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https://www.readbyqxmd.com/read/28817798/toward-a-wiring-diagram-understanding-of-appetite-control
#1
REVIEW
Mark L Andermann, Bradford B Lowell
Prior mouse genetic research has set the stage for a deep understanding of appetite regulation. This goal is now being realized through the use of recent technological advances, such as the ability to map connectivity between neurons, manipulate neural activity in real time, and measure neural activity during behavior. Indeed, major progress has been made with regard to meal-related gut control of appetite, arcuate nucleus-based hypothalamic circuits linking energy state to the motivational drive, hunger, and, finally, limbic and cognitive processes that bring about hunger-mediated increases in reward value and perception of food...
August 16, 2017: Neuron
https://www.readbyqxmd.com/read/28811669/paraventricular-thalamic-control-of-food-intake-and-reward-role-of-glucagon-like-peptide-1-receptor-signaling
#2
Zhi Yi Ong, Jing-Jing Liu, Zhiping P Pang, Harvey J Grill
Paraventricular thalamic nucleus (PVT) neurons receive hindbrain and hypothalamic inputs, and project to forebrain sites involved in reward and motivation function. The role of PVT in energy balance and reward control is however understudied. Given that PVT neurons express glucagon-like peptide-1 receptors (GLP-1R), which are critical to feeding and body weight control, we tested the hypothesis that PVT GLP-1R signaling contributes to food intake and reward inhibition. To assess the hypothesis, behavioral tests including chow and high-fat diet intake, meal patterns, conditioned place preference for high-fat food, cue-induced reinstatement of sucrose-seeking, and motivation to work for sucrose were employed following intra-PVT delivery of either GLP-1R agonist, exendin-4 (Ex4), or GLP-1R antagonist, exendin-9-39 (Ex9)...
July 19, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28808677/correction-mcmurray-et-al-brain-stimulation-reward-supports-more-consistent-and-accurate-rodent-decision-making-than-food-reward-eneuro-march-april-2017-4-2-e0015-17-2017-1-13-http-dx-doi-org-10-1523-eneuro-0015-17-2017
#3
(no author information available yet)
[This corrects the article DOI: 10.1523/ENEURO.0015-17.2017.][This corrects the article DOI: 10.1523/ENEURO.0015-17.2017.].
July 2017: ENeuro
https://www.readbyqxmd.com/read/28804788/pro-dopamine-regulator-kb220-to-balance-brain-reward-circuitry-in-reward-deficiency-syndrome-rds
#4
Kenneth Blum, Marcelo Febo, Lyle Fried, David Baron, Eric R Braverman, Kristina Dushaj, Mona Li, Zsolt Demetrovics, Rajendra D Badgaiyan
We are faced with a worldwide opiate/opioid epidemic that is devastating. According to the Centers for Disease Control and Prevention (CDC), at least 127 people, young and old, are dying every day in America due to narcotic overdose. The Food and Drug Administration (FDA) has approved Medication-Assisted Treatments (MATs) for opiate/opioids as well as alcohol and nicotine. The mechanism of action of most MATS favors either blocking of dopaminergic function or a form of Opiate Substitution Therapy (OST). These treatment options are adequate for short-term treatment of the symptoms of addiction and harm reduction but fail long-term to deal with the cause or lead to recovery...
2017: Journal of Reward Deficiency Syndrome and Addiction Science
https://www.readbyqxmd.com/read/28802575/military-experience-can-influence-women-s-eating-habits
#5
Jessica Y Breland, Rosemary Donalson, Andrea Nevedal, Julie V Dinh, Shira Maguen
BACKGROUND: Disordered eating, ranging from occasional binge eating or restriction to behaviors associated with eating disorder diagnoses, is common among military personnel and veterans. However, there is little information on how military service affects eating habits. OBJECTIVE: To describe possible pathways between military service and disordered eating among women veterans, a high risk group. MATERIALS AND METHODS: Twenty women veterans who reported changing eating habits in response to stress participated in audio-recorded focus groups or dyadic interviews between April 2013 and October 2014...
August 9, 2017: Appetite
https://www.readbyqxmd.com/read/28791553/sex-differences-in-discrimination-reversal-learning-in-the-guppy
#6
Maria Elena Miletto Petrazzini, Angelo Bisazza, Christian Agrillo, Tyrone Lucon-Xiccato
In several mammalian and avian species, females show a higher performance than males in tasks requiring cognitive flexibility such as the discrimination reversal learning. A recent study showed that female guppies are twice as efficient as males in a reversal learning task involving yellow-red discrimination, suggesting a higher cognitive flexibility in female guppies. However, the possibility exists that the superior performance exhibited by females does not reflect a general sex difference in cognitive abilities, but instead, is confined to colour discrimination tasks...
August 8, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28789870/relevance-of-the-nucleus-of-the-solitary-tract-gelatinous-part-in-learned-preferences-induced-by-intragastric-nutrient-administration
#7
María A Zafra, Antonio D Agüera, Filomena Molina, Amadeo Puerto
Food preferences have been investigated in Wistar rats utilizing a learned concurrent flavor preference behavioral procedure. Previous studies have demonstrated that the perivagal administration of neurotoxin capsaicin disrupts the learning of preferences induced by intragastric administration of rewarding nutrients (pre-digested milk). The vagus nerve projects almost exclusively towards the nucleus of the solitary tract (NST), a brain medullary gateway for visceral signals. The objective of this study was to investigate the participation of the lateral portion of the dorsomedial region, the gelatinous subnucleus (SolG), in the learning of a concurrent preference task...
August 5, 2017: Appetite
https://www.readbyqxmd.com/read/28781050/direct-midbrain-dopamine-input-to-the-suprachiasmatic-nucleus-accelerates-circadian-entrainment
#8
Ryan M Grippo, Aarti M Purohit, Qi Zhang, Larry S Zweifel, Ali D Güler
Dopamine (DA) neurotransmission controls behaviors important for survival, including voluntary movement, reward processing, and detection of salient events, such as food or mate availability. Dopaminergic tone also influences circadian physiology and behavior. Although the evolutionary significance of this input is appreciated, its precise neurophysiological architecture remains unknown. Here, we identify a novel, direct connection between the DA neurons of the ventral tegmental area (VTA) and the suprachiasmatic nucleus (SCN)...
July 26, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28768906/integration-of-homeostatic-signaling-and-food-reward-processing-in-the-human-brain
#9
Joe J Simon, Anne Wetzel, Maria Hamze Sinno, Mandy Skunde, Martin Bendszus, Hubert Preissl, Paul Enck, Wolfgang Herzog, Hans-Christoph Friederich
BACKGROUND: Food intake is guided by homeostatic needs and by the reward value of food, yet the exact relation between the two remains unclear. The aim of this study was to investigate the influence of different metabolic states and hormonal satiety signaling on responses in neural reward networks. METHODS: Twenty-three healthy participants underwent functional magnetic resonance imaging while performing a task distinguishing between the anticipation and the receipt of either food- or monetary-related reward...
August 3, 2017: JCI Insight
https://www.readbyqxmd.com/read/28766161/meerkats-suricata-suricatta-fail-to-prosocially-donate-food-in-an-experimental-set-up
#10
Federica Amici, Montserrat Colell Mimó, Christoph von Borell, Nereida Bueno-Guerra
Although humans are usually believed to be prosocial, the evolutionary origins of prosociality are largely debated. One hypothesis is that cooperative breeding has been one major precursor to the emergence of prosociality. In vertebrates, however, experimental evidence of prosociality has been mainly gathered in non-human primates. In this study, we tested the cooperative breeding hypothesis in cooperative breeding meerkats (Suricata suricatta). In particular, we tested whether meerkats take into account partners' benefits when distributing food rewards...
August 1, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28765857/why-the-public-health-sector-couldn-t-create-pok%C3%A3-mon-go
#11
Becky Freeman, Josephine Chau, Seema Mihrshahi
Pokémon Go has been subject to much attention - from both the players that download the augmented reality game and the news media. Amid the exaggerated media reports, Pokémon Go may have unintended health benefits. Players have reported walking more, spending more time with family, experiencing improvements in their mental health and feeling more connected to their communities. It is hard to imagine public health researchers developing a similar game that is fun, taps into pop culture, reaches a wide target audience, makes use of physical and virtual environments, creates a sense of both competition and community, and has spin-off health benefits...
July 26, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/28763133/physical-activity-and-exercise-self-regulation-in-cancer-survivors-a-qualitative-study
#12
Edward Tsai, Michael C Robertson, Elizabeth J Lyons, Maria C Swartz, Karen Basen-Engquist
OBJECTIVE: Despite the benefits of physical activity, many cancer survivors do not adhere to clinically recommended levels. This qualitative study investigated factors of self-regulation contributing to survivor physical activity patterns. METHODS: Participants attended focus groups with prompts on exercise habits and self-regulation based on Social Cognitive Theory, Self-Determination Theory, and Self-Regulation Theory. Content analysis with a priori codes was conducted to identify emergent themes...
August 1, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28762102/weight-loss-and-appetite-control-in-women
#13
REVIEW
Luzia Jaeger Hintze, Salma Mahmoodianfard, Coralie Bonaparte Auguste, Éric Doucet
PURPOSE OF REVIEW: The aim of this review is to describe and discuss weight loss-induced variations in appetite in women and factors responsible for these changes. RECENT FINDINGS: Studies have shown postweight loss increases in fasting and postprandial appetite in individuals engaged in weight loss trials, especially in women. Similarly, appetite-related peptides associated to the homeostatic control of feeding, such as leptin, ghrelin and peptide YY, were also found to be altered in way that promotes increased appetite after weight loss interventions...
July 31, 2017: Current Obesity Reports
https://www.readbyqxmd.com/read/28754348/neural-correlates-of-familial-obesity-risk-and-overweight-in-adolescence
#14
Susan Carnell, Leora Benson, Ku-Yu Virginia Chang, Zhishun Wang, Yuankai Huo, Allan Geliebter, Bradley S Peterson
BACKGROUND: Rates of adolescent obesity and overweight are high. The offspring of overweight parents are at increased risk of becoming obese later in life. Investigating neural correlates of familial obesity risk and current overweight status in adolescence could help identify biomarkers that predict future obesity and that may serve as novel targets for obesity interventions. OBJECTIVE: Our primary aim was to use functional MRI to compare neural responses to words denoting high or low energy density (ED) foods and non-foods, in currently lean adolescents at higher compared with lower familial risk for obesity, and in overweight compared with lean adolescents...
July 25, 2017: NeuroImage
https://www.readbyqxmd.com/read/28749419/consuming-almonds-vs-isoenergetic-baked-food-does-not-differentially-influence-postprandial-appetite-or-neural-reward-responses-to-visual-food-stimuli
#15
R Drew Sayer, Jaapna Dhillon, Gregory G Tamer, Marc-Andre Cornier, Ningning Chen, Amy J Wright, Wayne W Campbell, Richard D Mattes
Nuts have high energy and fat contents, but nut intake does not promote weight gain or obesity, which may be partially explained by their proposed high satiety value. The primary aim of this study was to assess the effects of consuming almonds versus a baked food on postprandial appetite and neural responses to visual food stimuli. Twenty-two adults (19 women and 3 men) with a BMI between 25 and 40 kg/m² completed the current study during a 12-week behavioral weight loss intervention. Participants consumed either 28 g of whole, lightly salted roasted almonds or a serving of a baked food with equivalent energy and macronutrient contents in random order on two testing days prior to and at the end of the intervention...
July 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28747648/resting-state-brain-connectivity-changes-in-obese-women-after-roux-en-y-gastric-bypass-surgery-a-longitudinal-study
#16
Gaia Olivo, Wei Zhou, Magnus Sundbom, Christina Zhukovsky, Pleunie Hogenkamp, Lamia Nikontovic, Julia Stark, Lyle Wiemerslage, Elna-Marie Larsson, Christian Benedict, Helgi B Schiöth
Bariatric surgery is an effective method to rapidly induce weight loss in severely obese people, however its impact on brain functional connectivity after longer periods of follow-up is yet to be assessed. We investigated changes in connectivity in 16 severely obese women one month before, one month after and one year after Roux-en-Y gastric bypass surgery (RYGB). 12 lean controls were also enrolled. Resting-state fMRI was acquired for all participants following an overnight fast and after a 260 kcal load...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28741081/capuchin-monkeys-use-of-human-and-conspecific-cues-to-solve-a-hidden-object-choice-task
#17
Jennifer L Essler, Lindsay P Schwartz, Mattea S Rossettie, Peter G Judge
Learning by watching others can provide valuable information with adaptive consequences, such as identifying the presence of a predator or locating a food source. The extent to which nonhuman animals can gain information by reading the cues of others is often tested by evaluating responses to human gestures, such as a point, and less often evaluated by examining responses to conspecific cues. We tested whether ten brown capuchin monkeys (Cebus [Sapajus] apella) were able to use cues from monkeys and a pointing cue from a human to obtain hidden rewards...
July 24, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28739583/tonic-or-phasic-stimulation-of-dopaminergic-projections-to-prefrontal-cortex-causes-mice-to-maintain-or-deviate-from-previously-learned-behavioral-strategies
#18
Ian T Ellwood, Tosha Patel, Varun Wadia, Anthony T Lee, Alayna T Liptak, Kevin J Bender, Vikaas S Sohal
Dopamine neurons in the ventral tegmental area (VTA) encode reward prediction errors and can drive reinforcement learning through their projections to striatum, but much less is known about their projections to prefrontal cortex (PFC). Here we studied these projections, and observed phasic VTA-PFC fiber photometry signals following the delivery of rewards. Next, we studied how optogenetic stimulation of these projections affects behavior, using conditioned place preference (CPP), and a task in which mice learn associations between cues and food rewards, then use those associations to make choices...
July 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28739295/dispositional-mindfulness-and-reward-motivated-eating-the-role-of-emotion-regulation-and-mental-habit
#19
Naomi R Fisher, Bethan R Mead, Paul Lattimore, Peter Malinowski
Evidence regarding the effectiveness of mindfulness based interventions (MBIs) for eating disorders, weight management and food craving is emerging and further studies are required to understand the underlying mechanisms of MBIs in these domains. The current study was designed to establish the role of specific mechanisms underlying the putative relationship between mindfulness and reward motivated eating. We predicted that mindfulness would be negatively related to features of reward motivated eating and that this association would be mediated by emotion regulation and habitual negative self-thinking...
July 21, 2017: Appetite
https://www.readbyqxmd.com/read/28739098/effects-of-bariatric-surgery-on-energy-homeostasis
#20
REVIEW
Wei Li, Denis Richard
Bariatric surgery represents the most efficient therapy for severe obesity. It reduces the size of fat stores or the amount of body fat gain. The bariatric surgery procedures currently used include Roux-en-Y gastric bypass and sleeve gastrectomy, which are the most commonly performed procedures. Other procedures are laparoscopic adjustable gastric banding and biliopancreatic diversion. The latter represents the most effective surgery for treatment of severe obesity as well as type 2 diabetes. Bariatric surgery reduces energy intake by restricting the size of the stomach reservoir and causing malabsorption, as in the case of biliopancreatic diversion...
August 2017: Canadian Journal of Diabetes
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