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Rheumatoid arthrits

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https://www.readbyqxmd.com/read/30306802/transdermal-delivery-system-of-nanostructured-lipid-carriers-loaded-with-celastrol-and-indomethacin-optimization-characterization-and-efficacy-evaluation-for-rheumatoid-arthritis
#1
Qian Kang, Jia Liu, Ying Zhao, Xin Liu, Xin-Yan Liu, Yong-Jie Wang, Nuo-Lan Mo, Qing Wu
Co-encapsulation of drugs provides a convenient means for treating different symptoms of a disease. Celastrol (Cel) shows potent anti-arthritic activity and Indomethacin (Indo) is effective in relieving inflammatory pain. Nanostructured lipid carriers loaded with Celastrol and Indomethacin (Cel-Indo-NLCs) were prepared by emulsification evaporation-solidification method, optimized by the Box-Behnken design and characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) and powder X-ray diffraction analysis (PXRD)...
October 11, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/30279685/low-dose-radiotherapy-ameliorates-advanced-arthritis-in-htnf-%C3%AE-tg-mice-by-particularly-positively-impacting-on-bone-metabolism
#2
Lisa Deloch, Anja Derer, Axel J Hueber, Martin Herrmann, Georg Andreas Schett, Jens Wölfelschneider, Jonas Hahn, Paul-Friedrich Rühle, Willi Stillkrieg, Jana Fuchs, Rainer Fietkau, Benjamin Frey, Udo S Gaipl
Inflammation and bone erosion are central in rheumatoid arthritis (RA). Even though effective medications for control and treatment of RA are available, remission is only seen in a subset of patients. Treatment with low-dose radiotherapy (LD-RT) which has been already successfully used for amelioration of symptoms in benign diseases should be a promising approach to reduce pain, inflammation, and particularly bone erosion in patients with RA. Even though anti-inflammatory effects of LD-RT are already described with non-linear dose response relationships, and pain-reducing effects have been clinically observed, the underlying mechanisms are widely unknown...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30268354/gant61-alleviates-arthritic-symptoms-by-targeting-fibroblast-like-synoviocytes-in-cia-rats
#3
Suping Qin, Dexu Sun, Xiangyang Li, Fanyun Kong, Qian Yu, Hui Hua, Kuiyang Zheng, Renxian Tang
BACKGROUND: Studies have identified that the fibroblast-like synoviocytes (FLS) exhibited tumor-like characteristics and was the key factor in the pathogenesis of Rheumatoid arthritis (RA). GANT61, an antagonist of the sonic hedgehog pathway, has been verified with inhibitory effect on many cancers. Here we investigated the effect of GANT61 on FLS and the development of collagen-induced arthritis (CIA). METHODS: 40 Sprague Dawley (SD) rats were randomly divided into four groups: normal, CIA, CIA+10 mg/kg GANT61 and CIA+20 mg/kg GANT61...
September 26, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/30266548/acetabular-chondral-lesions-associated-with-femoroacetabular-impingement-treated-by-autologous-matrix-induced-chondrogenesis-or-microfracture-a-comparative-study-at-eight-year-follow-up
#4
Laura de Girolamo, Eugenio Jannelli, Alberto Fioruzzi, Andrea Fontana
PURPOSE: The aim of this retrospective study was to investigate, at 8 years, the clinical follow-up and failure rate (revision rate/conversion to arthroplasty) of patients with hip chondral lesions associated with femoroacetabular impingement and to compare over time the treatment by microfracture (MFx) and autologous matrix-induced chondrogenesis (AMIC). METHODS: Patients aged between 18 and 55 years, with acetabular grade III and IV chondral lesions (Outerbridge), measuring 2 to 8 cm2 operated on at least 8 years before enrollment...
September 25, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/30259817/tmj-arthritis-imaging-conventional-radiograph-vs-ct-scan-is-ct-actually-needed
#5
Richa Modgil, Karandeep Singh Arora, Abhishek Sharma, Lalit Singh Negi, Shreeyam Mohapatra, Shubhangi Pareek
PURPOSE: The present study was conducted to evaluate the efficacy of conventional TMJ imaging in depicting osseous changes in mandibular condyle and glenoid fossa in patients with Rheumatoid arthritis and osteoarthritis by comparing the finding against CT and with an objective that if conventional TMJ imaging modality can appreciate the osseous changes in RA and OA then what is the need for CT scan. This further reducing the patient's radiation dose. MATERIALS AND METHOD: A total of 70 patients (40 Rheumatoid Arthritis; 30 Osteoarthritis) were taken in the study aged between 40 - 60 years and divided in to age groups...
September 26, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/30249062/inhibitory-effect-of-methotrexate-on-rheumatoid-arthritis-inflammation-and-comprehensive-metabolomics-analysis-using-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-uplc-q-tof-ms
#6
Zhiqiang Pang, Guoqiang Wang, Nan Ran, Hongqiang Lin, Ziyan Wang, Xuewa Guan, Yuze Yuan, Keyong Fang, Jinping Liu, Fang Wang
Rheumatoid arthritis (RA) is a common autoimmune disease. The inflammation in joint tissue and system endanger the human health seriously. Methotrexate have exhibited a satisfactory therapeutic effect in clinical practice. The aim of this research was to establish the pharmacological mechanism of methotrexate on RA therapy. Collagen induced arthritic rats were used to identify how methotrexate alleviates inflammation in vivo. Lipopolysaccharide-induced inflammatory proliferation in macrophages was also be detected in vitro...
September 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30244452/histological-analysis-of-arthritic-joints
#7
Takeshi Kiyoi
Histological analysis is a morphological technique and an effective method for understanding the pathology of rheumatoid arthritis (RA). Here, we describe the processes of paraffin samples, including fixation, decalcifying, embedding, sectioning, and staining (hematoxylin and eosin, tartrate-resistant acid phosphatase, and immunohistochemistry) for an RA model mouse.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30226571/3-5-di-c-%C3%AE-d-glucopyranosyl-phloroacetophenone-a-major-component-of-melicope-ptelefolia-suppresses-fibroblast-activation-and-alleviates-arthritis-in-a-mouse-model-potential-therapeutics-for-rheumatoid-arthritis
#8
Hyun Jong Kim, Ji Hyun Choi, Jung-Hwan Hwang, Kyong-Shim Kim, Jung-Ran Noh, Dong-Hee Choi, Sung Je Moon, Hyun-Yong Kim, Sang-Woo Kim, Sangho Choi, Sang Mi Eum, Tran The Bach, Jaerang Rho, Ju Yong Lee, Jung Geun Park, Sei-Ryang Oh, Chul-Ho Lee, Won Keun Oh, Yong-Hoon Kim
Melicope ptelefolia has been traditionally used to treat rheumatism and fever. The present study aimed to investigate the therapeutic effect of 3,5‑di‑C‑β‑D‑glucopyranosyl phloroacetophenone (βGP), a main component of M. ptelefolia, on rheumatoid arthritis (RA). A model of collagen‑induced arthritis (CIA) was established in mice using the RAW 264.7 murine macrophage cell line and mouse embryonic fibroblasts (MEFs). The clinical scores of arthritis, swelling, histopathological findings, and micro‑computed tomography in CIA mouse paws were assessed...
November 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30224931/investigation-of-lake-h%C3%A3-v%C3%A3-z-mineral-water-balneotherapy-and-h%C3%A3-v%C3%A3-z-mud-treatment-in-murine-osteoarthritis-and-rheumatoid-arthritis-models
#9
V Tékus, É Borbély, T Kiss, A Perkecz, Á Kemény, J Horváth, A Kvarda, E Pintér
Arthritic diseases are the most frequent causes of chronic pain and disability. Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and progressive structural joint damage. Osteoarthritis is a degenerative process of the articular cartilage associated with hypertrophic changes in the bone. The aim of the present study was to investigate the anti-inflammatory and analgesic effects of Hévíz thermal water and mud in monosodium iodoacetate- (MIA-) (25 mg/ml, 20 μ l i.a.) induced osteoarthritis and Complete Freund's adjuvant- (CFA-) (1 mg/ml, 50-50  μ l s...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30224512/therapeutic-potential-of-mesenchymal-cell-derived-mirna-150-5p-expressing-exosomes-in-rheumatoid-arthritis-mediated-by-the-modulation-of-mmp14-and-vegf
#10
Zhe Chen, Hanqi Wang, Yang Xia, Fuhua Yan, Yong Lu
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial tissue inflammation and joint destruction associated with the activation of angiogenesis. Exosomes, which play a role in cell-to-cell communication as carriers of genetic information, transfer microRNAs (miRNAs or miRs) between cells and have been studied as delivery vehicles for therapeutic molecules. The aim of the current study was to investigate the therapeutic effect of mesenchymal stem cell (MSC)-derived miR-150-5p exosomes on joint destruction in RA...
October 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30219231/necrostatin-1-ameliorates-adjuvant-arthritis-rat-articular-chondrocyte-injury-via-inhibiting-asic1a-mediated-necroptosis
#11
Yong Chen, Chuan-Jun Zhu, Fei Zhu, Bei-Bei Dai, Su-Jing Song, Zhi-Qiang Wang, Yu-Bin Feng, Jin-Fang Ge, Ren-Peng Zhou, Fei-Hu Chen
Necroptosis, a necrotic cell death pathway regulated by receptor interacting protein (RIP) 1 and 3, plays a key role in pathophysiological processes, including rheumatoid arthritis (RA). However, whether necroptosis is involved in RA articular cartilage damage processes remain unclear. The aim of present study was to investigate the dynamic changes in arthritic chondrocyte necroptosis and the effect of RIP1 inhibitor necrostatin-1 (Nec-1) and acid-sensing ion channels (ASICs) inhibitor amiloride on arthritic cartilage injury and acid-induced chondrocyte necroptosis...
October 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30210649/anti-inflammatory-and-antioxidant-actions-of-methyl-jasmonate-are-associated-with-metabolic-modifications-in-the-liver-of-arthritic-rats
#12
Anacharis B Sá-Nakanishi, Jamil Soni-Neto, Lucas S Moreira, Geferson A Gonçalves, Francielli M S Silva, Lívia Bracht, Ciomar A Bersani-Amado, Rosane M Peralta, Adelar Bracht, Jurandir F Comar
Methyl jasmonate (MeJA) is a fatty acid-derived cyclopentanone which shares structural similarities with prostaglandins and has been under study as a promising anti-inflammatory agent. This study investigated the actions of MeJA on systemic inflammation and oxidative status in rats with adjuvant-induced arthritis, a model for rheumatoid arthritis. MeJA (75 to 300 mg·kg-1 ) was administrated orally during 18 days after arthritis induction with Freund's adjuvant. Articular and systemic inflammation was greatly increased in arthritic rats, likewise the oxidative stress in plasma and liver...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30191389/-rheumatoid-arthritis-mimics-when-appearances-are-deceptive
#13
REVIEW
H Bastian, K Ziegeler, K G A Hermann, E Feist
Rheumatology represents a discipline full of differential diagnoses. Even for classical diseases, such as rheumatoid arthritis as the most frequent chronic inflammatory joint disease and described so clearly in many textbooks, it is not uncommon that it can be a diagnostic challenge in daily practice. This applies to arthritic joint involvement and also to frequently associated extra-articular manifestations. The patient history and results of the clinical examination are essential; however, laboratory and imaging findings often make a significant contribution to confirming the diagnosis, especially in early phases of the disease...
September 6, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/30191329/modeling-sex-differences-in-anti-inflammatory-effects-of-dexamethasone-in-arthritic-rats
#14
Dawei Song, Debra C DuBois, Richard R Almon, William J Jusko
PURPOSE: Collagen-induced arthritic (CIA) rats are used commonly for preclinical pharmacologic research into rheumatoid arthritis (RA). Dexamethasone (DEX), a potent corticosteroid (CS), remains an important component in combination therapy for RA. Although sex differences in RA and CS pharmacokinetics/pharmacodynamics (PK/PD) have been documented in humans, there has been no such comprehensive evaluation of sex differences in CIA rats. METHODS: Paw size measurements were obtained for males and females from four groups of animals: healthy controls, non-drug treated arthritic animals, and both 0...
September 6, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/30187188/co-delivery-of-teriflunomide-and-methotrexate-from-hydroxyapatite-nanoparticles-for-the-treatment-of-rheumatoid-arthritis-in-vitro-characterization-pharmacodynamic-and-biochemical-investigations
#15
Shweta Pandey, Vijay Kumar, Ankita Leekha, Nishant Rai, Farhan Jalees Ahmad, Anita Kamra Verma, Sushama Talegaonkar
PURPOSE: The present investigation was aimed at developing Teriflunomide (TEF) and Methotrexate (MTX) loaded hydroxyapatite nanoparticles and increasing tolerability towards combination therapy against rheumatoid arthritis by reducing hepatotoxicity. METHODS: Drug-loaded HAp-NPs were synthesized by wet-chemical precipitation method and optimized by Box-Behnken experimental design. The developed NPs were subjected to in vitro and in vivo characterization. In-vivo pharmacodynamics and biochemical studies were performed on adjuvant- induced arthritis model treated with different formulations; MTX-TEF-SOL, TEF-HAp-NP, MTX-HAp-NP, TEF-MTX-HAp-NP, FOLITRAX-10 and AUBAGIO...
September 5, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/30152858/3-sialyllactose-as-an-inhibitor-of-p65-phosphorylation-ameliorates-the-progression-of-experimental-rheumatoid-arthritis
#16
Li-Jung Kang, Eun-Soo Kwon, Kwang Min Lee, Chanmi Cho, Jae-In Lee, Young Bae Ryu, Tae Hyun Youm, Jimin Jeon, Mi Ra Cho, Seon-Yong Jeong, Sang-Rae Lee, Wook Kim, Siyoung Yang
BACKGROUND AND PURPOSE: 3'-Sialyllactose (3'-SL) is a safe compound that is present in high levels in human milk. Although it has anti-inflammatory properties and supports immune homeostasis, its effect on collagen-induced arthritis (CIA) is unknown. In this study, we investigated the prophylactic and therapeutic effect of 3'-SL on the progression of RA in in vitro and in vivo models. EXPERIMENTAL APPROACH: The anti-arthritic effect of 3'-SL was analysed with an in vitro cell based system and in vivo mouse model of CIA...
August 28, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/30149545/natural-products-for-the-treatment-of-autoimmune-arthritis-their-mechanisms-of-action-targeted-delivery-and-interplay-with-the-host-microbiome
#17
REVIEW
Steven Dudics, David Langan, Rakeshchandra R Meka, Shivaprasad H Venkatesha, Brian M Berman, Chun-Tao Che, Kamal D Moudgil
Rheumatoid arthritis (RA) is a chronic, debilitating illness characterized by painful swelling of the joints, inflammation of the synovial lining of the joints, and damage to cartilage and bone. Several anti-inflammatory and disease-modifying drugs are available for RA therapy. However, the prolonged use of these drugs is associated with severe side effects. Furthermore, these drugs are effective only in a proportion of RA patients. Hence, there is a need to search for new therapeutic agents that are effective yet safe...
August 24, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30141517/the-expanded-risk-score-in-rheumatoid-arthritis-ers-ra-performance-of-a-disease-specific-calculator-in-comparison-with-the-traditional-prediction-scores-in-the-assessment-of-the-10-year-risk-of-cardiovascular-disease-in-patients-with-rheumatoid-arthrit
#18
Fausto Salaffi, Marina Carotti, Marco Di Carlo, Marika Tardella, Valentina Lato, Andrea Becciolini, Ennio Giulio Favalli, Andrea Giovagnoni
AIMS OF THE STUDY: To assess the performance of the Expanded Risk Score in Rheumatoid Arthritis (ERS-RA), a disease-specific cardiovascular disease (CVD) prediction score, in evaluating the 10-year risk, in comparison with other traditional algorithms in patients with rheumatoid arthritis (RA). METHODS: Consecutive RA patients, aged 40-75 years, without established CVD, were included. We calculated the disease-specific ERS-RA and four traditional CVD prediction scores: the modified Systematic Coronary Risk Evaluation (mSCORE), the Framingham Risk Score using body mass index (FRS BMI), the calculator developed by the American College of Cardiology / American Heart Association in 2013 (ACC/AHA 2013) and the QRISK3...
August 13, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/30132972/%C3%AE-caryophyllene-the-major-constituent-of-copaiba-oil-reduces-systemic-inflammation-and-oxidative-stress-in-arthritic-rats
#19
Ana P Ames-Sibin, Camila L Barizão, Cristiane V Castro-Ghizoni, Francielli M S Silva, Anacharis B Sá-Nakanishi, Lívia Bracht, Ciomar A Bersani-Amado, Maria R Marçal-Natali, Adelar Bracht, Jurandir F Comar
The current study investigated the action of β-caryophyllene, the major constituent of copaiba oil, on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis, a model for rheumatoid arthritis. This study also compared the actions of β-caryophyllene with those previously reported for copaiba oil on arthritic rats. For this purpose, Holtzman healthy and arthritic rats received 215 and 430 mg·kg-1 β-caryophyllene orally once a day during 18 days. Both doses of β-caryophyllene reduced the adjuvant-induced paw edema, swollen of lymph nodes, and number of circulating and articular leukocytes...
August 21, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30114517/therapeutic-effects-of-caesalpinia-minax-hance-on-complete-freund-s-adjuvant-cfa-induced-arthritis-and-the-anti-inflammatory-activity-of-cassane-diterpenes-as-main-active-components
#20
Ziwei Tong, Li Cheng, Jizhou Song, Miao Wang, Jiuzhi Yuan, Xianzhe Li, Huiyuan Gao, Zhaohua Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Seeds of Caesalpinia minax Hance called 'Ku-Shi-Lian' (KSL) in China have been used as Zhuang or Dai folk medicines for treatment of common cold, fever, rheumatoid arthritis and dysentery for hundred years. AIM OF THE STUDY: This study aimed to investigate therapeutic efficacy of KSL extract using complete Freund's adjuvant (CFA) induced arthritis in a rat model and the anti-inflammatory activity of cassane diterpenes as the main active material basis of this herb...
November 15, 2018: Journal of Ethnopharmacology
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