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https://www.readbyqxmd.com/read/30317798/-research-progress-in-prognostic-factors-of-hepatitis-b-virus-associated-end-stage-liver-disease
#1
X Feng, X F Shi
Hepatitis B remains a worldwide health problem with a high mortality rate associated with end-stage liver diseases. The Model for End-Stage Liver Disease and Child-Pugh score is still widely used as the prognostic model for liver cirrhosis and inflammatory reaction, B-type natriuretic peptide and portal vein thrombosis are independent risk factors. Many new models have been proposed for liver failure, including a new model HINAT ACLF. HINAT ACLF is better than its preceding models and increased neutrophil-to-lymphocyte ratio is a single factor to promote thyroid hormone, cholinesterase, and antiviral treatment response in this model...
August 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/30317596/update-on-pathological-platelet-activation-in-coronary-thrombosis
#2
REVIEW
Edoardo Elia, Fabrizio Montecucco, Piero Portincasa, Amirhossein Sahebkar, Hamid Mollazadeh, Federico Carbone
Although coronary thrombosis (CT) is integral to cardiovascular outcomes, the underlying pathophysiological mechanisms remain unclear. CT may occur in case of atherosclerotic plaque erosion/rupture, or even after stenting implantation. Platelets (PLT) activation is the keystone of atherothrombosis and depends on many dysregulated elements, including endothelial dysfunction, oxidized lipoproteins, and immune response. Besides the classical view of PLT as an effector of hemostatic response, a new repertoire of PLT activities is emerging...
October 14, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30232279/neutrophil-accumulation-and-net-release-contribute-to-thrombosis-in-hit
#3
Kandace Gollomp, Minna Kim, Ian Johnston, Vincent Hayes, John Welsh, Gowthami M Arepally, Mark Kahn, Michele P Lambert, Adam Cuker, Douglas B Cines, Lubica Rauova, M Anna Kowalska, Mortimer Poncz
Heparin-induced thrombocytopenia (HIT) is an immune-mediated thrombocytopenic disorder associated with a severe prothrombotic state. We investigated whether neutrophils and neutrophil extracellular traps (NETs) contribute to the development of thrombosis in HIT. Using an endothelialized microfluidic system and a murine passive immunization model, we show that HIT induction leads to increased neutrophil adherence to venous endothelium. In HIT mice, endothelial adherence is enhanced immediately downstream of nascent venous thrombi, after which neutrophils undergo retrograde migration via a CXCR2-dependent mechanism to accumulate into the thrombi...
September 20, 2018: JCI Insight
https://www.readbyqxmd.com/read/30191120/primary-antiphospholipid-syndrome-associated-liebman-sachs-endocarditis-leading-to-diffuse-alveolar-hemorrhage-a-case-report
#4
Ryan Hyde, Martin Runnstrom, Austin Anderson, Leonard Riley, Ali Ataya
A 26 year old female presented for recurrent blood tinged sputum during the previous year with development of frank hemoptysis three days prior to admission. Diffuse alveolar hemorrhage (DAH) was confirmed with serial lavages. The patient had no history of autoimmune disease, vascular thrombosis or pregnancy morbidity including miscarriages or pre-eclampsia. High dose steroids were initiated along with noninvasive ventilatory support. Transthoracic echocardiogram showed severe mitral regurgitation and a vegetation on the mitral valve; transesophageal echocardiogram determined the lesion highly suggestive of Libman-Sachs endocarditis...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/30175267/vasculitis-with-superior-ophthalmic-vein-thrombosis-compatible-with-neuro-neutrophilic-disease
#5
Mari Sakamoto, Takuji Kurimoto, Sotaro Mori, Kaori Ueda, Yukako Keshi, Yuko Yamada, Atsushi Azumi, Taro Shimono, Makoto Nakamura
Purpose: To present a unique case of neuro-neutrophilic disease with inflammation and thrombosis of the superior ophthalmic vein (SOV). Observations: A 43-year-old Japanese man with past histories of oculomotor paralysis, auditory disorder, ischemic enteritis, and recurrent oral ulceration was referred to our hospital because of blurred vision in his right eye. Ophthalmic examination revealed decreased best corrected visual acuity and central scotoma in his right eye...
December 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/30169667/histopathology-of-listeria-meningitis
#6
Joo-Yeon Engelen-Lee, Merel M Koopmans, Matthijs C Brouwer, Eleonora Aronica, Diederik van de Beek
Listeria monocytogenes meningitis is the third most common cause of bacterial meningitis in adults and has high mortality and morbidity rates. We describe the clinical course and score brain pathology of 5 patients who died of listeria meningitis. All patients were immunocompromised and ages ranged between 48 and 76 years. Three cases were confirmed by cerebrospinal fluid culture; one was confirmed by brain culture; and one diagnosis was based on a positive blood culture and neuropathological findings. Mild inflammation of meningeal arteries was found in 3 of 5 cases (60%)...
October 1, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/30148454/neutralize-the-neutrophils-neutrophil-%C3%AE-1-%C3%AE-2-integrin-activation-contributes-to-jak2-v617f-driven-thrombosis
#7
Stephen T Oh
No abstract text is available yet for this article.
October 1, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/30138777/the-role-of-neutrophils-in-thrombosis
#8
REVIEW
Sargam Kapoor, Aman Opneja, Lalitha Nayak
Despite significant evidence implicating an important role for neutrophils in thrombosis, their impact on the thrombotic process has remained a matter of controversy. Until 2010, platelets, coagulation factors, fibrinogen and monocytes were implicated in the thrombotic process. Several studies conducted over the last decade now support the growing notion that neutrophils indeed do contribute significantly to this process. Neutrophils can contribute to pathologic venous and arterial thrombosis or 'immunothrombosis' by the release of neutrophil extracellular traps (NETs) and NET release is emerging as a major contributor to thrombogenesis in pathologic situations such as sepsis and malignancy...
October 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30135284/-the-use-of-immunomodulators-antioxidants-and-hepatoprotectors-for-the-correction-of-the-liver-erythrocites-and-the-immune-system-disorders-in-chronic-ethanol-intoxication
#9
S A Dolgareva, A V Sorokin, N A Konoplya, O N Bushmina, N A Bystrova, A I Ovod
The effectiveness of three various combinations of an immunomodulator with an antioxidant and a membrane protector in the correction of metabolic and immune disorders has been studied in the experiment under 60-days ethanol intoxication. The development of such biochemical syndromes of the liver damage as cytolysis, intrahepatic, intracellular cholestasis, toxic liver damage by necrotic type, insufficiency of synthetic processes and inflammatory has been revealed. Oxidative stress development and the activation of lipid peroxidation on the systemic (blood plasma) and local level (erythrocytes) have been established...
August 2018: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/30126133/the-channel-kinase-trpm7-as-novel-regulator-of-immune-system-homeostasis
#10
REVIEW
Wiebke Nadolni, Susanna Zierler
The enzyme-coupled transient receptor potential channel subfamily M member 7, TRPM7, has been associated with immunity and immune cell signalling. Here, we review the role of this remarkable signalling protein in lymphocyte proliferation, differentiation, activation and survival. We also discuss its role in mast cell, neutrophil and macrophage function and highlight the potential of TRPM7 to regulate immune system homeostasis. Further, we shed light on how the cellular signalling cascades involving TRPM7 channel and/or kinase activity culminate in pathologies as diverse as allergic hypersensitivity, arterial thrombosis and graft versus host disease (GV HD), stressing the need for TRPM7 specific pharmacological modulators...
August 17, 2018: Cells
https://www.readbyqxmd.com/read/30124642/neutrophil-extracellular-traps-generated-by-low-density-neutrophils-obtained-from-peritoneal-lavage-fluid-mediate-tumor-cell-growth-and-attachment
#11
Rihito Kanamaru, Hideyuki Ohzawa, Hideyo Miyato, Hironori Yamaguchi, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
Activated neutrophils release neutrophil extracellular traps (NETs), which can capture and destroy microbes. Recent studies suggest that NETs are involved in various disease processes, such as autoimmune disease, thrombosis, and tumor metastases. Here, we show a detailed in vitro technique to detect NET activity during the trapping of free tumor cells, which grow after attachment to NETs. First, we collected low density neutrophils (LDN) from postoperative peritoneal lavage fluid from patients who underwent laparotomies...
August 3, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30089551/endothelial-driven-increase-in-plasma-thrombin-generation-characterising-a-new-hypercoagulable-phenotype-in-acute-heart-failure
#12
Batric Popovic, Faiez Zannad, Huguette Louis, Isabelle Clerc-Urmès, Cécile Lakomy, Sébastien Gibot, Cécile V Denis, Patrick Lacolley, Véronique Regnault
BACKGROUND: Subjects with heart failure (HF) are at higher risk of developing thrombosis. We investigated whether endothelium activation and inflammation induce a prothrombotic biological profile in patients with acute decompensated HF (ADHF) and sinus rhythm. METHODS: Our prospective study included 34 ADHF patients, 30 patients with stable chronic HF (CHF) and 30 control inpatients without HF. In vitro thrombin generation and its downregulation by activated protein C (APC) was monitored by calibrated automated thrombography at hospital admission, at the day of discharge and after discharge, following at least six weeks of clinical stability...
July 25, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30065836/platelets-regulate-leucocyte-responses-to-toll-like-receptor-stimulation
#13
Kathryn E Hally, Anne C La Flamme, Scott A Harding, Peter D Larsen
Objectives: Platelets are important regulators of vascular thrombosis and inflammation and are known to express Toll-like receptors (TLRs). Through TLRs, platelets mediate a number of responses by interacting with leucocytes. Here, we report the extent to which platelets modulate in vitro peripheral blood mononuclear cells (PBMCs) and granulocyte responses to TLR4, TLR2/1 and TLR2/6 stimulation in healthy subjects. Methods: Peripheral blood mononuclear cells and granulocytes from 10 healthy volunteers were cultured alone or cocultured with platelets...
2018: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/30062055/activated-platelets-induce-mlkl-driven-neutrophil-necroptosis-and-release-of-neutrophil-extracellular-traps-in-venous-thrombosis
#14
Daigo Nakazawa, Jyaysi Desai, Stefanie Steiger, Susanne Müller, Satish Kumar Devarapu, Shrikant R Mulay, Takamasa Iwakura, Hans-Joachim Anders
Venous thromboembolic (VTE) disease, often manifesting as deep vein thrombosis or pulmonary embolism, involves clot formation consisting of blood cells and platelets locked in plasma protein and chromatin networks. The latter derives from neutrophil extracellular traps released by dying neutrophils; however, the molecular mechanisms of neutrophil death in VTE remains unknown. We speculated that mixed lineage kinase-like (MLKL)-driven neutrophil necroptosis contributes to VTE. Indeed, human inferior venous cava thrombus material stained positive for phosphorylated MLKL, the activated version of MLKL that executes necroptotic cell death...
2018: Cell Death Discovery
https://www.readbyqxmd.com/read/30053822/unusual-case-of-chronic-recurrent-multifocal-osteomyelitis
#15
Ausra Snipaitiene, Rima Sileikiene, Justina Klimaite, Edita Jasinskiene, Rimantas Uktveris, Lina Jankauskaite
BACKGROUND: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare auto-inflammatory bone disorder that primarily affects young girls, with a mean age of 10 years at onset. Generally, it is a self-limited disease. However, recent data indicate that more than 50% of patients have a chronic persistent disease and about 20% a recurring course of this condition. Also, there are more cases reported with associated auto-inflammatory and autoimmune diseases. In this case report, we present a rare case of sporadic CRMO in which the patient eventually developed C-ANCA (cytoplasmic anti-neutrophil cytoplasmic antibodies)-associated renal vasculitis and hyperparathyroidism...
July 27, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/30049243/start-a-fire-kill-the-bug-the-role-of-platelets-in-inflammation-and-infection
#16
Carsten Deppermann, Paul Kubes
Platelets are the main players in thrombosis and hemostasis; however they also play important roles during inflammation and infection. Through their surface receptors, platelets can directly interact with pathogens and immune cells. Platelets form complexes with neutrophils to modulate their capacities to produce reactive oxygen species or form neutrophil extracellular traps. Furthermore, they release microbicidal factors and cytokines that kill pathogens and influence the immune response, respectively. Platelets also maintain the vascular integrity during inflammation by a mechanism that is different from classical platelet activation...
August 2018: Innate Immunity
https://www.readbyqxmd.com/read/30046725/glycoprotein-vi-in-securing-vascular-integrity-in-inflamed-vessels
#17
Yacine Boulaftali, Marie-Anne Mawhin, Martine Jandrot-Perrus, Benoît Ho-Tin-Noé
<AbstractText>Glycoprotein VI (GPVI), the main platelet receptor for collagen, has been shown to play a central role in various models of thrombosis, and to be a minor actor of hemostasis at sites of trauma. These observations have made of GPVI a novel target for antithrombotic therapy, as its inhibition would ideally combine efficacy with safety. Nevertheless, recent studies have indicated that GPVI could play an important role in preventing bleeding caused by neutrophils in the inflamed skin and lungs...
April 2018: Research and Practice in Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/30030160/neutrophil-extracellular-traps-the-core-player-in-vascular-complications-of-diabetes-mellitus
#18
REVIEW
Alexander Berezin
Diabetes mellitus (DM) is the most important metabolic disease with major threat for public health and increased risk of premature death. The prevalence of DM steadily rises in developing and developed countries achieving the epidemic level. Manifestation and progression of DM corresponds to developing vasculopathies, such as retinopathy, micro- and macro angiopathies, which negatively influence on clinical outcomes and quality-of-life. Although there are remarkable differences in the prevalence of vasculopathy in various types of DM, hyperglycemia and lipotoxicity are discussed as a major factors contributing to vascular complications partly through inducing neutrophil extracellular trap (NET)...
July 17, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29976772/neutrophil-extracellular-traps-induce-endothelial-cell-activation-and-tissue-factor-production-through-interleukin-1%C3%AE-and-cathepsin-g
#19
Eduardo J Folco, Thomas L Mawson, Amélie Vromman, Breno Bernardes-Souza, Grégory Franck, Oscar Persson, Momotaro Nakamura, Gail Newton, Francis W Luscinskas, Peter Libby
OBJECTIVE: Coronary artery thrombosis can occur in the absence of plaque rupture because of superficial erosion. Erosion-prone atheromata associate with more neutrophil extracellular traps (NETs) than lesions with stable or rupture-prone characteristics. The effects of NETs on endothelial cell (EC) inflammatory and thrombogenic properties remain unknown. We hypothesized that NETs alter EC functions related to erosion-associated thrombosis. APPROACH AND RESULTS: Exposure of human ECs to NETs increased VCAM-1 (vascular cell adhesion molecule 1) and ICAM-1 (intercellular adhesion molecule 1) mRNA and protein expression in a time- and concentration-dependent manner...
July 5, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29960272/deletion-of-extra-domain-a-of-fibronectin-reduces-acute-myocardial-ischaemia-reperfusion-injury-in-hyperlipidaemic-mice-by-limiting-thrombo-inflammation
#20
Mehul R Chorawala, Prem Prakash, Prakash Doddapattar, Manish Jain, Nirav Dhanesha, Anil K Chauhan
BACKGROUND:  Fibronectin splicing variant containing extra domain A (Fn-EDA), which is an endogenous ligand for Toll-like receptor 4 (TLR4), is present in negligible amounts in the plasma of healthy humans, but markedly elevated in patients with co-morbid conditions including diabetes and hyperlipidaemia, which are risk factors for myocardial infarction (MI). Very little is known about the role of Fn-EDA in the pathophysiology of acute MI under these co-morbid conditions. MATERIALS AND METHODS:  We determined the role of Fn-EDA in myocardial ischaemia/reperfusion (I/R) injury in the hyperlipidaemic apolipoprotein E-deficient (ApoE-/- ) mice...
August 2018: Thrombosis and Haemostasis
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