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https://www.readbyqxmd.com/read/28923177/androgens-and-cardiovascular-disease-in-women-and-men
#1
REVIEW
Eleni Armeni, Irene Lambrinoudaki
Cardiovascular disease is the leading cause of death in both women and men. Its pathogenesis is multifactorial, with sex hormones playing an important role. Androgens have both direct and indirect effects on the vasculature. This review summarizes evidence on the association of both endogenous and exogenous androgens with subclinical and overt cardiovascular disease in women and men. Concerning women, both high and low levels of endogenous androgens have been associated with cardiovascular disease, while other studies have reported no association...
October 2017: Maturitas
https://www.readbyqxmd.com/read/28919579/mri-and-prediction-of-pathologic-complete-response-in-the-breast-and-axilla-after-neoadjuvant-chemotherapy-for-breast-cancer-mri-and-pathologic-complete-response
#2
Joseph J Weber, Maxine S Jochelson, Anne Eaton, Emily C Zabor, Andrea V Barrio, Mary L Gemignani, Melissa Pilewskie, Kimberly J Van Zee, Monica Morrow, Mahmoud El-Tamer
BACKGROUND: In the setting where determining extent of residual disease is key for surgical planning after neoadjuvant chemotherapy (NAC), herein we evaluate reliability of MRI in predicting pathologic complete response (pCR) of the breast primary and axillary nodes following NAC. STUDY DESIGN: Patients who had MRI before and after NAC between 06/2014-08/2015 were identified in a prospective database following IRB approval. Post NAC-MRI of the breast and axillary nodes was correlated with residual disease on final pathology...
September 14, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28912106/vascular-activation-of-k-channels-and-na-k-atpase-activity-of-estrogen-deficient-female-rats
#3
Rogério Faustino Ribeiro, Jonaina Fiorim, Vinicius Bermond Marques, Karoline de Sousa Ronconi, Tatiani Botelho, Marcella D Grando, Lusiane M Bendhack, Dalton Valentim Vassallo, Ivanita Stefanon
The goal of the present study was to evaluate vascular potassium channels and Na(+)-K(+)-ATPase activity in estrogen deficient female rats. Female rats that underwent ovariectomy were assigned to receive daily treatment with placebo (OVX) or estrogen replacement (OVX+E2, 1mg/kg, once a week, i.m.). Aortic rings were used to examine the involvement of K(+) channels and Na(+)-K(+)-ATPase in vascular reactivity. Acetylcholine (ACh)-induced relaxation was analyzed in the presence of L-NAME (100μM) and K(+) channels blockers: tetraethylammonium (TEA, 5mM), 4-aminopyridine (4-AP, 5mM), iberiotoxin (IbTX, 30nM), apamin (0...
September 11, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28904736/beer-polyphenols-and-menopause-effects-and-mechanisms-a-review-of-current-knowledge
#4
REVIEW
Berner Andrée Sandoval-Ramírez, Rosa M Lamuela-Raventós, Ramon Estruch, Gemma Sasot, Monica Doménech, Anna Tresserra-Rimbau
Beer is one of the most frequently consumed fermented beverages in the world, and it has been part of the human diet for thousands of years. Scientific evidence obtained from the development of new techniques of food analysis over the last two decades suggests that polyphenol intake derived from moderate beer consumption may play a positive role in different health outcomes including osteoporosis and cardiovascular risk and the relief of vasomotor symptoms, which are commonly experienced during menopause and are an important reason why women seek medical care during this period; here, we review the current knowledge regarding moderate beer consumption and its possible effects on menopausal symptoms...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28884514/estrogenic-regulation-of-skeletal-muscle-proteome-a-study-of-premenopausal-women-and-postmenopausal-mz-cotwins-discordant-for-hormonal-therapy
#5
Eija K Laakkonen, Rabah Soliymani, Sira Karvinen, Jaakko Kaprio, Urho M Kujala, Marc Baumann, Sarianna Sipilä, Vuokko Kovanen, Maciej Lalowski
Female middle age is characterized by a decline in skeletal muscle mass and performance, predisposing women to sarcopenia, functional limitations, and metabolic dysfunction as they age. Menopausal loss of ovarian function leading to low circulating level of 17β-estradiol has been suggested as a contributing factor to aging-related muscle deterioration. However, the underlying molecular mechanisms remain largely unknown and thus far androgens have been considered as a major anabolic hormone for skeletal muscle...
September 7, 2017: Aging Cell
https://www.readbyqxmd.com/read/28883865/does-genetic-testing-for-er%C3%AE-gene-polymorphisms-provide-new-possibilities-of-treatment-for-cognitive-function-disorders-in-postmenopausal-women
#6
Mariusz Gujski, Jarosław Pinkas, Anna Wierzbińska-Stępniak, Alfred Owoc, Iwona Bojar
It is commonly considered that cognitive abilities decrease with age, especially with respect to processing and psychomotor speed. It is an interesting issue whether, apart from the ageing process, the undergoing of menopause itself deteriorates cognitive functions, compared to women at reproductive age. Hopes for improvement of cognitive functions were pinned on the use of menopausal hormone therapy. However, the results of studies concerning the effect of hormone replacement therapy on cognition proved to be contradictory...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28871193/estradiol-regulates-txnip-and-prevents-intermittent-hypoxia-induced-vascular-injury
#7
Xiao Fei Lan, Xiu Juan Zhang, Ying Ni Lin, Qiong Wang, Hua Jun Xu, Li Na Zhou, Pei Li Chen, Qing Yun Li
Chronic intermittent hypoxia (IH) contributes to obstructive sleep apnea (OSA)-related cardiovascular diseases through increasing oxidative stress. It has been widely recognized that estradiol decreases the risk for cardiovascular disease, but the estrogen replacement therapy is limited for its side effects. Thioredoxin (Trx) and its endogenous inhibitor, thioredoxin-interacting protein (Txnip), are associated with the protective effect of estradiol in some conditions. In this study, we aimed to explore whether estradiol could protect against IH-induced vascular injury, and the possible effect of Trx-1/Txnip in this process...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28843780/epidemiology-of-estrogen-and-dementia-in-women-with-down-syndrome
#8
REVIEW
Nicole Schupf, Joseph H Lee, Deborah Pang, Warren B Zigman, Benjamin Tycko, Sharon Krinsky-McHale, Wayne Silverman
Several lines of investigation have shown a protective role for estrogen in Alzheimer's disease through a number of biological actions. This review examines studies of the role of estrogen-related factors in age at onset and risk for Alzheimer's disease in women with Down syndrome, a population at high risk for early onset of dementia. The studies are consistent in showing that early age at menopause and that low levels of endogenous bioavailable estradiol in postmenopausal women with Down syndrome are associated with earlier age at onset and overall risk for dementia...
August 31, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28843271/vitamin-d-proliferates-vaginal-epithelium-through-rhoa-expression-in-postmenopausal-atrophic-vagina-tissue
#9
Arum Lee, Man Ryul Lee, Hae-Hyeog Lee, Yeon-Suk Kim, Jun-Mo Kim, Temuulee Enkhbold, Tae-Hee Kim
Postmenopausal atrophic vagina (PAV) is the thinning of the walls of the vagina and decreased lugae of the vagina. PAV is caused by decreased estrogen levels in postmenopausal women. However, the harmful effects of hormone replacement therapy (HRT) have resulted in considerable caution in its use. Various estrogen agonist treatment options are available. Vitamin D is influences the regulation of differentiation and proliferation of various cells, especially tissues lining stratified squamous epithelium, such as the vaginal epithelium...
August 25, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28836408/effects-of-estradiol-on-histological-parameters-and-secretory-ability-of-pituitary-mammotrophs-in-ovariectomized-female-rats
#10
Natasa Ristic, Vladimir Ajdzanovic, Milica Manojlovic-Stojanoski, Jovana Maliković, Gordana Uscebrka, Zorica Markovic, Verica Milosevic
OBJECTIVES: Estrogen replacement therapy remains current as a therapeutic approach to treat menopausal symptoms and may significantly affect hormone-producing cells in the female pituitaries. The aim of this study was to examine the histological parameters of pituitary mammotrophs and prolactin secretion after chronic estradiol treatment in ovariectomized adult female rats, reflecting premature menopause. MATERIALS AND METHODS: In this experimental study, adult female Wistar rats were divided into non-ovariectomized (C), ovariectomized (OVX) and estradiol-treated ovariectomized (OVX+E) groups...
October 2017: Cell Journal
https://www.readbyqxmd.com/read/28835399/a-case-control-study-of-hormonal-exposures-as-etiologic-factors-for-als-in-women-euro-motor
#11
James P K Rooney, Anne E Visser, Fabrizio D'Ovidio, Roel Vermeulen, Ettore Beghi, Adriano Chio, Jan H Veldink, Giancarlo Logroscino, Leonard H van den Berg, Orla Hardiman
OBJECTIVE: To investigate the role of hormonal risk factors for amyotrophic lateral sclerosis (ALS) among women from 3 European countries. METHODS: ALS cases and matched controls were recruited over 4 years in Ireland, Italy, and the Netherlands. Hormonal exposures, including reproductive history, breastfeeding, contraceptive use, hormonal replacement therapy, and gynecologic surgical history, were recorded with a validated questionnaire. Logistic regression models adjusted for age, education, study site, smoking, alcohol, and physical activity were used to determine the association between female hormones and ALS risk...
August 23, 2017: Neurology
https://www.readbyqxmd.com/read/28827068/endometrium-and-steroids-a-pathologic-overview
#12
REVIEW
Francisca Plaza-Parrochia, Carmen Romero, Luis Valladares, Margarita Vega
Normal endometrial function requires of cell proliferation and differentiation; therefore, disturbances in these processes could lead to pathological entities such as hyperplasia and endometrial adenocarcinoma, where cell proliferation is increased. The development of these pathologies is highly related to alterations in the levels and/or action of sexual steroids. In the present review, it has been analyzed how steroids, particularly estrogens, androgens and progestagens are involved in the etiopathogenesis of hyperplasia and endometrial endometrioid adenocarcinoma...
October 2017: Steroids
https://www.readbyqxmd.com/read/28816930/associations-among-circulating-csf-1-estrogen-and-bone-mineral-density-in-postmenopausal-women-results-from-a-randomized-placebo-controlled-trial
#13
Andrea V Haas, Elaine Cong, Christine A Simpson, Nitin Sukumar, Yanhong Deng, Karl L Insogna
OBJECTIVE: This study addresses the relationship between circulating levels of colony-stimulating factor 1 (CSF-1) and rates of postmenopausal bone loss. The purpose was to test the hypothesis that CSF-1 levels would correlate with the rate of bone loss in estrogen-deficient woman. We further hypothesized that estrogen replacement would eliminate this association. METHODS: This was an ancillary study to the parent Kronos Early Estrogen Prevention Study (KEEPS)-a 4-year randomized placebo-controlled study that evaluated the effects of estrogen therapy on cardiovascular endpoints...
August 14, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28814476/phase-i-trial-of-the-androgen-receptor-modulator-cr1447-in-breast-cancer-patients
#14
Martin Zweifel, Beat Thürlimann, Salome Riniker, Patrik Weder, Roger von Moos, Olivia Pagani, Martin Bigler, Karin M Rothgiesser, Christiane Pilop, Hanne Hawle, Peter Brauchli, Coya Tapia, Wolfgang Schoenfeld, Cristiana Sessa
CR1447 (4-hydroxytestosterone, 4-OHT) binds to the androgen receptor and has antiproliferative activity in both ER-positive and ER-negative/AR-positive breast cancer cells in preclinical studies. The objective of this first-in man trial was to evaluate the safety and to determine the dose of CR1447, administered as an ointment, for Phase II. Escalating doses (100, 200, 400 mg) of CR1447 were administered topically on a daily basis to patients with ER-positive/AR-positive/HER2-negative advanced breast cancer pretreated with several lines of therapy...
October 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28813586/breast-cancer-and-exposure-to-aircraft-road-and-railway-noise-a-case-control-study-based-on-health-insurance-records
#15
Janice Hegewald, Melanie Schubert, Mandy Wagner, Patrik Dröge, Ursel Prote, Enno Swart, Ulrich Möhler, Hajo Zeeb, Andreas Seidler
Objectives Aircraft, road, and rail traffic noise can cause sleep disturbances. Since night work and shorter sleep durations have been linked to increased risks of breast cancer, we examined if 24-hour, or day- or night-time traffic noise exposure may also increase the risk of breast cancer. Methods To investigate the noise-related risks of breast cancer, the pseudonymized insurance records of three large statutory health companies (2005-2010) for women aged ≥40 years living in the region surrounding the Frankfurt international airport were analyzed with address-specific acoustic data representing aircraft, road, and rail-traffic noise...
August 16, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28804245/dna-microarray-analysis-of-estrogen-responsive-genes-in-ishikawa-cells-by-glabridin
#16
Poh Su Wei Melissa, Yong Voon Chen Phelim, Visweswaran Navaratnam, Chia Yoke Yin
Based on a previous study, glabridin displayed a dose-dependent increase in estrogenic activity and cell proliferative activity in Ishikawa cells. However, when treated in combination with 17β-E2, synergistic estrogenic effect was observed but without the same synergistic increase in cell proliferative effect. This study aimed to identify the estrogen and nonestrogen-regulated activities induced by glabridin and in combination with 17β-E2 in comparison with 17β-E2. The results showed that 10 µM glabridin and the combination treatment of 100 nM glabridin with 1 nM 17β-E2 regulated both the genomic and nongenomic estrogen pathways to possibly provide benefits of estrogens in cardiovascular, circulatory, and vasculature systems...
2017: Biochemistry Insights
https://www.readbyqxmd.com/read/28783064/estrogen-estrogen-receptor-and-lung-cancer
#17
REVIEW
Li-Han Hsu, Nei-Min Chu, Shu-Huei Kao
Estrogen has been postulated as a contributor for lung cancer development and progression. We reviewed the current knowledge about the expression and prognostic implications of the estrogen receptors (ER) in lung cancer, the effect and signaling pathway of estrogen on lung cancer, the hormone replacement therapy and lung cancer risk and survival, the mechanistic relationship between the ER and the epidermal growth factor receptor (EGFR), and the relevant clinical trials combining the ER antagonist and the EGFR antagonist, to investigate the role of estrogen in lung cancer...
August 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28777295/soymilk-improves-muscle-weakness-in-young-ovariectomized-female-mice
#18
Yuriko Kitajima, Shizuka Ogawa, Shintaro Egusa, Yusuke Ono
Estrogens play a key role in an extensive range of physiological functions in various types of tissues throughout the body in females. We previously showed that estrogen insufficiency caused muscle weakness that could be rescued by estrogen administration in a young female ovariectomized (OVX) mouse model. However, long-term estrogen replacement therapy increases risks of breast cancer and cardiovascular diseases. Soymilk contains plant-based protein and isoflavones that exert estrogen-like activity. Here we examined the effects of prolonged soymilk intake on muscle and its resident stem cells, called satellite cells, in the estrogen-insufficient model...
August 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28768651/combined-bioavailable-isoflavones-and-probiotics-improve-bone-status-and-estrogen-metabolism-in-postmenopausal-osteopenic-women-a-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Max Norman Tandrup Lambert, Catrine Bundgaard Thybo, Simon Lykkeboe, Lars Melholt Rasmussen, Xavier Frette, Lars Porskjær Christensen, Per Bendix Jeppesen
Background: Female age-related estrogen deficiency increases the risk of osteoporosis, which can be effectively treated with the use of hormone replacement therapy. However, hormone replacement therapy is demonstrated to increase cancer risk. Bioavailable isoflavones with selective estrogen receptor affinity show potential to prevent and treat osteoporosis while minimizing or eliminating carcinogenic side effects.Objective: In this study, we sought to determine the beneficial effects of a bioavailable isoflavone and probiotic treatment against postmenopausal osteopenia...
September 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28765273/cross-sex-testosterone-therapy-in-ovariectomized-mice-addition-of-low-dose-estrogen-preserves-bone-architecture
#20
Laura G Goetz, Ramanaiah Mamillapalli, Maureen J Devlin, Amy E Robbins, Masoumeh Majidi-Zolbin, Hugh S Taylor
Cross-sex hormone therapy (XHT) is widely used by transgender people to alter secondary sex characteristics to match their desired gender presentation. Here we investigate the long-term effects of XHT on bone health, using a murine model. Female mice underwent ovariectomy at either 6 or 10 weeks, and began weekly testosterone or vehicle injections. Dual-energy X-ray Absorptiometry (DXA) was performed to measure bone mineral density (BMD) and microCT was performed to compare femoral cortical and trabecular bone architecture...
August 1, 2017: American Journal of Physiology. Endocrinology and Metabolism
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