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https://www.readbyqxmd.com/read/27919751/less-head-motion-during-mri-under-task-than-resting-state-conditions
#1
Willem Huijbers, Koene R A Van Dijk, Meta M Boenniger, Rüdiger Stirnberg, Monique M B Breteler
Head motion reduces data quality of neuroimaging data. In three functional magnetic resonance imaging (MRI) experiments we demonstrate that people make less head movements under task than resting-state conditions. In Experiment 1, we observed less head motion during a memory encoding task than during the resting-state condition. In Experiment 2, using publicly shared data from the UCLA Consortium for Neuropsychiatric Phenomics LA5c Study, we again found less head motion during several active task conditions than during a resting-state condition, although some task conditions also showed comparable motion...
December 2, 2016: NeuroImage
https://www.readbyqxmd.com/read/27916665/task-modulations-and-clinical-manifestations-in-the-brain-functional-connectome-in-1615-fmri-datasets
#2
Tobias Kaufmann, Dag Alnæs, Christine Lycke Brandt, Nhat Trung Doan, Karolina Kauppi, Francesco Bettella, Trine V Lagerberg, Akiah O Berg, Srdjan Djurovic, Ingrid Agartz, Ingrid S Melle, Torill Ueland, Ole A Andreassen, Lars T Westlye
OBJECTIVE: An abundance of experimental studies have motivated a range of models concerning the cognitive underpinnings of severe mental disorders, yet the conception that cognitive and brain dysfunction is confined to specific cognitive domains and contexts has limited ecological validity. Schizophrenia and bipolar spectrum disorders have been conceptualized as disorders of brain connectivity; yet little is known about the pervasiveness across cognitive tasks. METHOD: To address this outstanding issue of context specificity, we estimated functional network connectivity from fMRI data obtained during five cognitive tasks (0-back, 2-back, go/no-go, recognition of positive faces, negative faces) in 90 patients with schizophrenia, 97 patients with bipolar spectrum disorder, and 136 healthy controls, including 1615 fMRI datasets in total...
December 1, 2016: NeuroImage
https://www.readbyqxmd.com/read/27873290/aims-and-structure-of-the-german-research-consortium-bipolife-for-the-study-of-bipolar-disorder
#3
REVIEW
Philipp S Ritter, Felix Bermpohl, Oliver Gruber, Martin Hautzinger, Andreas Jansen, Georg Juckel, Tilo Kircher, Martin Lambert, Christoph Mulert, Andrea Pfennig, Andreas Reif, Otto Rienhoff, Thomas G Schulze, Emanuel Severus, Thomas Stamm, Michael Bauer
BACKGROUND: Bipolar disorder is a severe and heterogeneous mental disorder. Despite great advances in neuroscience over the past decades, the precise causative mechanisms at the transmitter, cellular or network level have so far not been unraveled. As a result, individual treatment decisions cannot be tailor-made and the uncertain prognosis is based on clinical characteristics alone. Although a subpopulation of patients have an excellent response to pharmacological monotherapy, other subpopulations have been less well served by the medical system and therefore require more focused attention...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27870507/stress-and-reward-processing-in-bipolar-disorder-a-functional-magnetic-resonance-imaging-study
#4
Lisa H Berghorst, Poornima Kumar, Doug N Greve, Thilo Deckersbach, Dost Ongur, Sunny J Dutra, Diego A Pizzagalli
OBJECTIVES: A link between negative life stress and the onset of mood episodes in bipolar disorder (BD) has been established, but processes underlying such a link remain unclear. Growing evidence suggests that stress can negatively affect reward processing and related neurobiological substrates, indicating that a dysregulated reward system may provide a partial explanation. The aim of this study was to test the impact of stress on reward-related neural functioning in BD. METHODS: Thirteen euthymic or mildly depressed individuals with BD and 15 controls performed a Monetary Incentive Delay (MID) task while undergoing functional magnetic resonance imaging during no-stress and stress (negative psychosocial stressor involving poor performance feedback and threat of monetary deductions) conditions...
November 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27870505/distinguishing-medication-free-subjects-with-unipolar-disorder-from-subjects-with-bipolar-disorder-state-matters
#5
Maria M Rive, Ronny Redlich, Lianne Schmaal, André F Marquand, Udo Dannlowski, Dominik Grotegerd, Dick J Veltman, Aart H Schene, Henricus G Ruhé
OBJECTIVES: Recent studies have indicated that pattern recognition techniques of functional magnetic resonance imaging (fMRI) data for individual classification may be valuable for distinguishing between major depressive disorder (MDD) and bipolar disorder (BD). Importantly, medication may have affected previous classification results as subjects with MDD and BD use different classes of medication. Furthermore, almost all studies have investigated only depressed subjects. Therefore, we focused on medication-free subjects...
November 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27869904/-neural-basis-of-social-cognition-in-bipolar-disorder
#6
Filippo Turchi, Giovanni Amodeo, Ettore Favaretto, Stefania Righini, Eugenia Mellina, Carmelo La Mela, Andrea Fagiolini
AIM: This article review studies social and interpersonal functioning in patients with bipolar disorder (BD), and reports on the neurobiological underpinnings of the dysfunctions in emotion recognition, i.e. one of the main domains of social cognition. METHODS: A bibliographical research of controlled studies from 1967 to 2015 was completed in PubMed and PsycINFO using the keywords: "fMRI", "emotion comprehension", "emotion perception", "affect comprehension", "affect perception", "facial expression", "prosody", "theory of mind", "mentalizing", "attributional style", "social perception", "empathy" and "bipolar disorder" or "unipolar depression"...
September 2016: Rivista di Psichiatria
https://www.readbyqxmd.com/read/27867834/neurobiology-of-risk-for-bipolar-disorder
#7
REVIEW
Ayşegül Özerdem, Deniz Ceylan, Güneş Can
Bipolar disorder (BD) is a chronic mental illness which follows a relapsing and remitting course and requires lifetime treatment. The lack of biological markers for BD is a major difficulty in clinical practice. Exploring multiple endophenotypes to fit in multivariate genetic models for BD is an important element in the process of finding tools to facilitate early diagnosis, early intervention, prevention of new episodes, and follow-up of treatment response in BD. Reviewing of studies on neuroimaging, neurocognition, and biochemical parameters in populations with high genetic risk for the illness can yield an integrative perspective on the neurobiology of risk for BD...
2016: Current Treatment Options in Psychiatry
https://www.readbyqxmd.com/read/27857885/the-polygenic-risk-for-bipolar-disorder-influences-brain-regional-function-relating-to-visual-and-default-state-processing-of-emotional-information
#8
Danai Dima, Simone de Jong, Gerome Breen, Sophia Frangou
Genome-wise association studies have identified a number of common single-nucleotide polymorphisms (SNPs), each of small effect, associated with risk to bipolar disorder (BD). Several risk-conferring SNPs have been individually shown to influence regional brain activation thus linking genetic risk for BD to altered brain function. The current study examined whether the polygenic risk score method, which models the cumulative load of all known risk-conferring SNPs, may be useful in the identification of brain regions whose function may be related to the polygenic architecture of BD...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27847486/enhancing-executive-function-and-neural-health-in-bipolar-disorder-through-reasoning-training
#9
Erin E Venza, Sandra B Chapman, Sina Aslan, Jennifer E Zientz, David L Tyler, Jeffrey S Spence
Cognitive deficits in executive function and memory among individuals with bipolar disorder (BD) are well-documented; however, only recently have efforts begun to address whether such cognitive deficits can be ameliorated through cognitive training. This pilot study examined the effects of a top-down, cognitive reasoning training program in adults with BD on both brain and cognitive measures. Twenty-seven participants (11 males, 16 females), aged 21-70 years old, completed the study. Participants completed neurocognitive testing and functional magnetic resonance imaging (fMRI) before and after training, consisting of 8 h (2 h/week) of training in small groups...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27834153/childhood-trauma-is-associated-with-increased-brain-responses-to-emotionally-negative-as-compared-with-positive-faces-in-patients-with-psychotic-disorders
#10
M Aas, K Kauppi, C L Brandt, M Tesli, T Kaufmann, N E Steen, I Agartz, L T Westlye, O A Andreassen, I Melle
BACKGROUND: Childhood trauma increases risk of a range of mental disorders including psychosis. Whereas the mechanisms are unclear, previous evidence has implicated atypical processing of emotions among the core cognitive models, in particular suggesting altered attentional allocation towards negative stimuli and increased negativity bias. Here, we tested the association between childhood trauma and brain activation during emotional face processing in patients diagnosed with psychosis continuum disorders...
November 11, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27814962/neural-complexity-as-a-potential-translational-biomarker-for-psychosis
#11
Brandon Hager, Albert C Yang, Roscoe Brady, Shashwath Meda, Brett Clementz, Godfrey D Pearlson, John A Sweeney, Carol Tamminga, Matcheri Keshavan
BACKGROUND: The adaptability of the human brain to the constantly changing environment is reduced in patients with psychotic disorders, leading to impaired cognitive functions. Brain signal complexity, which may reflect adaptability, can be readily quantified via resting-state functional magnetic resonance imaging (fMRI) signals. We hypothesized that resting-state brain signal complexity is altered in psychotic disorders, and is correlated with cognitive impairment. METHODS: We assessed 156 healthy controls (HC) and 330 probands, including 125 patients with psychotic bipolar disorder (BP), 107 patients with schizophrenia (SZ), 98 patients with schizoaffective disorder (SAD) and 230 of their unaffected first-degree relatives (76 BPR, 79 SADR, and 75 SZR) from four sites of the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium...
October 26, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27814457/functional-connectivity-during-masked-and-unmasked-face-emotion-processing-in-bipolar-disorder
#12
Wan-Ling Tseng, Laura A Thomas, Elizabeth Harkins, Joel Stoddard, Carlos A Zarate, Daniel S Pine, Ellen Leibenluft, Melissa A Brotman
Little is known regarding the neural connectivity and correlates during automatic, unconscious face emotion processing in individuals with bipolar disorder (BD). In this study, 14 adults with BD and 14 healthy volunteers (HV) underwent fMRI scanning while completing an affective priming task with unconsciously perceived and consciously perceived faces (angry, happy, neutral, blank oval). We found that, regardless of awareness level and emotion types, BD patients exhibited diminished functional connectivity between amygdala and ventromedial prefrontal cortex (vmPFC) compared to HV...
December 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27813234/differential-neural-correlates-of-autobiographical-memory-recall-in-bipolar-and-unipolar-depression
#13
Kymberly D Young, Jerzy Bodurka, Wayne C Drevets
OBJECTIVES: Autobiographical memory (AM) recall is impaired in both bipolar depression (BD) and major depressive disorder (MDD). The current study used functional magnetic resonance imaging (fMRI) to investigate differences between healthy controls (HCs) and depressed participants with either BD or MDD as they recalled AMs that varied in emotional valence. METHODS: Unmedicated adults in a current major depressive episode who met criteria for either MDD or BD and HCs (n=16/group) underwent fMRI while recalling AMs in response to emotionally valenced cue words...
November 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27806866/neurofunctional-differences-among-youth-with-and-at-varying-risk-for-developing-mania
#14
Jeffrey A Welge, Lawrence J Saliba, Jeffrey R Strawn, James C Eliassen, L Rodrigo Patino, Caleb M Adler, Wade Weber, Marguerite Reid Schneider, Drew H Barzman, Stephen M Strakowski, Melissa P DelBello, Robert K McNamara
OBJECTIVE: To examine prefrontal and amygdala activation during emotional processing in youth with or at varying risk for developing mania to identify candidate central prodromal risk biomarkers. METHOD: Four groups of medication-free adolescents (10-20 years old) participated: adolescents with first-episode bipolar I disorder (BP-I; n = 32), adolescents with a parent with bipolar disorder and a depressive disorder (at-risk depressed [ARD]; n = 32), healthy adolescents with a parent with bipolar disorder (at-risk healthy [ARH]; n = 32), and healthy adolescents with no personal or family history of psychiatric illness (healthy comparison [HC]; n = 32)...
November 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27805291/rethinking-the-use-of-neutral-faces-as-a-baseline-in-fmri-neuroimaging-studies-of-axis-i-psychiatric-disorders
#15
Megan M Filkowski, Brian W Haas
Major Axis-I disorders including major depressive disorder (MDD), bipolar disorder (BD), anxiety disorder, and schizophrenia are associated with a host of aberrations in the way social stimuli are processed. Face perception tasks are often used in neuroimaging research of emotion processing in both healthy and patient populations, and to date, there exists a mounting body of evidence, both behavioral and within the brain, indicating that emotional faces compared to neutral faces are processed abnormally by those with Axis-I disorders relative to healthy control (HC) groups...
November 2, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/27744225/differential-brain-network-activity-across-mood-states-in-bipolar-disorder
#16
Roscoe O Brady, Neeraj Tandon, Grace A Masters, Allison Margolis, Bruce M Cohen, Matcheri Keshavan, Dost Öngür
BACKGROUND: This study aimed to identify how the activity of large-scale brain networks differs between mood states in bipolar disorder. The authors measured spontaneous brain activity in subjects with bipolar disorder in mania and euthymia and compared these states to a healthy comparison population. METHODS: 23 subjects with bipolar disorder type I in a manic episode, 24 euthymic bipolar I subjects, and 23 matched healthy comparison (HC) subjects underwent resting state fMRI scans...
January 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27647671/fmri-brain-activation-changes-following-treatment-of-a-first-bipolar-manic-episode
#17
Stephen M Strakowski, David E Fleck, Jeffrey Welge, James C Eliassen, Matthew Norris, Michelle Durling, Richard A Komoroski, Wen-Jang Chu, Wade Weber, Jonathan A Dudley, Thomas J Blom, Amanda Stover, Christina Klein, Jeffrey R Strawn, Melissa P DelBello, Jing-Huei Lee, Caleb M Adler
OBJECTIVES: We tested the hypothesis that, with treatment, functional magnetic resonance imaging (fMRI) regional brain activation in first-episode mania would normalize - i.e., that differences from healthy subjects would diminish over time, and would be associated with clinical remission status, potentially identifying neuroanatomic treatment response markers. METHODS: Forty-two participants with bipolar I disorder were recruited during their first manic episode, pseudo-randomized to open-label lithium or quetiapine, and followed for 8 weeks...
September 19, 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27622393/towards-person-centered-neuroimaging-markers-for-resilience-and-vulnerability-in-bipolar-disorder
#18
Sophia Frangou, Danai Dima, Jigar Jogia
Improved clinical care for Bipolar Disorder (BD) relies on the identification of diagnostic markers that can reliably detect disease-related signals in clinically heterogeneous populations. At the very least, diagnostic markers should be able to differentiate patients with BD from healthy individuals and from individuals at familial risk for BD who either remain well or develop other psychopathology, most commonly Major Depressive Disorder (MDD). These issues are particularly pertinent to the development of translational applications of neuroimaging as they represent challenges for which clinical observation alone is insufficient...
September 10, 2016: NeuroImage
https://www.readbyqxmd.com/read/27617780/brain-functional-effects-of-psychopharmacological-treatments-in-bipolar-disorder
#19
Charles Laidi, Josselin Houenou
Functional magnetic resonance imaging (fMRI) studies have contributed to the understanding of bipolar disorder. However the effect of medication on brain activation remains poorly understood. We conducted an extensive literature review on PubMed and ScienceDirect to investigate the influence of medication in fMRI studies, including both longitudinal and cross-sectional studies, which aimed at assessing this influence. Although we reported all reviewed studies, we gave greater emphasis to studies with the most robust methodology...
September 8, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27573157/neural-alterations-of-fronto-striatal-circuitry-during-reward-anticipation-in-euthymic-bipolar-disorder
#20
S Schreiter, S Spengler, A Willert, S Mohnke, D Herold, S Erk, N Romanczuk-Seiferth, E Quinlivan, C Hindi-Attar, C Banzhaf, C Wackerhagen, L Romund, M Garbusow, T Stamm, A Heinz, H Walter, F Bermpohl
BACKGROUND: Bipolar disorder (BD), with the hallmark symptoms of elevated and depressed mood, is thought to be characterized by underlying alterations in reward-processing networks. However, to date the neural circuitry underlying abnormal responses during reward processing in BD remains largely unexplored. The aim of this study was to investigate whether euthymic BD is characterized by aberrant ventral striatal (VS) activation patterns and altered connectivity with the prefrontal cortex in response to monetary gains and losses...
August 30, 2016: Psychological Medicine
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