dauber-Decker, Pai-Chi Tsai, Pauline Marangoni, Ophir D Klein, Ya-Chieh Hsu, Ting Chen, Marja L Mikkola, Elena Ezhkova
Merkel cells are innervated mechanosensory cells responsible for light-touch sensations. In murine dorsal skin, Merkel cells are located in touch domes and found in the epidermis around primary hairs. While it has been shown that Merkel cells are skin epithelial cells, the progenitor cell population that gives rise to these cells is unknown. Here, we show that during embryogenesis, SOX9-positive (+) cells inside hair follicles, which were previously known to give rise to hair follicle stem cells (HFSCs) and cells of the hair follicle lineage, can also give rise to Merkel Cells...
June 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29867522/transcriptome-reveals-long-non-coding-rnas-and-mrnas-involved-in-primary-wool-follicle-induction-in-carpet-sheep-fetal-skin
#2
Yangfan Nie, Shaomei Li, XinTing Zheng, Wenshuo Chen, Xueer Li, Zhiwei Liu, Yong Hu, Haisheng Qiao, Quanqing Qi, Quanbang Pei, Danzhuoma Cai, Mei Yu, Chunyan Mou
Murine primary hair follicle induction is driven by the communication between the mesenchyme and epithelium and mostly governed by signaling pathways including wingless-related integration site (WNT), ectodysplasin A receptor (EDAR), bone morphogenetic protein (BMP), and fibroblast growth factor (FGF), as observed in genetically modified mouse models. Sheep skin may serve as a valuable system for hair research owing to the co-existence of sweat glands with wool follicles in trunk skin and asynchronized wool follicle growth pattern similar to that of human head hair follicles...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29793441/dynamic-transcriptome-profiling-towards-understanding-the-morphogenesis-and-development-of-diverse-feather-in-domestic-duck
#3
Jing Yang, Yanhua Qu, Yuan Huang, Fumin Lei
BACKGROUND: Feathers with complex and fine structure are hallmark avian integument appendages, which have contributed significantly to the survival and breeding for birds. Here, we aimed to explore the differentiation, morphogenesis and development of diverse feathers in the domestic duck. RESULTS: Transcriptome profiles of skin owing feather follicle from two body parts at three physiological stages were constructed to understand the molecular network and excavate the candidate genes associated with the development of plumulaceous and flight feather structures...
May 24, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29771334/%C3%AE-catenin-activation-in-hair-follicle-dermal-stem-cells-induces-ectopic-hair-outgrowth-and-skin-fibrosis
#4
Yixin Tao, Qingchun Yang, Lei Wang, Jie Zhang, Xuming Zhu, Qianqian Sun, Yunbin Han, Qian Luo, Yushu Wang, Xizhi Guo, Ji Wu, Baojie Li, Xiao Yang, Lin He, Gang Ma
Hair follicle dermal sheath (DS) harbors hair follicle dermal stem cells (hfDSCs), which can be recruited to replenish DS and dermal papilla (DP). Cultured DS cells can differentiate into various cell lineages in vitro. However, it is unclear how its plasticity is modulated in vivo. Wnt/β-catenin signaling plays an important role in maintaining stem cells of various lineages and is required for HF development and regeneration. Here we report that activation of β-catenin in DS generates ectopic HF outgrowth (EF) by reprogramming HF epidermal cells and DS cells themselves, and endows DS cells with hair inducing ability...
May 16, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29723542/effects-of-fibroblast-growth-factors-and-the-transcription-factor-early-growth-response-1-on-bovine-theca-cells
#5
Peng Han, Hilda Guerrero-Netro, Anthony Estienne, Christopher A Price
The theca cell layer of the ovarian follicle secretes growth factors that impact the function of granulosa cells. One such factor is fibroblast growth factor 18 (FGF18) that causes apoptosis of granulosa cells, however it is not known if FGF18 induces apoptosis also in theca cells. Addition of recombinant FGF18 to bovine theca cells in vitro inhibited steroidogenesis but, in contrast to previous data in granulosa cells, decreased the incidence of apoptosis. FGF18 activated typical FGF signaling pathways in theca cells, which was not previously observed in granulosa cells...
November 15, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29367194/construction-of-fgf21-knockout-mouse-models-by-the-crispr-cas9-system
#6
Xu Liu, Ping Zhang, Xiao-Feng Zhang, Xing Li, Yu Bai, Ke-Rong Jia, Xiao-Dong Guo, Hao Zhang, Xiao-Yan Ma, Ming Cang, Dong-Jun Liu, Xu-Dong Guo
Fibroblast growth factors (FGFs) are multifunctional signal molecules between cells, regulating the various physiological functions of the organism. FGF21 is a regulatory factor of the FGF family and has been postulated to play important roles in hair follicle development and hair follicle growth cycle. To evaluate the roles of FGF21, we had established a FGF21 knockout mouse model, using the CRISPR/Cas9 technology. We had constructed a FGF21 targeting vector and microinjected it with Cas9 mRNA and gRNA into fertilized ova of FVB mice...
January 20, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29269444/the-fibroblast-growth-factor-8-family-in-the-female-reproductive-tract
#7
REVIEW
Anthony Estienne, Christopher A Price
Several growth factor families have been shown to be involved in the function of the female reproductive tract. One subfamily of the fibroblast growth factor (FGF) superfamily, namely the FGF8 subfamily (including FGF17 and FGF18), has become important as Fgf8 has been described as an oocyte-derived factor essential for glycolysis in mouse cumulus cells and aberrant expression of FGF18 has been described in ovarian and endometrial cancers. In this review, we describe the pattern of expression of these factors in normal ovaries and uteri in rodents, ruminants and humans, as well as the expression of their receptors and intracellular negative feedback regulators...
January 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28740887/fgf18-signaling-in-the-hair-cycle-resting-phase-determines-radioresistance-of-hair-follicles-by-arresting-hair-cycling
#8
Mitsuko Kawano, Sachiko Umeda, Takeshi Yasuda, Mayumi Fujita, Atsuko Ishikawa, Toru Imamura, Takashi Imai, Fumiaki Nakayama
PURPOSE: Telogen (resting phase) hair follicles (HFs) are more radioresistant than their anagen (growth phase) counterparts. Fibroblast growth factor (FGF) 18 is strongly expressed in telogen HFs to maintain the telogen phase, whereas several other FGFs exert radioprotective effects; however, the role of FGF18 in the radioresistance of HFs remains unknown. This study focused on clarifying the role of FGF18 in the radioresistance of telogen HFs and its potential as a radioprotector. METHODS AND MATERIALS: BALB/c mice with telogen or plucking-induced anagen HFs were exposed to total body irradiation with γ-rays at 4 to 12 Gy after intraperitoneal treatment with FGF18 or an FGF receptor inhibitor...
July 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28700594/hierarchical-patterning-modes-orchestrate-hair-follicle-morphogenesis
#9
James D Glover, Kirsty L Wells, Franziska Matthäus, Kevin J Painter, William Ho, Jon Riddell, Jeanette A Johansson, Matthew J Ford, Colin A B Jahoda, Vaclav Klika, Richard L Mort, Denis J Headon
Two theories address the origin of repeating patterns, such as hair follicles, limb digits, and intestinal villi, during development. The Turing reaction-diffusion system posits that interacting diffusible signals produced by static cells first define a prepattern that then induces cell rearrangements to produce an anatomical structure. The second theory, that of mesenchymal self-organisation, proposes that mobile cells can form periodic patterns of cell aggregates directly, without reference to any prepattern...
July 2017: PLoS Biology
https://www.readbyqxmd.com/read/28162994/thyroid-progenitors-are-robustly-derived-from-embryonic-stem-cells-through-transient-developmental-stage-specific-overexpression-of-nkx2-1
#10
Keri Dame, Steven Cincotta, Alex H Lang, Reeti M Sanghrajka, Liye Zhang, Jinyoung Choi, Letty Kwok, Talitha Wilson, Maciej M Kańduła, Stefano Monti, Anthony N Hollenberg, Pankaj Mehta, Darrell N Kotton, Laertis Ikonomou
The clinical importance of anterior foregut endoderm (AFE) derivatives, such as thyrocytes, has led to intense research efforts for their derivation through directed differentiation of pluripotent stem cells (PSCs). Here, we identify transient overexpression of the transcription factor (TF) NKX2-1 as a powerful inductive signal for the robust derivation of thyrocyte-like cells from mouse PSC-derived AFE. This effect is highly developmental stage specific and dependent on FOXA2 expression levels and precise modulation of BMP and FGF signaling...
February 14, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28074842/analysis-of-the-fgf-gene-family-provides-insights-into-aquatic-adaptation-in-cetaceans
#11
Kiwoong Nam, Kyeong Won Lee, Oksung Chung, Hyung-Soon Yim, Sun-Shin Cha, Sae-Won Lee, JeHoon Jun, Yun Sung Cho, Jong Bhak, João Pedro de Magalhães, Jung-Hyun Lee, Jae-Yeon Jeong
Cetacean body structure and physiology exhibit dramatic adaptations to their aquatic environment. Fibroblast growth factors (FGFs) are a family of essential factors that regulate animal development and physiology; however, their role in cetacean evolution is not clearly understood. Here, we sequenced the fin whale genome and analysed FGFs from 8 cetaceans. FGF22, a hair follicle-enriched gene, exhibited pseudogenization, indicating that the function of this gene is no longer necessary in cetaceans that have lost most of their body hair...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27815159/expression-and-functional-role-of-bone-morphogenetic-proteins-bmps-in-cyclical-corpus-luteum-in-buffalo-bubalus-bubalis
#12
G Rajesh, Avishek Paul, S R Mishra, Jaya Bharati, Nipuna Thakur, Tanmay Mondal, Sanjhali Soren, S Harikumar, K Narayanan, V S Chouhan, Sadhan Bag, B C Das, G Singh, V P Maurya, G Taru Sharma, Mihir Sarkar
The role of growth factors in the modulation of ovarian function is an interesting area of research in reproductive biology. Recently, we have shown the expression and role of IGF, EGF, VEGF and FGF in the follicle and CL. Here, we report the presence of Bone Morphogenetic Proteins (BMPs) and their functional receptors in the corpus luteum (CL) of buffalo. The bubaline CL was classified into four stages according to the morphology and progesterone (P4 ) concentration. The qPCR, immunoblot and immunohistochemistry studies revealed that BMP2 and BMP Receptors (BMPR1A, BMPR1B and BMPR2) were significantly upregulated during the mid stage whereas BMP4 and BMP7 were upregulated during the early stage of CL (P<0...
January 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27795451/3-deoxysappanchalcone-promotes-proliferation-of-human-hair-follicle-dermal-papilla-cells-and-hair-growth-in-c57bl-6-mice-by-modulating-wnt-%C3%AE-catenin-and-stat-signaling
#13
Young Eun Kim, Hyung Chul Choi, In-Chul Lee, Dong Yeon Yuk, Hyosung Lee, Bu Young Choi
3-Deoxysappanchalcone (3-DSC) has been reported to possess anti-allergic, antiviral, anti-inflammatory and antioxidant activities. In the present study, we investigated the effects of 3-DSC on the proliferation of human hair follicle dermal papilla cells (HDPCs) and mouse hair growth in vivo. A real-time cell analyzer system, luciferase assay, Western blot and real-time polymerase chain reaction (PCR) were employed to measure the biochemical changes occurring in HDPCs in response to 3-DSC treatment. The effect of 3-DSC on hair growth in C57BL/6 mice was also examined...
November 1, 2016: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/27663377/expression-and-localization-of-fibroblast-growth-factor-fgf-family-in-buffalo-ovarian-follicle-during-different-stages-of-development-and-modulatory-role-of-fgf2-on-steroidogenesis-and-survival-of-cultured-buffalo-granulosa-cells
#14
S R Mishra, N Thakur, A Somal, M S Parmar, R Reshma, G Rajesh, V P Yadav, M K Bharti, Jaya Bharati, A Paul, V S Chouhan, G T Sharma, G Singh, M Sarkar
The present study investigated the expression and localization of FGF and its functional receptors in the follicle of buffalo and the treatment of FGF2 on mRNA expression of CYP19A1 (aromatase), PCNA, and BAX (BCL-2 associated X protein) in cultured buffalo granulosa cells (GCs). Follicles were classified into four groups based on size and E2 level in follicular fluid (FF): F1, 4-6mm diameter, E2<0.5ng/ml of FF; F2, 7-9mm, E2=0.5-5ng/ml; F3, 10-13mm, E2=5-40ng/ml; F4, >14mm, E2>180ng/ml. The qPCR studies revealed that the mRNA expression of FGF1, FGF2 and FGF7 were maximum (P<0...
October 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27604347/chronic-effects-of-an-anti-angiogenic-thrombospondin-1-mimetic-peptide-abt-898-on-female-mouse-reproductive-outcomes
#15
Andrew K Edwards, Irina Olariu, Diane S Nakamura, Soo Hyun Ahn, Chandrakant Tayade
BACKGROUND: Angiogenesis is an essential process in endometriosis disease progression. Earlier, we demonstrated that anti-angiogenic peptide, ABT-898 prevents neoangiogenesis of human endometriotic lesions in a xenograft mouse model. Since angiogenesis is essential for normal ovarian and uterine function, we evaluated effects of ABT-898 on normal female reproductive processes in mice. METHODS: Cycling female C57BL/6N mice were dosed with ABT-898 (100 mg/kg) or 5 % dextrose control for 21 consecutive days to cover multiple estrous cycles (average estrous cycle 4 to 5 days in mice)...
September 7, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27386946/hominis-placenta-facilitates-hair-re-growth-by-upregulating-cellular-proliferation-and-expression-of-fibroblast-growth-factor-7
#16
Hyung-Sik Seo, Dong-Jin Lee, Jae-Ho Chung, Chang-Hyun Lee, Ha Rim Kim, Jae Eun Kim, Byung Joo Kim, Myeong Ho Jung, Ki-Tae Ha, Han-Sol Jeong
BACKGROUND: Hominis Placenta (HP) known as a restorative medicine in Traditional Chinese Medicine (TCM), has been widely applied in the clinics of Korea and China as an anti-aging agent to enhance the regeneration of tissue. This study was conducted to investigate whether topical treatment of HP promotes hair regrowth in the animal model. METHODS: The dorsal hairs of 8-week-old C57BL/6 mice were depilated to synchronize hair follicles to the anagen phase. HP was applied topically once a day for 15 days...
July 7, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27386145/cornu-cervi-pantotrichum-pharmacopuncture-solution-facilitate-hair-growth-in-c57bl-6-mice
#17
Seon-Yong Lee, Dong-Jin Lee, Kang Kwon, Chang-Hyun Lee, Hyun Jong Shin, Jai Eun Kim, Ki-Tae Ha, Han-Sol Jeong, Hyung-Sik Seo
OBJECTIVES: Cornu cervi pantotrichum (CCP) has been widely used in Korean and China, as an anti-fatigue, anti-aging, and tonic agent to enhance the functions of the reproductive and the immune systems. Because CCP has various growth factors that play important roles in the development of hair follicles, we examined whether CCP pharmacopuncture solution (CCPPS) was capable of promoting hair growth in an animal model. METHODS: One day after hair depilation, CCPPS were topically applied to the dorsal skin of C57BL/6 mice once a day for 15 days...
June 2016: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/27234307/laminin-%C3%AE-5-in-the-keratinocyte-basement-membrane-is-required-for-epidermal-dermal-intercommunication
#18
Jeannine Wegner, Karin Loser, Gunita Apsite, Roswitha Nischt, Beate Eckes, Thomas Krieg, Sabine Werner, Lydia Sorokin
Laminin α5 is broadly expressed in the epidermal basement membrane (BM) of mature mice and its elimination at this site (Lama5Ker5 mouse) results in hyperproliferation of basal keratinocytes and a delay in hair follicle development, which correlated with upregulation of the dermally-derived laminin α2 and laminin α4 chains in the epidermal BM and of tenascin-C subjacent to the BM. In vitro studies revealed laminin 511 to be strongly adhesive for primary keratinocytes and that loss of laminin α5 does not result in cell autonomous defects in proliferation...
December 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27128731/the-effects-of-negative-pressure-by-external-tissue-expansion-device-on-epithelial-cell-proliferation-neo-vascularization-and-hair-growth-in-a-porcine-model
#19
Hui-Yi Hsiao, Jia-Wei Liu, Eric M Brey, Ming-Huei Cheng
While pre-treating a fat transplant recipient site with negative pressure has shown promise for increasing the fat survival rate, the underlying mechanisms have not been investigated, partly due to challenges related to immobilization of vacuum domes on large animal subjects. The aim of this study was to examine the effect of negative pressure treatment by External Tissue Expansion Device (ETED) on fat grating recipient sites in a porcine model. The ETED was designed to provide negative pressure on the dorsum of swine...
2016: PloS One
https://www.readbyqxmd.com/read/26998386/the-success-of-thread-embedding-therapy-in-generating-hair-re-growth-in-mice-points-to-its-possibly-having-a-similar-effect-in-humans
#20
Hyun Jong Shin, Dong-Jin Lee, Kang Kwon, Hyung-Sik Seo, Han-Sol Jeong, Ji-Yeon Lee, Ki-Tae Ha, Chang-Hyun Lee, Yong-Suk Jang, Byung-Wook Lee, Byung Joo Kim, Myeong-Ho Jung
OBJECTIVES: Recently, thread-embedding therapy (TET) has been widely applied in Korean medicine for cosmetic purposes such as reducing skin wrinkles. An inserted thread was reported to have induced continuous stimulation, followed by support for connective tissue regeneration. However, the potential role of TET in hairgrowth has not yet been reported. METHODS: We designed this study to evaluate whether TET has a hair-growth-promoting effect. C57 black 6 (C57BL/6) mice were divided into three groups: normal saline-treated, minoxidil-treated, and thread-embedded groups...
December 2015: Journal of Pharmacopuncture
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