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Vitamin D and hepatitis C

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https://www.readbyqxmd.com/read/27888359/low-25-oh-vitamin%C3%A2-d-levels-reflect-hepatic-dysfunction-and-are-associated-with-mortality-in-patients-with-liver-cirrhosis
#1
Rafael Paternostro, Doris Wagner, Thomas Reiberger, Mattias Mandorfer, Remy Schwarzer, Monika Ferlitsch, Michael Trauner, Markus Peck-Radosavljevic, Arnulf Ferlitsch
BACKGROUND AND AIMS: Vitamin D deficiency is frequent in patients with cirrhosis. The aims of this study were to evaluate the relation of vitamin D status to portal hypertension, degree of liver dysfunction and survival. METHODS: Patients with cirrhosis who have been tested for 25-OH-vitamin D levels were retrospectively included. Vitamin D deficiency was defined as 25-OH-vitamin D levels <10 ng/ml. Child-Pugh score, model for end-stage liver disease (MELD) and available hepatic venous pressure gradient (HVPG) were recorded...
November 25, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27863206/assessment-of-3-epi-25-hydroxyvitamin-d-levels-during-cholecalciferol-supplementation-in-adults-with-chronic-liver-diseases
#2
Caroline S Stokes, Dietrich A Volmer
Recently, hepatic immaturity was cited as a possible reason for high levels of the C-3 epimer of 25-hydroxyvitamin (25(OH)D) in premature infants: however what role, if any, the liver plays in controlling epimer concentrations is unknown. This study assesses 3-epi-25-hydroxyvitamin D (3-epi-25(OH)D) levels during the course of cholecalciferol supplementation in adults with chronic liver diseases (CLD). Vitamin D metabolites were analyzed in 65 CLD patients with 25(OH)D <30 ng/mL who received 20 000 IU cholecalciferol/week for 6 months...
December 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27853723/evaluation-of-the-protective-role-of-vitamin-c-on-the-metabolic-and-enzymatic-activities-of-the-liver-in-the-male-rats-after-exposure-to-2-45-ghz-of-wi-fi-routers
#3
F Shekoohi-Shooli, S M J Mortazavi, M B Shojaei-Fard, S Nematollahi, M Tayebi
BACKGROUND: The use of devices emitted microwave radiation such as mobile phones, wireless fidelity (Wi-Fi) routers, etc. is increased rapidly. It has caused a great concern; the researchers should identify its effects on people's health. We evaluated the protective role of Vitamin C on the metabolic and enzymatic activities of the liver after exposure to Wi-Fi routers. MATERIAL AND METHODS: 70 male Wistar rats weighing 200-250 g were randomly divided into 7 groups (10 rats in each group)...
September 2016: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/27813318/bleeding-and-liver-transplantation-outcomes-in-haemophilia
#4
K D Mehta, M V Ragni
BACKGROUND: Hepatitis C is the major cause of end-stage liver disease and the major indication for orthotopic liver transplantation (OLTx) in individuals with haemophilia. AIM: To assess the epidemiology and outcomes of OLTx in U.S. haemophilia patients. METHODS: We investigated haemophilia liver transplant recipients between 1993 and 2012, using the Nationwide Inpatient Sample, identified by ICD9 code 50.59. RESULTS: Of the 11 267 (weighted n = 54 691) patients undergoing OLTx, 44 (0...
November 4, 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27806685/prepartum-body-condition-score-and-plane-of-nutrition-affect-the-hepatic-transcriptome-during-the-transition-period-in-grazing-dairy-cows
#5
M Vailati-Riboni, S Meier, C R Burke, J K Kay, M D Mitchell, C G Walker, M A Crookenden, A Heiser, S L Rodriguez-Zas, J R Roche, J J Loor
BACKGROUND: A transcriptomic approach was used to evaluate potential interactions between prepartum body condition score (BCS) and feeding management in the weeks before calving on hepatic metabolism during the periparturient period. METHODS: Thirty-two mid-lactation grazing dairy cows of mixed age and breed were randomly allocated to one of four treatment groups in a 2 × 2 factorial arrangement: two prepartum BCS categories [4.0 (thin, BCS4) and 5.0 (optimal, BCS5); based on a 10-point scale], and two levels of energy intake during the 3 weeks preceding calving (75 and 125 % of estimated requirements)...
November 2, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27787390/high-25-hydroxyvitamin-d-is-associated-with-unexpectedly-high-plasma-inflammatory-markers-in-hiv-patients-on-antiretroviral-therapy
#6
Louie Mar A Gangcuangco, Lindsay B Kohorn, Dominic C Chow, Sheila M Keating, Philip J Norris, Lorna S Nagamine, Lishomwa C Ndhlovu, Scott A Souza, Kalpana J Kallianpur, Cecilia M Shikuma
Inflammation associated with low 25-hydroxyvitamin D (25(OH)D) is associated with increased morbidity and mortality among HIV-infected patients with vitamin D deficiency. We investigated the association between 25(OH)D and soluble biomarkers among HIV-infected patients on stable antiretroviral therapy. This is a cross-sectional study. This study focuses on assessment in subjects 40 years or older on stable antiretroviral therapy (ART) for >3 months. Chemiluminescent immunoassay was used to determine plasma 25(OH)D levels...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27696253/vitamin-d-and-gallstone-disease-a-population-based-study
#7
Daniel Mønsted Shabanzadeh, Torben Jørgensen, Allan Linneberg, Lars Tue Sørensen, Tea Skaaby
Gallstone disease is highly prevalent in the general population and is a major gastrointestinal cause of hospital admissions. The objectives were to determine whether circulating levels of 25-hydroxyvitamin D were associated to ultrasound proven gallstones or cholecystectomy in a general population sample. Determinants of vitamin D status were also explored. A random sample of 4130 people from the population of Copenhagen with ages 41-71 years were invited (N = 4130) and 2650 participants were included...
October 1, 2016: Endocrine
https://www.readbyqxmd.com/read/27694737/relationships-between-low-serum-vitamin-d-levels-and-hbv-a-determinant-mutations-in-chronic-hepatitis-b-patients
#8
Huijuan Zhu, Xingxiang Liu, Yi Ding, Hui Zhou, Yiying Wang, Zhiwei Zhou, Xinxin Li, Zengli Zhang, Chen Dong
INTRODUCTION: Vitamin D is significantly associated with virus replication in chronic hepatitis B virus (HBV) infection. However, the relationship between low serum vitamin D levels and HBV "a" determinant mutations remains unknown. METHODOLOGY: A total of 133 chronically HBV-infected, treatment-naive patients were randomly selected in the present study. Serum vitamin D levels were measured by using liquid chromatography-mass spectrometry. The HBV "a" determinant was amplified, sequenced, and analyzed by nested polymerase chain reaction (PCR)...
September 30, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27659316/association-of-vitamin-d-deficiency-with-hepatitis-b-virus-related-liver-diseases
#9
Nghiem Xuan Hoan, Nguyen Khuyen, Mai Thanh Binh, Dao Phuong Giang, Hoang Van Tong, Phan Quoc Hoan, Ngo Tat Trung, Do Tuan Anh, Nguyen Linh Toan, Christian G Meyer, Peter G Kremsner, Thirumalaisamy P Velavan, Le Huu Song
BACKGROUND: As an immune modulator, vitamin D is involved in various pathophysiological mechanisms in a plethora of diseases. This study aims to correlate the vitamin D deficiency status and clinical progression of liver diseases associated with hepatitis B virus (HBV) infection in patients in Vietnam and to compare it to healthy controls. METHODS: We quantified the levels of total vitamin D [25-(OH) D2 and D3] in serum samples from 400 HBV patients (chronic hepatitis B infection [CHB], n = 165; HBV-associated liver cirrhosis [LC], n = 127; HBV-associated hepatocellular carcinoma [HCC], n = 108) and 122 unrelated healthy controls (HC)...
September 23, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27501393/regulation-of-nutritional-metabolism-in-transition-dairy-cows-energy-homeostasis-and-health-in-response-to-post-ruminal-choline-and-methionine
#10
Feifei Sun, Yangchun Cao, Chuanjiang Cai, Shengxiang Li, Chao Yu, Junhu Yao
This study investigated the effects of rumen-protected methionine (RPM) and rumen-protected choline (RPC) on energy balance, postpartum lactation performance, antioxidant capacity and immune response in transition dairy cows. Forty-eight multiparous transition cows were matched and divided into four groups: control, 15 g/d RPC, 15 g/d RPM or 15 g/d RPC + 15 g/d RPM. Diet samples were collected daily before feeding, and blood samples were collected weekly from the jugular vein before morning feeding from 21 days prepartum to 21 days postpartum...
2016: PloS One
https://www.readbyqxmd.com/read/27487797/association-between-vitamin-d-deficiency-and-preexisting-resistance-associated-hcv-ns5a-variants
#11
Tomomi Okubo, Masanori Atsukawa, Akihito Tsubota, Noritomo Shimada, Hiroshi Abe, Kai Yoshizawa, Taeang Arai, Ai Nakagawa, Norio Itokawa, Chisa Kondo, Yoshio Aizawa, Katsuhiko Iwakiri
AIM: Although interferon-free therapy with direct acting antivirals has developed as a standard of care for chronic hepatitis C, the existence of resistance-associated variants (RAVs) has a negative impact on treatment results. Recently several studies indicated a relationship between chronic hepatitis C and serum vitamin D levels. However, the relationship between RAVs at the HCV NS5A region and serum vitamin D level has not yet been examined. METHODS: Among patients with genotype 1 chronic hepatitis C who were enrolled in a multicenter cooperative study, our subjects comprised 247 patients in whom it was possible to measure RAVs at the NS5A region...
August 2, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27461011/ameliorative-effect-of-vitamin-c-against-hepatotoxicity-induced-by-emamectin-benzoate-in-rats
#12
H Khaldoun Oularbi, C Richeval, N Lebaili, N Zerrouki-Daoudi, M Baha, N Djennas, D Allorge
In the present study, we aimed to assess the potential protective effect of ascorbic acid (AA) against emamectin benzoate (EMB)-induced hepatotoxicity. For this purpose, biochemical, histopathological and analytical investigations were performed. Male Wistar rats were distributed into three groups, that is, a control group, an EMB group given 10 mg EMB/kg body weight (BW) by gavage and an EMB + AA group given 10 mg EMB/kg BW and vitamin C intraperitoneally (200 mg/kg). The duration of the treatment was 28 days and the duration of the study was 42 days...
July 26, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27459945/the-roles-of-bile-acids-and-sphingosine-1-phosphate-signaling-in-the-hepatobiliary-diseases
#13
REVIEW
Masayuki Nagahashi, Kizuki Yuza, Yuki Hirose, Masato Nakajima, Rajesh Ramanathan, Nitai C Hait, Phillip B Hylemon, Huiping Zhou, Kazuaki Takabe, Toshifumi Wakai
Based on research carried out over the last decade, it has become increasingly evident that bile acids act not only as detergents, but also as important signaling molecules that exert various biological effects via activation of specific nuclear receptors and cell signaling pathways. Bile acids also regulate the expression of numerous genes encoding enzymes and proteins involved in the synthesis and metabolism of bile acids, glucose, fatty acids, and lipoproteins, as well as energy metabolism. Receptors activated by bile acids include, farnesoid X receptor α, pregnane X receptor, vitamin D receptor, and G protein-coupled receptors, TGR5, muscarinic receptor 2, and sphingosine-1-phosphate receptor (S1PR)2...
September 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27366029/vitamin-d-deficiency-in-patients-with-liver-cirrhosis
#14
REVIEW
Christos Konstantakis, Paraskevi Tselekouni, Maria Kalafateli, Christos Triantos
There is ongoing evidence that vitamin D is related to the pathophysiology of cirrhosis. Although the incidence of vitamin D deficiency in chronic liver diseases and cirrhosis is strongly documented, its pathogenic association with advanced liver fibrosis remains controversial. There is evidence of a significant relation of 25(OH)D levels with the degree of liver dysfunction, considering that an inverse correlation of 25(OH)D levels with both Child-Pugh score and Model for End-Stage Liver Disease has been reported...
July 2016: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/27263300/-association-of-vitamin-d-receptor-polymorphisms-with-response-to-antiviral-therapy-in-patients-with-chronic-hepatitis-c
#15
Cong Wang, Qin Wu, Xiu-tian Wei, Zhen-zhen Li, Xue-zhong Lei
OBJECTIVE: To assess the influence of vitamin D receptor (VDR) gene Bsm I, Fok I, Taq I and Apa I polymorphisms on the response to antiviral therapy in patients with chronic hepatitis C (CHC). METHODS: There were total 124 patients with CHC treated with pegylated interferon plus ribavirin. VDR gene Bsm I, Fok I Taq I and Apa I polymorphisms were analyzed in 71 patients with sustained virological response (SVR) and 53 patients without SVR (non-SVR) by polymerase chain reaction-MassARRAY (PCR-MassARRAY)...
March 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/27262368/the-vitamin-d-metabolites-25-oh-d-and-1-25-oh-2d-are-not-related-to-either-glucose-metabolism-or-insulin-action-in-obese-women
#16
K W Ter Horst, R I Versteeg, P W Gilijamse, M T Ackermans, A C Heijboer, J A Romijn, S E la Fleur, R Trinko, R J DiLeone, M J Serlie
AIM: Vitamin D deficiency has been proposed to be involved in obesity-induced metabolic disease. However, data on the relationship between 25-hydroxycholecalciferol (25(OH)D) and insulin resistance have been inconsistent, and few studies have investigated the active vitamin D metabolite, 1,25-dihydroxycholecalciferol (1,25(OH)2D). This study aimed to determine the relationship between circulating levels of both 25(OH)D and 1,25(OH)2D and direct measures of glucose metabolism and insulin action in obese women...
June 1, 2016: Diabetes & Metabolism
https://www.readbyqxmd.com/read/27246833/bone-health-and-vitamin-d-status-in-alcoholic-liver-disease
#17
REVIEW
M Kizilgul, O Ozcelik, T Delibasi
Alcohol consumption is harmful to many organs and tissues, including bones, and it leads to osteoporosis. Hepatic osteodystrophy is abnormal bone metabolism that has been defined in patients with chronic liver disease (CLD), including osteopenia, osteoporosis, and osteomalacia. Decreased bone density in patients with CLD results from decreased bone formation or increased bone resorption. The prevalence of osteopenia in alcoholic liver disease (ALD) patients is between 34 % and 48 %, and the prevalence of osteoporosis is between 11 % and 36 %...
July 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27245430/hepatocyte-vitamin-d-receptor-regulates-lipid-metabolism-and-mediates-experimental-diet-induced-steatosis
#18
Milica Bozic, Carla Guzmán, Marta Benet, Sonia Sánchez-Campos, Carmelo García-Monzón, Eloi Gari, Sonia Gatius, José Manuel Valdivielso, Ramiro Jover
BACKGROUND & AIMS: The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid metabolism and can promote hepatosteatosis, but the possible role of vitamin D receptor (VDR) in NAFLD has not been investigated. METHODS: The expression of liver VDR was investigated in apolipoprotein E knockout (apoE(-/-)) mice on a high fat diet, in wild-type mice on methionine and choline deficient diet and in NAFLD patients with hepatosteatosis and non-alcoholic steatohepatitis...
October 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27236148/%C3%A2-the-relation-of-fibrosis-stage-with-nutritional-deficiencies-and-bioelectrical-impedance-analysis-of-body-composition-in-patients-with-chronic-hepatitis-c
#19
Beatriz Mateos-Muñoz, María J Devesa-Medina, María P Matía-Martín, María J Torrejón, Avelina Suárez, Angélica Larrad-Sáinz, Enrique Rey-Díaz-Rubio, María C Cárdenas, Luis Ortega-Medina, José M Ladero
UNLABELLED:  Background. Nutritional deficiencies may aggravate the course of chronic hepatitis C (CHC). Our aim has been to perform a comprehensive analysis of body composition and nutritional deficiencies in CHC patients in non-cirrhotic and compensated cirrhotic stages to correlate the detected deficiencies with the fibrosis stage. MATERIAL AND METHODS: Body multifrequency bioimpedance analysis (BIA) and a wide and simultaneous analytical profile were prospectively performed in 74 CHC patients (36 male) with known METAVIR fibrosis stage established with liver biopsy or transient elastography...
July 2016: Annals of Hepatology
https://www.readbyqxmd.com/read/27234962/pro-inflammatory-signaling-by-24-25-dihydroxyvitamin-d3-in-hepg2-cells
#20
Kent Wehmeier, Luisa M Onstead-Haas, Norman C W Wong, Arshag D Mooradian, Michael J Haas
The vitamin D metabolite 24,25-dihydroxyvitamin D3 (24, 25[OH]2D3) was shown to induce nongenomic signaling pathways in resting zone chondrocytes and other cells involved in bone remodeling. Recently, our laboratory demonstrated that 24,25-[OH]2D3 but not 25-hydroxyvitamin D3, suppresses apolipoprotein A-I (apo A-I) gene expression and high-density lipoprotein (HDL) secretion in hepatocytes. Since 24,25-[OH]2D3 has low affinity for the vitamin D receptor (VDR) and little is known with regard to how 24,25-[OH]2D3 modulates nongenomic signaling in hepatocytes, we investigated the capacity of 24,25-[OH]2D3 to activate various signaling pathways relevant to apo A-I synthesis in HepG2 cells...
August 2016: Journal of Molecular Endocrinology
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