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Xiaochuan Chen, Bo Yang, Jun Tian, Hong Hong, Yu Du, Kun Li, Xin Li, Nan Wang, Xiaoqi Yu, Xi Wei
BACKGROUND/AIMS: Increasing evidence has demonstrated the novel roles of mesenchymal stem cells (MSCs) in immunotherapy. However, difficulty in acquiring these cells and possible ethical issues limited their application. Recently, we have isolated a unique MSC population from dental follicles with potent stem cell-like properties. This study focused on the effects of dental follicle stem cells (DFSCs) on macrophage activation and polarization to determine their role in immunomodulation and to test if DFSCs are a promising cell source for MSC-based immunotherapy...
2018: Cellular Physiology and Biochemistry
Karel Lábr, Jindřich Špinar, Jiří Pařenica, Lenka Špinarová, Filip Málek, Monika Špinarová, Ondřej Ludka, Jiří Jarkovský, Klára Benešová, Monika Goldbergová-Pávková, Růžena Lábrová
BACKGROUND/AIMS: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients...
December 7, 2018: Kidney & Blood Pressure Research
Allison A Bay, Ariel R Hart, W Michael Caudle, Daniel M Corcos, Madeleine E Hackney
INTRODUCTION: Parkinson's disease (PD) is a neurodegenerative condition associated with aging characterized by loss of dopamine-producing neurons in the substantia nigra pars compacta and a reduction in dopamine levels in the striatum. PD is commonly treated using dopamine-replacement medication called levodopa. Levodopa has decreasing efficacy over time. Periods when levodopa is not effective at controlling symptoms of PD are called "OFF-time" or "medication-related motor fluctuations," (MRMF)...
December 4, 2018: Journal of the Neurological Sciences
Kristine Ravina, Ben A Strickland, Ian A Buchanan, Robert C Rennert, Paul E Kim, Vance L Fredrickson, Jonathan J Russin
Large, broad-based basilar artery (BA) apex aneurysms involving multiple arterial origins are complex lesions commonly not amenable to direct clipping or endovascular management. BA proximal (Hunterian) occlusion with extracranial-to-intracranial bypass is a supported strategy if one or both posterior communicating arteries are small. Hunterian ligation risks sudden aneurysm thrombosis and thromboembolism in the perforator rich BA apex. There currently exists no guidelines for antiplatelet and anticoagulant therapy following Hunterian ligation for complex BA apex aneurysm treatment...
December 8, 2018: World Neurosurgery
Jun Zhang, Xiao Zhang, Jinping Zhang, Yun Song, Ju Han
BACKGROUND: Endovascular therapy has been increasingly recommended for the treatment of acute ischemic stroke with large vessel occlusion of the anterior circulation. However, occlusions of the distal cerebral artery are not uncommon and may cause clinical deficits, especially when combined with ipsilateral chronic large vessel occlusion. Therefore, in this patient population, the recognition of chronic occlusion and recanalization of the distal occlusive artery might be of great value for flow compensation...
December 8, 2018: World Neurosurgery
Kilian Fröhlich, Ralf A Linker, Tobias Engelhorn, Arnd Dörfler, De-Hyung Lee, Konstantin Huhn, Stefan Schwab, Max J Hilz, Frank Seifert, Klemens Winder
BACKGROUND AND PURPOSE: Bowel incontinence in multiple sclerosis might be associated with specific lesion sites. This study intended to determine associations between bowel incontinence and cerebral multiple sclerosis lesions using a voxel-wise lesion symptom mapping analysis. METHODS: We conducted a retrospective study of multiple sclerosis patients with self-reported bowel incontinence and matched controls. Lesions were manually outlined on T2-weighted MRI scans and transformed into stereotaxic space...
December 11, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Gemma Radley, Ina Laura Pieper, Bethan R Thomas, Karl Hawkins, Catherine A Thornton
Medical devices, such as ventricular assist devices (VADs), introduce both foreign materials and artificial shear stress to the circulatory system. The effects these have on leukocytes and the immune response are not well understood. Understanding how these two elements combine to affect leukocytes may reveal why some patients are susceptible to recurrent device-related infections and provide insight into the development of pump thrombosis. Biomaterials - DLC: diamond-like carbon coated stainless steel; Sap: single-crystal sapphire; and Ti: titanium alloy (Ti6Al4V) were attached to the parallel plates of a rheometer...
December 8, 2018: Artificial Organs
Leticia E Sewaybricker, Ellen A Schur, Susan J Melhorn, Brunno M Campos, Mary K Askren, Guilherme A S Nogueira, Mariana P Zambon, Maria Angela R G M Antonio, Fernando Cendes, Licio A Velloso, Gil Guerra-Junior
OBJECTIVE: In adults, hypothalamic gliosis has been documented using quantitative T2 neuroimaging, whereas functional magnetic resonance imaging (fMRI) has shown a defective hypothalamic response to nutrients. No studies have yet evaluated these hypothalamic abnormalities in children with obesity. METHODS: Children with obesity and lean controls underwent quantitative MRI measuring T2 relaxation time, along with continuous hypothalamic fMRI acquisition to evaluate early response to glucose ingestion...
December 10, 2018: Pediatric Obesity
Martin J Herrmann, Ann-Katrin Tesar, Jennifer Beier, Max Berg, Bodo Warrings
Obesity is a major problem in the modern world causing a higher risk for various cerebrovascular diseases causing a profound individual and societal burden. The neurobiological foundation bears potential to understand the complex interaction of individual differences in brain structure and function and ingestive behaviour. This systematic review was performed on the current evidence of structural abnormalities in grey matter volume (GMV) in patients with obesity based on studies published until December 2017, which were selected through search in PubMed, CENTER (Cochrane Library), PsycINFO, Web of Science, and Ovid MEDLINE...
December 10, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
Asmaa Mohammed ShamsEldeen, Hend Ashour, Heba Samy Shoukry, Mostafa Fadel, Samaa Samir Kamar, Marwan Aabdelbaset, Laila Ahmed Rashed, Hania Ibrahim Ammar
Wnt/β-catenin signaling pathway plays a crucial role in diabetic cardiomyopathy (DCM), thus we aimed at investigating the effect of one therapeutic approach with resveratrol (RSV) given systemically and combined treatment of RSV with mesenchymal stem cells (MSCs) that was either RSV-preconditioned or not on Wnt/β-catenin signaling pathway in streptozotocin-induced DCM, and to evaluate effects of RSV preconditioning on MSCs therapeutic potential. The rats were divided into control (C, n = 8), diabetic (DM, n = 8), diabetic treated with systemic RSV (DM-RSV, n = 8), diabetic treated with RSV and nonconditioned MSCs (DM-RSV-MSCs, n = 8), diabetic treated with RSV and RSV-incubated with MSCs (DM-RSV-MSCc, n = 8) and diabetic treated with RSV-conditioned MSCs (DM-MSCc, n = 8)...
December 7, 2018: Journal of Cellular Physiology
Andréa Araujo de Oliveira Cortines, Patrícia Corrêa-Faria, Liselotte Paulsson, Paulo Sucasas Costa, Luciane Rezende Costa
OBJECTIVE: Developmental defects of enamel (DDE) in preterm infants still require clarification and may favour dental caries, lower food intake, and greater difficulty with weight-height gain. We evaluated factors associated with DDE in preterm infants. SUBJECTS AND METHODS: In this prospective cohort study, we monitored 54 prematurely born infants from birth to 24 months of age. Trained and calibrated dentists examined the oral cavity of these children to identify and categorize DDE...
December 7, 2018: Oral Diseases
Priya Mitra, Donna Coch
In a cross-modal rhyming study with visual pseudoword primes and auditory word targets, we found a typical ERP rhyming effect such that nonrhyming targets elicited a larger N400/N450 than rhyming targets. An orthographic effect was also apparent in the same 350- to 600-ms epoch as the phonological effect: The rhyming effect for targets with rime orthography that did not match their primes' (e.g., tain-"sane") was smaller over the left hemisphere than the rhyming effect for targets with rime orthography that did match their primes' (e...
December 9, 2018: Psychophysiology
Fahimeh Mamashli, Sheraz Khan, Jonas Obleser, Angela D Friederici, Burkhard Maess
An event related potential, known as the N400, has been particularly useful in investigating language processing as it serves as a neural index for semantic prediction. There are numerous studies on the functional segregation of N400 neural sources; however, the oscillatory dynamics of functional connections among the relevant sources has remained elusive. In this study we acquired magnetoencephalography data during a classic N400 paradigm, where the semantic predictability of a fixed target noun was manipulated in simple German sentences...
December 7, 2018: Human Brain Mapping
Mohamad El Moheb, Johny Nicolas, Assem M Khamis, Ghida Iskandarani, Elie A Akl, Marwan Refaat
BACKGROUND: There is evidence that implantable cardioverter-defibrillator (ICD) for primary prevention in people with an ischaemic cardiomyopathy improves survival rate. The evidence supporting this intervention in people with non-ischaemic cardiomyopathy is not as definitive, with the recently published DANISH trial finding no improvement in survival rate. A systematic review of all eligible studies was needed to evaluate the benefits and harms of using ICDs for primary prevention in people with non-ischaemic cardiomyopathy...
December 8, 2018: Cochrane Database of Systematic Reviews
Daniel Oren, Peter Chau, Melanie Manning, Joann Kwong, Beth D Kaufman, Katsuhide Maeda, David N Rosenthal, Seth A Hollander
Danon disease (DD) is an X-linked dominant disorder caused by a mutation in the lysosomal-associated membrane protein-2 (LAMP-2) gene coding for the LAMP-2 protein. We report two cases of successful heart transplantation (HT) in adolescent brothers with DD, including one who was bridged to HT for 34 days with a HeartWare left ventricular assist device. In both patients, the post-transplant course was complicated by profound skeletal muscle weakness that resolved with corticosteroid withdrawal. These cases highlight that both HT and ventricular assist device support are feasible in patients with DD...
December 7, 2018: Pediatric Transplantation
Lijian Cheng, Zhenhong Chen, Lihua Wang, Yunping Lan, Lihua Zheng, Fangpu Wu
Peripheral inflammation in male C57BL/6 mice was induced by intraplantar injection of 20 μL complete freund's adjuvant (CFA) in the left hind paw. Mice were randomly divided into three groups: Sham, CFA, and propofol+CFA. Mechanical allodynia was assessed by von Frey analysis, and heat hyperalgesia was detected by exposure of the plantar surface to a beam of radiant heat. Propofol significantly attenuated the severity and duration of CFA-induced pain hypersensitivity, heat hyperalgesia, and paw edema. Propofol inhibited CFA-induced microglia activation, and markedly decreased CFA-induced ionized calcium binding adapter molecule 1 (IBA-1) expression...
December 9, 2018: Journal of Cellular Biochemistry
Tomo Ando, Shunsuke Aoi, Said Ashraf, Pedro A Villablanca, Tesfaye Telila, Alexandros Briasoulis, Hisato Takagi, Luis Afonso, Cindy L Grines
OBJECTIVES: To assess the efficacy and safety of transradial (TR) versus transfemoral (TF) percutaneous coronary intervention (PCI) in left main (LM) lesion. BACKGROUND: TR-PCI is the preferred approach compared with TF approach because of less bleeding risk. LM-PCI is often challenging because of the anatomical complexity and uniqueness of supplying a large myocardium territory. We performed a systematic review and meta-analysis to assess the safety and efficacy of TR-PCI compared with TF-PCI of the LM lesions...
December 10, 2018: Catheterization and Cardiovascular Interventions
Ting-Ting Zhang, Yong-Juan Fu, Yue-Shan Piao, Guang-Zhi Liu, Lei-Ming Wang, Shi-Yun Chen, De-Hong Lu, Xu-Guang Gao
No abstract text is available yet for this article.
November 2018: Brain Pathology
Alvaro Torres, Seppo K Koskinen, Henrik Gjertsen, Björn Fischler
Our main goal with this study was to share our off-label experience with CEUS for identifying circulatory complications after liver transplantation in children. A total of 74 CEUS examinations performed on 34 pediatric patients who underwent a liver transplant were retrospectively included. About 53% of the examinations were performed on children 2 years old or younger. About 82% of the examinations were performed within 30 days from the transplant. About 62% of patients were transplanted due to a cholestatic disease, 11% due to a metabolic disease, 8% were re-transplanted due to graft failure, and 19% was due to other conditions...
December 7, 2018: Pediatric Transplantation
Joshua Newman, Max Liebo, Brian D Lowes, Haseeb Ilias Basha, Yael Peled, Emily Cendrowski, Ronald Zolty, Dylan Douglas, John Y Um, Edwin McGee, Alain Heroux, Eugenia Raichlin
BACKGROUND: Current guidelines recommend against the use of hearts from donors that abuse alcohol. We explored the effect of donor alcohol abuse (AA) on cardiac allograft function and outcomes in heart transplant (HTx) recipients. METHODS: Overall, 370 HTx recipients were divided into two groups: (1) the alcoholic donor group (AD, n=58), and (2) the non-alcoholic donor group (NAD, n=312). RESULTS: Recipients in the AD group had a slower heart rate (86±13 vs...
December 11, 2018: Clinical Transplantation
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