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Bisphenol A

Xanthi D Andrianou, Stephanie Gängler, Andra Piciu, Pantelis Charisiadis, Christina Zira, Kyriacos Aristidou, Doina Piciu, Russ Hauser, Konstantinos C Makris
Although the increasing prevalence of thyroid nodular disease (TND) has been partially attributed to the more frequent usage of improved diagnostics, environmental factors, such as exposures to thyroid-disrupting chemicals may contribute to TND and altered thyroid function. We investigated the association between exposures to bisphenol A (BPA), its chlorinated derivatives (ClxBPA), and bisphenol F (BPF) with TND and thyroid measures in adult women. A case-control study in Cyprus and Romania (n = 212) was conducted, where cases were those with thyroid nodules (diameter >3mm), and controls without nodules...
2016: PloS One
Donatella Paola Provvisiero, Claudia Pivonello, Giovanna Muscogiuri, Mariarosaria Negri, Cristina de Angelis, Chiara Simeoli, Rosario Pivonello, Annamaria Colao
Bisphenol A (BPA) is an organic synthetic compound employed to produce plastics and epoxy resins. It is used as a structural component in polycarbonate beverage bottles and as coating for metal surface in food containers and packaging. The adverse effects of BPA on human health are widely disputed. BPA has been recently associated with a wide variety of medical disorders and, in particular, it was identified as potential endocrine-disrupting compound with diabetogenic action. Most of the clinical observational studies in humans reveal a positive link between BPA exposure, evaluated by the measurement of urinary BPA levels, and the risk of developing type 2 diabetes mellitus...
October 6, 2016: International Journal of Environmental Research and Public Health
Sai Zheng, Jia-Chen Shi, Jian-Ying Hu, Wen-Xin Hu, Jing Zhang, Bing Shao
The reaction kinetics and transformation pathways between bisphenol F (BPF) and sodium hypochlorite were investigated at pH values ranging from 6.5 to 8.5 and with different initial concentration ratios. The reaction rate was pH- and free available chlorine (FAC)-dependent: the reaction rate at pH 8.5 was almost 10 times than that at pH 6.5. A total of 40 compounds were tentatively identified as chloro-substituted BPF and polyphenolic compounds by liquid chromatography quadrupole time-of-flight mass spectrometry operating in electrospray ionization mode (LC-ESI-Q-ToF), and 4 main byproducts were confirmed by (1)H and (13)C nuclear magnetic resonance (NMR)...
October 19, 2016: Water Research
Penghui Shao, Xiaoguang Duan, Jun Xu, Jiayu Tian, Wenxin Shi, Shanshan Gao, Mingjun Xu, Fuyi Cui, Shaobin Wang
Recently, tremendous efforts have been devoted to developing carbon-based metal-free catalysts as an alternative to metal-based catalysts for remediation of emerging contaminants. However, further investigations have demonstrated that the durability of carbocatalysts is poor. Therefore, it is extremely desirable to seek a novel metal-free catalyst with high efficiency and superb stability. Herein, we first discovered that amorphous boron (A-boron) can be used as a metal-free catalyst for peroxymonosulfate (PMS) activation to produce free radicals for effective degradation of bisphenol S (BPS), which is a newly-occurring estrogenic endocrine-disrupting chemical...
October 13, 2016: Journal of Hazardous Materials
I Porreca, L Ulloa-Severino, P Almeida, D Cuomo, A Nardone, G Falco, M Mallardo, C Ambrosino
Several studies associate foetal human exposure to bisphenol A (BPA) to metabolic/endocrine diseases, mainly diabesity. They describe the role of BPA in the disruption of pancreatic beta cell, adipocyte and hepatocyte functions. Indeed, the complexity of the diabesity phenotype is due to the involvement of different endoderm-derived organs, all targets of BPA. Here, we analyse this point delineating a picture of different mechanisms of BPA toxicity in endoderm-derived organs leading to diabesity. Moving from epidemiological data, we summarize the in vivo experimental data of the BPA effects on endoderm-derived organs (thyroid, pancreas, liver, gut, prostate and lung) after prenatal exposure...
October 24, 2016: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
Nataša Milošević, Vladimir Jakšić, Jan Sudji, Bojan Vuković, Tijana Ičin, Nataša Milić, Milica Medić Stojanoska
Bisphenol A (BPA) is a ubiquitous environmental pollutant which is often associated with various health issues. In this study 103 healthy female volunteers in reproductive age from Serbian north province Vojvodina were enrolled and examined for the BPA exposure in the urine samples after 12 h of fasting. BPA was found in 35.92 % (37/103) of subjects. Statistically significant increment in waist circumference (p = 0.045) and waist-to-height ratio (p = 0.037) was observed among the BPA positive women in comparison with the women who had the same energetic balance and had not been exposed to BPA...
October 24, 2016: International Journal of Environmental Health Research
Darja Gramec Skledar, Lucija Peterlin Mašič
Structural analogs of bisphenol A are commonly used as its alternatives in industrial and commercial applications. Nevertheless, the question arises whether the use of other bisphenols is justified as replacements for bisphenol A in mass production of plastic materials. To evaluate the influence of metabolic reactions on endocrine activities of bisphenols, we conducted a systematic review of the literature. Knowledge about the metabolic pathways and enzymes involved in metabolic biotransformations is essential for understanding and predicting mechanisms of toxicity...
September 22, 2016: Environmental Toxicology and Pharmacology
Dimosthenis A Sarigiannis, Spyros P Karakitsios, Evangelos Handakas, Konstantina Simou, Ermioni Solomou, Alberto Gotti
The current study aims at a comprehensive risk characterization of bisphenol A (BPA) supported by an integrated exposure modelling framework that comprises far field and near field exposure modelling coupled to a dynamic lifetime PBTK model. Exposure analysis was done on European data of BPA food residues and human biomonitoring (HBM). The latter were further assimilated through an advanced exposure reconstruction modelling framework to estimate the corresponding external and internal systemic dose of BPA and its metabolites...
October 18, 2016: Food and Chemical Toxicology
Ziliang Wang, Dekun Li, Maohua Miao, Hong Liang, Jianping Chen, Zhijun Zhou, Chunhua Wu, Wei Yuan
BACKGROUND: Bisphenol A (BPA) is an environmental endocrine disruptor and is found in many consumer products. Animal studies suggest that BPA may perturb pubertal development in males, although studies in humans are limited. OBJECTIVE: This study investigated the association between BPA exposure and pubertal onset and progression among school-aged boys in Shanghai, China. METHODS: A total of 671 boys aged 9-18 years from three schools (one elementary, one middle, and one high school) in Shanghai were enrolled in a cross-sectional study...
October 15, 2016: International Journal of Hygiene and Environmental Health
D Papadogiannis, A Iliadi, T G Bradley, N Silikas, G Eliades, T Eliades
OBJECTIVE: To evaluate the viscoelastic properties of two experimental BPA-free and one BisGMA-based orthodontic resin composite adhesives for bonding fixed retainers. METHODS: A commercially available BisGMA-based (TXA: Transbond LR) and two bisphenol A-free experimental adhesives (EXA and EXB) were included in the study. The viscoelastic behavior of the adhesives was evaluated under static and dynamic conditions at dry and wet states and at various temperatures (21, 37, 50°C)...
October 18, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Olivier Taboureau, Karine Audouze
During the past decades, many epidemiological, toxicological and biological studies have been performed to assess the role of environmental chemicals as potential toxicants for diverse human disorders. However, the relationships between diseases based on chemical exposure have been rarely studied by computational biology. We developed a human environmental disease network (EDN) to explore and suggest novel disease-disease and chemical-disease relationships. The presented scored EDN model is built upon the integration on systems biology and chemical toxicology using chemical contaminants information and their disease relationships from the reported TDDB database...
October 21, 2016: ALTEX
Xiaotong Cao, Jianquan Luo, John M Woodley, Yinhua Wan
Micro-pollutants present in water have many detrimental effects on the ecosystem. Membrane technology plays an important role in the removal of micro-pollutants but there remain significant challenges such as concentration polarization, membrane fouling and variable permeate quality. The work reported here uses a multifunctional membrane with rejection, adsorption and catalysis functions to solve these problems. Based on mussel-inspired chemistry and biological membrane properties, a multifunctional membrane was prepared by applying 'reverse filtration' of a laccase solution and subsequent 'dopamine coating' on a nanofiltration (NF) membrane support, which was tested on bisphenol A (BPA) removal...
October 21, 2016: ACS Applied Materials & Interfaces
Masaru Nakagawa, Akifumi Nakaya, Yasuto Hoshikawa, Shunya Ito, Nobuya Hiroshiba, Takashi Kyotani
Ultraviolet (UV) nanoimprint lithography is a promising nanofabrication technology with cost efficiency and high throughput for sub-20 nm size semiconductor, data storage, and optical devices. To test formability of organic resist mask patterns, we investigated whether the type of polymerizable di(meth)acrylate monomer affected the fabrication of cured resin nanopillars by UV nanoimprinting using molds with pores of around 20 nm. We used carbon-coated, porous, anodic aluminum oxide (AAO) films prepared by electrochemical oxidation and thermal chemical vapor deposition as molds, because the pore diameter distribution in the range of 10-40 nm was suitable for combinatorial testing to investigate whether UV-curable resins comprising each monomer were filled into the mold recesses in UV nanoimprinting...
October 21, 2016: ACS Applied Materials & Interfaces
Mădălina-Anca Lazar, Horaţiu Rotaru, Ioana Bâldea, Adina B Boşca, Cristian P Berce, Cristina Prejmerean, Doina Prodan, Radu S Câmpian
This study aims to assess the biocompatibility of new advanced fiber-reinforced composites (FRC) to be used for custom-made cranial implants. Four new formulations of FRC were obtained using polymeric matrices (combinations of monomers bisphenol A glycidylmethacrylate [bis-GMA], urethane dimethacrylate [UDMA], triethylene glycol dimethacrylate [TEGDMA], hydroxyethyl methacrylate [HEMA]) and E-glass fibers (300 g/mp). Every FRC contains 65% E-glass and 35% polymeric matrix. Composition of polymeric matrices are: bis-GMA (21%), TEGDMA (14%) for FRC1; bis-GMA (21%), HEMA (14%) for FRC2; bis-GMA (3...
October 2016: Journal of Craniofacial Surgery
Liang Yan, Di Lv, Xinwen Huang, Huixiang Shi, Geshan Zhang
The adsorption behavior of pharmaceuticals and personal care product, Bisphenol-A (BPA), according to four coal-based and four wood-based granular activated carbons modified using outgassing treatment, acidic treatment or alkaline treatment was studied. The adsorption isotherm results indicated that carbon surface acidity played a very important role in the adsorption of BPA. It was found that increasing surface acidity would increase the hydrogen bonding effects and increase adsorption of BPA on activated carbon...
October 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Maria R Hartono, Ariel Kushmaro, Robert S Marks, Xiaodong Chen
In this study, composite calcium-alginate/carbon nanotubes/TiO2 beads were prepared and tested for their potential in the removal of bisphenol A (BPA) from aqueous solutions. The removal traits were inspected using a fixed-bed sorption column. By varying parameters such as bed height (15-20 cm), flow rate (2.0-6.0 mL.min(-1)) and inlet BPA concentration (10-30 mg.L(-1)) we assessed the removal capacity of these composites. The highest sorption capacity of 5.46 mg.g(-1) was achieved at 10 mg.L(-1) BPA concentration, 2...
October 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Hye-Hyeon Byeon, Seung-Woo Lee, Eun-Hee Lee, Woong Kim, Hyunjung Yi
Delicately assembled composites of semiconducting nanomaterials and biological materials provide an attractive interface for emerging applications, such as chemical/biological sensors, wearable health monitoring devices, and therapeutic agent releasing devices. The nanostructure of composites as a channel and a sensing material plays a critical role in the performance of field effect transistors (FETs). Therefore, it is highly desirable to prepare elaborate composite that can allow the fabrication of high performance FETs and also provide high sensitivity and selectivity in detecting specific chemical/biological targets...
October 20, 2016: Scientific Reports
Sohrab Kazemi, Nader Bahramifar, Ali Akbar Moghadamnia, Seyed Gholam Ali Jorsarae
INTRODUCTION: Bisphenol A (BPA) and Nonylphenol (NP) have estrogen-like activity, and some of their adverse biological effects have been demonstrated. This study was designed to determine the association of plasma and tissue concentrations of BPA and NP and changes in the parameters of the reproductive system in rats. METHODS: Male Wistar rats were administered three doses of BPA and NP (5, 25, and 125 μg/kg) by gavage for 35 consecutive days in 2014-2015, and a 2-ml blood sample was taken from each treated rat...
August 2016: Electronic Physician
Guanwu Li, Zheng Xu, Lingmi Hou, Xuefeng Li, Xin Li, Wei Yuan, Maki Polat, Shixin Chang
Bisphenol A diglycidyl ether (BADGE), a PPARγ2 antagonist, has been shown to inhibit marrow adipogenesis and promotes bone formation in intact animals. We investigated the impact of BADGE on a new and more clinically relevant physiological model, the ovariectomized (OVX) rat model. Forty female Wistar rats were divided into four treatment groups (n=10/group): sham+vehicle, sham+BADGE, OVX+vehicle and OVX+BADGE for 12 weeks. Postmortem analyses included MRI, micro-CT, serological test, histomorphometry, biomechanical tests, RT-PCR and western blot...
October 18, 2016: American Journal of Physiology. Endocrinology and Metabolism
Noof A Alenazi, Jeffrey M Manthorpe, Edward P C Lai
Bisphenol A (BPA) is an estrogen-mimicking chemical that can be selectively detected in water using a chemical sensor based on molecularly imprinted polymers (MIPs). However, the utility of BPA-MIPs in sensor applications is limited by the presence of non-specific binding sites. This study explored a dual approach to eliminating these sites: optimizing the molar ratio of the template (bisphenol A) to functional monomer (methacrylic acid) to cross-linker (ethylene glycol dimethacrylate), and esterifying the carboxylic acid residues outside of specific binding sites by treatment with diazomethane...
October 14, 2016: Sensors
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