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https://www.readbyqxmd.com/read/29718247/emerging-resistance-mutations-in-pi-naive-patients-failing-an-atazanavir-based-regimen-anrs-multicentre-observational-study
#1
S Lambert-Niclot, M Grude, M L Chaix, C Charpentier, S Reigadas, H Le Guillou-Guillemette, A Rodallec, C Amiel, A Maillard, J Dufayard, T Mourez, A Mirand, J Guinard, B Montes, S Vallet, A G Marcelin, D Descamps, P Flandre, C Delaugerre, L Morand-Joubert
Background: Atazanavir is a PI widely used as a third agent in combination ART. We aimed to determine the prevalence and the patterns of resistance in PI-naive patients failing on an atazanavir-based regimen. Methods: We analysed patients failing on an atazanavir-containing regimen used as a first line of PI therapy. We compared the sequences of reverse transcriptase and protease before the introduction of atazanavir and at failure [two consecutive viral loads (VLs) >50 copies/mL]...
August 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29354658/human-immunodeficiency-virus-hepatits-c-virus-coinfection-in-spain-elimination-is-feasible-but-the-burden-of-residual-cirrhosis-will-be-significant
#2
Juan Berenguer, Inmaculada Jarrín, Leire Pérez-Latorre, Víctor Hontañón, María J Vivancos, Jordi Navarro, María J Téllez, Josep M Guardiola, José A Iribarren, Antonio Rivero-Juárez, Manuel Márquez, Arturo Artero, Luis Morano, Ignacio Santos, Javier Moreno, María C Fariñas, María J Galindo, María A Hernando, Marta Montero, Carmen Cifuentes, Pere Domingo, José Sanz, Lourdes Domíngez, Oscar L Ferrero, Belén De la Fuente, Carmen Rodríguez, Sergio Reus, José Hernández-Quero, Gabriel Gaspar, Laura Pérez-Martínez, Coral García, Lluis Force, Sergio Veloso, Juan E Losa, Josep Vilaró, Enrique Bernal, Sari Arponen, Amat J Ortí, Ángel Chocarro, Ramón Teira, Gerardo Alonso, Rafael Silvariño, Ana Vegas, Paloma Geijo, Josep Bisbe, Herminia Esteban, Juan González-García
Background: We assessed the prevalence of antibodies against hepatitis C virus (HCV-Abs) and active HCV infection in patients infected with human immunodeficiency virus (HIV) in Spain in 2016 and compared the results with those of similar studies performed in 2002, 2009, and 2015. Methods: The study was performed in 43 centers during October-November 2016. The sample was estimated for an accuracy of 2% and selected by proportional allocation and simple random sampling...
January 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28984015/genotype-4-hepatitis-e-virus-is-a-cause-of-chronic-hepatitis-in-renal-transplant-recipients-in-hong-kong
#3
S Sridhar, J F W Chan, D Y H Yap, J L L Teng, C Huang, C C Y Yip, I F N Hung, S C W Tang, S K P Lau, P C Y Woo, K-Y Yuen
No abstract text is available yet for this article.
February 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28680838/utility-of-electronic-medical-record-based-fibrosis-scores-in-predicting-advanced-cirrhosis-in-patients-with-hepatitic-c-virus-infection
#4
Mohammad Qasim Khan, Vijay Anand, Norbert Hessefort, Ammar Hassan, Alya Ahsan, Amnon Sonnenberg, Claus J Fimmel
OBJECTIVE: To determine whether advanced cirrhosis - defined by the detection of nodular liver contours or portal venous collaterals on imaging studies - could be predicted by fibrosis algorithms, calculated using laboratory and demographic features extracted from patients' electronic medical records. To this end, we compared seven EMR-based fibrosis scores with liver imaging studies in a cohort of HCV patients. METHODS: A search of our health system's patient data warehouse identified 867 patients with chronic HCV infection...
March 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28232517/impact-of-sustained-virological-response-to-chronic-hepatitic-c-antiviral-therapy-on-new-onset-diabetes-mellitus-type-2-after-controlling-for-metabolic-syndrome
#5
Prashant Pandya, Chaitanya Pant, Ryan Taylor, Olurinde Oni
The high cost associated with antiviral treatment for chronic hepatitis C virus (HCV) infection mandates further investigation in the context of preventing complications such as type 2 diabetes mellitus (DM2). We determined the cumulative incidence of DM2 in subjects with chronic HCV infection who received concomitant pegylated interferon (Peg-IFN) and ribavirin. We conducted a retrospective analysis of data obtained from Veterans Administrations Informatics and Computing Infrastructure (VINCI) to identify an adult cohort of patients without diabetes with chronic HCV infection who received Peg-IFN-based therapy between October 2001 and December 2011...
April 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27899297/validation-of-the-afp-model-as-a-predictor-of-hcc-recurrence-in-patients-with-viral-hepatitis-related-cirrhosis-who-had-received-a-liver-transplant-for-hcc
#6
Andrea Notarpaolo, Richard Layese, Paolo Magistri, Maria Gambato, Michele Colledan, Giulia Magini, Lucia Miglioresi, Alessandro Vitale, Giovanni Vennarecci, Cecilia D Ambrosio, Patrizia Burra, Fabrizio Di Benedetto, Stefano Fagiuoli, Marco Colasanti, Giuseppe Maria Ettorre, Arnoldo Andreoli, Umberto Cillo, Alexis Laurent, Sandrine Katsahian, Etienne Audureau, Françoise Roudot-Thoraval, Christophe Duvoux
BACKGROUND & AIMS: The AFP model was shown to be superior to the Milan criteria for predicting hepatocellular carcinoma (HCC) recurrence after liver transplantation in a French population. Our aim was to test the AFP model in a non-French, post-hepatitic cirrhosis-based population of HCC candidates. METHODS: 574 patients transplanted for HCC in four Italian centers were studied. AFP score was assessed at the last evaluation before liver transplantation (LT)...
March 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/27829381/seroprevalence-of-hepatitis-c-virus-among-people-living-with-hiv-aids-in-latin-america-and-the-caribbean-a-systematic-review
#7
REVIEW
Fatima Mitiko Tengan, Karim Yakub Ibrahim, Bianca Peixoto Dantas, Caroline Manchiero, Mariana Cavalheiro Magri, Wanderley Marques Bernardo
BACKGROUND: Studies have shown that the immunosuppression induced by the human immunodeficiency virus (HIV) accelerates the natural history of liver disease associated with hepatitis C virus (HCV), with 3- to 5-fold higher odds of coinfected individuals developing cirrhosis. However, estimates of the seroprevalence of hepatitis C among people living with HIV/acquired immune deficiency syndrome (AIDS) (PLHA) in Latin America and the Caribbean (LAC) are widely variable. METHODS: We performed a systematic review to estimate the seroprevalence of HCV among PLHA...
November 9, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27625202/prevalence-of-and-factors-associated-with-depression-among-people-living-with-hiv-in-france
#8
COMPARATIVE STUDY
P Feuillet, F Lert, L Tron, C Aubriere, B Spire, R Dray-Spira
OBJECTIVES: Depression is common among people living with HIV (PLWHIV) and is associated with poorer therapeutic outcomes and risky behaviours. We sought to estimate the prevalence of major depressive episode (MDE) across PLWHIV groups, to compare this with its prevalence in the general population and to assess factors associated with it. METHODS: We used data from the Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS)-Vespa2 study, a national study on a representative sample of PLWHIV conducted in France in 2011...
July 2017: HIV Medicine
https://www.readbyqxmd.com/read/27622858/safety-and-efficacy-of-daclatasvir-sofosbuvir-in-hcv-genotype-1-mono-infected-patients
#9
MULTICENTER STUDY
Stanislas Pol, Marc Bourliere, Sandy Lucier, Christophe Hezode, Céline Dorival, Dominique Larrey, Jean-Pierre Bronowicki, Victor D E Ledinghen, Fabien Zoulim, Albert Tran, Sophie Metivier, Jean-Pierre Zarski, Didier Samuel, Dominique Guyader, Patrick Marcellin, Anne Minello, Laurent Alric, Dominique Thabut, Olivier Chazouilleres, Ghassan Riachi, Valérie Bourcier, Philippe Mathurin, Véronique Loustaud-Ratti, Louis D'Alteroche, Isabelle Fouchard-Hubert, François Habersetzer, Xavier Causse, Claire Geist, Isabelle Rosa, Jérôme Gournay, Eric Saillard, Eric Billaud, Ventzislava Petrov-Sanchez, Alpha Diallo, Hélène Fontaine, Fabrice Carrat
BACKGROUND & AIMS: We report the first real-life results of the sofosbuvir+daclatasvir combination in hepatitis C virus (HCV) genotype 1 infected patients. METHODS: The France REcherche Nord&Sud Sida-hiv Hépatites (ANRS) CO22 HEPATHER "Therapeutic options for hepatitis B and C: A French cohort" is a multicentre observational cohort which aims to include 15,000 HCV- and 10,000 HBV-infected patients. We selected all participants (n=768) with a HCV genotype 1 who initiated sofosbuvir (400mg/day) and daclatasvir (60mg/day) before October 1st 2014, with or without ribavirin (1-1...
January 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/27476823/molecular-mechanisms-of-hepatitis-c-virus-induced-hepatocellular-carcinoma
#10
REVIEW
T Vescovo, G Refolo, G Vitagliano, G M Fimia, M Piacentini
Hepatitis C virus (HCV) is a major leading cause of hepatocellular carcinoma (HCC). HCV-induced hepatocarcinogenesis is a multistep process resulting from a combination of pathway alterations that are either caused directly by viral factors or immune mediated as a consequence of a chronic state of inflammation. Host genetic variation is now emerging as an additional element that contribute to increase the risk of developing HCC. The advent of direct-acting antiviral agents foresees a rapid decline of HCC rate in HCV patients...
October 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27453412/the-correlation-analysis-of-primary-liver-cancer-with-type-2-diabetes
#11
Q Su, F Sun, J Li, H Zhang, M Wang, H Zhou, L Qiao
OBJECTIVE: To explore the relationship between Type 2 diabetes and primary liver cancer. MATERIALS AND METHODS: In the period from December 2008 to December 2014, all blood sugar data of patients in our hospital was collected, and the total number is 18213. Except for repeatedly hospitalized diabetic person, newborn stress status, or venous transfusion blood glucose, gestational diabetes, etc., By retrieving the medical record information of patients in the hospital, and using telephone or letter follow-up the patients, we collected 127 people with type 1 diabetes and found no liver cancer patients; Type 2 diabetes, 10,794 cases of patient information, 59 with primary liver cancer...
December 2015: Indian Journal of Cancer
https://www.readbyqxmd.com/read/27262758/multicentre-experience-using-daclatasvir-and-sofosbuvir-to-treat-hepatitis-c-recurrence-the-anrs-cupilt-study
#12
COMPARATIVE STUDY
Audrey Coilly, Claire Fougerou-Leurent, Victor de Ledinghen, Pauline Houssel-Debry, Christophe Duvoux, Vincent Di Martino, Sylvie Radenne, Nassim Kamar, Louis D'Alteroche, Vincent Leroy, Valérie Canva, Pascal Lebray, Christophe Moreno, Jérôme Dumortier, Christine Silvain, Camille Besch, Philippe Perre, Danielle Botta-Fridlund, Rodolphe Anty, Claire Francoz, Armando Abergel, Maryline Debette-Gratien, Filomena Conti, François Habersetzer, Alexandra Rohel, Emilie Rossignol, Hélène Danjou, Anne-Marie Roque-Afonso, Didier Samuel, Jean-Charles Duclos-Vallée, Georges-Philippe Pageaux
BACKGROUND & AIMS: HCV recurrence remains a major issue in the liver transplant field, as it has a negative impact on both graft and patient survival. The purpose of this study was to investigate the efficacy and safety of treating HCV recurrence with sofosbuvir (SOF) and daclatasvir (DCV) combination therapy. METHODS: From October 2013 to March 2015, 559 liver recipients were enrolled in the prospective multicentre France REcherche Nord&Sud Sida-hiv Hépatites (ANRS) Compassionate use of Protease Inhibitors in viral C Liver Transplantation cohort...
October 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27234582/hepatocellular-carcinoma-incidentally-detected-at-second-hepatectomy-for-repeated-colorectal-liver-metastasis-in-a-patient-with-hepatitis-c-virus-related-cirrhosis-a-case-report
#13
Atsuo Kobayashi, Daisuke Morioka, Chizuru Matsumoto, Yasuhiko Miura, Masaru Miura
BACKGROUND: It has been reported that liver metastasis rarely occurs in a cirrhotic/hepatitic liver. Thus, coexistence of liver metastasis and hepatocellular carcinoma has been scarcely reported. To the best of our knowledge, there are no cases with hepatocellular carcinoma, which developed during an observational period after hepatectomy for colorectal liver metastasis, in the worldwide English literature. Here we present a case of hepatocellular carcinoma which occurred during a period between the first and second hepatectomy for repeated colorectal liver metastasis...
May 27, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27187027/psychiatric-and-substance-use-disorders-in-hiv-hepatitis-c-virus-hcv-coinfected-patients-does-hcv-clearance-matter-agence-nationale-de-recherche-sur-le-sida-et-les-h%C3%A3-patites-virales-anrs-hepavih-co13-cohort
#14
L Michel, C Lions, M Winnock, J-P Lang, M-A Loko, E Rosenthal, B Marchou, M-A Valantin, P Morlat, P Roux, P Sogni, B Spire, I Poizot-Martin, K Lacombe, C Lascoux-Combe, C Duvivier, D Neau, F Dabis, D Salmon-Ceron, M P Carrieri
OBJECTIVES: The objective of this nested study was to assess the prevalence of psychiatric disorders in a sample of HIV/hepatitis C virus (HCV)-coinfected patients according to their HCV status. METHODS: The nested cross-sectional study, untitled HEPAVIH-Psy survey, was performed in a subset of HIV/HCV-coinfected patients enrolled in the French Agence Nationale de Recherche sur le SIDA et les Hépatites Virales (ANRS) CO13 HEPAVIH cohort. Psychiatric disorders were screened for using the Mini International Neuropsychiatric Interview (MINI 5...
November 2016: HIV Medicine
https://www.readbyqxmd.com/read/27128845/molecular-assessment-of-vitamin-d-receptor-polymorphism-as-a-valid-predictor-to-the-response-of-interferon-ribavirin-based-therapy-in-egyptian-patients-with-chronic-hepatitis-c
#15
Ahmed Abdelsalam, Laila Rashed, Tarek Salman, Lamiaa Hammad, Dina Sabry
OBJECTIVE: The aim of this study was to find an association between serum concentration of vitamin D and vitamin D receptor (VDR) polymorphisms to achieve a sustained virological response (SVR). METHODS: We conducted a case-control study in which 250 participants were recruited and divided into three groups (100 chronic hepatitis C [CHC] patients who achieved SVR, 100 CHC patients who did not achieve SVR and 50 apparently healthy individuals as controls). Blood samples were collected to measure serum vitamin D concentration, and four VDR polymorphisms (FokI, ApaI, TaqI, and BsmI) were detected using polymerase chain reaction-restriction fragment length polymorphism...
August 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27006578/cellular-immune-function-and-liver-damage-in-post-hepatitic-cirrhosis
#16
Z J Feng, R M Niu, X L Ren, X X Yao
AIM: To study cellular immune function in patients with post-hepatitic cirrhosis (PHC) and its relationship with different types of liver damage. METHODS: Fifty-one patients with PHC, including 20 cases of Child-Pugh class A, 18 of class B, 13 of class C and 22 normal subjects as controls were studied. After peripheral blood mononuclear cells were isolated by Ficoll-Hypaque gradient centrifugation, lymphocyte transformation (LT) test, IL-2 activity and NK cell activity were measured by the (3)H-TdR incorporation technique...
March 15, 1997: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26968010/comparison-of-therapeutic-response-and-clinical-outcome-between-hcv-patients-with-normal-and-abnormal-alanine-transaminase-levels
#17
COMPARATIVE STUDY
Cheng-Kung Wu, Kuo-Chin Chang, Po-Lin Tseng, Sheng-Nan Lu, Chien-Hung Chen, Jing-Houng Wang, Chuan-Mo Lee, Ming-Tsung Lin, Yi-Hao Yen, Chao-Hung Hung, Tsung-Hui Hu
BACKGROUND AND AIMS: Patients with chronic hepatitic C (HCV) infection and normal serum alanine transaminase (ALT) levels were considered to have mild disease. In Taiwan, these patients were not suggested for interferon (IFN) based therapies. The aim of study is to compare therapeutic outcomes between HCV patients with normal and elevated ALT levels. METHODS: We conducted a retrospective study on 3241 HCV patients treated by IFN based therapies. Patients with normal ALT levels were classified as group A (n = 186) while those with elevated ALT levels were group B (n = 3055)...
2016: PloS One
https://www.readbyqxmd.com/read/26762993/hiv-1-virological-remission-lasting-more-than-12-years-after-interruption-of-early-antiretroviral-therapy-in-a-perinatally-infected-teenager-enrolled-in-the-french-anrs-epf-co10-paediatric-cohort-a-case-report
#18
Pierre Frange, Albert Faye, Véronique Avettand-Fenoël, Erianna Bellaton, Diane Descamps, Mathieu Angin, Annie David, Sophie Caillat-Zucman, Gilles Peytavin, Catherine Dollfus, Jerome Le Chenadec, Josiane Warszawski, Christine Rouzioux, Asier Sáez-Cirión
BACKGROUND: Durable HIV-1 remission after interruption of combined antiretroviral therapy (ART) has been reported in some adults who started treatment during primary infection; however, whether long-term remission in vertically infected children is possible was unknown. We report a case of a young adult perinatally infected with HIV-1 with viral remission despite long-term treatment interruption. METHODS: The patient was identified in the ANRS EPF-CO10 paediatric cohort among 100 children infected with HIV perinatally who started ART before 6 months of age...
January 2016: Lancet HIV
https://www.readbyqxmd.com/read/26534641/a-hepatite-c-cr%C3%A3-nica-diminui-a-qualidade-de-vida
#19
C M Perlin, H H Borba, L F Wzorek, T Piazza, C Madeira, R Pontarolo, A Wiens
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/26534639/custo-efetividade-do-tenofovir-para-o-tratamento-da-hepatite-b-cr%C3%A3-nica-uma-revis%C3%A3-o-sistem%C3%A3-tica
#20
J C Balbinot, A Wiens, R Pontarolo, A C Sanches
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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