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Excessive exercise

Hashim Islam, Logan K Townsend, Tom J Hazell
PURPOSE: Few studies have directly compared excess postexercise oxygen consumption (EPOC) and fat utilization following different exercise intensities, and the effect of continuous exercise exceeding 75% of maximal oxygen uptake (VO2 max) on these parameters remains unexplored. The current study examined EPOC and fat utilization following acute moderate- and vigorous-intensity continuous training (MICT and VICT) and sprint interval training (SIT). METHODS: Eight active young men performed 4 experimental sessions: (a) MICT (30 min of running at 65% VO2 max); (b) VICT (30 min of running at 85% VO2 max); (c) SIT (4 30-s "all-out" sprints with 4 min of rest); and (d) no exercise (REST)...
October 16, 2018: Research Quarterly for Exercise and Sport
Luciana da C Oliveira, Gustavo P de Morais, Alisson L da Rocha, Giovana R Teixeira, Ana P Pinto, Larissa G de Vicente, José R Pauli, Leandro P de Moura, Rania A Mekary, Eduardo R Ropelle, Dennys E Cintra, Adelino S R da Silva
Exhaustive and chronic physical exercise leads to peripheral inflammation, which is one of the molecular mechanisms responsible for the impairment of the insulin signaling pathway in the heart. Recently, 3 different running overtraining models performed downhill (OTR/down), uphill (OTR/up), and without inclination (OTR) increased the serum levels of proinflammatory cytokines. This proinflammatory status induced insulin signaling impairment in the skeletal muscle; however, the response of this signaling pathway in the cardiac muscle of overtrained mice was still unknown...
October 15, 2018: Journal of Cellular Biochemistry
Joana Ribeiro da Silva, Luísa Proença, Adélia Rodrigues, Rolando Pinho, Ana Ponte, Jaime Rodrigues, Mafalda Sousa, Rita Almeida, João Carvalho
Background: Obesity is an increasing worldwide problem associated with a vast number of comorbidities. Decreasing body weight by only 5-10% has been shown to slow and even prevent the onset of obesity-related comorbidities. Between pharmacological therapy and bariatric surgery a great variety of endoscopic techniques are available, the most common being intragastric balloon (IGB). The purpose of this study was to assess the safety, tolerance, and kinetics of IGBs in weight loss. The kinetics of weight loss were evaluated in 2 different contexts and phases: after the IGB's removal and after follow-up that varied between 6 and 12 months...
September 2018: GE Portuguese Journal of Gastroenterology
David Macutkiewicz, Caroline Sunderland
Team sports, such as field hockey, incorporate high-intensity repeated sprints, interspersed with low-intensity running, which can result in acidosis. The aim of the present study was to examine the effect of acute sodium bicarbonate (SB) supplementation on team sport running and skill performance. Eight elite female field hockey players (age 23 ± 5 years, body mass 62.6 ± 8.4 kg, height 1.66 ± 0.05 m) completed three Field Hockey Skill Tests (FHST) interspersed with four sets of the Loughborough Intermittent Shuttle Test (LIST)...
September 2018: Physiological Reports
Angus Lindsay, Preston M McCourt, Peter Karachunski, Dawn A Lowe, James M Ervasti
Generation of superoxide by xanthine oxidase can be stimulated under ischemic and aberrant calcium homeostasis. Because patients and mice with Duchenne muscular dystrophy (DMD) suffer from ischemia and excessive calcium influx, we tested the hypothesis that xanthine oxidase activity is elevated and contributes to disease pathology. Xanthine oxidase activity was measured by urinary isoxanthopterin in DMD patients at rest and in response to exercise. Urinary isoxanthopterin/creatinine was elevated compared to age-matched controls and Becker muscular dystrophy (BMD) patients...
October 10, 2018: Free Radical Biology & Medicine
Danielle A N Chapa, Kelsey E Hagan, Kelsie T Forbush, Victoria L Perko, Daria A Sorokina, Ahmed Y Alasmar, Carolyn B Becker, Roberta T Sherman, Ron A Thompson, Jennifer G Farrell, Tiffany M Stewart
OBJECTIVE: Several studies indicate that eating-disorder (ED) psychopathology is elevated in athletes compared to non-athletes. The assessment of excessive exercise among athletes is a challenge because, compared to non-athletes, athletes are required to train at higher intensities and for longer periods of time. However, individuals participating in competitive sports are still susceptible to unhealthy physical-activity patterns. Most ED assessments were developed and normed in non-athlete samples and, therefore, do not capture the nuances of athletes' training experiences...
October 12, 2018: International Journal of Eating Disorders
Yue Yang, Yang Wang, Yawei Kong, Xiaoning Zhang, He Zhang, Yi Gang, Lunhao Bai
Mechanical stress plays a key role in regulating cartilage degradation in osteoarthritis (OA). The aim of this study was to evaluate the effects and mechanisms of mechanical stress on articular cartilage. A total of 80 male Sprague-Dawley rats were randomly divided into eight groups (n = 10 for each group): control group (CG), OA group (OAG), and CG or OAG subjected to low-, moderate-, or high-intensity treadmill exercise (CL, CM, CH, OAL, OAM, and OAH, respectively). Chondrocytes were obtained from the knee joints of rats; they were cultured on Bioflex 6-well culture plates and subjected to different durations of cyclic tensile strain (CTS) with or without exposure to interleukin-1β (IL-1β)...
October 12, 2018: Journal of Cellular Physiology
Charlène Bredy, François-Pierre Mongeon, Line Leduc, Annie Dore, Paul Khairy
Atrial septal defect (ASD) is the most common form of congenital heart disease. Left-to-right shunting leads to right ventricular (RV) volume overload with excessive pulmonary blood flow. Complications include exercise intolerance, pulmonary vascular disease, RV dysfunction, paradoxical thromboemboli, and atrial arrhythmias. Women with coexisting severe pulmonary hypertension should be counselled against pregnancy due to high incidence of maternal and fetal morbidity and mortality. In the absence of pulmonary hypertension, pregnancy is generally well tolerated in the setting of an ASD...
September 2018: Journal of Thoracic Disease
Julie Dupas, Annie Feray, Anthony Guernec, Morgane Pengam, Manon Inizan, François Guerrero, Jacques Mansourati, Christelle Goanvec
Background: Metabolic Syndrom has become a public health problem. It mainly results from the increased consumption of fat and sugar. In this context, the benefits of personalized moderate exercise training were investigated on a metabolic syndrome male wistar rat model food with fructose drinking water (20-25% w / v ). Different markers including body weight, metabolic measurements, blood biochemistry related to metabolic syndrome complications have been evaluated. Methods: Male Wistar rats were randomly allocated to 4 groups: control (sedentary (C, n  = 8) and exercise trained (Ex, n = 8)), fructose fed (sedentary (FF, n = 8) and exercise trained fructose fed rats (ExFF, n  = 10))...
2018: Nutrition & Metabolism
Ida Åberg, Gustav Mattsson, Peter Magnusson
Postural orthostatic tachycardia syndrome (POTS) is a condition where the patient experiences tachycardia (a rise in heart rate of at least 30 beats per minute, 40 in people between the ages of 12 and 19) upon assuming the upright position, in the absence of orthostatic hypotension (a fall in systolic blood pressure of more than 20 mmHg). The majority of patients are young women. Symptoms are experienced frequently during standing, and include dizziness, fatigue, palpitations, tremulousness, blurred vision and sometimes syncope - although presyncope is more common...
October 9, 2018: Läkartidningen
Willian E Miyagi, Romulo C Bertuzzi, Fabio Y Nakamura, Rodrigo A B de Poli, Alessandro M Zagatto
The aim of this study was to verify the effects of caffeine on anaerobic capacity estimated by the sum of the estimated glycolytic [E[La] ] and phosphagen [EPCr ] metabolism based on blood lactate and excess post-oxygen consumption responses (AC[La-]+EPOCfast ). Fourteen male cyclists were submitted to a graded exercise test to determine the maximal oxygen uptake ( <mml:math xmlns:mml=""> <mml:mover> <mml:mrow> <mml:mi>V</mml:mi> </mml:mrow> <mml:mo>°</mml:mo> </mml:mover> <mml:msub> <mml:mrow> <mml:mi>O</mml:mi> </mml:mrow> <mml:mrow> <mml:mn>2</mml:mn> <mml:mi>m</mml:mi> <mml:mi>a</mml:mi> <mml:mi>x</mml:mi> </mml:mrow> </mml:msub> </mml:math> ) and intensity associated with <mml:math xmlns:mml="http://www...
2018: Frontiers in Nutrition
Livia P Carvalho, Charlotte H Pion, Guy El Hajj Boutros, Pierrette Gaudreau, Stéphanie Chevalier, Marc Bélanger, José A Morais, Mylène Aubertin-Leheudre
INTRODUCTION: Mobility disability affects nearly 15% of people aged 65 or over worldwide. Excess weight or obesity (OB), along with an accentuated loss of muscle strength (dynapenia), is recognized to be one of the most common risk factors for mobility impairment among the elderly. OBJECTIVE: To investigate the effect of a 12-week mixed power training (MPT high-velocity resistance training mixed with functional exercises) on physical function in obese older men exhibiting different severities of dynapenia...
October 6, 2018: Aging Clinical and Experimental Research
Li Xiang, Hongsong Zhang, Juntong Wei, Xiao Yu Tian, Hemi Luan, Shangfu Li, Hongzhi Zhao, Guodong Cao, Arthur C K Chung, Chunxue Yang, Yu Huang, Zongwei Cai
Type 2 diabetes mellitus (T2DM) is characterized by hyperinsulinemia, hyperglycemia and insulin resistance, which correlated with high mortality worldwide. Exercise is one of the effective lifestyle interventions in maintaining blood glucose level in the normal range and lowering risk factors. Metabolomics approaches are powerful tools in systematic study of overall metabolic changes in response to disease or interventions. In this study, mass spectrometry-based metabolomics studies were performed to investigate the regulatory effect of moderate intensity of exercise on db/db diabetic mice in skeletal muscle...
December 11, 2018: Analytica Chimica Acta
Carly Thompson-Memmer, Tavis Glassman, Aaron Diehr
Individuals who restrict their caloric intake and/or exercise excessively to mitigate the calories from alcohol consumption may suffer from an eating disorder, substance abuse disorder, or both. While the term "drunkorexia" has been used in both academic articles and popular culture, issues persist with respect to diagnosing and treating this condition. Classifying the behavior as a subcategory of Other Specified Feeding and Eating Disorders (OSFED) would provide patients with an increased likelihood of receiving insurance coverage for this condition...
October 4, 2018: Journal of American College Health: J of ACH
Vijay Kumar Mishra, Souvik Chaudhuri, Rajesh Kumar Singh, Ajay Kumar Singh
Unilateral pulmonary artery agenesis (UPAA) is a rare condition where the patient may remain asymptomatic for a long period till adulthood. Presentation may be in the form of dyspnea, cough, hemoptysis, decreased exercise tolerance, and recurrent respiratory tract infections. Ventilation-perfusion mismatch and excessive blood flow to the normal lung may eventually lead to unilateral acute respiratory distress syndrome (ARDS). We present a case of a 40-year-old gentleman with nonresolving pneumonia who was diagnosed to have unilateral ARDS due to UPAA...
July 2018: Anesthesia, Essays and Researches
Burcu Duyur Cakıt, Secil Pervane Vural, F Figen Ayhan
BACKGROUND: The aim of this prospective clinical study was to compare the long-term efficacy of complex decongestive therapy (CDT) in obese and nonobese patients with breast cancer-related lymphedema (BCRL). MATERIALS AND METHODS: A total of 59 patients (29 obese patients group 1, 30 normoweight overweight patients group 2) with unilateral BCRL were enrolled. All patients underwent CDT that included manual lymphatic drainage, intermittent pneumatic compression pump, multilayer compression bandaging, lymphedema exercises, and skin care...
October 3, 2018: Lymphatic Research and Biology
Shirin M Shallwani, Anna Towers
Purpose: Malignant lymphedema is an accumulation of interstitial fluid caused by tumour infiltration or compression of lymphatic vessels. Our objective is to describe self-management strategies for malignant lymphedema using a case report. Client Description: A 50-year-old woman with advanced breast cancer was referred to our centre with a 3-month history of unexplained left-arm edema, subsequently diagnosed as malignant lymphedema caused by tumour compression of the axillary lymph nodes. Intervention: She undertook a physiotherapist-guided, modified lymphedema treatment programme, with self-management interventions including self-bandaging and exercise...
2018: Physiotherapy Canada. Physiothérapie Canada
Marco Antonio Hernández-Lepe, José Alberto López-Díaz, Marco Antonio Juárez-Oropeza, Rosa Patricia Hernández-Torres, Abraham Wall-Medrano, Arnulfo Ramos-Jiménez
Excess weight and obesity are major risk factors for many chronic diseases, and weight-loss interventions often include systematic exercise and nutritional supplements. The purpose of this study was to determine the independent/synergistic effects of Arthrospira (Spirulina) maxima supplementation (six weeks, 4.5 g·day-1 ) and a systematic physical exercise program (six weeks, twice weekly) on the body composition and cardiorespiratory fitness of overweight and obese subjects. To achieve this, 27 overweight and 25 obese sedentary male subjects were assigned to four interventions through a randomized double-blind, crossover controlled trial: A physical exercise program, with (SE) or without (Ex) Spirulina maxima ; or no-exercise program, with (Sm) and without (C) Spirulina maxima ...
October 1, 2018: Marine Drugs
Bahadır Geniş, Behcet Coşar
Bortezomib, an antineoplastic agent used in Multiple Myeloma, is a modified dipeptidyl boronic acid that is selectively and reversibly attached to the 26S proteasome. Bortezomib may be combined with corticosteroids in treatment-resistant multiple myeloma patients. Corticosteroids can cause many psychiatric disorders ncluding mania, depression, psychosis, delirium, suicide and aggression. To date only one case of mania associated with the use of bortezomib was reported in which the patient responded to the treatment with olanzapine and valproic acid...
2018: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
M Choudhury, N Black, A Alghamdi, A D'Souza, R Wang, J Yanni, H Dobrzynski, P A Kingston, H Zhang, M R Boyett, G M Morris
KEY POINTS: The sinoatrial node (SAN) is the primary pacemaker of the heart. SAN dysfunction, or 'sick sinus syndrome', can cause excessively slow heart rates and pauses, leading to exercise limitation and syncope, currently treated by implantation of an electronic pacemaker. 'Biopacemaking' utilises gene therapy to restore pacemaker activity by manipulating gene expression. Overexpressing the HCN pacemaker ion channel has been widely used with limited success. We utilised bradycardic rat subsidiary atrial pacemaker tissue to evaluate alternative gene targets: the Na+ /Ca2+ exchanger NCX1, and the transcription factors TBX3 and TBX18 known to be involved in SAN embryonic development...
September 26, 2018: Journal of Physiology
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