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https://www.readbyqxmd.com/read/30550937/levels-of-circulating-soluble-lr11-a-regulator-of-smooth-muscle-cell-migration-are-highly-associated-with-atherosclerotic-plaques-in-patients-with-carotid-artery-stenosis
#1
Masashi Harada, Meizi Jiang, Kensuke Terai, Hiroyuki Ebinuma, Nobuyuki Hiruta, Wolfgang J Schneider, Nobuo Sugo, Takeki Nagao, Hideaki Bujo
BACKGROUND: The levels of plasma sLR11, released from intimal SMCs, are positively associated with intima-media thickness (IMT) in asymptomatic subjects. We have evaluated the yet unknown pathological significance of sLR11 for plaque conditions in patients with carotid artery stenosis. METHODS: The presence of LR11 in carotid plaques was investigated using autopsy specimens. A clinical ultrasonography study for elucidating relationships between sLR11 and plaque condition was performed in 46 patients...
December 11, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/30550852/copi-localizes-to-the-early-golgi-in-aspergillus-nidulans
#2
Miguel Hernández-González, Ignacio Bravo-Plaza, Vivian de Los Ríos, Mario Pinar, Areti Pantazopoulou, Miguel A Peñalva
Coatomer-I (COPI) is a heteromeric protein coat that facilitates the budding of membranous carriers mediating Golgi-to-ER and intra-Golgi transport. While the structural features of COPI have been thoroughly investigated, its physiological role is insufficiently understood. Here we exploit the amenability of A. nidulans for studying intracellular traffic, taking up previous studies by Breakspear et al. (2007) with the α-COP/CopA subunit of COPI. Endogenously tagged α-COP/CopA largely localizes to SedVSed5 syntaxin-containing early Golgi cisterna, and acute inactivation of ER-to-Golgi traffic delocalizes COPI to a haze, consistent with the cisternal maturation model...
December 11, 2018: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/30550504/effects-of-intimate-partner-violence-and-home-environment-on-child-language-development-in-the-first-3-years-of-life
#3
Catherine C Peterson, Jessica Riggs, Katherine Guyon-Harris, Lauren Harrison, Alissa Huth-Bocks
OBJECTIVE: Intimate partner violence (IPV) can adversely affect children's cognitive development, but links between IPV exposure and language development in the earliest years of life remain unknown. The present study examined the effects of IPV and the quality of the home environment on children's language development at age 3 years. METHODS: In a prospective, 5-panel, longitudinal study of 79 mother-child dyads assessed prenatally to age 3 years, we examined standardized measures of receptive and expressive language development at age 3 years...
December 13, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/30550330/self-control-development-in-adolescence-predicts-love-and-work-in-adulthood
#4
Mathias Allemand, Veronika Job, Daniel K Mroczek
This longitudinal study over a 23-year time span examined predictive associations between self-control development in adolescence and love and work outcomes in adulthood. Participants were 1,527 adults aged 35 years (48.3% female). The predictor variable self-control was measured yearly at the ages of 12 to 16 years. Adult outcome variables were measured at the age of 35 years. Three important results stand out. First, the measure of adolescent self-control functioned equivalently across the adolescent years...
December 13, 2018: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/30547723/sexual-coercion-consent-and-negotiation-processes-of-change-amongst-couples-participating-in-the-indashyikirwa-programme-in-rwanda
#5
Erin Stern, Lori Heise
Sexual coercion among married or cohabitating couples is a complex phenomenon with few effective strategies for prevention. This paper explores sexual coercion among couples from rural Rwanda who participated in Indashyikirwa, a 4-year intimate partner violence prevention programme that included a 5-month couples curriculum to promote equalitarian, non-violent relationships. Drawing on three rounds of longitudinal qualitative interviews with partners from 14 couples (28 individuals), this paper explores processes of change in experiences and conceptualisations of coerced sex over the course of the intervention and 1 year after...
December 14, 2018: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/30547718/an-exploration-of-the-link-between-masculinity-and-endorsement-of-ipv-myths-in-american-men
#6
Alida Novarese Gage, Suzanne H Lease
Current research has established a connection between men's endorsement of traditional masculinity ideology and their perpetration of intimate partner violence (IPV) toward women. However, research has not yet identified the cognitive and affective pathways that link the endorsement of masculinity ideology and men's beliefs about IPV. The current study examined men's fear of intimacy, ambivalent (i.e., hostile and benevolent) sexism, and relationship dominance as potential mediating factors of the relationship between endorsement of traditional masculinity ideology and the acceptance of myths about male-to-female IPV in a community sample of 101 American men...
December 14, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/30547130/robotic-versus-freehand-s2-alar-iliac-fixation-in-depth-technical-considerations
#7
REVIEW
Joseph L Laratta, Jamal N Shillingford, Joshua S Meredith, Lawrence G Lenke, Ronald A Lehman, Jeffrey L Gum
Achieving fixation and fusion across the lumbosacral junction has been a challenge for spinal deformity surgeons ever since the development of instrumentation. The S2 alar-iliac (S2AI) trajectory has been introduced as a method of pelvic fixation to decrease strain on S1 screws. The S2AI screws differ in several ways from traditional iliac screws. The trajectory of these screws helps avoid the use of offset connectors due to the screws alignment with the proximal pedicle screw instrumentation. Current literature shows that S2AI screws are effective with low complication rates, but the path of these screws is intimately associated with major neural and vascular structures...
September 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/30546939/bone-marrow-endothelial-cells-sustain-a-tumor-specific-cd8-t-cell-subset-with-suppressive-function-in-myeloma-patients
#8
Patrizia Leone, Giuseppe Di Lernia, Antonio Giovanni Solimando, Sebastiano Cicco, Ilaria Saltarella, Aurelia Lamanuzzi, Roberto Ria, Maria Antonia Frassanito, Maurilio Ponzoni, Paolo Ditonno, Franco Dammacco, Vito Racanelli, Angelo Vacca
Endothelial cells (EC) line the bone marrow microvasculature and are in close contact with CD8+ T cells that come and go across the permeable capillaries. Because of these intimate interactions, we investigated the capacity of EC to act as antigen-presenting cells (APC) and modulate CD8+ T cell activation and proliferation in bone marrow of patients with multiple myeloma (MM) and monoclonal gammopathy of undetermined significance. We found that EC from MM patients show a phenotype of semi-professional APC given that they express low levels of the co-stimulatory molecules CD40, CD80 and CD86, and of the inducible co-stimulator ligand (ICOSL)...
2019: Oncoimmunology
https://www.readbyqxmd.com/read/30546176/do-marriage-and-cohabitation-provide-benefits-to-health-in-mid-life-the-role-of-childhood-selection-mechanisms-and-partnership-characteristics-across-countries
#9
Brienna Perelli-Harris, Stefanie Hoherz, Fenaba Addo, Trude Lappegård, Ann Evans, Sharon Sassler, Marta Styrc
Extensive research has found that marriage provides health benefits to individuals, particularly in the U.S. The rise of cohabitation, however, raises questions about whether simply being in an intimate co-residential partnership conveys the same health benefits as marriage. Here, we use OLS regression to compare differences between partnered and unpartnered, and cohabiting and married individuals with respect to self-rated health in mid-life, an understudied part of the lifecourse. We pay particular attention to selection mechanisms arising in childhood and characteristics of the partnership...
2018: Population Research and Policy Review
https://www.readbyqxmd.com/read/30544355/de-novo-formation-of-a-carotid-web-case-report
#10
(no author information available yet)
A carotid web is a shelf-like intraluminal filling defect typically arising from the posterolateral wall of the proximal internal carotid artery. It is recognized as a possible cause of ischemic stroke in young adults. However, its etiopathogenesis is controversial and remains to be fully elucidated. The authors report de novo formation of a carotid web from an intimal dissection documented on serial imaging studies. The findings in this case suggest that a focal intimal dissection could be the underlying cause of a carotid web...
November 1, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30543775/intimate-crosstalk-in-lower-airways-at-the-beginning-of-life
#11
Erika von Mutius
The early life formation of the immunological and microbial environment of the human lower airways remains unknown. In this issue of Cell Host & Microbe, Pattaroni et al. (2018) shed light on this critical period, which is important for maturation or dysregulation of the microbiome and immune responses and disease development.
December 12, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/30543628/validation-and-psychometric-properties-of-the-russian-version-of-the-touch-experiences-and-attitudes-questionnaire-teaq-37-rus
#12
Paula Trotter, Elena Belovol, Francis McGlone, Anton Varlamov
It has been demonstrated that nurturing and affiliative touch is essential for human emotional and physical well-being throughout our entire life. Within the last 30 years a system of low-threshold mechanosensitive C fibers innervating the hairy skin was discovered and described; this system is hypothesized to represent the neurobiological substrate for the affective and rewarding properties of touch. This discovery opens new perspectives for multidisciplinary research of the role of affiliative social touch in health and disease, and calls for establishing novel psychometric tools assessing individual differences in the domain of affective touch...
2018: PloS One
https://www.readbyqxmd.com/read/30543494/overlapping-intimate-partner-violence-and-sex-trading-among-high-risk-women-implications-for-practice
#13
Tina Jiwatram-Negrón, Nabila El-Bassel
Despite research indicating higher than average rates of intimate partner violence (IPV) across groups of vulnerable women, less is known about the prevalence and types of IPV experienced by women who trade sex for money, drugs, shelter or food, a high risk group for poor health and psychosocial outcomes. Using a cross-sectional design and multivariate logistic regression analyses, this study examined the relationship between IPV and sex trading in a convenience sample of 346 HIV-negative, drug-involved women in relationships, recruited during 2005-2010 in New York City...
December 13, 2018: Women & Health
https://www.readbyqxmd.com/read/30543258/strain-rate-dependent-nanostructure-of-hydrogels-with-reversible-hydrophobic-associations-during-uniaxial-extension
#14
Chao Wang, Clinton G Wiener, Masafumi Fukuto, Ruipeng Li, Kevin G Yager, R A Weiss, Bryan D Vogt
An energy dissipation mechanism during deformation is required to impart toughness to hydrogels. Here we describe how in situ small angle X-ray scattering (SAXS) provides insight into possible energy dissipation mechanisms for a tough hydrogel based on an amphiphilic copolymer where nanoscale associations of the hydrophobic moieties act as effective crosslinks. The mechanical properties of the hydrogels are intimately coupled with the nanostructure that provides reversible crosslinks and evolves during deformation...
December 13, 2018: Soft Matter
https://www.readbyqxmd.com/read/30542713/curcumin-attenuates-hyperglycemia-driven-egf-induced-invasive-and-migratory-abilities-of-pancreatic-cancer-via-suppression-of-the-erk-and-akt-pathways
#15
Wei Li, Zheng Wang, Xue Xiao, Liang Han, Zheng Wu, Qingyong Ma, Lei Cao
The relationship between diabetes mellitus and pancreatic cancer is complex. Diabetes has been postulated to be both an independent risk factor and a consequence of pancreatic cancer. Our previous study confirmed that curcumin plays a vital role in inhibiting the epithelial-mesenchymal transition of pancreatic cancer cells. However, whether curcumin attenuates hyperglycemia-induced cancer invasive and migratory abilities and the underlying mechanisms are not yet well understood. As high glucose is able to induce the expression of epidermal growth factor (EGF), which is intimately related with tumor progression, the aim of this study was to evaluate whether curcumin could influence the high glucose-induced EGF/EGFR pathway and the biological activity of pancreatic cancer cells...
October 30, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30542577/gating-the-electron-transfer-at-a-monocopper-centre-through-the-supramolecular-coordination-of-water-molecules-within-a-protein-chamber-mimic
#16
Nicolas Le Poul, Benoit Colasson, Grégory Thiabaud, Dany Jeanne Dit Fouque, Claudio Iacobucci, Antony Memboeuf, Bénédicte Douziech, Jan Řezáč, Thierry Prangé, Aurélien de la Lande, Olivia Reinaud, Yves Le Mest
Functionality of enzymes is strongly related to water dynamic processes. The control of the redox potential for metallo-enzymes is intimately linked to the mediation of water molecules in the first and second coordination spheres. Here, we report a unique example of supramolecular control of the redox properties of a biomimetic monocopper complex by water molecules. It is shown that the copper complex based on a calix[6]arene covalently capped with a tetradentate [tris(2-methylpyridyl)amine] (tmpa) core, embedding the metal ion in a hydrophobic cavity, can exist in three different states...
November 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/30541403/prevalence-and-determinants-of-unprotected-sex-in-intimate-partnerships-of-men-who-inject-drugs-findings-from-a-prospective-intervention-study
#17
Vartika Sharma, Waimar Tun, Avina Sarna, Lopamudra R Saraswati, Minh D Pham, Ibou Thior, Stanley Luchters
Unprotected sex, common among people who inject drugs, puts them and their partners at risk of sexually transmitted infections including human immunodeficiency virus (HIV). This analysis assesses the changes in sexual risk behavior with regular female partners (RFPs), among married men who inject drugs, before and after implementation of a HIV prevention intervention, and identifies correlates of unprotected sex. People who inject drugs (PWID) were assessed at three points: baseline, preintervention follow-up visit (FV)1, and postintervention FV2...
December 12, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/30541103/a-coordinate-based-meta-analysis-comparing-brain-activation-between-adhd-and-total-sleep-deprivation
#18
Jared M Saletin, Stephanie Jackvony, Katherina A Rodriguez, Daniel P Dickstein
Study Objectives: Sleep disruption is common in attention-deficit-hyperactivity-disorder (ADHD). Likewise, deficits in attention are a hallmark of sleep deprivation in healthy individuals. Whether ADHD and sleep deprivation modulate common, or disparate, neural systems is unknown. No study has yet utilized fMRI to investigate sleep loss in ADHD. We address this gap by performing a novel meta-analysis to compare patterns of fMRI activation during sleep deprivation and ADHD. Methods: We performed a coordinate-based activation-likelihood-estimate (ALE) meta-analysis using the GingerALE software...
December 12, 2018: Sleep
https://www.readbyqxmd.com/read/30541066/haemodynamic-stress-induced-breaches-of-the-arterial-intima-trigger-inflammation-and-drive-atherogenesis
#19
Grégory Franck, Guillaume Even, Alexandre Gautier, Manuel Salinas, Alexia Loste, Emanuele Procopio, Anh-Thu Gaston, Marion Morvan, Sébastien Dupont, Catherine Deschildre, Sophie Berissi, Jamila Laschet, Patrick Nataf, Antonino Nicoletti, Jean-Baptiste Michel, Giuseppina Caligiuri
Aims: Inflammatory mediators, including blood cells and their products, contribute critically to atherogenesis, but the igniting triggers of inflammation remain elusive. Atherosclerosis develops at sites of flow perturbation, where the enhanced haemodynamic stress could initiate the atherogenic inflammatory process due to the occurrence of mechanic injury. We investigated the role of haemodynamic stress-induced breaches, allowing the entry of blood cells in the arterial intima, in triggering inflammation-driven atherogenesis...
December 11, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30540814/fingerprints-of-cd8-t-cells-on-human-pre-plasma-and-memory-b-cells
#20
Ulrike Strittmatter-Keller, Caroline Walter, Celine Rauld, Nicole Egli, Camille Regairaz, Sabine Rabe, Gerhard Zenke, José Carballido, Tamás Schweighoffer
Differentiation of B cells is a stringently controlled multi-step process, which is still incompletely understood. Here we identify and characterize a rare population of human B cells, which surprisingly carry CD8AB on their surface. Existence of such cells was demonstrated both in tonsils and in human apheresis material. Gene expression profiling and real time PCR detected however no CD8A or CD8B message in these cells. Instead, we found that surface CD8 was hijacked from activated CD8+ T cells by a transfer process that required direct cell-to-cell contact...
2018: PloS One
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