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Rheumatoid arthrits

Benjamin J Buckley, Michael J Kelso, Umar Ali, Marie Ranson
Rheumatoid arthritis (RA) is a chronic and progressive inflammatory disease characterized in its early stages by synovial hyperplasia and inflammatory cell infiltration and later by irreversible joint tissue destruction. The plasminogen activation system (PAS) is associated with a wide range of physiological and pathophysiological states involving fibrinolysis, inflammation and tissue remodeling. Various components of the PAS are implicated in the pathophysiology of RA. Urokinase plasminogen activator (uPA) in particular is a pro-inflammatory mediator that appears to play an important role in the bone and cartilage destruction associated with RA...
December 4, 2018: Current Drug Targets
Eman A Abd El-Ghffar, Omayma A Eldahshan, Alaa Barakat, Thomas Efferth
Rheumatoid arthritis (RA) is the most common human autoimmune disease. A petroleum ether extract of Eugenia aquea (E. aquea) was analyzed by GC/MS. Antioxidant and anti-inflammatory activities were investigated in rats with adjuvant-induced arthritis (AIA). An AIA rat model received orally/daily a vehicle, diclofenac (100 mg per kg b.w.), and E. aquea extract (50 or 100 or 200 mg per kg b.w.; for 21 days). Fifty-five out of 70 compounds (97.77%) were identified: eucalyptol (34.14%), α-pinene (15.91%), l-verbenone (8...
December 4, 2018: Food & Function
Ádám Horváth, Éva Borbély, Kata Bölcskei, Nikolett Szentes, Tamás Kiss, Mátyás Belák, Tibor Rauch, Tibor Glant, Róza Zákány, Tamás Juhász, Edina Karanyicz, Ferenc Boldizsár, Zsuzsanna Helyes, Bálint Botz
OBJECTIVE: The regulatory role of capsaicin-sensitive peptidergic sensory nerves has been shown in acute inflammation, but little is known about their involvement in T/B-cell driven autoimmune arthritis. This study integratively characterized the function of these nerve endings in the proteoglycan-induced chronic arthritis (PGIA), a translational model of rheumatoid arthritis. METHODS: Peptidergic afferents were defunctionalized by resiniferatoxin (RTX) pretreatment in BALB/c mice, PGIA was induced by repeated antigen challenges...
December 3, 2018: Journal of Neuroinflammation
Manjusri Das, Dipranjan Laha, Suman Kanji, Matthew Joseph, Reeva Aggarwal, Obiajulu H Iwenofu, Vincent J Pompili, Mukesh K Jain, Hiranmoy Das
Krüppel-like factor 2 (KLF2) critically regulates activation and function of monocyte, which plays important pathogenic role in progressive joint destruction in rheumatoid arthritis (RA). It is yet to be established the molecular basis of KLF2-mediated regulation of monocytes in RA pathogenesis. Herein, we show that a class of compound, HDAC inhibitors (HDACi) induced KLF2 expression in monocytes both in vitro and in vivo. KLF2 level was also elevated in tissues, such as bone marrow, spleen and thymus in mice after infusion of HDACi...
December 3, 2018: Journal of Cellular and Molecular Medicine
Kosuke Yamaguchi, Haruka Sudo, Kazushi Imai
An increase in the vasculature is one of most representative changes in the synovial tissue of joints in rheumatoid arthritis (RA) and is closely associated with disease progression. Although the vasculatures are believed to be a result of VE-cadherin-dependent angiogenesis and a possible therapeutic target of the disease, synovial fibroblastic cells express VE-cadherin and form tube-like structures, suggesting that vasculatures in RA synovium may not simply result from angiogenesis. This paper analyzes a mechanism of VE-cadherin expression by rheumatoid arthritic synovial fibroblast-like cells (RSFLs) and their involvement in the tube-like formation...
November 28, 2018: Biochemical and Biophysical Research Communications
Oliver Frey, Marion Hückel, Mieczyslaw Gajda, Peter K Petrow, Rolf Bräuer
BACKGROUND: Fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA) are autonomously activated to maintain inflammation and joint destruction in co-transplantation models. To elucidate inducing mechanisms involved in this altered behavior, the arthritogenic potential of FLSs from murine antigen-induced arthritis (AIA) were investigated in a transfer model. METHODS: FLSs were isolated, expanded in vitro, and transferred into knee joint cavities of severe combined immunodeficient (SCID) mice...
November 22, 2018: Arthritis Research & Therapy
Sarah A Woller, Cody Ocheltree, Stephanie Y Wong, Anthony Bui, Yuya Fujita, Gilson Gonçalves Dos Santos, Tony L Yaksh, Maripat Corr
In rheumatoid arthritis, joint pain can persist despite resolution of swelling. Similarly, in the murine K/BxN serum transfer model, a persistent tactile allodynia is observed after the resolution of joint inflammation (post-inflammatory pain) in male mice. Here, we found female wild type (WT) mice show inflammatory, but reduced post-inflammatory tactile allodynia. The transition to the post-inflammatory phenotype is dependent on TLR4 signaling. At the spinal level, we found differences in TNF and IFNβ mRNA expression in WT and TLR4 deficient males...
November 19, 2018: Brain, Behavior, and Immunity
Umme Habiba Hasan, Alamgeer, Muhammad Shahzad, Shah Jahan, Zahid Rasul Niazi, Ishfaq Ali Bukhari, Asaad Mohamed Assiri, Hamayun Riaz
Clematis orientalis Linn has long been used as ethnopharmacy for the treatment of arthritis. This study is intended to evaluate the curative efficacy of Clematis orientalis in treating polyarthritis in rats. Aqueous ethanolic extract and fractions (hexane, butanol and aqueous) were administered orally at 200 mg/kg for 28 days after CFA immunization. Paw swelling, paw diameter, arthritic score, body weight, hematological parameters, radiographic and histological analysis of ankle joints were evaluated. Moreover, levels of various inflammatory markers through RT-PCR and ELISA were measured...
November 16, 2018: Inflammopharmacology
Mahmood Ahmad Khan, Rafat Sultana Ahmed, Nilesh Chandra, Vinod Kumar Arora, Athar Ali
Rheumatoid arthritis (RA) is a devastating disease characterized by continual addition of leukocytes and T cells within the articular cavity causing inflammation. Withania somnifera is reported to have antioxidant, anti-inflammatory, immunomodulatory properties. The purpose of this study was to evaluate anti-inflammatory activity of aqueous extract of Withania somnifera roots (WSAq) in collagen induced arthritic (CIA) rats. To achieve this, we assess the level of inflammatory cytokines such as tumor necrosis factor (TNF)-α, IL-1β, IL-6 and IL-10 in CIA rats...
November 15, 2018: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
Xinming Wang, Xiaoyun Chen, Wei Huang, Pengying Zhang, Yawei Guo, Heinrich Körner, Huaxun Wu, Wei Wei
The angiotensin II type 1 receptor (AT1R) antagonist losartan has been confirmed to have a moderate anti-inflammatory effect in vitro and in vivo. However, how it affects immune cells in Rheumatoid Arthritis (RA) is still unknown. We found that in human synovial tissues, AT1R is significantly expressed on T cells and B cells. Treatment with losartan (15 mg/kg) alone and in combination with a low dose of methotrexate (MTX 0.25 mg/kg/3 days) significantly suppressed the progression of CIA. Secondary paw swelling, joint destruction and the presence of pro-inflammatory cytokines (TNF-α and IFN-γ) in the serum were alleviated after treatment...
November 13, 2018: Inflammopharmacology
Silvana Pérez, María Santa Cruz, Julia Sosa, Paula Kohan, María Medina, Diana Klajn, Silvia Papasidero, José Caracciolo, Gisela Pendón, Federico Giordano, Dora Pereira, Damaris Alvarez, Valeria Astudillo, Eduardo Kerzberg, Adriana Perez Dávila, Analía Bohr, Fernando Melo, Nicolás Lloves, Marta Mamani, Claudia Hartvig, Gabriela Sanchez, Mónica Sacnum, Yamila Chichotky, José Velazco Zamora, Mariana Benegas, Javier Rosa, María García, Laura Raiti, Vanesa Cruzat, Rosana Quintana, Bernardo Pons-Estel, Karin Kirmayr, Andrea D'Orazio, Cinthya Retamozo, Olga Romano, Rodolfo Perez Alamino, María Correa, Gustavo Citera, Oscar Rillo, María Zalazar, Ana Costi, Mercedes García, Graciela Gomez, Hernán Maldonado Ficco
BACKGROUND: The SpENAT, a Spanish version of the Educational Needs Assessment Tool, is a self-completed questionnaire that assesses educational needs (ENs) with the purpose of providing tailored and patient-centered information. It consists of 39 questions grouped into the 7 following domains: Pain management, Movement, Feelings, Arthritic process, Treatments, Self-help measures and Support system. OBJECTIVES: The objective of the study was to describe the ENs of rheumatoid arthritis (RA) patients using the SpENAT and to determine the main sources of information consulted by these patients...
October 29, 2018: Reumatología Clinica
Elvira Lazić Mosler, Nina Lukač, Darja Flegar, Martina Fadljević, Igor Radanović, Hrvoje Cvija, Tomislav Kelava, Sanja Ivčević, Alan Šućur, Antonio Markotić, Vedran Katavić, Ana Marušić, Danka Grčević, Nataša Kovačić
Rheumatoid arthritis (RA) is inflammatory joint disease that eventually leads to permanent bone and cartilage destruction. Fas has already been established as the regulator of inflammation in RA, but its role in bone formation under arthritic conditions is not completely defined. The aim of this study was to assess the effect of Fas inactivation on the bone damage during murine antigen-induced arthritis. Subchondral bone of wild-type (WT) and Fas-knockout (Fas-/- ) mice was evaluated by histomorphometry and microcomputerized tomography...
November 1, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Danielle Fokam, Christian Lehmann
Background Infrared thermography (IRT) provides accurate measurements of surface temperatures. In inflammatory conditions such as arthritis, tissue temperature is elevated, which can be measured on the periarticular skin surface by IRT. The aim of this review is to evaluate the evidence for the relationship between skin temperature (measured by IRT) and arthritic knee pain and discuss the limitations of IRT in clinical settings of arthritis. Method To reach this goal, a mini-review of all the relevant papers indexed in PubMed was conducted...
October 31, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Éva Borbély, Tamás Kiss, Krisztina Szabadfi, Erika Pintér, János Szolcsányi, Zsuzsanna Helyes, Bálint Botz
Capsaicin-sensitive afferents have complex regulatory functions in the joints orchestrated via neuropeptides. This study aimed to determine their role in the collagen-antibody induced rheumatoid arthritis model. Capsaicin-sensitive nerves were defunctionalized by the capsaicin receptor agonist resiniferatoxin in C57Bl/6 mice. Arthritis was induced by the ArithroMab antibody cocktail and adjuvant. Arthritis was monitored by measuring body weight, joint edema by plethysmometry, arthritis severity by clinical scoring, mechanonociceptive threshold by plantar esthesiometry, thermonociceptive threshold by hot plate, cold tolerance by paw withdrawal latency from 0 °C water...
October 29, 2018: Scientific Reports
Varsha S Honmore, Amit D Kandhare, Parag P Kadam, Vijay M Khedkar, Arun D Natu, Supada R Rojatkar, Subhash L Bodhankar
ETHNOPHARMACOLOGICAL RELEVANCE: Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease that affects the worldwide population. Alpinia officinarum Hance (Zingiberaceae), rhizomes are widely used ethnobotanically as an anti-inflammatory, analgesic, and antioxidant agent in traditional medicine. AIM: To investigate the efficacy and possible mechanism of isolated phytoconstituent from the methanol extract of A. officinarum (MEAO) rhizomes against Freund's complete adjuvant (FCA)-induced arthritis in rats...
October 15, 2018: Journal of Ethnopharmacology
Qian Kang, Jia Liu, Ying Zhao, Xin Liu, Xin-Yan Liu, Yong-Jie Wang, Nuo-Lan Mo, Qing Wu
Co-encapsulation of drugs provides a convenient means for treating different symptoms of a disease. Celastrol (Cel) shows potent anti-arthritic activity and Indomethacin (Indo) is effective in relieving inflammatory pain. Nanostructured lipid carriers loaded with Celastrol and Indomethacin (Cel-Indo-NLCs) were prepared by emulsification evaporation-solidification method, optimized by the Box-Behnken design and characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) and powder X-ray diffraction analysis (PXRD)...
October 11, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Lisa Deloch, Anja Derer, Axel J Hueber, Martin Herrmann, Georg Andreas Schett, Jens Wölfelschneider, Jonas Hahn, Paul-Friedrich Rühle, Willi Stillkrieg, Jana Fuchs, Rainer Fietkau, Benjamin Frey, Udo S Gaipl
Inflammation and bone erosion are central in rheumatoid arthritis (RA). Even though effective medications for control and treatment of RA are available, remission is only seen in a subset of patients. Treatment with low-dose radiotherapy (LD-RT) which has been already successfully used for amelioration of symptoms in benign diseases should be a promising approach to reduce pain, inflammation, and particularly bone erosion in patients with RA. Even though anti-inflammatory effects of LD-RT are already described with non-linear dose response relationships, and pain-reducing effects have been clinically observed, the underlying mechanisms are widely unknown...
2018: Frontiers in Immunology
Suping Qin, Dexu Sun, Xiangyang Li, Fanyun Kong, Qian Yu, Hui Hua, Kuiyang Zheng, Renxian Tang
BACKGROUND: Studies have identified that the fibroblast-like synoviocytes (FLS) exhibited tumor-like characteristics and was the key factor in the pathogenesis of Rheumatoid arthritis (RA). GANT61, an antagonist of the sonic hedgehog pathway, has been verified with inhibitory effect on many cancers. Here we investigated the effect of GANT61 on FLS and the development of collagen-induced arthritis (CIA). METHODS: 40 Sprague Dawley (SD) rats were randomly divided into four groups: normal, CIA, CIA+10 mg/kg GANT61 and CIA+20 mg/kg GANT61...
September 26, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Laura de Girolamo, Eugenio Jannelli, Alberto Fioruzzi, Andrea Fontana
PURPOSE: The aim of this retrospective study was to investigate, at 8 years, the clinical follow-up and failure rate (revision rate/conversion to arthroplasty) of patients with hip chondral lesions associated with femoroacetabular impingement and to compare over time the treatment by microfracture (MFx) and autologous matrix-induced chondrogenesis (AMIC). METHODS: Patients aged between 18 and 55 years, with acetabular grade III and IV chondral lesions (Outerbridge), measuring 2 to 8 cm2 operated on at least 8 years before enrollment...
September 25, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Richa Modgil, Karandeep Singh Arora, Abhishek Sharma, Lalit Singh Negi, Shreeyam Mohapatra, Shubhangi Pareek
PURPOSE: The present study was conducted to evaluate the efficacy of conventional TMJ imaging in depicting osseous changes in mandibular condyle and glenoid fossa in patients with Rheumatoid arthritis and osteoarthritis by comparing the finding against CT and with an objective that if conventional TMJ imaging modality can appreciate the osseous changes in RA and OA then what is the need for CT scan. This further reducing the patient's radiation dose. MATERIALS AND METHOD: A total of 70 patients (40 Rheumatoid Arthritis; 30 Osteoarthritis) were taken in the study aged between 40 - 60 years and divided in to age groups...
September 26, 2018: Current Rheumatology Reviews
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