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Chlamydia vaccine

Kathryn M Frietze, Rebeccah Lijek, Bryce Chackerian
Chlamydia trachomatis (Ct), the most common bacterial STI, leads to pelvic inflammatory disease, infertility, and ectopic pregnancy in women. In this Perspective, we discuss the successful human papillomavirus (HPV) vaccine as a case-study to inform Ct vaccine efforts. Areas covered: The immunological basis of HPV vaccine-elicited protection is high-titer, long-lasting antibody responses in the genital tract which provides sterilizing immunity. These antibodies are elicited through parenteral administration of a subunit vaccine based on virus-like particles (VLPs) of HPV...
October 9, 2018: Expert Review of Vaccines
Thomas M Lietman, Michael S Deiner, Catherine E Oldenburg, Scott D Nash, Jeremy D Keenan, Travis C Porco
BACKGROUND: In many infectious diseases, a core group of individuals plays a disproportionate role in transmission. If these individuals were effectively prevented from transmitting infection, for example with a perfect vaccine, then the disease would disappear in the remainder of the community. No vaccine has yet proven effective against the ocular strains of chlamydia that cause trachoma. However, repeated treatment with oral azithromycin may be able to prevent individuals from effectively transmitting trachoma...
October 2018: PLoS Neglected Tropical Diseases
Delia F Tifrea, Sukumar Pal, Christel Le Bon, Fabrice Giusti, Jean-Luc Popot, Melanie J Cocco, Manuela Zoonens, Luis M de la Maza
INTRODUCTION: Chlamydial infections are spread worldwide and a vaccine is needed to control this pathogen. The goals of this study were to determine if the delivery of an adjuvant associated to the antigen, via a derivatized amphipol, and adjuvant combinations improve vaccine protection. METHODS: A novel approach, trapping the Chlamydia muridarum (Cm) native MOMP (nMOMP) with amphipols (A8-35), bearing a covalently conjugated peptide (EP67), was used. Adjuvants incorporated were: EP67 either conjugated to A8-35, which was used to trap nMOMP (nMOMP/EP67-A8-35), or free as a control, added to nMOMP/A8-35 complexes (nMOMP/A8-35+EP67); Montanide ISA 720 to enhance humoral responses, and CpG-1826 to elicit robust cell-mediated immunity (CMI)...
October 4, 2018: Vaccine
Ryosuke Omori, Hiam Chemaitelly, Christian L Althaus, Laith J Abu-Raddad
OBJECTIVES: To explore whether existence of long-lasting partial immunity against reinfection with Chlamydia trachomatis is necessary to explain C. trachomatis prevalence patterns by age and sexual risk, and to provide a plausible estimate for the effect size, defined here as a reduction in susceptibility to reinfection. METHODS: A population-based mathematical model was constructed to describe C. trachomatis natural history and transmission dynamics by age and sexual risk...
September 4, 2018: Sexually Transmitted Infections
Jasmine C Labuda, Stephen J McSorley
Chlamydia trachomatis is responsible for an increasing number of sexually transmitted infections in the United States and is a common cause of serious pathology in the female reproductive tract (FRT). Given the impact and incidence of these infections, the production of an effective Chlamydia vaccine is a public health priority. Mouse models of Chlamydia infection have been utilized to develop a detailed and mechanistic understanding of protective immunity in the FRT. These studies reveal that MHC class-II restricted Chlamydia-specific CD4 T cells are critical for primary bacterial clearance and provide effective protection against secondary infection in the FRT...
October 2018: Immunology Letters
Robert W Hepler, Debbie D Nahas, Bob Lucas, Robin Kaufhold, Jessica A Flynn, Jennifer D Galli, Ryan Swoyer, James M Wagner, Amy Espeseth, Joseph G Joyce, James C Cook, Eberhard Durr
Chlamydial major outer membrane protein (MOMP) is the major protein constituent of the bacterial pathogen Chlamydia trachomatis. C. trachomatis serovars D-K are the leading cause of genital tract infections which can lead to infertility or ectopic pregnancies. A vaccine against Chlamydia is highly desirable but currently not available. MOMP accounts for ~ 60% of the chlamydial protein mass and is considered to be one of the lead vaccine candidates against C. trachomatis. We report on the spectroscopic analysis of C...
August 25, 2018: Protein Science: a Publication of the Protein Society
Horace C W Choi, Mark Jit, Gabriel M Leung, Kwok-Leung Tsui, Joseph T Wu
BACKGROUND: Although routine vaccination of females before sexual debut against human papillomavirus (HPV) has been found to be cost-effective around the world, its cost-benefit has rarely been examined. We evaluate both the cost-effectiveness and cost-benefit of routine female adolescent nonavalent HPV vaccination in Hong Kong to guide its policy, and by extension that of mainland China, on HPV vaccination. One major obstacle is the lack of data on assortativity of sexual mixing. Such difficulty could be overcome by inferring sexual mixing parameters from HPV epidemiologic data...
August 17, 2018: BMC Medicine
Yuan Tan, Yumeng Li, Yang Zhang, Jian Yu, Yating Wen, Chuan Wang, Man Xu, Qian Chen, Chunxue Lu, Yimou Wu
The present study evaluated the immune-protective efficacy of the Chlamydia psittaci (C. psittaci) plasmid protein CPSIT_p7 and analyzed the potential mechanisms of this protection. The current study used recombinant CPSIT_p7 protein with Freund's complete adjuvant and Freund's incomplete adjuvant to vaccinate BALB/c mice. Adjuvants alone or PBS formulated with the same adjuvants was used as negative controls. Mice were intranasally challenged with 105 inclusion-forming units (IFU) of C. psittaci. We found that CPSIT_p7 vaccination significantly decreased the mouse lung chlamydial load, interferon-γ (IFN-γ) level, and pathological injury...
August 2018: Immunologic Research
O Olagoke, D Miller, F Hemmatzadeh, T Stephenson, J Fabijan, P Hutt, S Finch, N Speight, P Timms
Koala retrovirus (KoRV) infects the majority of Australia's koalas ( Phascolarctos cinereus ) and has been linked to several life-threatening diseases such as lymphoma and leukemia, as well as Chlamydia and thus poses a threat to the continued survival of this species. While quarantine and antiretroviral drug treatment are possible control measures, they are impractical, leaving vaccination as the only realistic option. In this study, we examined the effect of a recombinant envelope protein-based anti-KoRV vaccine in two groups of South Australian koalas: KoRV infected or KoRV free...
2018: NPJ Vaccines
Marius Rademaker, Karen Agnew, Nicholas Anagnostou, Megan Andrews, Katherine Armour, Christopher Baker, Peter Foley, Kurt Gebauer, Monisha Gupta, Gillian Marshman, Diana Rubel, John Sullivan, Li-Chuen Wong
The Australasian Psoriasis Collaboration has developed a clinical practice narrative with respect to the relationship between psoriasis, its treatment and infection. The cutaneous microbiome of patients with psoriasis is different to those without psoriasis, although the significance of this is unclear. Whilst a wide range of microorganisms has been associated with psoriasis (including β-haemolytic streptococci, Staphylococcus aureus, Porphyromonas gingivalis, Candida albicans, Chlamydia psittaci, human immunodeficiency virus and hepatitis C virus), there is limited evidence that antimicrobial therapy is of direct benefit in preventing flares of psoriasis...
August 5, 2018: Australasian Journal of Dermatology
Weidang Li, Pareesha Gudipaty, Chuxi Li, Kyle K Henderson, Kyle H Ramsey, Ashlesh K Murthy
We have shown previously that intranasal vaccination with recombinant chlamydial protease-like activity factor (rCPAF: antigen) and interleukin-12 (IL-12) as an adjuvant induces robust protection against pathological consequences of female genital tract infection with Chlamydia muridarum, a closely related species and a rodent model for the human pathogen Chlamydia trachomatis. Another related species Chlamydia pneumoniae, a human respiratory pathogen, has been associated with exacerbation of atherosclerotic pathology...
July 27, 2018: Immunology and Cell Biology
Sarah C Woodhall, Rachel J Gorwitz, Stephanie J Migchelsen, Sami L Gottlieb, Patrick J Horner, William M Geisler, Catherine Winstanley, Katrin Hufnagel, Tim Waterboer, Diana L Martin, Wilhelmina M Huston, Charlotte A Gaydos, Carolyn Deal, Magnus Unemo, J Kevin Dunbar, Kyle Bernstein
Genital Chlamydia trachomatis infection is the most commonly diagnosed sexually transmitted infection. Trachoma is caused by ocular infection with C trachomatis and is the leading infectious cause of blindness worldwide. New serological assays for C trachomatis could facilitate improved understanding of C trachomatis epidemiology and prevention. C trachomatis serology offers a means of investigating the incidence of chlamydia infection and might be developed as a biomarker of scarring sequelae, such as pelvic inflammatory disease...
July 5, 2018: Lancet Infectious Diseases
María Teresa Tejedor-Junco, Margarita González-Martín, Juan Alberto Corbera, Ángelo Santana, Carmen Nieves Hernández, Carlos Gutiérrez
The aims of this cross-sectional study were to estimate the prevalence of IgG antibodies against Chlamydia abortus, the cause of enzootic abortion, in goats and to determine its associated risk factors on the Canary Islands. A total of 325 goats from 11 non-vaccinated herds were sampled and assessed using a commercial ELISA kit. Related data were also obtained for further statistical analysis and associated risk factors to seropositive flocks. For comparison, abortion rates between the vaccinated and non-vaccinated herds were compared...
July 6, 2018: Tropical Animal Health and Production
Letícia Rodrigues, Konstantinos N Raftopoulos, Signe Tandrup Schmidt, Fabian Schneider, Hendrik Dietz, Thomas Rades, Henrik Franzyk, Anders Elm Pedersen, Christine M Papadakis, Dennis Christensen, Gerhard Winter, Camilla Foged, Madlen Hubert
Nanocarriers based on inverse hexagonal liquid crystalline phases (hexosomes) show promising potential as vaccine delivery systems. Their unique internal structure, composed of both lipophilic domains and water-containing channels, renders them capable of accommodating immunopotentiating compounds and antigens. However, their adjuvant properties are poorly understood. We hypothesized that the supramolecular structure of the lyotropic liquid crystalline phase influences the immunostimulatory activity of lipid-based nanocarriers...
September 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Sharon Nyari, Shahneaz Ali Khan, Galit Rawlinson, Courtney A Waugh, Andrew Potter, Volker Gerdts, Peter Timms
Chlamydia pecorum is a mucosal infection, which causes debilitating disease of the urinary tract, reproductive tract and ocular sites of koalas (Phascolarctos cinereus). While antibiotics are available for treatment, they are detrimental to the koalas' gastrointestinal tract microflora leaving the implementation of a vaccine as an ideal option for the long-term management of koala populations. We have previously reported on the successes of an anti-chlamydial recombinant major outer membrane protein (rMOMP) vaccine however, recombinant protein based vaccines are not ideal candidates for scale up from the research level to small-medium production level for wider usage...
2018: PloS One
Vidisha Singh, Richard A Crosby, Beau Gratzer, Pamina M Gorbach, Lauri Markowitz, Elissa Meites
BACKGROUND: Men who have sex with men (MSM) are at high risk for sexually transmitted infections (STIs). National guidelines recommend that MSM receive HIV, syphilis, gonorrhea, and chlamydia screening at least annually, and hepatitis A and B and human papillomavirus vaccinations. We investigated associations between disclosure of male-male sexual orientation/behavior and receipt of this panel of services. METHODS: Gay, bisexual and other MSM aged 18-26 years were enrolled from health clinics serving lesbian, gay, bisexual, and transgender communities in Los Angeles and Chicago during 2012-2014...
June 25, 2018: Sexually Transmitted Diseases
David Mesher, Kavita Panwar, Sara L Thomas, Claire Edmundson, Yoon Hong Choi, Simon Beddows, Kate Soldan
Background: The national human papillomavirus (HPV) immunization program was introduced in England in September 2008 using the bivalent vaccine. Methods: We collected residual vulva-vaginal swab specimens from 16 to 24-year-old women attending for chlamydia screening between 2010 and 2016 and tested for HPV DNA. We compared changes in type-specific (vaccine and nonvaccine) HPV prevalence over time and association with vaccination coverage. For women with known vaccination status, vaccine effectiveness was estimated...
August 14, 2018: Journal of Infectious Diseases
Wayne Paes, Adam Dowle, Jamie Coldwell, Andrew Leech, Tim Ganderton, Andrzej Brzozowski
Chlamydia trachomatis (Ct) is the most common sexually transmitted bacterial pathogen, and the leading cause of infectious blindness worldwide. We have recently shown that immunization with the highly conserved antigenic passenger domain of recombinant Ct polymorphic membrane protein D (rPmpD) is protective in the mouse model of Ct genital tract infection, and previously, that ocular anti-rPmpD antibodies are elicited following vaccination. However, the mechanisms governing the assembly and structure-function relationship of PmpD are unknown...
2018: PloS One
Jizhang Zhou, Zhaocai Li, Zhongzi Lou, Yuanyuan Fei
Since the first case of Chlamydia infection in duck had been reported in 1956 and the first case from domestic animal had been reported in 1979 in China, the chlamydia prevalence in China was heavily according to the published data. The Chlamydi a in avian prevalence has been reported at least 11 provinces, Chlamydia in sheep and goats at least 11 provinces, in swine at least 15 provinces, in cows at least 13 provinces and in yaks at least 5 provinces with result of IHA detection. Different diagnostic method such as CFT, ELISA and ABC-ELISA (avidin-biotin-complex ELISA) had been established besides IHA...
2018: Frontiers in Veterinary Science
Emma Louise Walton
In this issue of the Biomedical Journal, we learn how biomarkers in saliva may be able to provide insight into the health of the brain and the central nervous system. We also discover how computational modeling can help to identify potential epitopes for vaccine development against Chlamydia, the world's most common sexually transmitted infection.
April 2018: Biomedical Journal
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