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https://www.readbyqxmd.com/read/30537771/systemic-arterial-hypertension-in-childhood-a-challenge-related-to-the-increasing-survival-of-very-low-birth-weight-preterm-infants
#1
Bruna Ossanai Schoenardie, Victória Bernardes Guimarães, Renato Soibelmann Procianoy, Rita C Silveira
OBJECTIVE:  To verify the prevalence of systemic arterial hypertension (SAH) and to identify possible early predictors of SAH at ages 2 and 4 years in very low birth weight (VLBW) infants. STUDY DESIGN:  This is a prospective cohort study including inborn children with birth weight (BW) <1,500 g. Arterial blood pressure measurements were performed at 2 and 4 years. Model 1 compared children with and those without SAH at age 4. Model 2 compared children who had SAH at ages 2 and 4 with the others...
December 11, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/30537637/prenatal-thallium-exposure-and-poor-growth-in-early-childhood-a-prospective-birth-cohort-study
#2
Juan Qi, Yaping Lai, Chunmei Liang, Shuangqin Yan, Kun Huang, Weijun Pan, Lanlan Feng, Liu Jiang, Peng Zhu, Jiahu Hao, Shilu Tong, Fangbiao Tao
BACKGROUND: Thallium (Tl) exposure remains a public health problem with potential impacts on humans. Studies have suggested that prenatal exposure to thallium may be associated with fetal growth, but no studies are known have explored its association with early childhood anthropometry. OBJECTIVE: To investigate the effects of prenatal Tl exposures on early child growth and development aged 0-2 years in a prospective birth cohort study. METHODS: 3080 pregnant women and their children participated in the study, which were recruited from a birth cohort in China...
December 8, 2018: Environment International
https://www.readbyqxmd.com/read/30537626/brief-reaching-training-with-sticky-mittens-in-preterm-infants-randomized-controlled-trial
#3
Andressa Lagoa Nascimento, Aline Martins Toledo, Leila Foerster Merey, Eloisa Tudella, Daniele de Almeida Soares-Marangoni
OBJECTIVE: To examine whether a brief reaching training with sticky mittens was effective to improve reaching behavior in newly reaching preterm infants. METHODS: In this randomized controlled trial, twenty four 5-month-old (±16-week-old corrected age) preterm infants were randomly allocated into experimental or control groups. Infants were assessed three times in a single session: pretraining (immediately before training), posttraining (immediately after training), and retention (4 min after the posttraining)...
December 8, 2018: Human Movement Science
https://www.readbyqxmd.com/read/30537393/timing-of-postnatal-corticosteroid-treatment-for-bronchopulmonary-dysplasia-and-its-effect-on-outcomes
#4
Alain Cuna, Tamorah Lewis, Hongying Dai, Michael Nyp, William E Truog
OBJECTIVE: To determine the association of timing of steroid therapy for bronchopulmonary dysplasia (BPD) and outcomes. METHODS: Retrospective cohort study of preterm infants treated with low-dose dexamethasone for BPD. Infants treated with steroids at day of life (DOL) 14-28 (moderately late group) were compared to infants treated at DOL 29-42 (delayed group). Inverse probability of treatment weighting (IPTW) adjusted propensity scores were used to correct for potential confounders...
December 10, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/30537361/emerging-technologies-for-low-cost-rapid-vaccine-manufacture
#5
REVIEW
Zoltán Kis, Robin Shattock, Nilay Shah, Cleo Kontoravdi
To stop the spread of future epidemics and meet infant vaccination demands in low- and middle-income countries, flexible, rapid and low-cost vaccine development and manufacturing technologies are required. Vaccine development platform technologies that can produce a wide range of vaccines are emerging, including: a) humanized, high-yield yeast recombinant protein vaccines; b) insect cell-baculovirus ADDomer vaccines; c) Generalized Modules for Membrane Antigens (GMMA) vaccines; d) RNA vaccines. Herein, existing and future platforms are assessed in terms of addressing challenges of scale, cost, and responsiveness...
November 22, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/30537356/high-versus-low-dose-caffeine-in-preterm-infants
#6
Petter Brattström, Chiara Russo, David Ley, Matteo Bruschettini
We are grateful to Vliegenthart et al for their letter (1) commenting on our systematic review, which compared the use of high versus low dose caffeine in preterm infants (2). A clear definition of the inclusion criteria in a systematic review is an essential step to minimise the risk of intellectual bias. Vliegenthart et al state that pooling the results of the studies they identified did not affect the estimate of the effect size of the outcome of bronchopulmonary dysplasia. This article is protected by copyright...
December 11, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/30537350/toward-a-solution-for-cardiac-failure-in-the-newborn
#7
Jeffrey L Platt, Lori J West, Richard E Chinnock, Marilia Cascalho
The newborn infant with severe cardiac failure owed to congenital structural heart disease or cardiomyopathy poses a daunting therapeutic challenge. The ideal solution for both might be cardiac transplantation if availability of hearts was not limiting and if tolerance could be induced, obviating toxicity of immunosuppressive therapy. If one could safely and effectively exploit neonatal tolerance for successful xenotransplantation of the heart, the challenge of severe cardiac failure in the newborn infant might be met...
December 11, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/30537331/providing-very-preterm-infants-with-donor-human-milk-led-to-faster-breastfeeding-rates-but-worse-biometric-gains
#8
Cecilia Castellano Yáñez, Beatriz Castillo Barrio, María Del Carmen Muñoz Labián, Roberto Ortiz Movilla, Nadia Raquel García Lara, Ana Royuela Vicente, Miguel A Marín Gabriel
AIM: To evaluate the immediate clinical impact of donor human milk availability in a NICU about nutritional, clinical and biometric parameters. METHODS: This retrospective-cohort study included 28-32 weeks gestational age born at our hospital in a three-year period before and after the donor human milk implementation. Data about starting, advance and discharge enteral nutrition, clinical outcomes, hospital stay and biometrics, was collected. RESULTS: Infants in period with donor human milk started enteral nutrition 16 hours earlier (p<0...
December 11, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/30537292/review-shows-that-thyroid-hormone-substitution-could-benefit-transient-hypothyroxinaemia-of-prematurity-but-treatment-strategies-need-to-be-clarified
#9
REVIEW
An Eerdekens, Lies Langouche, Greet Van den Berghe, Johan Verhaeghe, Gunnar Naulaers, Christine Vanhole
AIM: Thyroid hormones are crucial for fetal and neonatal brain development. This paper provides an overview of the normal role of thyroid hormones in fetal brain development and the pathophysiology of transient hypothyroxinaemia of prematurity (THOP). It also discusses the diagnostic and therapeutic controversies around THOP and looks at directions for future research. METHODS: We used the PubMed and Embase databases to identify papers published in English from 1969 to June 2018...
December 7, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/30537276/clinical-and-echocardiography-predictors-of-response-to-inhaled-nitric-oxide-in-hypoxic-preterm-neonates
#10
Mohamed Shalabi Ahmed, Regan E Giesinger, Mohamed Ibrahim, Michelle Baczynski, Deepak Louis, Karl P McNamara, Amish Jain, Dany E Weisz, Patrick J McNamara
AIM: To evaluate the clinical and echocardiography modulators of treatment response in hypoxemic preterm infants exposed to inhaled nitric oxide (iNO). METHODS: In this multicentre retrospective study, clinical parameters, including oxygenation, ventilation and haemodynamics, were collected for preterm infants <36 weeks gestation before and 2 h after initiation of iNO for acute hypoxemia. Comprehensive echocardiography, performed near the time iNO initiation, was analysed by experts blind to the clinical course...
December 8, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/30537268/probiotics-can-stimulate-initial-head-growth-in-premature-infants
#11
EDITORIAL
Olivier Claris
No abstract text is available yet for this article.
January 2019: Acta Paediatrica
https://www.readbyqxmd.com/read/30537250/aerodigestive-and-communicative-behaviors-in-anencephalic-and-hydranencephalic-infants
#12
REVIEW
Kate Radford, Ryan C Taylor, Judith G Hall, Bryan Gick
The aerodigestive and communicative behaviors of anencephalic and hydranencephalic patients are assessed from literature sources and are compared with documented neural structures present in the brainstem, subcortical, and cortical regions of the brain. Much of the data analyzed corroborate previous neurological studies, which focus on central pattern generators and development in model organisms. However, findings suggest that further research is necessary to determine which components of these systems support these behaviors...
December 10, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30537164/developmental-defects-of-enamel-in-the-deciduous-incisors-of-infants-born-preterm-prospective-cohort
#13
Andréa Araujo de Oliveira Cortines, Patrícia Corrêa-Faria, Liselotte Paulsson, Paulo Sucasas Costa, Luciane Rezende Costa
OBJECTIVE: Developmental defects of enamel (DDE) in preterm infants still require clarification and may favour dental caries, lower food intake, and greater difficulty with weight-height gain. We evaluated factors associated with DDE in preterm infants. SUBJECTS AND METHODS: In this prospective cohort study, we monitored 54 prematurely born infants from birth to 24 months of age. Trained and calibrated dentists examined the oral cavity of these children to identify and categorize DDE...
December 7, 2018: Oral Diseases
https://www.readbyqxmd.com/read/30536910/practice-variation-among-dutch-paediatricians-in-palivizumab-prescription-rates-the-importance-of-parental-counselling-approach
#14
L M P Kooiman, A W A Kamps, A C M Dassel, P L P Brand, J Bekhof
AIM: To investigate differences in palivizumab prescription rates between Dutch paediatricians, and the role of parent counselling in this practice variation. METHODS: A retrospective chart review of premature infants <32 weeks of gestation, aged <six months at the start of the winter season, born between January 2012 and July 2014, in three secondary hospital-based paediatric practices in the Netherlands. RESULTS: We included 208 patients, 133 (64%) of whom received palivizumab...
December 11, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/30536894/infants-who-die-in-shared-sleeping-situations-differ-from-those-who-die-while-sleeping-alone
#15
Lyndsey E Collins-Praino, Roger W Byard
AIM: To determine whether there are differences between infants who are sharing a sleeping surface with others, compared to those who die alone. METHODS: A literature review was undertaken of pubmed and google scholar databases using search terms: sudden infant death syndrome, SIDS, cosleeping and overlaying. RESULTS: Statistically significant differences were found between the two groups in the sex ratios, and in staining of brain sections for β-amyloid precursor protein (β-APP), glial fibrillary acidic protein (GFAP) and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL)...
December 10, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/30536827/pharmacotherapy-for-patent-ductus-arteriosus-closure
#16
REVIEW
John M Ferguson
Even though up to 60% of premature infants less than 28 weeks gestation develop persistent patent ductus arteriosus (PDA), there remains controversy regarding if, when, and how to close the PDA. Failure to close the PDA has been associated with significant morbidity but no cause-and-effect has been proven for short-term or long-term outcomes in modern times. Surgical closure has the advantage of eliminating the PDA, but short-term complications and long-term adverse outcomes are worrisome. Intravenous indomethacin has been the "gold standard" for pharmacologic treatment over the past 40 years with high closure rates and decreased incidence of severe intraventricular hemorrhage (IVH) and pulmonary hemorrhage with early treatment but without improvement in long-term outcomes and with risk of renal toxicity...
December 11, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/30536768/iron-fortified-formula-use-in-young-children-and-association-with-socioeconomic-factors-in-the-french-nationwide-elfe-cohort
#17
Anne-Sylvia Sacri, Blandine de Lauzon-Guillain, Marie-Noëlle Dufourg, Corinne Bois, Marie Aline Charles, Martin Chalumeau
Sacri A-S, de Lauzon-Guillain B, Dufourg M-D, Bois C, Charles M A, Chalumeau M. Iron-fortified formula use in young children and association with socioeconomic factors in the French nationwide ELFE cohort. AIM: To study the rate of iron-fortified infant formula (IFF) use in young children in France and its association with socioeconomic factors. METHODS: The ELFE national birth cohort included, in 2011, 18,329 living births in 349 hospitals randomly selected. The present analyses were restricted to children with follow-up at age 2 years...
December 7, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/30536707/model-that-predicted-death-or-disabilities-in-premature-infants-was-valid-at-seven-years-of-age
#18
Salvador Piris Borregas, María José Torres Valdivieso, Cristina Martín-Arriscado, Javier de la Cruz Bértolo, Purificación Sierra García, Carmen Rosa Pallás Alonso
AIM: Validated a model that used bronchopulmonary dysplasia (BPD), brain injuries measured using ultrasound and retinopathy of prematurity (ROP) to predict late death or disability in premature infants at seven years of age. METHODS: A retrospective study was performed at the 12 de Octubre Hospital neonatal unit in Madrid. A logistic model was applied to estimate the independent prognostic contribution of each morbidity and the effect that the combination of morbidities had on the seven-year outcomes...
December 8, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/30536580/fetal-myelomeningocele-surgery-only-treating-the-tip-of-the-iceberg
#19
Alyaa AlRefai, James Drake, Abhaya V Kulkarni, Kristin L Connor, Patrick Shannon, Ants Toi, David Chitayat, Susan Blaser, Paige T Church, Nimrah Abbasi, Greg Ryan, Tim Van Mieghem
OBJECTIVE: Fetal myelomeningocele (fMMC) surgery improves infant outcomes when compared with postnatal surgery. Surgical selection criteria and the option of pregnancy termination, however, limit the number of cases that are eligible for prenatal surgery. We aimed to quantify what proportion of cases could ultimately benefit from fetal therapy. METHODS: We retrospectively reviewed all cases of fMMC referred to a large tertiary care center over a 10-year period and assessed their eligibility for fetal surgery, pregnancy termination rates, and actual uptake of the surgery...
December 10, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/30536389/brain-structure-and-neurological-and-behavioural-functioning-in-infants-born-preterm
#20
Claire E Kelly, Deanne K Thompson, Jeanie Ly Cheong, Jian Chen, Joy E Olsen, Abbey L Eeles, Jennifer M Walsh, Marc L Seal, Peter J Anderson, Lex W Doyle, Alicia J Spittle
AIM: To examine: (1) relationships between brain structure, and concurrently assessed neurological and behavioural functioning, in infants born preterm at term-equivalent age (TEA; approximately 38-44wks); and (2) whether brain structure-function relationships differ between infants born very (24-29wks) and moderate-late (32-36wks) preterm. METHOD: A total of 257 infants (91 very preterm, 166 moderate-late preterm; 120 males, 137 females) had structural magnetic resonance imaging (MRI) and neurological and behavioural assessments (Prechtl's general movements assessment, Neonatal Intensive Care Unit Network Neurobehavioral Scale [NNNS] and Hammersmith Neonatal Neurological Examination [HNNE])...
December 10, 2018: Developmental Medicine and Child Neurology
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