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Optic glioma

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https://www.readbyqxmd.com/read/29651949/nerve-growth-factor-early-studies-and-recent-clinical-trials
#1
Maria Luisa Rocco, Marzia Soligo, Luigi Manni, Luigi Aloe
Since its discovery, nerve growth factor (NGF) has long occupied a critical role in developmental and adult neurobiology for its many important regulatory functions on the survival, growth and differentiation of nerve cells in the peripheral and central nervous system. NGF is the first discovered member of a family of neurotrophic factors, collectively indicated as neurotrophins, (which include brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin 4/5). NGF was discovered for its action on the survival and differentiation of selected populations of peripheral neurons...
April 11, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29617945/intracranial-neoplasms-in-the-first-year-of-life-results-of-a-third-cohort-of-patients-from-a-single-institution
#2
Sebastian M Toescu, Gregory James, Kim Phipps, Owase Jeelani, Dominic Thompson, Richard Hayward, Kristian Aquilina
BACKGROUND: Brain tumors in the first year of life are rare and their management remains challenging. OBJECTIVE: To report on the contemporary management of brain tumors in infants with reference to previous series from our institution. METHODS: Retrospective cohort study design. Electronic/paper case note review of all brain tumors diagnosed at our institution in children aged <1 yr since the publication of our previous series. RESULTS: Ninety-eight patients were seen...
April 3, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29610993/mno-nanoparticles-with-unique-excitation-dependent-fluorescence-for-multicolor-cellular-imaging-and-mr-imaging-of-brain-glioma
#3
Junxin Lai, Tingjian Wang, Hao Wang, Fengqiang Shi, Wei Gu, Ling Ye
The authors describe MnO nanoparticles (NPs) with unique excitation-dependent fluorescence across the entire visible spectrum. These NPs are shown to be efficient optical nanoprobe for multicolor cellular imaging. Synthesis of the NPs is accomplished by a thermal decomposition method. The MnO NPs exhibit a high r1 relaxivity of 4.68 mM-1  s-1 and therefore give an enhanced contrast effect in magnetic resonance (MR) studies of brain glioma. The cytotoxicity assay, hemolysis analysis, and hematoxylin and eosin (H&E) staining tests verify that the MnO NPs are biocompatible...
April 2, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29604507/confocal-scanning-microscopy-provides-rapid-detailed-intraoperative-histological-assessment-of-brain-neoplasms-experience-with-106-cases
#4
Nikolay L Martirosyan, Joseph Georges, Jennifer M Eschbacher, Evgenii Belykh, Alessandro Carotenuto, Robert F Spetzler, Peter Nakaji, Mark C Preul
OBJECTIVES: Frozen section histological analysis is currently the mainstay for intraprocedural tissue diagnosis during the resection of intracranial neoplasms and for evaluating tumor margins. However, frozen sections are time-consuming and often do not reveal the histological features needed for final diagnosis when compared with permanent sections. Confocal scanning microscopy (CSM) with certain stains may be a valuable technology that can add rapid and detailed histological assessment advantage for the neurosurgical operating room...
March 21, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29589985/a-giant-dermoid-cyst-of-the-orbit
#5
Bipasha Mukherjee, Akruti Desai
To describe a unique case of a non-germinomatous germ cell tumor, a giant orbital dermoid, present in adulthood. A 31-year-old male presented in our clinic with gradual, painless, progressive proptosis in the left eye since 28 years associated with gradual loss of vision. The left eye showed gross proptosis. Ocular structures could not be made out. Computed tomography scan showed a well-circumscribed oval heterogeneous mixed solid and cystic lesion completely filling the left orbit with calcification. The differential diagnosis was that of either teratoma or optic nerve glioma...
March 28, 2018: Orbit
https://www.readbyqxmd.com/read/29570532/endoscopic-transsphenoidal-surgery-for-an-adult-patient-with-giant-exophytic-chiasmatic-hypothalamic-glioma
#6
Jing Wang, Jianwu Jia, Zhaoyuan Hou, Xunhui Yuan, Gaoling Sun, Jianyi Niu, Zhiping Li
Optic pathway hypothalamic gliomas are intrinsic low-grade gliomas involving the optic nerve, chiasm, optic tract, and hypothalamus. The rarity of these tumors and their unpredictable course make assessment and standardization of treatment modalities difficult. Tumor debulking via various transcranial approaches was considered to be effective at controlling tumor growth, but with high rates of severe surgery-related complications. In the present case, endoscopic transsphenoidal surgery was initiated to debulk the exophytic chiasmatic/hypothalamic glioma with good preservation of hypothalamic and endocrine functions...
March 22, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29556577/obsessive-compulsive-disorder-after-therapy-for-an-optic-pathway-glioma
#7
Diana Guzman, Eeva Edds, Soumen Khatua, Susan L McGovern, Rhonda Robert
No abstract text is available yet for this article.
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29534899/single-and-multi-fraction-stereotactic-radiosurgery-dose-tolerances-of-the-optic-pathways
#8
Michael T Milano, Jimm Grimm, Scott G Soltys, Ellen Yorke, Vitali Moiseenko, Wolfgang A Tomé, Arjun Sahgal, Jinyu Xue, Lijun Ma, Timothy D Solberg, John P Kirkpatrick, Louis S Constine, John C Flickinger, Lawrence B Marks, Issam El Naqa
PURPOSE: Dosimetric and clinical predictors of radiation-induced optic nerve/chiasm neuropathy (RION) after single-fraction stereotactic radiosurgery (SRS) or hypofractionated (2-5 fractions) radiosurgery (fSRS) were analyzed from pooled data that were extracted from published reports (PubMed indexed from 1990 to June 2015). This study was undertaken as part of the American Association of Physicists in Medicine Working Group on Stereotactic Body Radiotherapy, investigating normal tissue complication probability (NTCP) after hypofractionated radiation...
January 31, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29527480/delineation-of-the-visual-pathway-in-paediatric-optic-pathway-glioma-patients-using-probabilistic-tractography-and-correlations-with-visual-acuity
#9
Patrick W Hales, Victoria Smith, Deepi Dhanoa-Hayre, Patricia O'Hare, Kshitij Mankad, Felice d'Arco, Jessica Cooper, Ramneek Kaur, Kim Phipps, Richard Bowman, Darren Hargrave, Christopher Clark
Background: Radiological biomarkers which correlate with visual function are needed to improve the clinical management of optic pathway glioma (OPG) patients. Currently, these are not available using conventional magnetic resonance imaging (MRI) sequences. The aim of this study was to determine whether diffusion MRI could be used to delineate the entire optic pathway in OPG patients, and provide imaging biomarkers within this pathway which correlate with a patient's visual acuity (VA)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29511546/intraorbital-ancient-pilocytic-astrocytoma-of-the-optic-nerve-in-neurofibromatosis-type-1-patient-presenting-with-sudden-ocular-pain
#10
Haesu Lee Motoyama, Sohsuke Yamada, Satoko Nakada, Nozomu Kurose, Akihide Tanimoto
Optic nerve pilocytic astrocytoma is an uncommon but well-known entity; however, intraorbital ancient pilocytic astrocytoma of the optic nerve is extremely rarely reported. To our knowledge, this is the first detailed description regarding the intraorbital ancient pilocytic astrocytoma, reported in available English literature, to date. We presented an extremely unusual neurofibromatosis type 1 case of a 17-year-old male's sudden ocular pain secondary to intraorbital pilocytic astrocytoma of the optic nerve with markedly cystic degeneration, fluid production, and hemorrhage, due to ancient and possibly ruptured glioma...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29503567/the-investigation-for-potential-modifier-genes-in-patients-with-neurofibromatosis-type-1-based-on-next-generation-sequencing
#11
Fan Yang, Song Xu, Renwang Liu, Tao Shi, Xiongfei Li, Xuebing Li, Gang Chen, Hongyu Liu, Qinghua Zhou, Jun Chen
Introduction: Neurofibromatosis type 1 (NF1) is a common Mendelian multi-system disorder that is characterized by café-au-lait spots (CLS), axillary freckling, optic glioma and plexiform neurofibroma. Various mutations of the NF1 gene are widely accepted to be the main cause of this disease, while whether there are still certain other modifier genes that could influence the phenotypes of NF1 is our concern. Patients and Methods: One proband and his father are involved, who are characterized by plexiform neurofibroma and cutaneous neurofibroma, respectively...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29502465/isolated-optic-nerve-glioma-in-children-with-and-without-neurofibromatosis-retrospective-characterization-and-analysis-of-outcomes
#12
Dima Hamideh, Mary Ellen Hoehn, Julie H Harreld, Paul D Klimo, Amar Gajjar, Ibrahim Qaddoumi
Isolated optic nerve glioma is a rare tumor with no consensus for the best therapeutic approach. Therefore, tumor control and preservation of visual function remain a challenge. In this retrospective study, we describe our experience over 30 years in a single-institutional cohort of children with isolated optic nerve glioma, focusing on treatments and visual outcomes. Seventeen children were followed for a median period of 8 years (range, 2-22 years). Diagnosis was based on typical neuroradiologic findings, and 3 patients had histologic confirmation of their tumors...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29483987/neurofibromatosis-type-1-with-massive-ventricular-polyposis-first-report-in-the-medical-literature
#13
Georgi Tchernev, Anastasiya Atanasova Chokoeva, Uwe Wollina, Torello Lotti, Georgi Konstantinov Maximov, Ilia Lozev
BACKGROUND: Neurofibromatosis type 1 ( NF1 ) is a multisystemic disorder with genetic background, characterised by specific cutaneous findings, skeletal dysplasias, and growth of both benign and malignant nervous system tumours. NF1 is caused by mutations in the NF1 gene, situated in chromosome 17q11.2, with an autosomal dominant pattern of inheritance and clinical manifestation of neurofibromas, malignant peripheral nerve sheath tumour, optic and non-optic nerve gliomas, congenital heart disease, cardiovascular and cerebrovascular disease and orthopaedic disorders...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29475609/moya-moya-syndrome-after-cranial-radiation-for-optic-glioma-with-nf1-case-report-and-literature-review-of-syndromic-cases
#14
P Brandicourt, L Bonnet, Y Béjot, C Drouet, T Moulin, L Thines
INTRODUCTION: Moya-Moya angiopathy is a neurovascular disease that predisposes to ischemic or hemorrhagic strokes. It is generated by a steno-occlusion of the terminal portion of the internal carotid arteries, which induces the development of abnormal neovessels in the deep regions of the brain. Some pathologies such as sickle cell disease, Down syndrome or Graves' disease may be associated with Moya-Moya angiopathy. These syndromic forms harbor several differences compared with idiopathic Moya-Moya disease...
March 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29455398/mr-imaging-of-neoplastic-and-non-neoplastic-lesions-of-the-brain-and-spine-in-neurofibromatosis-type-i
#15
Ahmed Abdel Khalek Abdel Razek
The aim of this work is to review the MR imaging of neoplastic and non-neoplastic lesions of the brain and spine in neurofibromatosis type I. Neoplastic lesions are optic pathway gliomas, brain stem gliomas, other gliomas of the brain, and peripheral nerve sheath tumors. Structural changes in the brain include unidentified bright objects, macrocephaly, and enlarged corpus callosum. Bony dysplasia changes as sphenoid ridge dysplasia, spinal scalloping, dural ectasia, and meningoceles. Vasculopathy and cortical cerebral and cerebellar malformations of the brain have been reported...
February 17, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29441040/intraoperative-photodynamic-diagnosis-using-talaporfin-sodium-simultaneously-applied-for-photodynamic-therapy-against-malignant-glioma-a-prospective-clinical-study
#16
Kazuhide Shimizu, Masayuki Nitta, Takashi Komori, Takashi Maruyama, Takayuki Yasuda, Yu Fujii, Ken Masamune, Takakazu Kawamata, Taketoshi Maehara, Yoshihiro Muragaki
Objective: The goal of this study was to demonstrate the feasibility of intraoperative photodynamic diagnosis (PDD) of malignant glioma using the fluorescence from talaporfin sodium (TS), which is used simultaneously for photodynamic therapy (PDT). Methods: Patients with suspected primary malignant glioma who were eligible for surgical removal of the tumor and PDT with TS were enrolled in this prospective study. Tissue samples were obtained from the contrast-enhanced (CE) region and from the surrounding non-contrast-enhanced (NCE) marginal tissue at the boundary between the tumor and normal tissue...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29426453/progressive-optic-nerve-glioma-orbital-biopsy-technique-using-a-surgical-navigation-system
#17
Ahsen Hussain, Michael Wan, Dan DeAngelis
No abstract text is available yet for this article.
February 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29424646/optic-pathway-hypothalamic-glioma-hemorrhage-a-series-of-9-patients-and-review-of-the-literature
#18
Kirsten van Baarsen, Jonathan Roth, Natalia Serova, Roger J Packer, Ben Shofty, Ulrich-W Thomale, Giuseppe Cinalli, Helen Toledano, Shalom Michowiz, Shlomi Constantini
OBJECTIVE Hemorrhage (also known as apoplexy) in optic pathway gliomas (OPGs) is rare. Because of the variable presentations and low incidence of OPG hemorrhages, little is known about their clinical course and the best treatment options. The aim of this work was to review risk factors, clinical course, and treatment strategies of optic glioma hemorrhages in the largest possible number of cases. METHODS A total of 34 patients were analyzed. Nine new cases were collected, and 25 were identified in the literature...
February 9, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29419946/photoacoustic-microscopy-for-evaluating-combretastatin-a4-phosphate-induced-vascular-disruption-in-orthotopic-glioma
#19
Renzhe Bi, Ghayathri Balasundaram, Seungwan Jeon, Hui Chien Tay, Yang Pu, Xiuting Li, Mohesh Moothanchery, Chulhong Kim, Malini Olivo
The use of an optical resolution photoacoustic microscopy system (OR-PAM) to evaluate the vascular disruptive effect of Combretastatin A4 Phosphate (CA4P) on a murine orthotopic glioma with intact skull is described here. Second generation optical-resolution PAM scanner with a 532 nm pulsed diode-pumped solid-state (DPSS) laser that specifically matches the absorption maximum of haemoglobin in tissues was used to image orthotopic glioma inoculated in mouse brain. 2D maps of brain vasculature with a lateral resolution of 5 μm and a depth of 700 μm at a field of view 5 × 4 mm were acquired on normal brain and glioma brain...
February 8, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29397378/intraoperative-optical-imaging-of-metabolic-changes-after-direct-cortical-stimulation-a-clinical-tool-for-guidance-during-tumor-resection
#20
Martin Oelschlägel, Tobias Meyer, Gabriele Schackert, Matthias Kirsch, Stephan B Sobottka, Ute Morgenstern
Brain tumor resection is even today one of the most challenging disciplines in neurosurgery. The current state of the art for the identification of tumor tissue during the surgical procedure comprises a wide variety of different tools, each with its own limitations and drawbacks. In this paper, we present a novel approach, the use of optical imaging in connection with direct electrical cortical stimulation (DCS), for identification of impaired tumor tissue and functional intact normal brain tissue under intraoperative conditions...
February 5, 2018: Biomedizinische Technik. Biomedical Engineering
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