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https://www.readbyqxmd.com/read/30119077/added-value-of-whole-exome-and-transcriptome-sequencing-for-clinical-molecular-screenings-of-advanced-cancer-patients-with-solid-tumors
#1
Florence Koeppel, Alexandre Bobard, Céline Lefebvre, Marion Pedrero, Marc Deloger, Yannick Boursin, Catherine Richon, Romy Chen-Min-Tao, Guillaume Robert, Guillaume Meurice, Etienne Rouleau, Stefan Michiels, Christophe Massard, Jean-Yves Scoazec, Eric Solary, Jean-Charles Soria, Fabrice André, Ludovic Lacroix
Comprehensive genomic profiling using high-throughput sequencing brings a wealth of information, and its place in the clinical setting has been increasingly prominent. This review emphasizes the utility of whole-exome sequencing (WES) and transcriptome sequencing (RNAseq) in patient care and clinical research, based on published reports as well as our experience with the MOSCATO-01 (MOlecular Screening for CAncer Treatment Optimization) molecular triage trial at Gustave Roussy Cancer Center. In this trial, all contributive samples of patients with advanced solid tumors were analyzed prospectively with targeted gene sequencing (TGS) and comparative genomic hybridization...
July 2018: Cancer Journal
https://www.readbyqxmd.com/read/30119073/preventing-posttraumatic-stress-in-icu-survivors-a-single-center-pilot-randomized-controlled-trial-of-icu-diaries-and-psychoeducation
#2
Maia S Kredentser, Marcus Blouw, Nicole Marten, Jitender Sareen, O Joseph Bienvenu, Jennifer Ryu, Brooke E Beatie, Sarvesh Logsetty, Lesley A Graff, Shauna Eggertson, Sophia Sweatman, Braeden Debroni, Nina Cianflone, Rakesh C Arora, Ryan Zarychanski, Kendiss Olafson
OBJECTIVES: Critical illness can have a significant psychological impact on patients and their families. To inform the design of a larger trial, we assessed feasibility of ICU diaries and psychoeducation to prevent posttraumatic stress disorder, depression, and anxiety following ICU stays. DESIGN: Four-arm pilot randomized controlled trial. SETTING: A 10-bed tertiary ICU in Winnipeg, MB, Canada. PATIENTS: Critically ill patients greater than 17 years old with predicted ICU stays greater than 72 hours and mechanical ventilation duration greater than 24 hours...
August 16, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/30118814/timing-and-modes-of-death-after-pediatric-out-of-hospital-cardiac-arrest-resuscitation
#3
Geneviève Du Pont-Thibodeau, Michael Fry, Matthew Kirschen, Nicholas S Abend, Rebecca Ichord, Vinay M Nadkarni, Robert Berg, Alexis Topjian
AIM: To determine the timing and modes of death of children admitted to a pediatric critical care unit (PICU) of a tertiary care center after an out-of-hospital cardiac arrest (OHCA). METHODS: This is a retrospective descriptive study at a tertiary care PICU of all consecutive patients <18 years old who received ≥ 1 minute of chest compressions, had return of spontaneous circulation (ROSC) for ≥ 20 minutes, and were admitted to the PICU after an OHCA...
August 14, 2018: Resuscitation
https://www.readbyqxmd.com/read/30118761/accuracy-of-quick-sequential-organ-failure-assessment-score-to-predict-mortality-in-hospitalized-patients-with-suspected-infection-in-an-hiv-aids-reference-center-in-rio-de-janeiro-brazil
#4
José Moreira, Ariane Paixão, Juliana Oliveira, Waldir Jaló, Ofélio Manuel, Rafaela Rodrigues, Alexandra Oliveira, Leonardo Tinoco, João Lima, Beatriz Grinsztejn, Valdiléa G Veloso, André M Japiassú, Cristiane C Lamas
OBJECTIVES: To compare the discriminatory capacity of the quick Sequential Organ Failure Assessment (qSOFA) versus the Systemic Inflammatory Response Syndrome (SIRS) score for predicting 30-day mortality and intensive care unit (ICU) admission in patients with suspicion of infection at an HIV reference center. METHODS: Prospective cohort study including consecutive adult patients who had suspected infection and subsequently admitted to the medical ward. Variables related to qSOFA and SIRS were measured at admission...
August 14, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/30118642/a-videographic-assessment-of-the-quality-of-ems-to-ed-handoff-communication-during-pediatric-resuscitations
#5
Brian D Sumner, Emily A Grimsley, Niall H Cochrane, Ryan R Keane, Alexis B Sandler, Paul C Mullan, Karen J O'Connell
BACKGROUND: The National Association of EMS Physicians emphasizes the importance of high quality communication between emergency medical services (EMS) providers and emergency department (ED) staff for providing safe, effective care. The Joint Commission has identified ineffective handoff communication as a contributing factor in 80% of serious medical errors. The quality of handoff communication from EMS to ED teams for critically ill pediatric patients needs further exploration. OBJECTIVE: This study assessed the quality of handoff communication between EMS and ED staff during pediatric medical resuscitations...
August 17, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/30118535/tpte-and-tpte-qt-novel-markers-to-predict-sudden-cardiac-death-in-esrd
#6
Basil M Saour, Jeffrey H Wang, Michael P Lavelle, Roy O Mathew, Mandeep S Sidhu, William E Boden, Joseph D Sacco, Eric J Costanzo, Mohammad A Hossain, Tuhsar Vachharanji, Anas Alrefaee, Arif Asif
INTRODUCTION: Reliable markers to predict sudden cardiac death (SCD) in patients with end stage renal disease (ESRD) remain elusive, but echocardiogram (ECG) parameters may help stratify patients. Given their roles as markers for myocardial dispersion especially in high risk populations such as those with Brugada syndrome, we hypothesized that the Tpeak to Tend (TpTe) interval and TpTe/QT are independent risk factors for SCD in ESRD. METHODS: Retrospective chart review was conducted on a cohort of patients with ESRD starting hemodialysis...
August 16, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/30118449/the-context-of-patients-lives
#7
Anne Katz
I try to touch base with the clinic nurses each day before patients and physicians (in that order) start arriving and the usual busyness of the day takes over. A recent early morning conversation centered on one nurse's frustration with the spouse of a man who had been treated in another city and who was now under the care of a physician at our clinic. The woman had been calling the nurse repeatedly since her husband had returned home after the procedure. He was having complications, and she wanted something to be done about this immediately...
September 1, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/30118402/travel-cost-savings-and-practicality-for-low-vision-telerehabilitation
#8
Carolyn Ihrig
INTRODUCTION: Veterans with low vision who live in rural communities have limited access to low-vision rehabilitation services, unless they are able to travel several miles to a specialty low-vision clinic. A low-vision optometry telerehabilitation evaluation is a thorough assessment of patient's functional vision. Following each low-vision optometry telerehabilitation evaluation is a low-vision telerehabilitation initial assessment with a blind rehabilitation therapist. Our objective was to estimate the acceptance and practicality of low-vision telerehabilitation and investigate the travel cost and time savings...
August 17, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/30118365/challenges-of-burn-mass-casualty-incidents-in-the-prehospital-setting-lessons-from-the-formosa-fun-coast-park-color-party
#9
Chien-Hao Lin, Chih-Hao Lin, Chih-Yi Tai, Yu-You Lin, Frank Fuh-Yuan Shih
OBJECTIVE: A burn mass casualty incident (BMCI) involving 499 patients occurred at a "color party" in Taiwan in June 27, 2015. We implemented a study to identify critical challenges regarding the prehospital emergency care in BMCIs. METHODS: A three-stage, mixed methods study was conducted in 2016. First, a statistical analysis of prehospital management using the data retrieved from the Emergency Medical Management System of the Ministry of Health and Welfare, Taiwan was performed...
August 17, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/30118357/assessment-of-key-health-and-wellness-indicators-among-north-carolina-emergency-medical-service-providers
#10
Jane H Brice, Julianne M Cyr, Andrew T Hnat, Trent L Wei, Stephanie Principe, Sarah E Thead, Theodore R Delbridge, James E Winslow, Jonathan R Studnek, Antonio R Fernandez, Emily E Forrest
OBJECTIVE: To characterize key health indicators in Emergency Medical Services (EMS) personnel and identify areas for intervention in order to ensure a strong and capable emergency health workforce. METHODS: Participants were EMS personnel delivering patients to four regional tertiary care emergency departments within North Carolina (NC). After transferring patient care and agreeing to participate, height, weight, and blood pressure (BP) measurements were recorded and each participant completed a questionnaire regarding demographics, activity levels, alcohol consumption, smoking, and medical history...
August 17, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/30118160/preferred-weight-related-terminology-by-parents-of-children-with-obesity
#11
Lior Hirschfeld-Dicker, Roy David Samuel, Elinor Tiram Vakrat, Gal Dubnov-Raz
AIM: In order to improve weight-related discussion with patients and minimize their discomfort, the terminology used by medical staff should be carefully chosen. The study aim was to identify the most motivating weight-related terminology to use with children with obesity. METHODS: Focus groups were used to generate a list of 12 weight-related terms in Hebrew, sent by a questionnaire to parents of children and adolescents with obesity. Terms were graded according to how desirable, stigmatizing, blaming or motivating they were perceived...
August 17, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/30117797/implementation-of-an-enhanced-recovery-after-spine-surgery-program-at-a-large-cancer-center-a-preliminary-analysis
#12
Roxana M Grasu, Juan P Cata, Anh Q Dang, Claudio E Tatsui, Laurence D Rhines, Katherine B Hagan, Shreyas Bhavsar, Sally R Raty, Radha Arunkumar, Yury Potylchansky, Ian Lipski, Benjamin A Arnold, Thomas M McHugh, Justin E Bird, Andrea Rodriguez-Restrepo, Mike Hernandez, Keyuri U Popat
OBJECTIVE Enhanced Recovery After Surgery (ERAS) programs follow a multimodal, multidisciplinary perioperative care approach that combines evidence-based perioperative strategies to accelerate the functional recovery process and improve surgical outcomes. Despite increasing evidence that supports the use of ERAS programs in gastrointestinal and pelvic surgery, data regarding the development of ERAS programs in spine surgery are scarce. To evaluate the impact of an Enhanced Recovery After Spine Surgery (ERSS) program in a US academic cancer center, the authors introduced such a program and hypothesized that ERSS would have a significant influence on meaningful clinical measures of postoperative recovery, such as pain management, postoperative length of stay (LOS), and complications...
August 17, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/30117795/randomized-trial-of-cell-saver-in-2-to-3-level-lumbar-instrumented-posterior-fusions
#13
Mladen Djurasovic, Katlyn E McGraw, Kelly Bratcher, Charles H Crawford, John R Dimar, Rolando M Puno, Steven D Glassman, R Kirk Owens, Leah Y Carreon
OBJECTIVE The goal of this study was to determine efficacy and cost-effectiveness of Cell Saver in 2- and 3-level lumbar decompression and fusion. METHODS Patients seen at a tertiary care spine center who were undergoing a posterior 2- or 3-level lumbar decompression and fusion were randomized to have Cell Saver used during their surgery (CS group, n = 48) or not used (No Cell Saver [NCS] group, n = 47). Data regarding preoperative and postoperative hemoglobin and hematocrit, estimated blood loss, volume of Cell Saver blood reinfused, number of units and volume of allogeneic blood transfused intraoperatively and postoperatively, complications, and costs were collected...
August 17, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/30117782/perspectives-on-cervical-cancer-screening-and-prevention-challenges-faced-by-providers-and-patients-along-the-texas-mexico-border
#14
K Boom, M Lopez, M Daheri, R Gowen, A Milbourne, P Toscano, C Carey, L Guerra, J M Carvajal, E Marin, E Baker, S Fisher-Hoch, A M Rodriguez, N Burkalter, B Cavazos, M Gasca, M M Cuellar, E Robles, E Lopez, K Schmeler
BACKGROUND: The Rio Grande Valley (RGV) and Laredo regions located along the Texas-Mexico border consist of seven counties with a population of approximately 1.5 million people and a high uninsured rate (33.5%). Cervical cancer mortality in these border counties is approximately 30% higher than the rest of Texas. The RGV and Laredo areas were studied to better understand the state of access to cervical cancer prevention services along the Texas-Mexico border. METHODS: Data on the population served and the services provided were analyzed to determine the gap between cervical cancer screenings recommended versus those received...
August 17, 2018: Perspectives in Public Health
https://www.readbyqxmd.com/read/30117768/upfront-gamma-knife-radiosurgery-for-cushing-s-disease-and-acromegaly-a-multicenter-international-study
#15
Amitabh Gupta, Zhiyuan Xu, Hideyuki Kano, Nathaniel Sisterson, Yan-Hua Su, Michal Krsek, Ahmed M Nabeel, Amr El-Shehaby, Khaled A Karim, Nuria Martínez-Moreno, David Mathieu, Brendan J McShane, Roberto Martínez-Álvarez, Wael A Reda, Roman Liscak, Cheng-Chia Lee, L Dade Lunsford, Jason P Sheehan
OBJECTIVE Gamma Knife radiosurgery (GKS) is typically used after failed resection in patients with Cushing's disease (CD) and acromegaly. Little is known about the upfront role of GKS for patients with CD and acromegaly. In this study, the authors examine the outcome of upfront GKS for patients with these functioning adenomas. METHODS An international group of 7 Gamma Knife centers sent pooled data from 46 patients (21 with CD and 25 with acromegaly) undergoing upfront GKS to the coordinating center of the study for analysis...
August 17, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30117711/quality-of-life-and-treatment-goals-in-psoriasis-from-the-patient-perspective-results-of-an-austrian-cross-sectional-survey
#16
Peter Wolf, Wolfgang Weger, Franz Legat, Clemens Painsi, Werner Saxinger, Robert Müllegger, Paul Sator, Gudrun Ratzinger, Sylvia Selhofer, Leo Richter, Wolfgang Salmhofer, Bernhard Lange-Asschenfeldt, Franz Trautinger, Alexander Mlynek, Robert Strohal, Matthias Augustin, Franz Quehenberger
BACKGROUND: Patients with psoriasis experience impairment in quality of life. Thus, high-quality dermatological care is of particular importance. PATIENTS AND METHODS: We performed a nationwide cross-sectional survey in Austria (BQSAustria Psoriasis 2014/2015) with a special focus on quality of life and satisfaction with treatment among psoriasis patients predominantly treated at tertiary care centers. RESULTS: Overall, 70.2 % of 1,184 patients reported impaired quality of life (DLQI 2-5: 29...
August 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/30117586/driving-after-left-ventricular-assist-device-implantation
#17
Jasmin S Hanke, Julia Riebandt, Miena Wahabzada, Fatma Nur, Angela Wahabzada, Günes Dogan, Christina Feldmann, Axel Haverich, Aron-Friedrich Popov, Daniel Zimpfer, Jan D Schmitto
Literature on driving capacities of ventricular assist device patients is rare and driving restrictions differ from center to center. Currently, no guidelines exist on whether and when left ventricular assist device (LVAD) patients are allowed to begin driving cars after device implantation. In this study, we assess the driving abilities of patients after LVAD implantation. Three hundred and ninety LVAD patients have been surveyed in a worldwide, multicenter study. The single survey followed a multi-method design, including online, phone, and face-to-face interviews...
July 2018: Artificial Organs
https://www.readbyqxmd.com/read/30116951/the-effect-of-distance-on-short-term-outcomes-in-a-regionalized-publicly-funded-bariatric-surgery-model
#18
Aristithes G Doumouras, Fady Saleh, Dennis Hong
BACKGROUND: While high-volume Centers of Excellence (COE) for bariatric surgery may have improved clinical outcomes, their disparate distribution results in longer travel distances for patients. The purpose of this study was to investigate effect of distance from COE on outcomes and readmission. METHODS: This was a retrospective study of all adults, aged 18 years or older, receiving bariatric surgery from April 2009 to March 2012 in the province of Ontario. Main outcomes included 30-day complication rates and readmission...
August 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30116903/frequency-and-characteristics-of-traumatic-brain-injury-in-restrained-drivers-involved-in-road-traffic-accidents
#19
Joji Inamasu, Msasato Nakaya, Dai Kujirai, Keita Mayanagi, Masashi Nakatsukasa
BACKGROUND: While seatbelt is an important device protecting drivers from traumatic brain injury (TBI), it has rarely been reported how often and in what circumstances restrained drivers sustain TBI after road traffic accident (RTA). Whole-body computed tomography (WBCT) for blunt trauma patients may provide a unique opportunity to investigate the frequency and characteristics of TBI sustained by restrained drivers. METHODS: A single-center, retrospective observational study was conducted using prospectively acquired data...
August 17, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/30116796/fluorescence-lifetime-imaging-ophthalmoscopy-a-novel-way-to-assess-macular-telangiectasia-type-2
#20
Lydia Sauer, Rebekah H Gensure, Martin Hammer, Paul S Bernstein
Purpose: Macular Telangiectasia Type 2 (MacTel) is an uncommon, late-onset complex retinal disease that leads to central vision loss. No causative gene(s) have been identified so far, resulting in a challenging clinical diagnostic dilemma because retinal changes of early stages are often subtle. The objective of this study was to investigate the benefit of fluorescence lifetime imaging ophthalmoscopy (FLIO) for retinal imaging in patients with MacTel. Design: Cross-sectional study from a tertiary-care retinal referral practice...
June 2018: Ophthalmology Retina
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