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https://www.readbyqxmd.com/read/29781900/concomitant-use-of-1-550-nm-nonablative-fractional-laser-with-low-dose-isotretinoin-for-the-treatment-of-acne-vulgaris-in-asian-patients-a-randomized-split-face-controlled-study
#1
Jun Xia, Guanglei Hu, Die Hu, Songmei Geng, Weihui Zeng
BACKGROUND: Nonablative fractional laser (NAFL) has been shown to improve the appearance of inflammatory acne and acne scars. Isotretinoin is effective for the treatment of moderate-to-severe cases of recalcitrant acne. However, the recommended dose of isotretinoin can have profound effects. OBJECTIVE: To investigate the clinical efficacy and safety of performing NAFL treatment in patients with moderate-to-severe acne vulgaris under treatment with low-dose oral isotretinoin...
May 16, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29764244/kinetics-and-tissue-repair-process-following-fractional-bipolar-radiofrequency-treatment
#2
G Kokolakis, L von Eichel, M Ulrich, J Lademann, T Zuberbier, M A Hofmann
INTRODUCTION: Fractionated radiofrequency (RF) tissue tightening is an alternative method to fractionated laser treatment of skin wrinkling, laxity and acne scars, with reduced risk of scarring or persistent pigmentation. The aim of this study was to evaluate and quantify the wound healing process after RF treatment. MATERIALS AND METHODS: 12 patients were treated with a 64-pin fractional bipolar RF device with 60 mJ/pin applied energy. Confocal laser scanning microscopy (CLSM) examination was performed on day 1, day 2, day 7 and day 14 after treatment...
May 15, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29763564/inhibitors-of-melanogenesis-an-updated-review
#3
Thanigaimalai Pillaiyar, Vigneshwaran Namasivayam, Manoj Manickam, Sang Hun Jung
Melanins are pigment molecules that determine the skin, eye, and hair color of the human subject to its amount, quality and distribution. Melanocytes synthesize melanin and provide epidermal protection from various stimuli, such as harmful ultraviolet radiation, through the complex process called melanogenesis. However, a serious dermatological problems occur when the excessive production of melanin in different parts of the human body. These include freckles, melasma, senile lentigo, pigmented acne scars and cancer...
May 15, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29757041/successful-treatment-of-acne-keloidalis-nuchae-with-erbium-yag-laser-a-comparative-study
#4
Hend D Gamil, Elsayed M Khater, Fathia M Khattab, Mona A Khalil
BACKGROUND: Acne keloidalis nuchae (AKN) is a chronic inflammatory disease involving hair follicles of the neck. It is a form of keloidal scarring alopecia that is often refractory to medical or surgical management. OBJECTIVE: To evaluate the efficacy of Er:YAG laser in the treatment of AKN as compared to long pulsed Nd:YAG laser. PATIENTS AND METHODS: This study was conducted on 30 male patients with AKN. Their ages ranged from 19 to 47 years with a mean age of 36...
May 14, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29744784/acne-scarring-management-systematic-review-and-evaluation-of-the-evidence
#5
REVIEW
Shashank Bhargava, Paulo R Cunha, Jennifer Lee, George Kroumpouzos
BACKGROUND: Modalities for atrophic acne scarring can be classified depending upon the needs they satisfy; that is, resurfacing, lifting/volumization, tightening, or surgical removal/movement of tissue that is required for correction. A plethora of treatment options have resulted from the need to treat various acne scar types, variability of responses noted in various skin types, and increasing popularity of minimally invasive modalities. Still, there is a lack of consensus guidelines on treatment or combination therapies for various clinical scenarios...
May 9, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29731588/resurfacing-of-facial-acne-scars-with-a-new-variable-pulsed-er-yag-laser-in-fitzpatrick-skin-types-iv-and-v
#6
Namitha Chathra, Venkataram Mysore
Introduction: The Er:YAG laser, considered to be less effective than CO2 laser in its traditional form, in its new modulated version has variable pulse technology that is claimed to be superior to the earlier versions of the laser. Aim: The aim of the study was to check efficacy and safety of the new variable square pulse (VSP) Er:YAG laser in the management of acne scar in patients with Fitzpatrick skin types IV and V. Materials and Methods: This retrospective study consisted of 80 patients (Fitzpatrick skin types IV and V) with atrophic and hypertrophic facial acne scars...
January 2018: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29709603/photodynamic-therapy-for-hidradenitis-suppurativa-acne-inversa-case-report
#7
Yunjie Zhang, Yuguang Yang, Xianbiao Zou
Hidradenitis suppurativa/acne inversa (HS/AI) is a type of chronic suppurative inflammatory reaction of the hair follicles characterized by recurrent dermal abscesses, sinus tracts and scars. So far, there has not been any prospective study proving the efficacy and safety of photodynamic therapy for the disease. In this report, one case of HS/AI achieved resolution of skin lesions, ulcer healing and disappearance of symptoms after nine treatments with 5-aminolevulinic acid photodynamic therapy (ALA-PDT).
April 27, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29697605/evaluating-platelet-rich-therapy-for-facial-aesthetics-and-alopecia-a-critical-review-of-the-literature
#8
Catherine C Motosk O, Kimberly S Khouri, Grace Poudrier, Sammy Sinno, Alexes Hazen
BACKGROUND: Despite the growing popularity of platelet-rich plasma, existing evidence supporting its efficacy remains controversial due to the lack of large-scale studies and standardized protocols for preparation and application. This article reviews its use in facial rejuvenation, fat grafting, acne scarring, and androgenic alopecia. Emphasis is placed on comparing methods of platelet-rich plasma preparation and application across studies. METHODS: A systematic review was performed for articles published between 2006 and 2015...
May 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29682870/comparative-study-of-the-efficacy-of-platelet-rich-plasma-combined-with-carboxytherapy-vs-its-use-with-fractional-carbon-dioxide-laser-in-atrophic-acne-scars
#9
Abdul-Aziz Ibrahim Al Taweel, Abdul-Aziz Abdul-Salam Al Refae, Ahmed Mohamed Hamed, Asmaa Mostafa Kamal
BACKGROUND: Acne scars are a major concerning problem to all acne patients affecting their quality of life. Platelet-rich plasma (PRP) and fractional CO2 laser are innovative treatment modalities for acne scars. Carboxytherapy can also be used to improve scar tissue through the increase in collagen deposition and reorganization, and the improvement in skin texture and tone. AIMS: The aim of this work was to compare the efficacy, safety, and complications of the intradermal injection of PRP combined with carboxytherapy and PRP combined with fractional CO2 laser, in the treatment of atrophic acne scars...
April 22, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29675912/tumor-necrosis-factor-%C3%AE-308-g-a-and-interleukin-1-%C3%AE-511-c-t-gene-polymorphisms-in-patients-with-scarring-acne
#10
Gulsen Akoglu, Cagman Tan, Deniz Cagdas Ayvaz, Ilhan Tezcan
BACKGROUND: Acne is a chronic inflammatory skin disorder which may heal with scarring. Tumor necrosis factor alpha (TNF α) and interleukin 1 β (IL-1β) are considered as the main responsible proinflammatory mediators of acne pathogenesis. Oversecretion of these cytokines was found to be associated with TNF α-308 G>A and IL-1β-511 C<T polymorphisms. AIM: To evaluate the association of TNF α-308 and IL-1β-511 gene polymorphisms with acne and postacne scarring susceptibility and acne severity...
April 19, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29663460/treatment-of-atrophic-acne-scarring-with-fractional-micro-plasma-radio-frequency-in-chinese-patients-a-prospective-study
#11
Ting Lan, Yan Xiao, Li Tang, Michael R Hamblin, Rui Yin
BACKGROUND: Acne scarring is a common disfiguring sequela of acne vulgaris which can lead to serious psychosocial problems and have a negative effect on patients' quality of life. Although a variety of approaches can be used to treat atrophic acne scars, disadvantages such as long-healing time, dyspigmentation, infections, and prolonged erythema make these treatments unsatisfactory especially for Asians. Fractional micro-plasma radio-frequency is a novel technology that produces minor ablation to the epidermis to promote rapid re-epithelialization, while the radio-frequency evoked thermal effect can stimulate regeneration and remodeling of dermal fibroblasts...
April 16, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29663317/atrophic-scar-formation-in-acne-patients-involves-long-acting-immune-responses-with-plasma-cells-and-alteration-of-sebaceous-glands
#12
I Carlavan, B Bertino, M Rivier, P Martel, V Bourdes, M Motte, S Déret, P Reiniche, C Menigot, A Khammari, B Dreno, P Fogel, J J Voegel
BACKGROUND: Possible outcomes of acne lesions are atrophic scars which may cause serious psychological distress. Current treatments of post-acne scarring often require invasive procedures. Pathophysiological studies on acne scarring investigated only the first week of papule life. OBJECTIVES: Study the pathophysiology of atrophic scar formation to identify molecular and cellular pathways that can lead to new therapies for the prevention of acne scarring. METHODS: Large-scale gene expression profiling and immunohistochemistry analysis were performed on uninvolved skin and papules in both, scar-prone (SP) and non-scar-prone (NSP) acne patients, at different time points...
April 16, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29602240/optimizing-outcomes-with-polymethylmethacrylate-fillers
#13
REVIEW
Michael H Gold, Neil S Sadick
INTRODUCTION: The ideal filler should be long-lasting, biocompatible, chemically inert, soft and easy to use, and have a long history of safety. This review focuses on the evolution and development of the PMMA-collagen gel, Bellafill, and the 10 years of postmarketing experience of Bellafill since it received premarket approval (PMA) from the FDA as Artefill in 2006. Artefill was rebranded to Bellafill in 2015. METHODS: The authors conducted a literature search on PubMed for key articles describing the steps in which Arteplast, a PMMA filler developed in 1989, led to the development of Bellafill, the only PMMA filler approved by the US FDA for the treatment of nasolabial folds and acne scar correction...
March 30, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29587518/prospective-controlled-trial-for-the-treatment-of-acne-keloidalis-nuchae-with-a-long-pulsed-neodymium-doped-yttrium-aluminum-garnet-laser
#14
Denise K Woo, German Treyger, Marsha Henderson, Richard H Huggins, Diane Jackson-Richards, Iltefat Hamzavi
BACKGROUND: Acne keloidalis nuchae (AKN) is a chronic scarring folliculitis with limited interventions of both high efficacy and low morbidity. OBJECTIVE: To assess the efficacy of the long-pulsed 1064-nm neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser and topical steroids as a treatment for AKN compared to topical steroids alone. METHODS: We conducted a single-blinded, randomised, within-patient right-left controlled trial (n = 13)...
March 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29564872/reducing-the-oral-isotretinoin-skin-side-effects-efficacy-of-8-omega-ceramides-hydrophilic-sugars-5-niacinamide-cream-compound-in-acne-patients
#15
Maria V Cannizzaro, Annunziata Dattola, Virginia Garofalo, Ester Del Duca, Luca Bianchi
BACKGROUND: Acne vulgaris is a chronic inflammatory skin disease that manifests as open and closed comedones as well as inflammatory papules, pustules, and nodules localized on face and trunk. Oral isotretinoin demonstrated to be effective in controlling seborrhea, inflammation, Propionibacterium Acnes hyperproliferation and reducing scarring, nevertheless muco-cutaneous side effects, particularly dryness, itching, bruising are commonly seen in patients under treatment with isotretinoin reducing the compliance to the treatment...
April 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29549598/adapalene-0-3-gel-shows-efficacy-for-the-treatment-of-atrophic-acne-scars
#16
Manisha J Loss, Sherry Leung, Anna Chien, Nabil Kerrouche, Alexander H Fischer, Sewon Kang
INTRODUCTION: Scarring is an unfortunate clinical outcome of acne. Current treatment options for atrophic acne scars are dominated by non-pharmacological, invasive procedures which may not be suitable or affordable to all patients. This phase II, single-center, open-label, exploratory study assessed the efficacy, safety and subject-reported outcomes of adapalene 0.3% gel in the treatment of atrophic acne scars. METHODS: The study included subjects aged 18-50 years with past history of acne and moderate to severe facial atrophic acne scars...
March 16, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29549588/prevention-and-reduction-of-atrophic-acne-scars-with-adapalene-0-3-benzoyl-peroxide-2-5-gel-in-subjects-with-moderate-or-severe-facial-acne-results-of-a-6-month-randomized-vehicle-controlled-trial-using-intra-individual-comparison
#17
Brigitte Dréno, Robert Bissonnette, Angélique Gagné-Henley, Benjamin Barankin, Charles Lynde, Nabil Kerrouche, Jerry Tan
BACKGROUND: Very few clinical trials have investigated the effect of topical acne treatment on scarring. OBJECTIVES: Our objective was to evaluate the efficacy of adapalene 0.3%/benzoyl peroxide 2.5% gel (A0.3/BPO2.5) in atrophic acne scar formation in patients with acne. METHODS: In this multicenter, randomized, investigator-blinded, vehicle-controlled study, subjects with moderate or severe facial acne (Investigator's Global Assessment [IGA] score 3 or 4; ≥ 25 inflammatory lesions; ten or more atrophic acne scars) applied A0...
April 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29543377/skin-microneedling-for-acne-scars-associated-with-pigmentation-in-patients-with-dark-skin
#18
Firas Al Qarqaz, Ali Al-Yousef
BACKGROUND: Acne is very common skin condition. Most patients with acne will have a degree of scarring as a result of their acne. In patients with darker skin color the scarring can be further complicated by hyperpigmentation. Several treatment options can be used to improve acne scarring, however the problem of post acne hyperpigmentation is not often addressed. This study especially focus on the treatment of pigmented post acne scarring using skin microneedling. AIMS: The primary objective is to assess the improvement of pigmentation of acne scarring in patients with dark skin using microneedling...
March 15, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29541753/light-therapies-for-acne
#19
Pawel Posadzki, Josip Car
Clinical Question: Are light therapies effective and safe for treating acne? Bottom Line: The evidence for all light therapies remains weak and inconclusive. Red-light methyl aminolevulinate-photodynamic therapy (MAL-PDT) was the only treatment associated with a small though clinically insignificant reduction in the number of inflamed lesions and in global improvement as assessed by an investigator in moderate to severe acne. Red-light MAL-PDT was not associated with higher rates of severe adverse effects than placebo or no treatment...
March 14, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29524284/blunt-cannula-subcision-is-more-effective-than-nokor-needle-subcision-for-acne-scars-treatment
#20
Mehdi Gheisari, Behzad Iranmanesh, Bita Saghi
BACKGROUND AND AIM: A comprehensive study comparing two different modalities, Nokor needle subcision (NNS) and blunt cannula subcision (BCS), for treatment of acne scars, has not been reported previously. The aim was to compare the effectiveness of these two methods based on patient's and doctor's satisfaction measures, in addition to the late complications 3 months postsubcision. METHOD OF INTERVENTION: Patients had 18-65 years old, with acne scars on both malar sides...
March 9, 2018: Journal of Cosmetic Dermatology
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