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https://www.readbyqxmd.com/read/27900998/novel-mutations-in-psenen-gene-in-two-chinese-acne-inversa-families-manifested-as-familial-multiple-comedones-and-dowling-degos-disease
#1
Cheng Zhou, Guang-Dong Wen, Lwin Myint Soe, Hong-Jun Xu, Juan Du, Jian-Zhong Zhang
BACKGROUND: Acne inversa (AI), also called hidradenitis suppurativa, is a chronic, inflammatory, recurrent skin disease of the hair follicle. Familial AI shows autosomal-dominant inheritance caused by mutations in the γ-secretase genes. This study was aimed to identify the specific mutations in the γ-secretase genes in two Chinese families with AI. METHODS: In this study, two Chinese families with AI were investigated. All the affected individuals in the two families mainly manifested with multiple comedones, pitted scars, and a few inflammatory nodules on their face, neck, trunk, axilla, buttocks, upper arms, and thighs...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27855116/role-of-activated-platelets-in-severe-acne-scarring-and-adaptive-immunity-activation
#2
Sidra Younis, Fiza Rana, Miroslav Blumenberg, Qamar Javed
No abstract text is available yet for this article.
November 17, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27816123/consensus-based-acne-classification-system-and-treatment-algorithm-for-spain
#3
J L López-Estebaranz, P Herranz-Pinto, B Dréno
Acne is a chronic inflammatory disease whose psychosocial effects can greatly impair quality of life. Various scales are used to classify the severity of acne, and several treatment algorithms are currently applied: no consensus on a common scale or treatment guidelines has been reached. A group of Spanish experts therefore met to identify a scale the majority could accept as the most appropriate for classifying severity and treating accordingly. The group chose the following classifications: comedonal acne, mild or moderate papulopustular acne, severe papulopustular acne, moderate nodular acne, and nodular-cystic acne (or acne tending to leave scars)...
November 2, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27805273/comparison-between-er-yag-laser-and-bipolar-radiofrequency-combined-with-infrared-diode-laser-for-the-treatment-of-acne-scars-differential-expression-of-fibrogenetic-biomolecules-may-be-associated-with-differences-in-efficacy-between-ablative-and-non-ablative
#4
Seonguk Min, Seon Yong Park, Jungyoon Moon, Hyuck Hoon Kwon, Ji Young Yoon, Dae Hun Suh
BACKGROUND AND OBJECTIVE: Fractional Er:YAG minimizes the risk associated with skin ablation. Infrared diode laser and radiofrequency have suggested comparable improvements in acne scar. We compared the clinical efficacy of Er:YAG laser and bipolar radiofrequency combined with diode laser (BRDL) for the treatment of acne scars. Moreover, acute molecular changes of cytokine profile associated with wound healing have been evaluated to suggest mechanisms of improvement of acne scar. STUDY DESIGN: Twenty-four subjects with mild-to-moderate acne scars were treated in a split-face manner with Er:YAG and BRDL, with two treatment sessions, 4 weeks apart...
November 2, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27803511/survivin-as-a-novel-biomarker-in-the-pathogenesis-of-acne-vulgaris-and-its-correlation-to-insulin-like-growth-factor-i
#5
Hanan A Assaf, Wafaa M Abdel-Maged, Bakheet E M Elsadek, Mohammed H Hassan, Mohamed A Adly, Soher A Ali
Survivin, a member of the inhibitor of apoptosis protein family, has an important role in cell cycle regulation. Insulin-like growth factor-I (IGF-I) is a polypeptide hormone with wide range of biologic effects including stimulation of lipogenesis in sebaceous glands. Their overexpression in some fibrotic disorders suggests a possible implication of both IGF-I and survivin in the pathogenesis of acne and/or acne scars. The current study aimed to assess and correlate serum levels of IGF-I and survivin in patients with active acne vulgaris and postinflammatory acne scars and to evaluate their lesional expressions in comparison to healthy controls...
2016: Disease Markers
https://www.readbyqxmd.com/read/27790756/adapalene-0-1-benzoyl-peroxide-2-5-gel-reduces-the-risk-of-atrophic-scar-formation-in-moderate-inflammatory-acne-a-split-face-randomized-controlled-trial
#6
B Dreno, J Tan, M Rivier, P Martel, R Bissonnette
BACKGROUND: The efficacy of current topical acne treatments in mitigating the potential for acne scarring is not known. OBJECTIVE: Evaluate the effect of adapalene 0.1%/benzoyl peroxide 2.5% (A/BPO) gel compared to vehicle in reducing the risk of acne scarring. METHODS: Multi-center, randomized, investigator-blinded, vehicle-controlled, split-face study conducted over 6 months. Subjects were adults with active moderate facial acne vulgaris and at least 10 atrophic acne scars at Baseline...
October 28, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27762652/polydeoxyribonucleotide-improves-wound-healing-of-fractional-laser-resurfacing-in-rat-model
#7
Mi Yu, Jun Young Lee
BACKGROUND: Polydeoxyribonucleotide (PDRN) is an active compound that can promote wound healing. PDRN stimulates wound healing by enhancing angiogenesis and increasing fibroblast growth rates. Laser skin resurfacing is a popular cosmetic procedure for skin rejuvenation. Despite excellent improvement of photo-damaged skin and acne scarring, it is accompanied with drawbacks, such as prolonged erythema and crusting. OBJECTIVE: This study was designed to assess the effect of PDRN on wounds induced by fractional laser resurfacing...
December 2, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27755171/microneedling-a-comprehensive-review
#8
Angela Hou, Brandon Cohen, Adele Haimovic, Nada Elbuluk
BACKGROUND: Microneedling is a minimally invasive procedure that uses fine needles to puncture the epidermis. The microwounds created stimulate the release of growth factors and induce collagen production. The epidermis remains relatively intact, therefore helping to limit adverse events. The indications for microneedling therapy have grown significantly, and it is becoming a more widely used treatment in dermatology. OBJECTIVE: A comprehensive review of microneedling in human subjects and its applications in dermatology...
October 13, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27749646/epidemiology-of-acne-vulgaris-in-adolescent-male-students-in-arar-kingdom-of-saudi-arabia
#9
Nagah M Abo El-Fetoh, Naif G Alenezi, Nasser G Alshamari, Omar G Alenezi
BACKGROUND: Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Small, noninflamed acne lesions may not be more than a slight nuisance, but, in individuals with more severe inflammatory disease, pain, social embarrassment, and both physical and psychological scarring can be life altering. Despite its high prevalence, no previous community-based studies have been conducted in Arar, northern border of Kingdom of Saudi Arabia, addressing this issue...
September 2016: Journal of the Egyptian Public Health Association
https://www.readbyqxmd.com/read/27743393/adjuvant-alternative-treatment-with-chemical-peeling-and-subsequent-iontophoresis-for-postinflammatory-hyperpigmentation-erosion-with-inflamed-red-papules-and-non-inflamed-atrophic-scars-in-acne-vulgaris
#10
Ichiro Kurokawa, Naoki Oiso, Akira Kawada
The standard management of acne vulgaris in Japan includes a combination of topical treatment with benzoyl peroxide (BPO) and BPO/clindamycin (CLDM), topical adapalene and systemic antimicrobials. However, the treatment of therapy-resistant complications such as postinflammatory hyperpigmentation (PIH), erosions with inflamed red papules and atrophic scars has not been established. We performed chemical peeling with glycolic acid and iontophoresis with ascorbyl 2-phosphate 6-palmitate and DL-α-tocopherol phosphate for the treatment of PIH, erosions with inflamed red papules and non-inflamed atrophic scars in 31 patients with acne vulgaris (mild to severe severity), and evaluated the efficacy and safety of these interventions...
October 15, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27733225/effect-of-dermabrasion-and-recell-%C3%A2-on-large-superficial-facial-scars-caused-by-burn-trauma-and-acnes-%C3%A2
#11
Pan-Xi Yu, Wen-Qi Diao, Zuo-Liang Qi, Jing-Long Cai
<strong>Objective</strong> To explore the effects of dermabrasion combined with ReCell(®) on large superficial facial scars caused by burn, trauma and acnes.<strong>Methods</strong> Nineteen patients with large superficial facial scars were treated by the same surgeon with dermabrasion combined with ReCell(®). According to the etiology, patients were classified into post-burning group (n=5), post-traumatic group (n=7) and post-acne group (n=7). Fifteen patients completed the follow-ups, 5 patients in each group...
September 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/27699859/acne-fulminans-case-series-and-review-of-the-literature
#12
Abdullah Alakeel, Marie Ferneiny, Nicole Auffret, Christine Bodemer
Acne fulminans (AF) is a rare manifestation and the most severe form of the entire clinical spectrum of acne. The disease is destructive and is characterized by the sudden onset of painful and ulcerative pustules and systemic symptoms including high fever, hepatomegaly, polyarthralgia, leukocytosis, plaquetose, and increased inflammatory markers and transaminases. Osteolytic lesions in multiple skeletal sites could also be associated. The use of isotretinoin is considered a related trigger, as well as the use and cessation of testosterone, although a bacterial infection, a drug-induced disease, or an intake of anabolic androgenic steroids has been suggested...
October 4, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27688440/the-psychosocial-impact-of-acne-vulgaris
#13
Neirita Hazarika, M Archana
BACKGROUND: Acne vulgaris causes erythematous papulopustular lesions in active stage and often leave behind residual scarring and pigmentation. Its onset in adolescence may add to the emotional and psychological challenges experienced during this period. AIMS: To assess the impact of acne on the various psychosocial domains of daily life. MATERIALS AND METHODS: This was a prospective, cross-sectional study done in the dermatology out-patient department of a tertiary care hospital from January to March 2015...
September 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27680526/the-downside-of-fat-avoiding-and-treating-complications
#14
Irene A Kim, Gregory Keller, Michael J Groth, Vishad Nabili
Three-dimensional facial volume restoration using fat has become widely accepted as an essential component of facial rejuvenation. Transplanted fat has benefits due to its inherently nonallergenic nature. The versatility of fat grafts allows for their use in all types of facial enhancement-improving the appearance of nasolabial folds, mesolabial grooves, flattened cheeks and upper lips, glabellar furrows, lipoatrophy, acne scars, and temporal hollowing. Yet despite its virtues as the ideal filler, autologous fat has its shortcomings with risks of complications...
October 2016: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/27670126/light-therapies-for-acne
#15
Jelena Barbaric, Rachel Abbott, Pawel Posadzki, Mate Car, Laura H Gunn, Alison M Layton, Azeem Majeed, Josip Car
BACKGROUND: Acne vulgaris is a very common skin problem that presents with blackheads, whiteheads, and inflamed spots. It frequently results in physical scarring and may cause psychological distress. The use of oral and topical treatments can be limited in some people due to ineffectiveness, inconvenience, poor tolerability or side-effects. Some studies have suggested promising results for light therapies. OBJECTIVES: To explore the effects of light treatment of different wavelengths for acne...
September 27, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27646558/risk-factors-of-keloids-in-syrians
#16
Abeer Shaheen, Jamal Khaddam, Fadi Kesh
BACKGROUND: Keloid is a benign fibrous growth, which presents in scar tissue of predisposed individuals. It is a result of irregular wound healing, but the exact mechanism is unknown. However, several factors may play a role in keloid formation. To date, there are no studies of keloids in Syria, and limited studies on Caucasians, so we have investigated the risk factors of keloids in Syrians (Caucasians), and this is the main objective of this study. METHODS: Diagnosis of keloids was clinically made after an interview and physical examination...
2016: BMC Dermatology
https://www.readbyqxmd.com/read/27640402/objective-severity-does-not-capture-the-impact-of-rosacea-acne-scarring-and-photoaging-in-patients-seeking-laser-therapy
#17
C L Thomas, B Kim, J Lam, S Richards, A See, S Kalouche, R D Paver, P Fernández Peñas
BACKGROUND: Measures of quality of life (QOL) and patient satisfaction are of great importance in dermatology, as both impact upon treatment adherence and health outcomes. Patients' assessment of QOL often differs from their doctors' predictions and their assessments of skin disease severity do not correlate with patients' own perceptions. The development of laser technology has facilitated successful treatment of many skin conditions, but studies on patient satisfaction are lacking. OBJECTIVES: Our aim was to determine the extent of discordance between patient and dermatologist-assessed disease severity and assess the impact of acne scarring, rosacea and photoaging on QOL...
September 18, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27631461/single-session-treatment-of-rolling-acne-scars-using-tumescent-anesthesia-20-trichloracetic-acid-extensive-subcision-and-fractional-co2-laser
#18
Mark B Taylor, Lisa Zaleski-Larsen, Timothy A McGraw
BACKGROUND: Successful treatment of acne scars is challenging. Many modalities have been used with marginal success. OBJECTIVE: The authors describe a combination of a superficial chemical peel, subcision, and fractional carbon dioxide (CO2) laser resurfacing in a single-treatment session as a novel treatment approach for rolling acne scars. METHODS: A total of 114 patients (75 women and 39 men) with predominantly rolling acne scars were treated with a 20% trichloracetic acid chemical peel, subcision with a novel dissecting instrument, and the CO2 laser under tumescent anesthesia...
September 14, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27622255/impact-of-acne-vulgaris-on-quality-of-life-and-self-esteem
#19
Abhineetha Hosthota, Swapna Bondade, Vinay Basavaraja
The psychological impact of acne is determined by various factors including age, sex, personality, grade of disease, scarring, and environmental and ethnic background. Apart from managing the clinical manifestations of acne, clinicians also have to deal with the psychological aspects of the disease by assessing patients' quality of life (QOL) and self-esteem. These measures will aid in better management of acne patients. This study examined the relationship between acne and QOL and self-esteem. The results showed that acne severity may have a considerable adverse impact on QOL and self-esteem...
August 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27605395/evaluation-of-the-in-vivo-effects-of-various-laser-light-or-ultrasound-modalities-on-human-skin-treated-with-a-collagen-and-polymethylmethacrylate-microsphere-dermal-filler-product
#20
Douglas C Wu, Jwala Karnik, Tara Margarella, Vivien L Nguyen, Antoanella Calame, Mitchel P Goldman
BACKGROUND: Bellafill® is a soft tissue dermal filler composed of non-resorbable polymethylmethacrylate (PMMA) microspheres, suspended in a water-based carrier gel composed of 3.5% bovine collagen. It has been approved by the FDA for the correction of nasolabial folds and atrophic facial acne scars. Energy-based therapies are used for facial rejuvenation and treatment of acne scarring. However, little has been published about the effects of energy devices on previously placed PMMA. This prospective, in vivo clinical study evaluated the safety and histopathological effects of a number of different laser, light, and ultrasound treatment modalities on PMMA-collagen filler previously injected into human tissue...
September 8, 2016: Lasers in Surgery and Medicine
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