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Lung Failure

Alex Fourdrain, Florence De Dominicis, Jules Iquille, Sophie Lafitte, Geoni Merlusca, Alejandro Witte-Pfister, Jonathan Meynier, Patrick Bagan, Pascal Berna
OBJECTIVES: Intraoperative conversion may be required during video-assisted thoracoscopic surgery (VATS) for lung cancer. We evaluated the morbidity and mortality rates associated with VATS for anatomical pulmonary resection with conversion to thoracotomy and compared this technique with full VATS and an open thoracotomic approach. METHODS: We performed a retrospective, single-centre study between January 2011 and January 2017 and included 610 consecutive patients having undergone either VATS (with or without intraoperative conversion) or open thoracotomy for anatomical pulmonary resection...
October 16, 2018: European Journal of Cardio-thoracic Surgery
Barbara Rath, Maximilian Hochmair, Adelina Plangger, Gerhard Hamilton
Lung cancer is a leading cause of tumor-associated mortality. Fascaplysin, a bis-indole of a marine sponge, exhibit broad anticancer activity as specific CDK4 inhibitor among several other mechanisms, and is investigated as a drug to overcome chemoresistance after the failure of targeted agents or immunotherapy. The cytotoxic activity of fascaplysin was studied using lung cancer cell lines, primary Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC) cells, as well as SCLC circulating tumor cell lines (CTCs)...
October 14, 2018: Marine Drugs
Laura Sommerauer, Alois Philipp, Matthias Lubnow, Thomas Müller, Dirk Lunz, Hans-Stefan Hofmann, Michael Ried
INTRODUCTION: Patients with severe respiratory failure and veno-venous extracorporeal membrane oxygenation (vv-ECMO) often require diagnostic or therapeutic thoracic surgery. METHODS: Retrospective analysis of prospectively collected data (Regensburg ECMO Registry) on all patients requiring vv-ECMO between December 2010 and December 2016 due to acute lung failure (ALF) with diagnostic or therapeutic thoracic surgery. Endpoints were the indications for thoracic surgery as well as postoperative morbidity and in-hospital mortality...
October 15, 2018: Zentralblatt Für Chirurgie
Michael W Sjoding, Timothy P Hofer, Ivan Co, Jakob I McSparron, Theodore J Iwashyna
RATIONALE: Because the Berlin ARDS definition has only moderate reliability, physicians disagree about the diagnosis of ARDS in some patients. Understanding the clinical differences between patients with agreement and disagreement in the diagnosis of ARDS may provide insight into the epidemiology and pathophysiology of this syndrome, and inform strategies to improve reliability of ARDS diagnosis. OBJECTIVES: To characterize patients with diagnostic disagreement in ARDS among critical care trained physicians and compare them to patients with a consensus that ARDS developed...
October 15, 2018: Annals of the American Thoracic Society
M A Cherniavskiĭ, A G Edemskiĭ, Iu A Kudaev, A M Cherniavskiĭ
Analysed herein are the results of pulmonary endarterectomy (PEA) performed in a total of 169 patients presenting with chronic thromboembolic pulmonary hypertension (CTEPH) at the National Medical Research Centre named after Academician E.N. Meshalkin over the period from 2004 to 2014. Pulmonary endarterectomy was carried out according to the standard technique in the conditions of assisted circulation with the use of hypothermia and circulatory arrest. The duration of follow up of patients after surgical treatment amounted to 10 years...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Víctor Lago Leal, Luis Martínez Cortés, Carlos Seco Del Cacho
Congenital high airway obstruction syndrome (CHAOS) is a rare sequence due to a complete obstruction of the fetal airway that blocks the larynx or trachea, either intrinsic atresia or extrinsic compression (e.g., congenital neck mass). Despite the true incidence of CHAOS is unknown, an incidence of 1 per 50,000 newborns is described. If any obstruction occurs in the tracheobronchial airway, this secretion cannot be extricated. Because of this situation, a knock-on effect starts: the enlargement of the lungs squeezes the heart and great veins, what results in a replacement of the heart to the center of the chest becoming small and dysfunctional...
July 2018: Indian Journal of Radiology & Imaging
Valentina Sala, Alessandra Murabito, Alessandra Ghigo
BACKGROUND: Cystic Fibrosis, one of the most frequent genetic diseases, is characterized by the production of viscous mucus in several organs. In the lungs, mucus clogs the airways and traps bacteria, leading to recurrent/resistant infections and lung damage. For Cystic Fibrosis patients, respiratory failure is still lethal in early adulthood since available treatments display incomplete efficacy. OBJECTIVE: The objective of this review is to extend the current knowledge in the field of available treatments for Cystic Fibrosis...
October 11, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
Killen Harold Briones-Claudett, Antonio Esquinas Rodriguez, Mónica H Briones-Claudett, Miguel Puga-Tejada, Mariuxi Del Pilar Cabrera Baños, Christian Roberto Pazmiño Dueñas, Carlos Israel Torres Herrera, Michelle Grunauer
BACKGROUND: This study was designed to determine the results associated with the use of noninvasive mechanical ventilation (NIV) using the BiPAP S/T-AVAPS ventilation strategy in subjects with mild to moderate de novohypoxaemicrespiratory failure. METHODS: This is a prospective study that includes subjects with de novohypoxaemic respiratory failure (not produced by acute exacerbations of COPD, chronic lung disease, or congestive heart failure) with mild to moderate PaO₂/FiO₂, who were admitted to the Intensive Care Unit (ICU) of Santa Maria Clinic in Guayaquil, Ecuador...
October 14, 2018: Anaesthesiology Intensive Therapy
Flavia Squeglia, Alessia Ruggiero, Rita Berisio
The scenario of chemical reactions prompted by the infection by Mycobacterium tuberculosis is huge. The infection generates a localized inflammatory response, with the recruitment of neutrophils, monocytes, and T-lymphocytes. Consequences of this immune reaction can be the eradication or containment of the infection, but these events can be deleterious to the host inasmuch as lung tissue can be destroyed. Indeed, a hallmark of tuberculosis (TB) is the formation of lung cavities, which increase disease development and transmission, as they are sites of high mycobacterial burden...
October 11, 2018: Biochemical Journal
Leonardo Jönck Staub, Roberta Rodolfo Mazzali Biscaro, Erikson Kaszubowski, Rosemeri Maurici
BACKGROUND: Lung ultrasound can accelerate the diagnosis of life-threatening diseases in adults with respiratory symptoms. OBJECTIVE: Systematically review the accuracy of lung ultrasonography (LUS) for emergency diagnosis of pneumonia, acute heart failure, and exacerbation of chronic obstructive pulmonary disease (COPD)/asthma in adults. METHODS: PubMed, Embase, Scopus, Web of Science, and LILACS (Literatura Latino Americana e do Caribe em Ciências da Saúde; until 2016) were searched for prospective diagnostic accuracy studies...
October 9, 2018: Journal of Emergency Medicine
Qi Gao, Chengdong Wang, Desheng Li, Hemin Zhang, Linhua Deng, Caiwu Li, Zhengli Chen
BACKGROUND: Ovarian cancer is diagnosed clinically by detecting ovarian cancer-related factors and markers. Here, we report a case of giant panda ovarian tumor metastasis with a combination of clinical and histopathological diagnosis. CASE PRESENTATION: Histopathological studies revealed severe lesions and tumor cells in the ovaries, lungs, spleen, kidneys and perianal tissue. Immunohistochemistry staining showed that the ovarian cancer markers B7-H4, CA125, and HE4 were highly expressed in the lungs, kidneys, spleen, ovaries and perianal tissue...
October 12, 2018: BMC Veterinary Research
Tomonori Hirashima, Yoshitaka Tamura, Yuki Han, Shoji Hashimoto, Ayako Tanaka, Takayuki Shiroyama, Naoko Morishita, Hidekazu Suzuki, Norio Okamoto, Shinobu Akada, Makoto Fujishima, Yoshihisa Kadota, Kazuya Sakata, Akiko Nishitani, Satoru Miyazaki, Takayuki Nagai
BACKGROUND: In our previous study, colorectal cancer (CRC) patients with active Mycobacterium tuberculosis (MTB) tolerated concurrent anti-cancer chemotherapy (anti-CCT) and anti-MTB chemotherapy. In this study, we retrospectively confirmed the efficacy and safety of concurrent chemotherapy in a greater number of patients with different types of malignancies. METHODS: We enrolled 30 patients who were treated concurrently with anti-CCT and anti-MTB regimens between January 2006 and February 2016...
October 12, 2018: BMC Cancer
Fengmei Yang, Bo Gao, Wei Chen, Enfu Du, Yong Liang, Xiuxue Hu, Xiaofeng Yang
The sensitivity of tumor cells to chemotherapy drugs may become attenuated accounts for various reasons. Reduced drug sensitivity may cause the failure of chemotherapy and affect the prognosis of patients with cancer. This study investigates the relationship between the expression levels of lung resistance protein (LRP) and placental glutathione S-transferase-P1 (GSTP1), the resistance of primary epithelial ovarian cancer (PEOC) to chemotherapy, and the prognosis of patients with platinum drug-resistant PEOC...
October 2018: Medicine (Baltimore)
Pavol Sajgalik, Chul-Ho Kim, John M Stulak, Sudhir S Kushwaha, Simon Maltais, David L Joyce, Lyle D Joyce, Bruce D Johnson, John A Schirger
AIM: The lungs-and particularly the alveolar-capillary membrane-may be sensitive to continuous flow (CF) and pulmonary pressure alterations in heart failure (HF). We aimed to investigate long-term effects of CF pumps on respiratory function. METHODS AND RESULTS: We conducted a retrospective study of patients with end-stage HF at our institution. We analysed pulmonary function tests [e.g. forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1 )] and diffusing capacity of the lung for carbon monoxide (DLCO ) from before and after left ventricular assist device (LVAD) implantation and compared them with invasive haemodynamic studies...
October 12, 2018: ESC Heart Failure
Makoto Komatsuzaki, Shinsuke Hamaguchi
Although there is no remarkable change of anesthetics or anesthesia methods in recent years, several new technologies are used for safety management of cardiac, lung or thoracic surgery. Stroke volume variation (SVV) monitoring indicates SVV, a parameter to optimize fluid infusion and is used to avoid edema or congestive heart damage due to over hydration. SmartPilot View, a pharmacokinetic simulator during anesthesia, represents the measured effective site concentration of anesthetics and contributes the optimization of induction and maintenance of anesthesia...
September 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Nozomu Motono, Syun Iwai, Aika Funasaki, Atsushi Sekimura, Katsuo Usuda, Hidetaka Uramoto
A 59-year-old man who had postoperative recurrence of lung adenosquamous cell carcinoma was administered nivolumab as 3rd-line chemotherapy. Although nivolumab was considered effective, bleeding from a metastatic lesion at the jejunum was recognized by double-balloon enteroscopy, and partial resection was performed. Although the re-administration of nivolumab was planned, the patient died of acute respiratory failure 6 days postoperatively.
October 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Suguru Ohira, Hiroaki Miyata, Sachiko Yamazaki, Satoshi Numata, Noboru Motomura, Shinichi Takamoto, Hitoshi Yaku
OBJECTIVES: Despite its survival benefits, bilateral internal thoracic artery (BITA) grafting is not commonly utilized due to concerns over deep sternal wound infection (DSWI). The present study investigated the early outcome of BITA grafting and analyzed the risk of DSWI using a Japanese national database (the Japan Adult Cardiovascular Surgery Database). METHODS: Data from 560 hospitals were used. Between April 2012 and December 2015, BITA was harvested in 14,249 patients, corresponding to 32...
September 7, 2018: Journal of Thoracic and Cardiovascular Surgery
Josje D Schoufour, Jessica C Kiefte-de Jong, Trudy Voortman
OBJECTIVE: We aimed to evaluate the criterion validity of the 2015 food-based Dutch dietary guidelines, which were formulated based on evidence on the relation between diet and major chronic diseases. DESIGN: We studied 9,701 participants of the Rotterdam Study, a population-based prospective cohort in individuals aged 45 years and over. METHOD: Dietary intake was assessed at baseline with a food-frequency questionnaire. For all participants, we examined adherence (yes/no) to fourteen items of the guidelines: vegetables (≥200g/d), fruit (≥200g/d), whole-grains (≥90g/d), legumes (≥135g/wk), nuts (≥15g/d), dairy (≥350g/d), fish (≥100g/wk), tea (≥450mL/d), ratio whole-grains:total grains (≥50%), ratio unsaturated fats & oils:total fats (≥50%), red and processed meat (<300g/wk), sugar-containing beverages (<150mL/d), alcohol (<10 g/d) and salt (≤6g/d)...
September 19, 2018: Nederlands Tijdschrift Voor Geneeskunde
Sara Roversi, Piera Boschetto, Bianca Beghe', Michela Schito, Martina Garofalo, Mariarita Stendardo, Valentina Ruggieri, Roberto Tonelli, Alessandro Fucili, Roberto D'Amico, Federico Banchelli, Leonardo M Fabbri, Enrico M Clini
Chronic obstructive pulmonary disease (COPD) is a common comorbidity of heart failure (HF), but remains often undiagnosed, and we aimed to identify symptoms predicting COPD in HF. As part of an observational, prospective study, we investigated stable smokers with a confirmed diagnosis of HF, using the 8-item COPD-Assessment-Test (CAT) questionnaire to assess symptoms. All the items were correlated with the presence of COPD, and logistic regression models were used to identify independent predictors. 96 HF patients were included, aged 74, 33% with COPD...
2018: Multidisciplinary Respiratory Medicine
Shikma Katz, Nissim Arish, Ariel Rokach, Yacov Zaltzman, Esther-Lee Marcus
BACKGROUND: Pulmonary function tests (PFTs) are routinely performed in the upright position due to measurement devices and patient comfort. This systematic review investigated the influence of body position on lung function in healthy persons and specific patient groups. METHODS: A search to identify English-language papers published from 1/1998-12/2017 was conducted using MEDLINE and Google Scholar with key words: body position, lung function, lung mechanics, lung volume, position change, positioning, posture, pulmonary function testing, sitting, standing, supine, ventilation, and ventilatory change...
October 11, 2018: BMC Pulmonary Medicine
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