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https://www.readbyqxmd.com/read/29137838/fusion-of-fmri-and-non-imaging-data-for-adhd-classification
#1
Atif Riaz, Muhammad Asad, Eduardo Alonso, Greg Slabaugh
Resting state fMRI has emerged as a popular neuroimaging method for automated recognition and classification of different brain disorders. Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common brain disorders affecting young children, yet its underlying mechanism is not completely understood and its diagnosis is mainly dependent on behavior analysis. This paper addresses the problem of classification of ADHD based on resting state fMRI and proposes a machine learning framework with integration of non-imaging data with imaging data to investigate functional connectivity alterations between ADHD and control subjects (not diagnosed with ADHD)...
October 19, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29122720/connectome-based-predictive-modeling-of-attention-comparing-different-functional-connectivity-features-and-prediction-methods-across-datasets
#2
Kwangsun Yoo, Monica D Rosenberg, Wei-Ting Hsu, Sheng Zhang, Chiang-Shan R Li, Dustin Scheinost, R Todd Constable, Marvin M Chun
Connectome-based predictive modeling (CPM; Finn et al., 2015; Shen et al., 2017) was recently developed to predict individual differences in traits and behaviors, including fluid intelligence (Finn et al., 2015) and sustained attention (Rosenberg et al., 2016a), from functional brain connectivity (FC) measured with fMRI. Here, using the CPM framework, we compared the predictive power of three different measures of FC (Pearson's correlation, accordance, and discordance) and two different prediction algorithms (linear and partial least square [PLS] regression) for attention function...
November 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/29104944/psychotropic-medication-use-in-autism-spectrum-disorders-may-affect-functional-brain-connectivity
#3
Annika C Linke, Lindsay Olson, Yangfeifei Gao, Inna Fishman, Ralph-Axel Müller
Background: Prescription of psychotropic medications is common in autism spectrum disorders (ASDs), either off-label or to treat comorbid conditions such as ADHD or depression. Psychotropic medications are intended to alter brain function. Yet, studies investigating the functional brain organization in ASDs rarely take medication usage into account. This could explain some of the inconsistent findings of atypical brain network connectivity reported in the autism literature. Methods: The current study tested whether functional connectivity patterns, as assessed with functional magnetic resonance imaging (fMRI), differed in a cohort of 49 children and adolescents with ASDs based on psychotropic medication status, and in comparison with 50 matched typically developing (TD) participants...
September 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29075206/abnormal-resting-state-functional-connectivity-of-insular-subregions-and-disrupted-correlation-with-working-memory-in-adults-with-attention-deficit-hyperactivity-disorder
#4
Qihua Zhao, Hui Li, Xiaoyan Yu, Fang Huang, Yanfei Wang, Lu Liu, Qingjiu Cao, Qiujin Qian, Yufeng Zang, Li Sun, Yufeng Wang
OBJECTIVES: Executive function (EF) deficits are major impairments in adults with attention deficit/hyperactivity disorder (ADHD). Previous studies have shown that the insula is involved in cognitive and EFs. However, the insula is highly heterogeneous in function, and few studies have focused on functional networks which related to specific insular subregions in adults with ADHD. We explored the functional networks of the insular subregions [anterior insula (AI), mid-insula (MI), and posterior insula (PI)]...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29052617/adhd-smoking-withdrawal-and-inhibitory-control-results-of-a-neuroimaging-study-with-methylphenidate-challenge
#5
Maggie M Sweitzer, Scott H Kollins, Rachel V Kozink, Matt Hallyburton, Joseph English, Merideth A Addicott, Jason A Oliver, F Joseph McClernon
Smoking withdrawal negatively impacts inhibitory control, and these effects are greater for smokers with pre-existing attention problems, such as attention deficit/hyperactivity disorder (ADHD). The current study preliminarily evaluated changes in inhibitory control-related behavior and brain activation during smoking withdrawal among smokers with ADHD. Moreover, we investigated the role of catecholamine transmission in these changes by examining effects of 40 mg methylphenidate (MPH) administration. Adult daily smokers with (n=17) and without (n=20) ADHD completed fMRI scanning under each of three conditions: (a) smoking as usual+placebo; (b) 24 hr smoking abstinence+placebo and (c) 24 hr smoking abstinence+MPH...
October 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29049910/an-improved-synchronization-likelihood-method-for-quantifying-neuronal-synchrony
#6
Sina Khanmohammadi
Indirect quantification of the synchronization between two dynamical systems from measured experimental data has gained much attention in recent years, especially in the computational neuroscience community where the exact model of the neuronal dynamics is unknown. In this regard, one of the most promising methods for quantifying the interrelationship between nonlinear non-stationary systems is known as Synchronization Likelihood (SL), which is based on the likelihood of the auto-recurrence of embedding vectors (similar patterns) in multiple dynamical systems...
October 3, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29036764/hippotherapy-and-neurofeedback-training-effect-on-the-brain-function-and-serum-brain-derived-neurotrophic-factor-level-changes-in-children-with-attention-deficit-or-and-hyperactivity-disorder
#7
Namju Lee, Sok Park, Jongkyu Kim
PURPOSE: The purpose of this study was to investigate the effect of hippotherapy and electroencephalography (EEG) neurofeedback on brain function and blood brain-derived neurotrophic factor (BDNF) level in children with attention-deficit or/and hyperactivity disorder (ADHD). METHODS: Sixteen children with ADHD participated in this study and were randomly divided into 2 groups, a 1-time hippotherapy group (W1G, n = 8) and a 2-time hippotherapy group (W2G, n = 8)...
September 30, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/29033857/an-update-overview-on-brain-imaging-studies-of-internet-gaming-disorder
#8
REVIEW
Aviv M Weinstein
There are a growing number of studies on structural and functional brain mechanisms underlying Internet gaming disorder (IGD). Recent functional magnetic resonance imaging studies showed that IGD adolescents and adults had reduced gray matter volume in regions associated with attention motor coordination executive function and perception. Adolescents with IGD showed lower white matter (WM) integrity measures in several brain regions that are involved in decision-making, behavioral inhibition, and emotional regulation...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28988149/neural-dysfunction-during-temporal-discounting-in-paediatric-attention-deficit-hyperactivity-disorder-and-obsessive-compulsive-disorder
#9
Luke J Norman, Christina O Carlisi, Anastasia Christakou, Kaylita Chantiluke, Clodagh Murphy, Andrew Simmons, Vincent Giampietro, Michael Brammer, David Mataix-Cols, Katya Rubia
Both Attention-Deficit/Hyperactivity Disorder (ADHD) and Obsessive-Compulsive Disorder (OCD) are associated with choice impulsivity, i.e. the tendency to prefer smaller immediate rewards over larger delayed rewards. However, the extent to which this impulsivity is mediated by shared or distinct underlying neural mechanisms is unclear. Twenty-six boys with ADHD, 20 boys with OCD and 20 matched controls (aged 12-18) completed an fMRI version of an individually adjusted temporal discounting (TD) task which requires choosing between a variable amount of money now or £100 in one week, one month or one year...
November 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28943846/a-computational-model-for-the-automatic-diagnosis-of-attention-deficit-hyperactivity-disorder-based-on-functional-brain-volume
#10
Lirong Tan, Xinyu Guo, Sheng Ren, Jeff N Epstein, Long J Lu
In this paper, we investigated the problem of computer-aided diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) using machine learning techniques. With the ADHD-200 dataset, we developed a Support Vector Machine (SVM) model to classify ADHD patients from typically developing controls (TDCs), using the regional brain volumes as predictors. Conventionally, the volume of a brain region was considered to be an anatomical feature and quantified using structural magnetic resonance images. One major contribution of the present study was that we had initially proposed to measure the regional brain volumes using fMRI images...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28938222/inter-hemispherical-asymmetry-in-default-mode-functional-connectivity-and-baiap2-gene-are-associated-with-anger-expression-in-adhd-adults
#11
R Hasler, M G Preti, D E Meskaldji, J Prados, W Adouan, C Rodriguez, S Toma, N Hiller, T Ismaili, J Hofmeister, I Sinanaj, P Baud, S Haller, P Giannakopoulos, S Schwartz, N Perroud, D Van De Ville
Attention deficit hyperactivity disorder (ADHD) is accompanied by resting-state alterations, including abnormal activity, connectivity and asymmetry of the default-mode network (DMN). Concurrently, recent studies suggested a link between ADHD and the presence of polymorphisms within the gene BAIAP2 (i.e., brain-specific angiogenesis inhibitor 1-associated protein 2), known to be differentially expressed in brain hemispheres. The clinical and neuroimaging correlates of this polymorphism are still unknown. We investigated the association between BAIAP2 polymorphisms and DMN functional connectivity (FC) asymmetry as well as behavioral measures in ADHD adults...
September 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28938219/age-dependent-effects-of-acute-methylphenidate-on-amygdala-reactivity-in-stimulant-treatment-naive-patients-with-attention-deficit-hyperactivity-disorder
#12
Marco A Bottelier, Anouk Schrantee, Bart Ferguson, Hyke G H Tamminga, Cheima Bouziane, J J Sandra Kooij, Michiel B de Ruiter, Liesbeth Reneman
In the present study, we investigate whether methylphenidate (MPH) affects emotional processing and whether this effect is modulated by age. We measured amygdala reactivity with functional Magnetic Resonance Imaging (fMRI) during processing of angry and fearful facial expressions in male stimulant treatment-naive patients with ADHD (N = 35 boys; N = 46 men) and 23 healthy control subjects (N = 11 boys; N = 12 men). In ADHD patients, we also measured amygdala reactivity 90min after an acute oral challenge with MPH (0...
September 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28868337/the-adolescent-brain-at-risk-for-substance-use-disorders-a-review-of-functional-mri-research-on-motor-response-inhibition
#13
Maki S Koyama, Muhammad A Parvaz, Rita Z Goldstein
Youth with family history (FH+) of substance use disorders (SUDs) are at increased risk for developing SUDs. Similarly, childhood attention deficit hyperactivity disorder (ADHD) is considered to be a risk factor for developing SUDs. Recent research has suggested a close association between SUDs and impaired inhibitory control. As such, it is crucial to examine common and distinct neural alterations associated with inhibitory control in these at-risk groups, particularly prior to the initiation of heavy substance use...
February 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/28863310/altered-patterns-of-resting-state-functional-connectivity-between-the-caudate-and-other-brain-regions-in-medication-na%C3%A3-ve-children-with-attention-deficit-hyperactivity-disorder
#14
Zhilong Yang, Hongxing Li, Wenjuan Tu, Suhong Wang, Yanling Ren, Yang Yi, Ting Wu, Kaihua Jiang, Huijuan Shen, Jian Wu, Xuan Dong
BACKGROUND: Structural and functional alterations occur in the caudate of patients with attention-deficit/hyperactivity disorder (ADHD). Here we aimed to investigate the functional connectivity between the dorsal caudate and other brain regions in ADHD children. METHODS: Resting-state functional connectivity from 30 ADHD and 33 age- and gender-matched "normal" children were measured by functional Magnetic Resonance Imaging. RESULTS: Positive connectivity with dorsal caudate was observed in the prefrontal areas, cingulate cortex and temporal lobe...
July 28, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28863139/gut-microbiome-in-adhd-and-its-relation-to-neural-reward-anticipation
#15
Esther Aarts, Thomas H A Ederveen, Jilly Naaijen, Marcel P Zwiers, Jos Boekhorst, Harro M Timmerman, Sanne P Smeekens, Mihai G Netea, Jan K Buitelaar, Barbara Franke, Sacha A F T van Hijum, Alejandro Arias Vasquez
BACKGROUND: Microorganisms in the human intestine (i.e. the gut microbiome) have an increasingly recognized impact on human health, including brain functioning. Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder associated with abnormalities in dopamine neurotransmission and deficits in reward processing and its underlying neuro-circuitry including the ventral striatum. The microbiome might contribute to ADHD etiology via the gut-brain axis. In this pilot study, we investigated potential differences in the microbiome between ADHD cases and undiagnosed controls, as well as its relation to neural reward processing...
2017: PloS One
https://www.readbyqxmd.com/read/28861338/increased-default-mode-variability-is-related-to-reduced-task-performance-and-is-evident-in-adults-with-adhd
#16
Athanasia M Mowinckel, Dag Alnæs, Mads L Pedersen, Sigurd Ziegler, Mats Fredriksen, Tobias Kaufmann, Edmund Sonuga-Barke, Tor Endestad, Lars T Westlye, Guido Biele
Insufficient suppression and connectivity of the default mode network (DMN) is a potential mediator of cognitive dysfunctions across various disorders, including attention deficit/hyperactivity disorder (ADHD). However, it remains unclear if alterations in sustained DMN suppression, variability and connectivity during prolonged cognitive engagement are implicated in adult ADHD pathophysiology, and to which degree methylphenidate (MPH) remediates any DMN abnormalities. This randomized, double-blinded, placebo-controlled, cross-over clinical trial of MPH (clinicaltrials...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28843999/predicting-clinical-symptoms-of-attention-deficit-hyperactivity-disorder-based-on-temporal-patterns-between-and-within-intrinsic-connectivity-networks
#17
Xun-Heng Wang, Yun Jiao, Lihua Li
Attention deficit hyperactivity disorder (ADHD) is a common brain disorder with high prevalence in school-age children. Previously developed machine learning-based methods have discriminated patients with ADHD from normal controls by providing label information of the disease for individuals. Inattention and impulsivity are the two most significant clinical symptoms of ADHD. However, predicting clinical symptoms (i.e., inattention and impulsivity) is a challenging task based on neuroimaging data. The goal of this study is twofold: to build predictive models for clinical symptoms of ADHD based on resting-state fMRI and to mine brain networks for predictive patterns of inattention and impulsivity...
August 24, 2017: Neuroscience
https://www.readbyqxmd.com/read/28831377/centrality-of-prefrontal-and-motor-preparation-cortices-to-tourette-syndrome-revealed-by-meta-analysis-of-task-based-neuroimaging-studies
#18
Liliana Polyanska, Hugo D Critchley, Charlotte L Rae
Tourette Syndrome (TS) is a neurodevelopmental condition characterized by chronic multiple tics, which are experienced as compulsive and 'unwilled'. Patients with TS can differ markedly in the frequency, severity, and bodily distribution of tics. Moreover, there are high comorbidity rates with attention deficit hyperactivity disorder (ADHD), obsessive compulsive disorder (OCD), anxiety disorders, and depression. This complex clinical profile may account for apparent variability of findings across neuroimaging studies that connect neural function to cognitive and motor behavior in TS...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28700674/effects-of-taurine-on-resting-state-fmri-activity-in-spontaneously-hypertensive-rats
#19
Vincent Chin-Hung Chen, Tsai-Ching Hsu, Li-Jeng Chen, Hong-Chun Chou, Jun-Cheng Weng, Bor-Show Tzang
Attention deficit hyperactivity disorder (ADHD) is a global behavior illness among children and adults. To investigate the effects of taurine on resting-state fMRI activity in ADHD, a spontaneously hypertensive rat (SHR) animal model was adopted. Significantly decreased serum C-reactive protein (CRP) was detected in rats of Wistar Kyoto (WKY) high-taurine group and significantly decreased interleukin (IL)-1β and CRP were detected in rats of SHR low-taurine and high-taurine groups. Moreover, significantly higher horizontal locomotion was detected in rats of WKY low-taurine and SHR low-taurine groups than in those of controls...
2017: PloS One
https://www.readbyqxmd.com/read/28667891/anomalous-prefrontal-limbic-activation-and-connectivity-in-youth-at-high-risk-for-bipolar-disorder
#20
Kiki Chang, Amy Garrett, Ryan Kelley, Meghan Howe, Erica Marie Sanders, Tenah Acquaye, Layla Bararpour, Sherrie Li, Manpreet Singh, Booil Jo, Joachim Hallmayer, Allan Reiss
OBJECTIVE: Abnormal prefrontal-limbic brain activation in response to facial expressions has been reported in pediatric bipolar disorder (BD). However, it is less clear whether these abnormalities exist prior to onset of mania, thus representing a biomarker predicting development of BD. METHODS: We examined brain activation in 50 youth at high risk for BD (HR-BD), compared with 29 age- and gender-matched healthy control (HC) subjects. HR-BD was defined as having a parent with BD, as well as current mood or attentiondeficit/ hyperactivity disorder (ADHD) symptoms, or a history of at least one depressive episode...
November 2017: Journal of Affective Disorders
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