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Bisphenol A

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https://www.readbyqxmd.com/read/28741288/predictions-of-tuning-spin-coupling-interactions-in-the-nitroxide-based-bisphenol-like-diradicals
#1
Meiyu Song, Xinyu Song, Yuxiang Bu
The intramolecular spin coupling interactions of bisphenol-like trinary-bridged diradicals (nitroxide-(para/meta)phenylene-X-phenylene(para/meta)-nitroxide, X= C=CH2,O,BH, NH, SO2) were explored with an emphasis on the tuning role of X at the B3LYP/6-311++G(d,p) level. The results indicate that all designed diradicals exhibit different diradical characters and magnetisms, depending on the structures and properties of X. Interestingly, although meta/para-phenylene supports a ferromagnetic (FM)/antiferromagnetic (AFM) coupling, their combinations with an inserting X as a trinary bridge can mediate spin coupling but the coupling magnitude strongly depends on X...
July 24, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28741210/effects-of-bpf-on-steroid-hormone-homeostasis-and-gene-expression-in-the-hypothalamic-pituitary-gonadal-axis-of-zebrafish
#2
Qian Yang, Xianhai Yang, Jining Liu, Wenjuan Ren, Yingwen Chen, Shubao Shen
Bisphenol F (BPF) has been frequently detected in various environmental compartments, and previous studies found that BPF exhibits similar estrogenic and anti-androgenic effects on the mammalian endocrine system to those of bisphenol A (BPA). However, the potential disrupting effects of BPF on aquatic organisms and the underling disrupting mechanisms have not been investigated. In this study, the potential disrupting mechanisms of BPF on the hypothalamic-pituitary-gonadal (HPG) axis and liver were probed by employing the OECD 21-day short-term fecundity assay in zebrafish...
July 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28739533/effect-of-bisphenol-a-bpa-on-insulin-signal-transduction-and-glut4-translocation-in-gastrocnemius-muscle-of-adult-male-albino-rat
#3
Mullainadhan Vigneswari, Viswanathan Mangala Priya, Karundevi Balasubramanian
Environmental estrogens bind to estrogen receptors, mimic estrogenic actions, and have adverse effects on human health like Bisphenol - A (BPA) which is used as a monomer in the production of polycarbonate plastics (PC) and epoxy resins which are used in variety of canned foods. Skeletal muscle plays an essential role in maintaining systemic glucose metabolism. In the present study, we investigated the possible effects of BPA on insulin signalling molecules and GLUT4 translocation in the gastrocnemius muscle of adult male rat...
July 21, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28738570/determination-of-selected-bisphenols-parabens-and-estrogens-in-human-plasma-using-lc-ms-ms
#4
Lucie Kolatorova Sosvorova, Tereza Chlupacova, Jana Vitku, Martin Vlk, Jiri Heracek, Luboslav Starka, David Saman, Marketa Simkova, Richard Hampl
In this study, a novel liquid chromatography - tandem mass spectrometry method for the simultaneous determination of bisphenols (BPA, BPS, BPF, BPAF), parabens (methyl-, ethyl-, propyl-, butyl-, benzyl-paraben) and estrogens (estrone, estradiol, estriol) in human plasma is presented. Since all analytes possess the phenolic group, dansyl chloride derivatization was applied in order to gain high sensitivity. The method was validated according to FDA guidelines, and all validation requirements were satisfactory...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738530/prenatal-low-level-phenol-exposures-and-birth-outcomes-in-china
#5
Guodong Ding, Caifeng Wang, Angela Vinturache, Shasha Zhao, Rui Pan, Wenchao Han, Limei Chen, Weiye Wang, Tao Yuan, Yu Gao, Ying Tian
Phenolic compounds are among the endocrine disruptors which are widely used in daily life products. Studies in laboratory animals showed reproductive and developmental effects. In spite of widespread exposure to phenols, only few studies examined their effects on human development. This study was designed to investigate the relationship between antenatal phenol exposure and birth outcomes in a Chinese obstetric population. Four hundred ninety-six mother-infant pairs recruited from the Laizhou Wan prospective birth cohort in northern China between 2010 and 2013 were included in the study...
July 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28736785/rapid-and-ultrasensitive-detection-of-endocrine-disrupting-chemicals-using-a-nanosensor-enabled-cell-based-platform
#6
Ngoc D B Le, Xian Wang, Yingying Geng, Rui Tang, Gulen Yesilbag Tonga, Ziwen Jiang, Vincent M Rotello
Endocrine disrupting chemicals (EDCs) interact with estrogen receptors (ERs), causing a broad range of adverse health effects. Current assays for EDC activity are slow and often lack sensitivity. We report here an ultra-sensitive nanosensor that can detect estrogenic cellular changes in ER(+) MCF-7 cells rapidly (minutes) at several orders of magnitude lower than the generally used assays. Notably, the sensor responses at these ultra-low EDC levels correlated with an increased synthesis phase (S-phase) cell population of EDC-treated cells...
July 24, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28736254/bisphenol-a-affects-trophoblast-invasion-by-inhibiting-cxcl8-expression-in-decidual-stromal-cells
#7
Xiaoqian Li, Yina Wang, Pu Wei, Dongyan Shi, Shuang Wen, Fengjiao Wu, Lixin Liu, Ninghe Ye, Hong Zhou
Bisphenol A (BPA), an environmental endocrine-disrupting organic chemical, has been positively associated with the rate of implantation failure of in vitro fertilization. However, the underlying mechanisms remain unclear. To reveal the impact and the underlying mechanism of BPA on the crosstalk between trophoblast and decidual stromal cells (DSCs), we determined whether BPA was able to affect trophoblast invasion in vitro. We found that BPA significantly inhibited CXCL8 expression in DSCs, which hindered trophoblast invasion, and activated the phosphorylation of ERK in DSCs...
July 20, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28736150/prenatal-environmental-chemical-exposures-and-longitudinal-patterns-of-child-neurobehavior
#8
Joseph M Braun, Kimberly Yolton, Shaina L Stacy, Bahar Erar, George D Papandonatos, David C Bellinger, Bruce P Lanphear, Aimin Chen
BACKGROUND: Prenatal chemical exposures may adversely affect neurodevelopment, but few studies have examined the persistence of these associations. We examined whether associations between prenatal bisphenol A (BPA) or polybrominated diphenyl ether (PBDE) exposures persist or resolve as children age. METHODS: We followed 346 mother-child pairs (enrolled 2003-2006) from Cincinnati, OH from pregnancy until children were 8 years old. We measured BPA in urine collected at 16 and 26 weeks gestation and PBDE-47 in serum collected at 16 weeks gestation...
July 20, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28735473/low-concentration-bpaf-and-bpf-induced-cell-biological-effects-are-mediated-by-ros-in-mcf-7-breast-cancer-cells
#9
Bingli Lei, Su Sun, Jie Xu, Chenglian Feng, Yingxin Yu, Gang Xu, Minghong Wu, Wei Peng
Reactive oxygen species (ROS) induced by bisphenol A (BPA) have been implicated in cellular oxidative damage and carcinogenesis. It is not known whether the potential alternatives of BPA, bisphenol AF (BPAF), and bisphenol F (BPF) can also induce ROS involved in mediating biological responses. This study evaluated the toxicity of BPAF and BPF on cell proliferation, DNA damage, intracellular calcium homeostasis, and ROS generation in MCF-7 human breast cancer cells. The results showed that BPAF at 0.001-1 μM and BPF at 0...
July 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28734604/a-hybrid-material-as-a-sorbent-phase-for-the-disposable-pipette-extraction-technique-enhances-efficiency-in-the-determination-of-phenolic-endocrine-disrupting-compounds
#10
Gabriela Corazza, Josias Merib, Hérica A Magosso, Otávio R Bittencourt, Eduardo Carasek
In this study, the hybrid material 3-n-propyl(3-methylpyridinium) silsesquioxane chloride (Si3Py(+)Cl(-)) was synthesized and investigated as a novel sorbent phase for the disposable pipette extraction (DPX) technique coupled to high-performance liquid chromatography-florescence detection. This sorbent phase was characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Aqueous samples containing the phenolic endocrine-disrupting compounds bisphenol A (BPA), 17α-ethynylestradiol (EE2), 4-tert-octylphenol (4-t-OP), 4-octylphenol (4-OP) and 4-nonylphenol (4-NP) were subjected to DPX procedures and a series of optimizations was performed to determine the ideal extraction conditions using this approach...
July 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28734567/effect-of-calcium-phosphate-nanocomposite-on-in-vitro-remineralization-of-human-dentin-lesions
#11
Michael D Weir, Jianping Ruan, Ning Zhang, Laurence C Chow, Ke Zhang, Xiaofeng Chang, Yuxing Bai, Hockin H K Xu
OBJECTIVE: Secondary caries is a primary reason for dental restoration failures. The objective of this study was to investigate the remineralization of human dentin lesions in vitro via restorations using nanocomposites containing nanoparticles of amorphous calcium phosphate (NACP) or NACP and tetracalcium phosphate (TTCP) for the first time. METHODS: NACP was synthesized by a spray-drying technique and incorporated into a resin consisting of ethoxylated bisphenol A dimethacrylate (EBPADMA) and pyromellitic glycerol dimethacrylate (PMGDM)...
July 19, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28733891/consequences-of-bisphenol-a-perinatal-exposure-on-immune-responses-and-gut-barrier-function-in-mice
#12
Yann Malaisé, Sandrine Ménard, Christel Cartier, Corinne Lencina, Caroline Sommer, Eric Gaultier, Eric Houdeau, Laurence Guzylack-Piriou
The potent immunomodulatory effect of the endocrine disruptor bisphenol A during development and consequences during life span are of increasing concern. Particular interests have been raised from animal studies regarding the risk of developing food intolerance and infection. We aimed to identify immune disorders in mice triggered by perinatal exposure to bisphenol A. Gravid mice were orally exposed to bisphenol (50 μg/kg body weight/day) from day 15 of pregnancy until weaning. Gut barrier function, local and systemic immunity were assessed in adult female offspring...
July 21, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28733818/occurrence-and-distribution-of-six-selected-endocrine-disrupting-compounds-in-surface-and-groundwaters-of-the-romagna-area-north-italy
#13
Emanuela Pignotti, Marinella Farré, Damià Barceló, Enrico Dinelli
Endocrine disrupting compounds (EDCs) are a wide group of contaminants of emerging concern known to be harmful for organisms. The aim of the study was to assess the occurrence and distribution of six EDCs (estrone-E1, ß-estradiol-E2, 17α-ethinylestradiol-EE2, bisphenol A-BPA, perfluooctanoic acid-PFOA, perfluorooctane sulfonate-PFOS) in the Apenninic rivers and groundwaters of the Romagna area (North of Italy). Groundwaters were unaffected by EDC contamination, while all classes of compounds were detected at concentrations above the method quantification limit (MQL) in the majority of the river bodies...
July 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28733001/degradation-of-endocrine-disruptor-bisphenol-a-by-ultrasound-assisted-electrochemical-oxidation-in-water
#14
Matz Dietrich, Marcus Franke, Michael Stelter, Patrick Braeutigam
Micropollutants are becoming an increasing problem for the environment and wastewater treatment. One example is Bisphenol A (BPA), an endocrinic disruptor, which is widely used in plastic production. Due to its endocrine disrupting effects on aquatic (micro-)organisms and its ubiquity, in surface- and wastewater alike, adequate treatment techniques are necessary. In this study, the degradation of BPA by a sonoelectrochemical hybrid system was investigated, using a low frequency (24kHz) ultrasound horn and two boron doped diamond electrodes...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732976/preparation-of-waterborne-dispersions-of-epoxy-resin-by-ultrasonic-assisted-supercritical-co2-nanoemulsification-technique
#15
Hanyang Gao, Guoxin Hu, Kun Liu, Liqun Wu
Waterborne nanoemulsion of diglycidyl ether of bisphenol A type epoxy resin (DGEBA) with droplet size of around 124nm was prepared by using an ultrasonic-assisted supercritical carbon dioxide (scCO2) technique in an autoclave reactor at a low temperature (32°C). A view cell positioned in-line with the ultrasonic probe allowed observation of the emulsification process. From the image analysis and droplet size measurement, the influence mechanisms of the ultrasonic power, the degree of mixing of scCO2 with DGEBA, the adding amount of emulsifier, and the system pressure on emulsification process and emulsion droplet size were investigated...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732298/stomatal-and-non-stomatal-factors-regulated-the-photosynthesis-of-soybean-seedlings-in-the-present-of-exogenous-bisphenol-a
#16
Liya Jiao, Lihong Wang, Qing Zhou, Xiaohua Huang
Bisphenol A (BPA) is an emerging environmental endocrine disruptor that has toxic effects on plants growth. Photosynthesis supplies the substances and energy required for plant growth, and regulated by stomatal and non-stomatal factors. Therefore, in this study, to reveal how BPA affects photosynthesis in soybean seedlings (Glycine max L.) from the perspective of stomatal and non-stomatal factors, the stomatal factors (stomatal conductance and behaviours) and non-stomatal factors (Hill reaction, apparent quantum efficiency, Rubisco activity, carboxylation efficiency, the maximum Rubisco carboxylation velocity, ribulose-1,5-bisphospate regeneration capacities mediated by maximum electron transport rates, and triose phosphate utilization rate) were investigated using a portable photosynthesis system...
July 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28729173/bisphenol-a-impairs-decidualization-of-human-uterine-stromal-fibroblasts
#17
Mark R Olson, Renwei Su, Jodi A Flaws, Asgerally T Fazleabas
This study examined the effect of bisphenol A (BPA) exposure on human uterine stromal fibroblast cells (HuF) undergoing decidualization. HuF cells were isolated and cultured for eight days in the presence of a decidualization-inducing cocktail, while concurrently exposed to physiological and supra-physiologic doses of BPA (1ng/mL, 10ng/mL, 0.5μg/mL, 10μg/mL and 20μg/mL). Decidualization markers, steroid hormone receptors and cell cycle gene expression were detected by qRT-PCR and cellular proliferation was assessed by KI-67 immunofluorescent staining and MTS assay...
July 17, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28728138/first-trimester-urinary-bisphenol-a-concentration-in-relation-to-anogenital-distance-an-androgen-sensitive-measure-of-reproductive-development-in-infant-girls
#18
Emily S Barrett, Sheela Sathyanarayana, Omar Mbowe, Sally W Thurston, J Bruce Redmon, Ruby H N Nguyen, Shanna H Swan
INTRODUCTION: Evidence from animal models suggests that prenatal exposure to bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, is associated with adverse reproductive outcomes in females. Exposure during early gestation, a critical period for reproductive development, is of particular concern. Anogenital distance (AGD) is a sensitive biomarker of the fetal hormonal milieu and a measure of reproductive toxicity in animal models. In some studies, the daughters of BPA-exposed dams have shorter AGD than controls...
July 11, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28728135/prostate-cancer-risk-and-dna-methylation-signatures-in-aging-rats-following-developmental-bpa-exposure-a-dose-response-analysis
#19
Gail S Prins, Shu-Hua Ye, Lynn Birch, Xiang Zhang, Ana Cheong, Han Lin, Esther Calderon-Gierszal, Jacob Groen, Wen-Yang Hu, Shuk-Mei Ho, Richard B van Breemen
BACKGROUND: Previous studies have uncovered heightened prostatic susceptibility to hormone-induced neoplasia from early-life exposure to low-dose bisphenol A (BPA). However, significant data gaps remain that are essential to address for biological relevance and necessary risk assessment. OBJECTIVES: A complete BPA dose-response analysis of prostate lesions across multiple prostatic lobes was conducted that included internal BPA dosimetry, progression to adenocarcinoma with aging and mechanistic connections to epigenetically reprogramed genes...
July 11, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28727988/environmental-exposures-and-pediatric-kidney-function-and-disease-a-systematic-review
#20
REVIEW
Laura Y Zheng, Alison P Sanders, Jeffrey M Saland, Robert O Wright, Manish Arora
BACKGROUND: Environmental chemical exposures have been implicated in pediatric kidney disease. No appraisal of the available evidence has been conducted on this topic. METHODS: We performed a systematic review of the epidemiologic studies that assessed association of environmental exposures with measures of kidney function and disease in pediatric populations. The search period went through July 2016. RESULTS: We found 50 studies that met the search criteria and were included in this systematic review...
July 17, 2017: Environmental Research
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