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Bisphenol A

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https://www.readbyqxmd.com/read/29775926/chlorophyll-a-%C3%AF-uorescence-and-transcriptome-reveal-the-toxicological-effects-of-bisphenol-a-on-an-invasive-cyanobacterium-cylindrospermopsis-raciborskii
#1
Rong Xiang, Junqiong Shi, Hongbo Zhang, Congcong Dong, Li Liu, JunKe Fu, Xinyu He, Yanjun Yan, Zhongxing Wu
Bisphenol A has attracted worldwide attention due to its harmful effects on humans, animals and plants. In this study, the toxicological effects of BPA on Cylindrospermopsis raciborskii were assessed based on chlorophyll a fluorescence and transcriptome analyses. The results showed that the growth of C. raciborskii was significantly inhibited when BPA exceeded 0.1 mg L-1 . A marked rise of phase J was observed at a concentration greater than 0.1 mg L-1 , while a K phase appeared at 20 mg L-1 . The chlorophyll a fluorescence parameters of RC/CS0 , F0 , φP0 , φE0 , and ψ0 , underwent a significant decline under all treatments of BPA, whereas a significant increase in both VJ and M0 occurred under all concentrations of BPA...
May 9, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29768847/synthesis-of-antioxidative-conductive-copper-inks-with-superior-adhesion
#2
Wei-Yang Ma, Yao-Yi Cheng, Jia-Kun Chen, Kai-Hsuan Chan, Zheng-Jie Lin, Wei-Hao Chou, Wei-Chen Chang
Conductive films have attracted much attention in the printed electronics industry. To date, expensive conductive silver inks have been utilized widely in these conductive films, which ultimately increase the cost. Hence the alternative low-cost copper inks will be of great interest in the future. This paper will present how to synthesize antioxidative conductive copper inks with superior adhesion to FR4 substrates. The antioxidative conductive copper inks were prepared by dispersing the antioxidative copper nanoparticles in diethylene glycol with the bisphenol-F type BEF170 epoxy resin as a binder and the Methyl-5-norbornene-2,3-dicarboxylic anhydride (NMA) as a curing agent, then were coated on FR4 substrates to form the copper films, followed by sintering at 250 °C in nitrogen atmosphere for 20 minutes...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29768248/bisphenol-a-decreases-the-spontaneous-contractions-of-rat-uterus-in-vitro-through-a-nitrergic-mechanism
#3
Hemlata Gupta, Shripad B Deshpande
BACKGROUND: Bisphenol A (BPA), a chemical used in the manufacture of plastics, has toxic effects on various systems of the human body including the reproductive system. BPA possesses estrogenic activity and is implicated in altering oogenesis, ovulation, and fertility. In addition to ovulatory changes, uterine contractility is an important factor for fertility. However, the effects of BPA on myometrial contractions are not known. Therefore, we examined the effect of BPA on rat uterine contractions...
May 16, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29763883/impact-of-common-environmental-chemicals-bisphenol-a-and-bisphenol-s-on-the-physiology-of-lumbriculus-variegatus
#4
Victoria Vought, Hong-Sheng Wang
Bisphenol A (BPA) is a component of polycarbonate plastics and a near ubiquitous environmental endocrine disrupting chemical. Bisphenol S (BPS), a substitute of BPA, is also hormonally active. This study examines the effects of aqueous exposure to BPA and BPS on the freshwater annelids Lumbriculus variegatus, a keystone species in shallow water ecosystems. Both BPA and BPS, at both low dose (10-9 M) and high dose (10-6 M), retarded the initial phase of body regrowth after cutting/fragmentation, which is the main mode of reproduction of L...
May 8, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29763587/mice-exposed-to-bisphenol-a-exhibit-depressive-like-behavior-with-neurotransmitter-and-neuroactive-steroid-dysfunction
#5
Frances Xin, Erin Fischer, Christopher Krapp, Elizabeth N Krizman, Yemin Lan, Clementina Mesaros, Nathaniel W Snyder, Amita Bansal, Michael B Robinson, Rebecca A Simmons, Marisa S Bartolomei
Fetal exposure to endocrine disrupting chemicals (EDCs) has been associated with adverse neurobehavioral outcomes across the lifespan and can persist across multiple generations of offspring. However, the underlying mechanisms driving these changes are not well understood. We investigated the molecular perturbations associated with EDC-induced behavioral changes in first (F1) and second (F2) filial generations, using the model EDC bisphenol A (BPA). C57BL/6J dams were exposed to BPA from preconception until lactation through the diet at doses (10 μg/kg bw/d-lower dose or 10 mg/kg bw/d-upper dose) representative of human exposure levels...
May 12, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29763311/thyroid-disruption-by-bisphenol-s-analogues-via-thyroid-hormone-receptor-%C3%AE-in-vitro-in-vivo-and-molecular-dynamics-simulation-study
#6
Liping Lu, Tingjie Zhan, Mei Ma, Chao Xu, Jingpeng Wang, Chunlong Zhang, Weiping Liu, Shulin Zhuang
Bisphenol S (4-hydroxyphenyl sulfone, BPS) is increasingly used as BPA alternatives. The global usage of BPS and its analogues (BPSs) caused the frequent detection of their residues in multiple environmental media. We investigated their potential endocrine disrupting effects toward thyroid hormone receptor (TR) β. The molecular interaction of BPSs toward TRβ ligand binding domain (LBD) was probed by fluorescence spectroscopy and molecular dynamics (MD) simulations. BPSs caused the static fluorescence quenching of TRβ LBD...
May 15, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29759594/liquid-chromatography-mass-spectrometry-based-metabolomics-and-lipidomics-reveal-toxicological-mechanisms-of-bisphenol-f-in-breast-cancer-xenografts
#7
Chao Zhao, Peisi Xie, Hailin Wang, Zongwei Cai
Bisphenol F (BPF) is a major alternative to bisphenol (BPA) and has been widely used. Although BPA exposure is known to generate various toxic effects, toxicity of BPF remains under-explored. A comprehensive method involving mass spectrometry (MS)-based global lipidomics and metabolomics, and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI)- MS imaging (MSI) was used to study toxic effects of BPF and the underlying mechanisms on tumor metastasis-related tissues (liver and kidney) in breast cancer xenografts...
May 5, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29758456/gper-hippo-yap-signal-is-involved-in-bisphenol-s-induced-migration-of-triple-negative-breast-cancer-tnbc-cells
#8
Qianqian Deng, Guanmin Jiang, Yingmin Wu, Jiexin Li, Weiting Liang, Likun Chen, Qiao Su, Wuguo Li, Jun Du, Chris K C Wong, Zhuojia Chen, Hongsheng Wang
Nowadays, risk factors of triple-negative breast cancer (TNBC) metastasis are not well identified. Our present study reveals that an industrial chemical, bisphenol S (BPS), can promote the migration, but not the proliferation, of TNBC cells in vitro. BPS activates YAP, a key effector of Hippo pathway, by inhibiting its phosphorylation, which promotes YAP nuclear accumulation and up-regulates its downstream genes such as CTGF and ANKRD1. Inhibition of YAP blocks the BPS-triggered cell migration and up-regulation of fibronectin (FN) and vimentin (Vim)...
May 8, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29758382/effects-of-exposure-to-bpf-on-development-and-sexual-differentiation-during-early-life-stages-of-zebrafish-danio-rerio
#9
Qian Yang, Xianhai Yang, Jining Liu, Yingwen Chen, Shubao Shen
Bisphenol F (BPF) has become a predominant bisphenol contaminant in recent years. It has significant estrogenic properties in both in vivo and in vitro studies. We have previously studied the disrupting mechanisms of BPF on the hypothalamic-pituitary-gonadal axis of adult zebrafish. However, the effects of BPF exposure on development and sexual differentiation of zebrafish embryos/larvae remain unclear. To determine the effects of BPF on the critical stage of sex differentiation in zebrafish, zebrafish embryos/larvae were exposed to 1, 10, 100, and 1000 μg/L BPF from fertilization to 60 days post-fertilization (dpf)...
May 11, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29757174/magnetic-solid-phase-extraction-for-the-analysis-of-bisphenol-a-naproxen-and-triclosan-in-wastewater-samples
#10
Guo Li, Ruoyu Deng, Guilong Peng, Chun Yang, Qiang He, Ying Lu, Huilan Shi
Magnetic Fe3 O4 graphene oxide nanocomposite was synthesized by chemical coprecipitation method and characterized by scanning electron microscopy, Fourier transform infrared spectra and X-ray diffraction. A simple, rapid, convenient and environmentally friendly method was developed for separation and pre-concentration of trace amounts of bisphenol A, naproxen and triclosan in wastewater samples by high performance liquid chromatography with magnetic Fe3 O4 graphene oxide nanocomposite as the adsorbent for magnetic solid-phase extraction...
May 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29754027/urinary-concentrations-of-phthalate-metabolites-bisphenols-and-personal-care-product-chemical-biomarkers-in-pregnant-women-in-israel
#11
Ronit Machtinger, Tamar Berman, Michal Adir, Abdallah Mansur, Andrea A Baccarelli, Catherine Racowsky, Antonia M Calafat, Russ Hauser, Ravit Nahum
Mounting evidence suggests possible adverse effects of intrauterine exposure to certain phenols and phthalates, two classes of endocrine disruptor chemicals, on the developing fetus, with consequences into later life. These findings have contributed to the replacement of some chemicals, such as di‑2‑ethylhexyl phthalate (DEHP) and bisphenol A (BPA), in consumer products. For the current study we quantified urinary concentrations of biomarkers of exposure among 50 pregnant women in Israel to several phthalates, bisphenols and personal care product chemicals, as well as DEHP and BPA alternatives...
May 10, 2018: Environment International
https://www.readbyqxmd.com/read/29753982/does-urinary-bisphenol-a-change-after-bariatric-surgery
#12
Carl L Dambkowski, Luis Garcia, Natalia Leva, John M Morton
BACKGROUND: One of the world's highest volume chemicals is bisphenol-A (BPA), an organic compound with a high solubility in fat. An emerging body of literature has suggested a link between BPA and obesity and insulin resistance. The study aim is to determine if surgical weight loss is associated with changes in BPA levels. METHODS: Demographic, preoperative, and 3, 6, and 12 month postoperative urine and laboratory data were prospectively collected on 22 bariatric surgery patients at a single academic institution...
May 10, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29753715/disposition-and-metabolism-of-the-bisphenol-analogue-bisphenol-s-in-harlan-sprague-dawley-rats-and-b6c3f1-n-mice-and-in-vitro-in-hepatocytes-from-rats-mice-and-humans
#13
Suramya Waidyanatha, Sherry R Black, Rodney W Snyder, Yun Lan Yueh, Vicki Sutherland, Purvi R Patel, Scott L Watson, Timothy R Fennell
With the removal of bisphenol A (BPA) from many consumer products, the potential use of alternatives such as bisphenol S (BPS) and its derivatives is causing some concerns. These studies investigated the comparative in vitro hepatic clearance and metabolism of BPS and derivatives and the disposition and metabolism of BPS in rats and mice following gavage and intravenous administration. The clearance of BPS and its derivatives was slower in human hepatocytes than in rodents. In male rats following gavage administration of 50, 150, and 500 mg/kg [14 C]BPS the main route of excretion was via urine; the urinary excretion decreased (72 to 48%) and the fecal excretion increased (16 to 30%) with increasing dose...
May 10, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29753456/quaternary-ammonium-functionalized-mcm-48-mesoporous-silica-as-a-sorbent-for-the-dispersive-solid-phase-extraction-of-endocrine-disrupting-compounds-in-water
#14
Shijuan Zhang, Fengli Lu, Xiaoyun Ma, Mingbo Yue, Yanxin Li, Jiammin Liu, Jinmao You
MCM-48 mesoporous silica was functionalized with dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride, a quaternary ammonium salt with a long hydrophobic chain, to prepare a new sorbent for the dispersive solid-phase extraction (DSPE) of seven endocrine disrupting compounds (EDCs) including 4-hexylphenol, 4-octylphenol, 4-nonylphenol, bisphenol A, estrone, 17β-estradiol and estriol in water. A series of differently functionalized MCM-48 materials were also synthesized, and they served as reference materials to study the mechanism...
May 7, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29752986/perinatal-bpa-exposure-and-reproductive-axis-function-in-cd-1-mice
#15
Nicole Acevedo, Beverly S Rubin, Cheryl M Schaeberle, Ana M Soto
Perinatal Bisphenol-A (BPA) exposure reduces fertility and fecundity in mice. This study examined effects of early BPA exposure on activation of gonadotropin releasing hormone (GnRH) neurons in conjunction with a steroid-induced luteinizing hormone (LH) surge, characterized patterns of estrous cyclicity and fertility over time, and assessed the ovarian follicular reserve to further explore factors responsible for the reduced fertility we previously described in this model. The percent activated GnRH neurons was reduced in BPA exposed females at 3-6 months, and periods of persistent proestrus was increased...
May 9, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29751307/systematic-screening-and-identification-of-the-chlorinated-transformation-products-of-aromatic-pharmaceuticals-and-personal-care-products-using-high-resolution-mass-spectrometry
#16
Wen-Ling Chen, Jiun-Yi Cheng, Xiao-Qian Lin
Pharmaceuticals and personal care products (PPCPs) are an emerging concern because of the large amount of PPCPs that is discharged and its potential ecological effects on the aquatic environment. Chlorination has proven efficient for removing some aromatic PPCPs from wastewater, but the formation of by-products has not been thoroughly investigated partly because of analytical difficulties. This study developed a method for systematically screening and identifying the transformation products (TPs) of multiple aromatic PPCPs through high-resolution mass spectrometry (HRMS)...
May 8, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29751163/associations-of-female-exposure-to-bisphenol-a-with-fecundability-evidence-from-a-preconception-cohort-study
#17
Bin Wang, Wei Zhou, Wenting Zhu, Lin Chen, Weiye Wang, Ying Tian, Lisong Shen, Jun Zhang
BACKGROUND: Human exposure to bisphenol A (BPA) is common. The reproductive toxicity of BPA has been well characterized. However, the impact of BPA exposure on fecundability in healthy women is less clear, and evidence from eastern countries is lacking. OBJECTIVES: We aimed to prospectively assess the associations of BPA with female fecundability, as measured by time to pregnancy (TTP). METHODS: From 2013 to 2015, we included 700 Chinese couples attempting pregnancy in two preconception care clinics and followed for 12 months or until a pregnancy occurred...
May 8, 2018: Environment International
https://www.readbyqxmd.com/read/29750099/the-effect-of-incorporating-different-concentrations-of-chlorhexidine-digluconate-on-the-degree-of-conversion-of-an-experimental-adhesive-resin
#18
Lamiaa-Mahmoud Moharam, Haidy-Nabil Salem, Hanaa-Mahmoud Elgamily
Background: The aim of this study was to evaluate the effect of chlorhexidine digluconate incorporation on the degree of conversion of an experimental adhesive resin. Material and Methods: The experimental resin was prepared from 70 wt% bisphenol A glycerolate dimethacrylate, 30 wt% hydroxyethyl methacrylate, silanized SiO2 nanofillers, 0.5% of camphorquinone and ethyl 4-dimethylaminebenzoate (binary photo-initiator system). Five chlorhexidine digluconate concentrations (0, 0...
April 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29748175/long-term-exposure-to-very-low-doses-of-bisphenol-s-affects-female-reproduction
#19
Jan Nevoral, Yaroslav Kolinko, Jiri Moravec, Tereza Zalmanova, Kristyna Hoskova, Sarka Prokesova, Pavel Klein, Kamar Ghaibour, Petr Hosek, Miriam Stiavnicka, Hedvika Rimnacova, Zbynek Tonar, Jaroslav Petr, Milena Kralickova
Bisphenols belong to the endocrine disruptors, affecting reproduction even in extremely low doses. Bisphenol S (BPS) has become widely used as a substitute for the earlier-used BPA; however, its harmnessless is questionable. The aim of this study was to evaluate the effect of BPS on folliculogenesis and oocyte quality after in vivo exposure to low doses of BPS. 4-week-old ICR females (N = 16 in each experimental group) were exposed to vehicle control (VC), BPS1 (0.001 ng BPS . g bw-1 . day-1), BPS2 (0.1 ng ...
May 10, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29746863/bisphenol-a-elicited-mir-146a-5p-impairs-murine-testicular-steroidogenesis-through-negative-regulation-of-mta3-signaling
#20
Guo-Zheng Gao, Yong Zhao, Hong-Xin Li, Wei Li
The epigenetic effects on expression of non-coding RNAs (e.g. microRNAs) of environmental toxin bisphenol A (BPA) have extended our understanding of the etiology of human reproductive disorders including hypospermatogenesis and androgen deficiency. BPA-induced miR-146a-5p is a potent regulator of endocrine and immune homeostasis, but its role in testis remain unexplored. We show here that in murine testis, miR-146a-5p was exclusively expressed in interstitial Leydig cells (LCs). This expression was significantly induced by BPA exposure...
May 7, 2018: Biochemical and Biophysical Research Communications
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