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https://www.readbyqxmd.com/read/30092832/high-mammographic-density-in-women-is-associated-with-protumor-inflammation
#1
Cecilia W Huo, Prue Hill, Grace Chew, Paul J Neeson, Heloise Halse, Elizabeth D Williams, Michael A Henderson, Erik W Thompson, Kara L Britt
BACKGROUND: Epidemiological studies have consistently shown that increased mammographic density (MD) is a strong risk factor for breast cancer. We previously observed an elevated number of vimentin+ /CD45+ leukocytes in high MD (HMD) epithelium. In the present study, we aimed to investigate the subtypes of immune cell infiltrates in HMD and low MD (LMD) breast tissue. METHODS: Fifty-four women undergoing prophylactic mastectomy at Peter MacCallum Cancer Centre or St...
August 9, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/30071645/an-augmented-reality-system-using-improved-iterative-closest-point-algorithm-for-on-patient-medical-image-visualization
#2
Ming-Long Wu, Jong-Chih Chien, Chieh-Tsai Wu, Jiann-Der Lee
In many surgery assistance systems, cumbersome equipment or complicated algorithms are often introduced to build the whole system. To build a system without cumbersome equipment or complicated algorithms, and to provide physicians the ability to observe the location of the lesion in the course of surgery, an augmented reality approach using an improved alignment method to image-guided surgery (IGS) is proposed. The system uses RGB-Depth sensor in conjunction with the Point Cloud Library (PCL) to build and establish the patient's head surface information, and, through the use of the improved alignment algorithm proposed in this study, the preoperative medical imaging information obtained can be placed in the same world-coordinates system as the patient's head surface information...
August 1, 2018: Sensors
https://www.readbyqxmd.com/read/30028839/the-same-video-game-in-2d-3d-or-virtual-reality-how-does-technology-impact-game-evaluation-and-brand-placements
#3
Johanna Roettl, Ralf Terlutter
Video game technology is changing from 2D to 3D and virtual reality (VR) graphics. In this research, we analyze how an identical video game that is either played in a 2D, stereoscopic 3D or Head-Mounted-Display (HMD) VR version is experienced by the players, and how brands that are placed in the video game are affected. The game related variables, which are analyzed, are presence, attitude towards the video game and arousal while playing the video game. Brand placement related variables are attitude towards the placed brands and memory (recall and recognition) for the placed brands...
2018: PloS One
https://www.readbyqxmd.com/read/30017525/knockdown-of-herp-alleviates-hyperhomocysteinemia-mediated-atherosclerosis-through-the-inhibition-of-vascular-smooth-muscle-cell-phenotype-switching
#4
Hui Lin, Tingjuan Ni, Jie Zhang, Liping Meng, Feidan Gao, Sunlei Pan, Hangqi Luo, Fukang Xu, Guomei Ru, Jufang Chi, Hangyuan Guo
BACKGROUND: Phenotypic switching of vascular smooth muscle cells (VSMCs) plays a key role in atherosclerosis. We aimed to investigate whether Homocysteine-responsive endoplasmic reticulum protein (Herp) was involved in VSMC phenotypic switching and affected atheroprogression. METHODS: To assess the role of Herp in homocysteine (Hcy)-associated atherosclerosis, Herp-/- and LDLR-/- double knockout mice were generated and fed with a high methionine diet (HMD) to induce Hyperhomocysteinemia (HHcy)...
July 12, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30010403/optimal-pressure-comfort-design-for-pilot-helmets
#5
Ying Xu, Lian Yun Chen, Hai Bo Zhang, Xin Zhao, Yin Sheng Tian, Li Ding
With the development of high-performance fighters, the function of pilot helmets is also constantly upgrading, and helmet-mounted display (HMD) has become a future development trend. To solve the inter-restriction between the eye position control and the pressure comfort under high overloads of pilot helmets, this paper optimizes the helmet design by building a head-helmet finite element model: (1) Under a 10 G overload, the deformation of helmet soft liner should not exceed 2 mm; and (2) The combination of liner materials used in various areas should satisfy the requirements of most comfortable head pressure distribution (Pfront : Ptop : Pside : Pback  = 2:2:1:3)...
July 16, 2018: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/30004050/a-study-of-spectrum-of-pulmonary-pathology-and-expression-of-thyroid-transcription-factor-1-during-neonatal-period
#6
Indranil Das, Ram Narayan Das, Biswanath Paul, Bappa Mandal, Suchandra Mukherjee, Uttara Chatterjee
Context: Neonatal period is the single most hazardous period of life. The major causes of neonatal death are prematurity and respiratory distress syndrome. We report a series of neonatal autopsies in our Neonatal Intensive Care Unit with special emphasis on pulmonary pathology. The spectrum of pathological changes in the lungs and thyroid transcription factor-1 (TTF-1) expression was studied in detail with reference to its spatial distribution. Aims: This study aims to analyze the causes of neonatal death with special attention to pulmonary pathology along with associated histopathological changes in lungs...
July 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29994119/realtime-hand-object-interaction-using-learned-grasp-space-for-virtual-environments
#7
Hao Tian, Changbo Wang, Dinesh Manocha, Xinyu Zhang
We present a realtime virtual grasping algorithm to model interactions with virtual objects. Our approach is designed for multi-fingered hands and makes no assumptions about the motion of the user's hand or the virtual objects. Given a model of the virtual hand, we use machine learning and particle swarm optimization to automatically pre-compute stable grasp configurations for that object. The learning pre-computation step is accelerated using GPU parallelization. At runtime, we rely on the pre-computed stable grasp configurations, and dynamics/non-penetration constraints along with motion planning techniques to compute plausible looking grasps...
June 21, 2018: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/29991732/social-event-memory-test-semt-a-video-based-memory-test-for-predicting-amyloid-positivity-for-alzheimer-s-disease
#8
Ko Woon Kim, Jong Doo Choi, Hyejoo Lee, Na Kyung Lee, Seongbeom Park, Juhee Chin, Byung Hwa Lee, Jiwon Shin, Yeshin Kim, Hyemin Jang, Jee Hyun Choi, Duk L Na
Recent improvements in neuroimaging and molecular markers of Alzheimer's disease (AD) have aided diagnosis in the early stage of the disease, which greatly increases the chance for successful prevention and treatment. However, the expanding resources for AD diagnosis are unlikely to benefit all elderly due to economic burden. Here, we aimed to develop an inexpensive and sensitive method to detect early-stage AD. A scenario for real-world social event memory test (SEMT) was created and filmed in 360° video...
July 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29972046/protocol-for-n-of-1-trials-with-replications-across-therapists-for-childhood-onset-dystonia-rehabilitation-study-2-protocole-des-essais-%C3%A3-effectif-unique-avec-r%C3%A3-p%C3%A3-titions-par-diff%C3%A3-rents-ergoth%C3%A3-rapeutes-pour-la-r%C3%A3-adaptation-de-la-dystonie-d%C3%A3-butant-dans
#9
Hortensia Gimeno, Helene J Polatajko, Victoria Cornelius, Jean-Pierre Lin, Richard G Brown
BACKGROUND: Currently, no evidence-based rehabilitation interventions are available for hyperkinetic movement disorders (HMD), including dyskinetic cerebral palsy (CP). Among these highly heterogeneous disorders, dystonia is the predominant disorder. The Cognitive Orientation to daily Occupational Performance (CO-OP) Approach-a task-oriented, performance-based intervention to enable participation-is currently being evaluated for its potential as an intervention option. PURPOSE: This paper reports the protocol for the second of two studies designed to evaluate the potential of CO-OP to improve functional outcomes for individuals with HMD following deep brain stimulation (DBS)...
June 2018: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/29972044/protocol-for-n-of-1-trials-proof-of-concept-for-rehabilitation-of-childhood-onset-dystonia-study-1-protocole-des-essais-de-validation-%C3%A3-effectif-unique-pour-la-r%C3%A3-adaptation-de-la-dystonie-d%C3%A3-butant-dans-l-enfance-%C3%A3-tude-1
#10
Hortensia Gimeno, Helene J Polatajko, Victoria Cornelius, Jean-Pierre Lin, Richard G Brown
BACKGROUND: Hyperkinetic movement disorders (HMD) are a heterogeneous group of neurological conditions among which dystonia is the predominant disorder and dyskinetic cerebral palsy the largest secondary dystonia group. Currently, there are no evidence-based, non-medical management options for childhood HMD. The Cognitive Orientation to daily Occupational Performance (CO-OP) Approach is a task-oriented, performance-based intervention that focuses on participation. PURPOSE: This paper reports the protocol for a proof-of-concept study to assess feasibility and preliminary evidence regarding efficacy of CO-OP for HMD following deep brain stimulation (DBS)...
June 2018: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/29958021/germ-line-predisposition-to-myeloid-malignancies-appearing-in-adulthood
#11
Martina Crysandt, Kira Brings, Fabian Beier, Christian Thiede, Tim H Brümmendorf, Edgar Jost
Germ line predisposition to myeloid neoplasms has been incorporated in the WHO 2016 classification of myeloid neoplasms and acute leukemia. The new category of disease is named hereditary myeloid disorder (HMD). Although most myeloid neoplasms are sporadic, germ line mutations and familial predisposition can contribute to development of chronic myeloid diseases and acute myeloid leukemia. This finding and upcoming frequent use of genome wide detection of molecular aberrations will lead to a higher detection rate of a genetic predisposition and influence treatment decisions...
August 2018: Expert Review of Hematology
https://www.readbyqxmd.com/read/29953573/ultrasound-based-assessment-of-hyomental-distances-in-neutral-ramped-and-maximum-hyperextended-positions-and-derived-ratios-for-the-prediction-of-difficult-airway-in-the-obese-population-a-pilot-diagnostic-accuracy-study
#12
Cristina Petrisor, Robert Szabo, Catalin Constantinescu, Adrian Prie, Natalia Hagau
BACKGROUND: Ultrasonography-assessed hyomental distance (HMD) ratio has been found to discriminate between obese patients with Cormack-Lehane grades 1 or 2 vs. those with grades 3 or 4. The aim of our study is to evaluate the performance of the HMD evaluated ultrasonographically in neutral, ramped, and maximum hyperextended positions, as well as for the ratios obtained by dividing the HMD in the ramped position to that in the neutral position (HMDR1) and by dividing the HMD in maximum hyperextension to that in the neutral position (HMDR2), in order to predict the occurrence of Cormack-Lehane grades 3 or 4 during direct laryngoscopy...
2018: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29934792/head-mounted-display-augmented-reality-to-guide-pedicle-screw-placement-utilizing-computed-tomography
#13
Jacob T Gibby, Samuel A Swenson, Steve Cvetko, Raj Rao, Ramin Javan
PURPOSE: Augmented reality has potential to enhance surgical navigation and visualization. We determined whether head-mounted display augmented reality (HMD-AR) with superimposed computed tomography (CT) data could allow the wearer to percutaneously guide pedicle screw placement in an opaque lumbar model with no real-time fluoroscopic guidance. METHODS: CT imaging was obtained of a phantom composed of L1-L3 Sawbones vertebrae in opaque silicone. Preprocedural planning was performed by creating virtual trajectories of appropriate angle and depth for ideal approach into the pedicle, and these data were integrated into the Microsoft HoloLens using the Novarad OpenSight application allowing the user to view the virtual trajectory guides and CT images superimposed on the phantom in two and three dimensions...
June 22, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29890368/get-ready-for-automated-driving-using-virtual-reality
#14
Daniele Sportillo, Alexis Paljic, Luciano Ojeda
In conditionally automated vehicles, drivers can engage in secondary activities while traveling to their destination. However, drivers are required to appropriately respond, in a limited amount of time, to a take-over request when the system reaches its functional boundaries. Interacting with the car in the proper way from the first ride is crucial for car and road safety in general. For this reason, it is necessary to train drivers in a risk-free environment by providing them the best practice to use these complex systems...
September 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29866306/does-wearable-device-bring-distraction-closer-to-drivers-comparing-smartphones-and-google-glass
#15
Jibo He, Jason S McCarley, Kirsten Crager, Murtuza Jadliwala, Lesheng Hua, Sheng Huang
BACKGROUND: Head-up and wearable displays, such as Google Glass™, are sometimes marketed as safe in-vehicle alternatives to phone-based displays, as they allow drivers to receive messages without eye-off-the-road glances. However, head-up displays can still compromise driver performance (e.g., He et al., 2015b), as the distracting effect of interacting with any device will depend on the user's multitasking strategies. The present experiment examined drivers' interaction with a head-down smartphone display and a wearable head-up display...
July 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29848559/image-guided-percutaneous-spine-procedures-using-an-optical-see-through-head-mounted-display-proof-of-concept-and-rationale
#16
Gerard Deib, Alex Johnson, Mathias Unberath, Kevin Yu, Sebastian Andress, Long Qian, Gregory Osgood, Nassir Navab, Ferdinand Hui, Philippe Gailloud
BACKGROUND AND PURPOSE: Optical see-through head mounted displays (OST-HMDs) offer a mixed reality (MixR) experience with unhindered procedural site visualization during procedures using high resolution radiographic imaging. This technical note describes our preliminary experience with percutaneous spine procedures utilizing OST-HMD as an alternative to traditional angiography suite monitors. METHODS: MixR visualization was achieved using the Microsoft HoloLens system...
May 30, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29813019/handheld-guides-in-inspection-tasks-augmented-reality-versus-picture
#17
Jarkko Polvi, Takafumi Taketomi, Atsunori Moteki, Toshiyuki Yoshitake, Toshiyuki Fukuoka, Goshiro Yamamoto, Christian Sandor, Hirokazu Kato
Inspection tasks focus on observation of the environment and are required in many industrial domains. Inspectors usually execute these tasks by using a guide such as a paper manual, and directly observing the environment. The effort required to match the information in a guide with the information in an environment and the constant gaze shifts required between the two can severely lower the work efficiency of inspector in performing his/her tasks. Augmented reality (AR) allows the information in a guide to be overlaid directly on an environment...
July 2018: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/29792201/cerium-dioxide-nanoparticles-exacerbate-house-dust-mite-induced-type-ii-airway-inflammation
#18
Kirsty Meldrum, Sarah B Robertson, Isabella Römer, Tim Marczylo, Lareb S N Dean, Andrew Rogers, Timothy W Gant, Rachel Smith, Terry D Tetley, Martin O Leonard
BACKGROUND: Nanomaterial inhalation represents a potential hazard for respiratory conditions such as asthma. Cerium dioxide nanoparticles (CeO2 NPs) have the ability to modify disease outcome but have not been investigated for their effect on models of asthma and inflammatory lung disease. The aim of this study was to examine the impact of CeO2 NPs in a house dust mite (HDM) induced murine model of asthma. RESULTS: Repeated intranasal instillation of CeO2 NPs in the presence of HDM caused the induction of a type II inflammatory response, characterised by increased bronchoalveolar lavage eosinophils, mast cells, total plasma IgE and goblet cell metaplasia...
May 23, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29791445/the-search-for-instantaneous-vection-an-oscillating-visual-prime-reduces-vection-onset-latency
#19
Stephen Palmisano, Bernhard E Riecke
Typically it takes up to 10 seconds or more to induce a visual illusion of self-motion ("vection"). However, for this vection to be most useful in virtual reality and vehicle simulation, it needs to be induced quickly, if not immediately. This study examined whether vection onset latency could be reduced towards zero using visual display manipulations alone. In the main experiments, visual self-motion simulations were presented to observers via either a large external display or a head-mounted display (HMD)...
2018: PloS One
https://www.readbyqxmd.com/read/29766147/the-non-preventive-effects-of-human-menopausal-gonadotropins-on-ovarian-tissues-in-nandrolone-decanoate-treated-female-rats-a-histochemical-and-ultra-structural-study
#20
Fakhroddin Mesbah, Hossein Bordbar, Tahereh Talaei Khozani, Farzaneh Dehghani, Hossein Mirkhani
Background: The follicular growth and development may be affected by abused drugs. Nandrolone decanoate (ND) as an anabolic androgenic steroid can damage the morphological and functional features of the ovary and may lead to reproductive failure. Objective: This study was designed to evaluate the effects of synchronized and non-synchronized administration of Human Menopausal Gonadotropins (hMG) with ND on ovarian tissue and level of sex hormones in the adult female rat...
March 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
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