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Vitamin D and hepatitis C

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https://www.readbyqxmd.com/read/28321328/effect-of-season-and-sunlight-on-viral-kinetics-during-hepatitis-c-virus-therapy
#1
Noemi Hernández-Alvarez, Juan Manuel Pascasio Acevedo, Enrique Quintero, Inmaculada Fernández Vázquez, María García-Eliz, Juan de la Revilla Negro, Javier Crespo García, Manuel Hernández-Guerra
BACKGROUND AND AIMS: Rapid viral response (RVR) during antiviral treatment for hepatitis C virus (HCV) predicts sustained viral response (SVR). Recently, vitamin D levels have been associated with SVR. As sunlight is the most important source of vitamin D and shows seasonal variation, we evaluated the effect of season on viral kinetics during peginterferon/ribavirin-based therapy for HCV. METHODS: Consecutive HCV patients treated with peginterferon/ribavirin and boceprevir/ telaprevir (June 2011-July 2014) were included...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28261385/influence-of-vitamin-d-on-liver-fibrosis-in-chronic-hepatitis-c-a-systematic-review-and-meta-analysis-of-the-pooled-clinical-trials-data
#2
Alia S Dadabhai, Behnam Saberi, Katie Lobner, Russell T Shinohara, Gerard E Mullin
AIM: To investigate the relationship between vitamin D and liver fibrosis in hepatitis C-monoinfected or hepatitis C virus (HCV)-human immunodeficiency virus (HIV) co-infected patients. METHODS: Pertinent studies were located by a library literature search in PubMed/Embase/Cochrane/Scopus/LILACS by two individual reviewers. Inclusion criteria: (1) studies with patients with HCV or co-infected HCV/HIV; (2) studies with patients ≥ 18 years old; (3) studies that evaluated liver fibrosis stage, only based on liver biopsy; and (4) studies that reported serum or plasma 25(OH)D levels...
February 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28225575/25-hydroxy-vitamin-d-suppresses-hepatitis-c-virus-replication-and-contributes-to-rapid-virological-response-of-treatment-efficacy
#3
Jee-Fu Huang, Yu-Min Ko, Chung-Feng Huang, Ming-Lun Yeh, Chia-Yen Dai, Meng-Hsuan Hsieh, Ching-I Huang, Hua-Ling Yang, Shu-Chi Wang, Zu-Yau Lin, Shinn-Chern Chen, Ming-Lung Yu, Wan-Long Chuang
AIM: 25-hydroxy vitamin D (Vit D) plays a role in treatment outcomes in chronic hepatitis C virus (HCV) infection (CHC). We aimed to clarify HCV replication is inhibited by Vit D in HCV replicon cells. Clinical implication was assessed for rapid virological response (RVR) and sustained virological response (SVR) among those patients receiving anti-viral therapy. METHODS: Cell survival and viral loads were observed in Con1 (genotype-1b) and J6/JFH (genotype-2a) cells treated with different doses of Vit D...
February 22, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28139365/vitamin%C3%A2-a-in-pediatrics-an-update-from-the-nutrition-committee-of-the-french-society-of-pediatrics
#4
M Vidailhet, D Rieu, F Feillet, A Bocquet, J-P Chouraqui, D Darmaun, C Dupont, M-L Frelut, J-P Girardet, R Hankard, J-C Rozé, U Siméoni, D Turck, A Briend
Vitamin A (retinol) fulfills multiple functions in vision, cell growth and differentiation, embryogenesis, the maintenance of epithelial barriers and immunity. A large number of enzymes, binding proteins and receptors facilitate its intestinal absorption, hepatic storage, secretion, and distribution to target cells. In addition to the preformed retinol of animal origin, some fruits and vegetables are rich in carotenoids with provitamin A precursors such as β-carotene: 6μg of β-carotene corresponds to 1μg retinol equivalent (RE)...
January 27, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28122934/riboflavin-deficiency-in-rats-decreases-de-novo-formate-production-but-does-not-affect-plasma-formate-concentration
#5
Luke MacMillan, Simon G Lamarre, Robin P daSilva, René L Jacobs, Margaret E Brosnan, John T Brosnan
BACKGROUND: The one-carbon metabolism pathway is highly dependent on a number of B vitamins in order to provide one-carbon units for purine and thymidylate biosynthesis as well as homocysteine remethylation. Previous studies have examined folate and vitamin B-12 deficiency and their effects on formate metabolism; as of yet, to our knowledge, no studies on the effects of riboflavin deficiency on formate metabolism have been published. OBJECTIVE: Our objective was to determine the effects of riboflavin deficiency on formate metabolism...
January 25, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28079241/is-there-an-association-between-vitamin-d-and-liver-fibrosis-in-patients-with-chronic-hepatitis-c
#6
Kalinca da Silva Oliveira, Caroline Buss, Cristiane Valle Tovo
BACKGROUND: - Vitamin D is known for its immunomodulatory, anti-inflammatory and antifibrotic properties, which are quite relevant in the pathogenesis and treatment of many causes of chronic liver disease. OBJECTIVE: - This study aimed to evaluate the association between serum vitamin D levels and the histopathological findings in patients with chronic hepatitis C virus infection. METHODS: - Cross-sectional study composed of patients with chronic hepatitis C...
January 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28062356/cyp4f2-repression-and-a-modified-alpha-tocopherol-vitamin-e-metabolism-are-two-independent-consequences-of-ethanol-toxicity-in-human-hepatocytes
#7
A Russo, D Bartolini, P Torquato, D Giusepponi, C Barola, R Galarini, M Birringer, S Lorkowski, F Galli
The expression of CYP4F2, a form of cytochrome P-450 with proposed role in α-tocopherol and long-chain fatty acid metabolism, was explored in HepG2 and HepaRG human hepatocytes during ethanol toxicity. Cytotoxicity, ROS production, and JNK and ERK1/2 kinase signaling increased in a dose and time-dependent manner during ethanol treatments; CYP4F2 gene expression decreased, while other CYP4F forms, namely 4F11 and 12, increased along with 3A4 and 2E1 isoforms. α-Tocopherol antagonized the cytotoxicity and CYP4F2 gene repression effect of ethanol in HepG2 cells...
January 3, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/27888359/low-25-oh-vitamin%C3%A2-d-levels-reflect-hepatic-dysfunction-and-are-associated-with-mortality-in-patients-with-liver-cirrhosis
#8
Rafael Paternostro, Doris Wagner, Thomas Reiberger, Mattias Mandorfer, Remy Schwarzer, Monika Ferlitsch, Michael Trauner, Markus Peck-Radosavljevic, Arnulf Ferlitsch
BACKGROUND AND AIMS: Vitamin D deficiency is frequent in patients with cirrhosis. The aims of this study were to evaluate the relation of vitamin D status to portal hypertension, degree of liver dysfunction and survival. METHODS: Patients with cirrhosis who have been tested for 25-OH-vitamin D levels were retrospectively included. Vitamin D deficiency was defined as 25-OH-vitamin D levels <10 ng/ml. Child-Pugh score, model for end-stage liver disease (MELD) and available hepatic venous pressure gradient (HVPG) were recorded...
January 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27863206/assessment-of-3-epi-25-hydroxyvitamin-d-levels-during-cholecalciferol-supplementation-in-adults-with-chronic-liver-diseases
#9
Caroline S Stokes, Dietrich A Volmer
Recently, hepatic immaturity was cited as a possible reason for high levels of the C-3 epimer of 25-hydroxyvitamin (25(OH)D) in premature infants: however what role, if any, the liver plays in controlling epimer concentrations is unknown. This study assesses 3-epi-25-hydroxyvitamin D (3-epi-25(OH)D) levels during the course of cholecalciferol supplementation in adults with chronic liver diseases (CLD). Vitamin D metabolites were analyzed in 65 CLD patients with 25(OH)D <30 ng/mL who received 20 000 IU cholecalciferol/week for 6 months...
December 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27853723/evaluation-of-the-protective-role-of-vitamin-c-on-the-metabolic-and-enzymatic-activities-of-the-liver-in-the-male-rats-after-exposure-to-2-45-ghz-of-wi-fi-routers
#10
F Shekoohi-Shooli, S M J Mortazavi, M B Shojaei-Fard, S Nematollahi, M Tayebi
BACKGROUND: The use of devices emitted microwave radiation such as mobile phones, wireless fidelity (Wi-Fi) routers, etc. is increased rapidly. It has caused a great concern; the researchers should identify its effects on people's health. We evaluated the protective role of Vitamin C on the metabolic and enzymatic activities of the liver after exposure to Wi-Fi routers. MATERIAL AND METHODS: 70 male Wistar rats weighing 200-250 g were randomly divided into 7 groups (10 rats in each group)...
September 2016: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/27813318/bleeding-and-liver-transplantation-outcomes-in-haemophilia
#11
K D Mehta, M V Ragni
BACKGROUND: Hepatitis C is the major cause of end-stage liver disease and the major indication for orthotopic liver transplantation (OLTx) in individuals with haemophilia. AIM: To assess the epidemiology and outcomes of OLTx in U.S. haemophilia patients. METHODS: We investigated haemophilia liver transplant recipients between 1993 and 2012, using the Nationwide Inpatient Sample, identified by ICD9 code 50.59. RESULTS: Of the 11 267 (weighted n = 54 691) patients undergoing OLTx, 44 (0...
March 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27806685/prepartum-body-condition-score-and-plane-of-nutrition-affect-the-hepatic-transcriptome-during-the-transition-period-in-grazing-dairy-cows
#12
M Vailati-Riboni, S Meier, C R Burke, J K Kay, M D Mitchell, C G Walker, M A Crookenden, A Heiser, S L Rodriguez-Zas, J R Roche, J J Loor
BACKGROUND: A transcriptomic approach was used to evaluate potential interactions between prepartum body condition score (BCS) and feeding management in the weeks before calving on hepatic metabolism during the periparturient period. METHODS: Thirty-two mid-lactation grazing dairy cows of mixed age and breed were randomly allocated to one of four treatment groups in a 2 × 2 factorial arrangement: two prepartum BCS categories [4.0 (thin, BCS4) and 5.0 (optimal, BCS5); based on a 10-point scale], and two levels of energy intake during the 3 weeks preceding calving (75 and 125 % of estimated requirements)...
November 2, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27787390/high-25-hydroxyvitamin-d-is-associated-with-unexpectedly-high-plasma-inflammatory-markers-in-hiv-patients-on-antiretroviral-therapy
#13
Louie Mar A Gangcuangco, Lindsay B Kohorn, Dominic C Chow, Sheila M Keating, Philip J Norris, Lorna S Nagamine, Lishomwa C Ndhlovu, Scott A Souza, Kalpana J Kallianpur, Cecilia M Shikuma
Inflammation associated with low 25-hydroxyvitamin D (25(OH)D) is associated with increased morbidity and mortality among HIV-infected patients with vitamin D deficiency. We investigated the association between 25(OH)D and soluble biomarkers among HIV-infected patients on stable antiretroviral therapy. This is a cross-sectional study. This study focuses on assessment in subjects 40 years or older on stable antiretroviral therapy (ART) for >3 months. Chemiluminescent immunoassay was used to determine plasma 25(OH)D levels...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27696253/vitamin-d-and-gallstone-disease-a-population-based-study
#14
Daniel Mønsted Shabanzadeh, Torben Jørgensen, Allan Linneberg, Lars Tue Sørensen, Tea Skaaby
Gallstone disease is highly prevalent in the general population and is a major gastrointestinal cause of hospital admissions. The objectives were to determine whether circulating levels of 25-hydroxyvitamin D were associated to ultrasound proven gallstones or cholecystectomy in a general population sample. Determinants of vitamin D status were also explored. A random sample of 4130 people from the population of Copenhagen with ages 41-71 years were invited (N = 4130) and 2650 participants were included...
December 2016: Endocrine
https://www.readbyqxmd.com/read/27694737/relationships-between-low-serum-vitamin-d-levels-and-hbv-a-determinant-mutations-in-chronic-hepatitis-b-patients
#15
Huijuan Zhu, Xingxiang Liu, Yi Ding, Hui Zhou, Yiying Wang, Zhiwei Zhou, Xinxin Li, Zengli Zhang, Chen Dong
INTRODUCTION: Vitamin D is significantly associated with virus replication in chronic hepatitis B virus (HBV) infection. However, the relationship between low serum vitamin D levels and HBV "a" determinant mutations remains unknown. METHODOLOGY: A total of 133 chronically HBV-infected, treatment-naive patients were randomly selected in the present study. Serum vitamin D levels were measured by using liquid chromatography-mass spectrometry. The HBV "a" determinant was amplified, sequenced, and analyzed by nested polymerase chain reaction (PCR)...
September 30, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27659316/association-of-vitamin-d-deficiency-with-hepatitis-b-virus-related-liver-diseases
#16
Nghiem Xuan Hoan, Nguyen Khuyen, Mai Thanh Binh, Dao Phuong Giang, Hoang Van Tong, Phan Quoc Hoan, Ngo Tat Trung, Do Tuan Anh, Nguyen Linh Toan, Christian G Meyer, Peter G Kremsner, Thirumalaisamy P Velavan, Le Huu Song
BACKGROUND: As an immune modulator, vitamin D is involved in various pathophysiological mechanisms in a plethora of diseases. This study aims to correlate the vitamin D deficiency status and clinical progression of liver diseases associated with hepatitis B virus (HBV) infection in patients in Vietnam and to compare it to healthy controls. METHODS: We quantified the levels of total vitamin D [25-(OH) D2 and D3] in serum samples from 400 HBV patients (chronic hepatitis B infection [CHB], n = 165; HBV-associated liver cirrhosis [LC], n = 127; HBV-associated hepatocellular carcinoma [HCC], n = 108) and 122 unrelated healthy controls (HC)...
September 23, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27501393/regulation-of-nutritional-metabolism-in-transition-dairy-cows-energy-homeostasis-and-health-in-response-to-post-ruminal-choline-and-methionine
#17
Feifei Sun, Yangchun Cao, Chuanjiang Cai, Shengxiang Li, Chao Yu, Junhu Yao
This study investigated the effects of rumen-protected methionine (RPM) and rumen-protected choline (RPC) on energy balance, postpartum lactation performance, antioxidant capacity and immune response in transition dairy cows. Forty-eight multiparous transition cows were matched and divided into four groups: control, 15 g/d RPC, 15 g/d RPM or 15 g/d RPC + 15 g/d RPM. Diet samples were collected daily before feeding, and blood samples were collected weekly from the jugular vein before morning feeding from 21 days prepartum to 21 days postpartum...
2016: PloS One
https://www.readbyqxmd.com/read/27487797/association-between-vitamin-d-deficiency-and-preexisting-resistance-associated-hcv-ns5a-variants
#18
Tomomi Okubo, Masanori Atsukawa, Akihito Tsubota, Noritomo Shimada, Hiroshi Abe, Kai Yoshizawa, Taeang Arai, Ai Nakagawa, Norio Itokawa, Chisa Kondo, Yoshio Aizawa, Katsuhiko Iwakiri
AIM: Although interferon-free therapy with direct acting antivirals has developed as a standard of care for chronic hepatitis C, the existence of resistance-associated variants (RAVs) has a negative impact on treatment results. Recently several studies indicated a relationship between chronic hepatitis C and serum vitamin D levels. However, the relationship between RAVs at the HCV NS5A region and serum vitamin D level has not yet been examined. METHODS: Among patients with genotype 1 chronic hepatitis C who were enrolled in a multicenter cooperative study, our subjects comprised 247 patients in whom it was possible to measure RAVs at the NS5A region...
August 2, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27461011/ameliorative-effect-of-vitamin-c-against-hepatotoxicity-induced-by-emamectin-benzoate-in-rats
#19
H Khaldoun Oularbi, C Richeval, N Lebaili, N Zerrouki-Daoudi, M Baha, N Djennas, D Allorge
In the present study, we aimed to assess the potential protective effect of ascorbic acid (AA) against emamectin benzoate (EMB)-induced hepatotoxicity. For this purpose, biochemical, histopathological and analytical investigations were performed. Male Wistar rats were distributed into three groups, that is, a control group, an EMB group given 10 mg EMB/kg body weight (BW) by gavage and an EMB + AA group given 10 mg EMB/kg BW and vitamin C intraperitoneally (200 mg/kg). The duration of the treatment was 28 days and the duration of the study was 42 days...
July 26, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27459945/the-roles-of-bile-acids-and-sphingosine-1-phosphate-signaling-in-the-hepatobiliary-diseases
#20
REVIEW
Masayuki Nagahashi, Kizuki Yuza, Yuki Hirose, Masato Nakajima, Rajesh Ramanathan, Nitai C Hait, Phillip B Hylemon, Huiping Zhou, Kazuaki Takabe, Toshifumi Wakai
Based on research carried out over the last decade, it has become increasingly evident that bile acids act not only as detergents, but also as important signaling molecules that exert various biological effects via activation of specific nuclear receptors and cell signaling pathways. Bile acids also regulate the expression of numerous genes encoding enzymes and proteins involved in the synthesis and metabolism of bile acids, glucose, fatty acids, and lipoproteins, as well as energy metabolism. Receptors activated by bile acids include, farnesoid X receptor α, pregnane X receptor, vitamin D receptor, and G protein-coupled receptors, TGR5, muscarinic receptor 2, and sphingosine-1-phosphate receptor (S1PR)2...
September 2016: Journal of Lipid Research
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