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Lucy R Nichols, Diana R Samek, Leanna McConnell
BACKGROUND: Studies have consistently shown that low constraint and high negative emotionality are associated with higher levels of alcohol use and greater alcohol related problems. Less research has examined associations between these traits and alcohol use disorder (AUD) from the first to second year of college, when alcohol use increases rapidly, or has evaluated gender differences in these associations. METHODS: The longitudinal College Experiences Study (N = 209, 60% female, 90% white) was used to detangle antecedent vs...
October 6, 2018: Addictive Behaviors
Alazne Aizpitarte, Olivia E Atherton, Lucy R Zheng, Itziar Alonso-Arbiol, Richard W Robins
Relational aggression-a psychological form of aggression-has numerous negative consequences for physical and emotional health. However, little is known about the risk factors that lead youth to engage in relational aggression. Using multimethod data from a longitudinal research of 674 Mexican-origin youth, this study examined the influence of parents, siblings, and peers on the development of relational aggression. Increases in relational aggression from age 10 to 16 were associated with: (a) low levels of parental monitoring and (b) increased association with deviant peers and siblings...
October 13, 2018: Child Development
Lucy Bird
No abstract text is available yet for this article.
October 12, 2018: Nature Reviews. Immunology
Hongtao Zhang, Lucy Gannon, Peter D Jones, Chelsea A Rundle, Kirsty L Hassall, Daniel J Gibbs, Michael J Holdsworth, Frederica L Theodoulou
The Arg/N-end rule pathway of ubiquitin-mediated proteolysis has multiple functions throughout plant development, notably in the transition from dormant seed to photoautotrophic seedling. PROTEOLYSIS6 (PRT6), an N-recognin E3 ligase of the Arg/N-end rule regulates the degradation of transcription factor substrates belonging to Group VII of the Ethylene Response Factor superfamily (ERFVIIs). It is not known whether ERFVIIs are associated with all known functions of the Arg/N-end rule, and the downstream pathways influenced by ERFVIIs are not fully defined...
October 12, 2018: Scientific Reports
Simon Fishel, Alison Campbell, Sue Montgomery, Rachel Smith, Lynne Nice, Samantha Duffy, Lucy Jenner, Kathryn Berrisford, Louise Kellam, Rob Smith, Fiona Foad, Ashley Beccles
RESEARCH QUESTION: Can blastocysts leading to live births be ranked according to morphokinetic-based algorithms? DESIGN: Retrospective analysis of 781 single blastocyst embryo transfers, including all patient clinical factors that might be potential confounders for the primary outcome measure of live birth, was weighed using separate multi-variable logistic regression models. RESULTS: There was strong evidence of effect of embryo rank on odds of live birth...
September 2018: Reproductive Biomedicine Online
Helena J V Rutherford, Michael J Crowley, Lucy Gao, Brianna Francis, Alysse Schultheis, Linda C Mayes
Pregnancy is shaped by unfolding psychological and biological changes in preparation for parenthood. A growing literature has examined the postpartum maternal brain. However, few studies examine the maternal brain during pregnancy, and whether brain function in pregnancy may have implications for postpartum caregiving. Using event-related potentials, we examined the late positive potential (LPP) elicited by infant distress and neutral faces in 35 women during their third trimester of pregnancy. Then, at 3 months postpartum, mothers completed a measure of parental reflective functioning to capture how they regarded their capacity to consider their child's thoughts and feelings...
October 9, 2018: Infant Behavior & Development
Jonathan Greenberg, Tosca D Braun, Marissa L Schneider, Lucy Finkelstein-Fox, Lisa A Conboy, Elizabeth D Schifano, Crystal Park, Sara W Lazar
Home practice is a major component of mind-body programs, yet little is known about how to optimize the amount of prescribed home practice in order to achieve an effective "dose" of practice while minimizing participant burden. This study tested how varying the amount of home practice in a mind-body program impacts compliance and stress reduction, and whether prescribing a flexible home practice schedule increases compliance. Eighty-four stressed participants undergoing a 12-week yoga program were randomized to low, medium, and high home practice conditions...
October 4, 2018: Behaviour Research and Therapy
Luci Ann P Kohn, Gabriele R Lubach
Skeletal morphology is important in evolutionary, genetic, developmental, physiological and functional studies. While samples from free-ranging individuals may be preferable, constraints of sample size, demography, or conservation status may necessitate the inclusion of captive-born individuals. Captivity may be associated with physical, physiological or behavioral differences that may affect skeletal form. This study assesses differences in postcranial skeletal form between free-range and captive-born Macaca mulatta and Saguinus oedipus...
October 12, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Rachel Bryant-Waugh, Nadia Micali, Lucy Cooke, Elizabeth A Lawson, Kamryn T Eddy, Jennifer J Thomas
OBJECTIVE: Avoidant/restrictive food intake disorder (ARFID), pica, and rumination disorder (RD) were added to the revised DSM-5 Feeding and Eating Disorders chapter in 2013. We developed a structured interview-the Pica, ARFID, and Rumination Disorder Interview (PARDI)-to assess the presence and severity of these diagnoses for evaluation and treatment planning in clinical and research settings. Here, we describe the development of the PARDI and provide a preliminary report on feasibility, acceptability, reliability, and validity in relation to ARFID...
October 12, 2018: International Journal of Eating Disorders
Lucy E Selman, Cynthia A Ochieng, Amanda L Lewis, Marcus J Drake, Jeremy Horwood
AIMS: To capture in-depth qualitative evidence regarding attitudes to and experiences of urodynamic testing among men with lower urinary tract symptoms (LUTS) at each end of the clinical pathway. METHODS: Semi-structured interview study conducted within the Urodynamics for Prostate Surgery: Randomized Evaluation of Assessment Methods (UPSTREAM) trial, which randomized men to a care pathway including urodynamics or routine non-invasive tests from 26 secondary care urology sites across England...
October 12, 2018: Neurourology and Urodynamics
Alice Breining, Antonin Negers, Lucie Mora, Laura Moïsi, Jean L Golmard, Ariel Cohen, Marc Verny, Jean P Collet, Jacques Boddaert
AIM: Myocardial infarction without chest pain misleads the clinician, resulting in a diagnosis delay and an increase of mortality. The main objective of the present study was to determine the risk factors of atypical presentation in older patients with myocardial infarction. METHODS: All consecutive patients aged ≥75 years presenting with myocardial infarction and hospitalized in the cardiology intensive care unit were included in the present prospective multicenter observational study...
October 11, 2018: Geriatrics & Gerontology International
Marta Meazza, Martin Kamlar, Lucie Jašíková, Bedřich Formánek, Andrea Mazzanti, Jana Roithová, Jan Veselý, Ramon Rios
The rapid generation of molecular complexity from simple reactants is a key challenge in organic synthesis. Spiro compounds, underrepresented 3D motifs in chemical libraries, represent a challenge due to the creation of spiro quaternary carbon and the need to control the 3D shape in one step. Herein, we report the first ring contraction/formal [6 + 2] cycloaddition using synergistic Pd(0)/secondary amine catalysis, obtaining [5,5]-spiropyrazolone derivatives in excellent yields and stereoselectivities. We demonstrate that this reaction has a broad scope of early and late stage derivatization that will benefit the creation of highly valuable chemical libraries using spiropyrazolone motifs...
August 14, 2018: Chemical Science
Tong-Chun Wen, Sophia Lall, Corey Pagnotta, James Markward, Disha Gupta, Shivakeshavan Ratnadurai-Giridharan, Jacqueline Bucci, Lucy Greenwald, Madelyn Klugman, N Jeremy Hill, Jason B Carmel
[This corrects the article DOI: 10.3389/fncir.2018.00028.].
2018: Frontiers in Neural Circuits
Brayden March, Lucy Leigh, Marcio Brussius-Coelho, Merran Holmes, Peter Pockney, Jon Gani
INTRODUCTION: Previous studies have shown single CRP measurements at time of presentation to have limited predictive benefit for appendicitis. Our objective was to determine the diagnostic utility of serial CRP measurements (to determine CRP velocity [CRPv]) in patients with right iliac fossa (RIF) pain. METHODS: A single-centre prospective observational study was conducted on adult patients admitted with RIF pain. CRP was measured on admission, at midnight, and the following morning...
October 8, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
Maja Kopczynska, Ben Sharif, Sian Cleaver, Naomi Spencer, Amit Kurani, Camilla Lee, Jessica Davis, Carys Durie, Jude Joseph-Gubral, Angelica Sharma, Lucy Allen, Billie Atkins, Alex Gordon, Llewelyn Jones, Amy Noble, Matthew Bradley, Henry Atkinson, Joy Inns, Harriet Penney, Carys Gilbert, Rebecca Walford, Louise Pike, Ross Edwards, Robyn Howcroft, Hazel Preston, Jennifer Gee, Nicholas Doyle, Charlotte Maden, Claire Smith, Nik Syakirah Nik Azis, Navrhinaa Vadivale, Tamas Szakmany
OBJECTIVE: Sepsis mortality is reported to be high worldwide, however recently the attributable fraction of mortality due to sepsis (AFsepsis) has been questioned. If improvements in treatment options are to be evaluated, it is important to know what proportion of deaths are potentially preventable or modifiable after a sepsis episode. The aim of the study was to establish the fraction of deaths directly related to the sepsis episode on the general wards and emergency departments. RESULTS: 839 patients were recruited over the two 24-h periods in 2016 and 2017...
October 11, 2018: BMC Research Notes
Pierre Vande Perre, Daniel Toledano, Carole Corsini, Elsa Escriba, Marine Laporte, Helena Bertet, Kevin Yauy, Alain Toledano, Virginie Galibert, Karen Baudry, Lucie Clotet, Elodie Million, Marie-Christine Picot, David Geneviève, Pascal Pujol
BACKGROUND: General practitioners (GPs) have an increasing role in referring patients with putative mutation in BRCA1/2 genes for genetics consultation and for long-term follow-up of mutation carriers. METHODS: We compared the expectations of the GPs' role according to BRCA1/2 mutation carriers and to GPs themselves. RESULTS: Overall, 38% (58/152) of eligible GPs and 70% (176/252) of eligible patients were surveyed. Although 81% of GPs collected the family history, only 24% considered that they know criteria indicating genetics consultation and 39% sufficient knowledge of BRCA1/2 guidelines to answer patients' questions...
October 11, 2018: Molecular Genetics & Genomic Medicine
Lucy Richards, Martin Healey, Claudia Cheng, Uri Dior
STUDY OBJECTIVE: To examine the surgical management and outcomes of patients treated laparoscopically for pelvic pain following ovary-sparing hysterectomy. DESIGN: Retrospective cohort study (Canadian Task Force II-2) SETTING: General gynecology unit at a tertiary university hospital. PATIENTS: A total of 99 patients from Jan 2008- Dec 2016 treated with laparoscopic oophorectomy for pelvic pain following ovary-sparing hysterectomy. INTERVENTIONS: Laparoscopic Oophorectomy MEASUREMENTS AND MAIN RESULTS: Patients undertaking surgery had a mean age of 48...
October 8, 2018: Journal of Minimally Invasive Gynecology
Tea Meulia, Lucy Stewart, Michael Goodin
The phosphoprotein (P) of the nucleorhabdovirus sonchus yellow net virus has been shown to accumulate in ring-shaped structures in virus-infected nuclei. Further examination by live-cell imaging, in combination with structural examination by transmission electron microscopy and immunolocalization demonstrated that P-rings do not form in association with nucleoli. Furthermore, viral cores were shown to condense on the nucleoplasm-contacting surface of the rings. The data presented here offer evidence for the site of nucleocapsid assembly in SYNV-infected nuclei...
October 8, 2018: Virus Research
Linda Schücker, Lucy Parrington
A number of studies have shown that attentional focus instructions can effect running economy. This study assessed spiroergometry, as well as running kinematics as a possible mechanism to explain these effects. Twelve runners had to focus their attention on either their running movement, their breathing or on a video while running on a treadmill at a set, submaximum speed. Spiroergometry and running kinematics were measured. Results revealed worse running economy in both internal focus conditions (breathing and movement) compared to the external focus condition (video), replicating previous findings...
October 11, 2018: Journal of Sports Sciences
Lucy M Bracken, Betty S H Chan, Nicholas A Buckley
CONTEXT: Recommended doses of digoxin-specific antibody fragments (digoxin-Fab) for treatment of acute digoxin poisoning are pharmacokinetically unsubstantiated and theoretically excessive. Physiologically based pharmacokinetic (PBPK) modelling creates clinical simulations which are closely related to physiological and pharmacokinetic behaviour. This paper details the formulation of a PBPK model of digoxin and explores its use as a simulation tool for acute digoxin toxicity and its management...
October 11, 2018: Clinical Toxicology
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