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Cecilia Granéli, Ryan Hicks, Gabriella Brolén, Jane Synnergren, Peter Sartipy
The global burden of diabetes has drastically increased over the past decades and in 2017 approximately 4 million deaths were caused by diabetes and cardiovascular complications. Diabetic cardiomyopathy is a common complication of diabetes with early manifestations of diastolic dysfunction and left ventricular hypertrophy with subsequent progression to systolic dysfunction and ultimately heart failure. An in vitro model accurately recapitulating key processes of diabetic cardiomyopathy would provide a useful tool for investigations of underlying disease mechanisms to further our understanding of the disease and thereby potentially advance treatment strategies for patients...
October 20, 2018: Stem Cell Reviews
Nicholas Di Mascio, Padraic MacMathuna, Sean Murphy, Eoin Carl Kavanagh
A 68-year-old gentleman was referred for elective upper gastrointestinal endoscopy on a background of dysphagia and esophageal candidiasis. A benign peptic stricture was noted, managed with balloon dilation without apparent immediate complication. At completion, however, the patient became confused and agitated, with no improvement despite the reversal of sedation. Two hours later, with all investigations for suspected complications including perforation, negative, he developed acute left-sided hemiparesis...
October 20, 2018: Clinical Journal of Gastroenterology
Hideki Nagano, Takanori Goi, Seiichi Taguchi, Takayoshi Tsubaki, Hidemasa Uematsu
BACKGROUND: Internal hernia is a rare cause of intestinal obstruction, and sigmoid mesocolon hernia is an extremely rare form of this condition. Among sigmoid mesocolon hernias, intramesosigmoid hernia is the least frequent subtype. We described a case of intramesosigmoid hernia through the orifice on the right leaf of the mesosigmoid with an incarcerated ileum of 6 cm in length without strangulation. This case was diagnosed by multidetector computed tomography with multiplanar reconstruction images and treated without resection of the small intestine in a 52-year-old man with characteristic diagnostic images...
October 20, 2018: Surgical Case Reports
S J Eschbach, M Gijtenbeek, N van Geloven, D Oepkes, M C Haak
BACKGROUND: To detect early cardiac deterioration, a simple and stable tool is needed. Measurement of time intervals in a simple 4-chamber view using color-coded tissue Doppler imaging is a relatively new approach to assess fetal cardiac function. The aim of this study was to evaluate the applicability of this modality and to construct reference ranges for cardiac time intervals. METHODS: We performed a prospective longitudinal cohort study in healthy fetuses. We used linear mixed models to construct age-adjusted reference ranges for shortening time (St) and lengthening time (Lt) in three cardiac regions: global heart and right and left ventricular wall...
October 20, 2018: Journal of Echocardiography
Abhishek Chakraborty, Cesar Mendoza, Juan Infante, Satinder K Sandhu
Anomalous origin of left coronary artery (LCA) from the right coronary cusp with an intramural course is usually managed with unroofing of the intramural segment. Available literature demonstrates an uneventful course following surgery in most patients. Coronary stenosis following the unroofing procedure treated with percutaneous coronary intervention has not been described in the past. We describe a case where an 11-year-old girl with anomalous origin of the LCA from the right coronary cusp presented with near syncope...
October 20, 2018: Pediatric Cardiology
Eda Didem Yalcin, Mahmut Koparal, Orhan Aksoy
PURPOSE: Ectodermal dysplasia (ED) is a congenital syndrome characterized by abnormal development of ectodermal structures, such as skin, hair, nails, teeth, or salivary glands. Patients with ED demonstrate craniofacial dysmorphology, midfacial hypoplasia and hypodontia. The aim of this study is to evaluate volume and surface area of maxillary sinus and craniofacial structures in patients with ectodermal dysplasia (ED) using cone-beam computed tomography (CBCT) images. METHODS: The CBCT images of 20 patients with ED (study group) and 20 healthy individuals (control) which are equal in terms of age and gender were evaluated...
October 20, 2018: European Archives of Oto-rhino-laryngology
Dong Woo Kang, Hyun Kook Lim, Soo-Hyun Joo, Na Rae Lee, Chang-Uk Lee
BACKGROUND: Previous research has separated spatial patterns of intra- and interregional intrinsic brain connectivity, as evaluated by regional homogeneity (ReHo) and functional connectivity (FC), respectively, in prodromal Alzheimer's disease (AD). Moreover, the intra- and interregional intrinsic brain connectivities have been demonstrated to have a significant relationship with each other. OBJECTIVE: To explore FCs from brain regions which display a difference in ReHo between an amnestic mild cognitive impairment (aMCI) group and healthy controls (HC) and to examine the relationship of intra- and interregional intrinsic brain connectivity to cognitive function in both groups...
October 19, 2018: Dementia and Geriatric Cognitive Disorders
Chisato Okamoto, Atsushi Okada, Hideaki Kanzaki, Kunihiro Nishimura, Yasuhiro Hamatani, Masashi Amano, Hiroyuki Takahama, Makoto Amaki, Takuya Hasegawa, Tomoyuki Fujita, Junjiro Kobayashi, Satoshi Yasuda, Chisato Izumi
OBJECTIVE: Appropriate timing of mitral valve surgery in asymptomatic mitral regurgitation (MR) remains controversial. Peak mitral inflow velocity (peak E wave velocity) has been reported as a simple and easy predictor of quantitative MR severity; however, its prognostic significance in asymptomatic MR remains unclear. Therefore, we sought to investigate the prognostic impact of peak E wave velocity in asymptomatic MR. METHODS: Among 529 consecutive patients with degenerative MR of grade 3+ (moderate to severe) or 4+ (severe), 188 asymptomatic patients in sinus rhythm without left ventricular (LV) dysfunction (end-systolic dimension ≥40 mm or ejection fraction <60%) or pulmonary hypertension were studied...
October 20, 2018: Heart: Official Journal of the British Cardiac Society
I C Chetter, A V Oswald, E McGinnis, N Stubbs, C Arundel, H Buckley, K Bell, J C Dumville, N A Cullum, M O Soares, P Saramago
BACKGROUND: Surgical wounds healing by secondary intention can be difficult and costly to manage and are profoundly under researched. This prospective inception, cohort study aimed to derive a better understanding of surgical wounds healing by secondary intention and to facilitate the design of future research investigating effective treatments. OBJECTIVES: To investigate the clinical characteristics of patients with surgical wounds healing by secondary intention and the surgeries that preceded their wounds; to clearly delineate the clinical outcomes of these patients, specifically focusing on time to wound healing and its determinants; to explore the types of treatments for surgical wounds healing by secondary intention; and to assess the impact surgical wounds healing by secondary intention have on patients' quality of life...
September 18, 2018: International Journal of Nursing Studies
Mayuresh S Korgaonkar, May Erlinger, Isabella A Breukelaar, Philip Boyce, Philip Hazell, Cassandra Antees, Sheryl Foster, Stuart M Grieve, Lavier Gomes, Leanne M Williams, Anthony W F Harris, Gin S Malhi
BACKGROUND: Mechanistically based neural markers, such as amygdala reactivity, offer one approach to addressing the challenges of differentiating bipolar and unipolar depressive disorders independently from mood state and acute symptoms. Although emotion-elicited amygdala reactivity has been found to distinguish patients with bipolar depression from patients with unipolar depression, it remains unknown whether this distinction is traitlike and present in the absence of an acutely depressed mood...
August 31, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Wook Ho Kang, Hyung Kyu Yang, Han Jeong Chang, Yong Taek Ko, Byung Eun Yoo, Cheong Ho Lim, Jae Kwan Hwang, Young Chan Lee, Hyeon Keun Shin, Hae Jung Son
BACKGROUND: Ligation of the intersphincteric fistula tract (LIFT) is a sphincter-preserving operation for anal fistulas. Although it has advantages in preserving continence after surgery, it is difficult to perform owing to the narrow field of view. We performed a modified surgical procedure based on the LIFT to overcome these drawbacks. MATERIALS AND METHODS: Twenty-eight patients who were scheduled to undergo high ligation of the anal fistula tract by the lateral approach for the treatment of transsphincteric anal fistulas were prospectively studied...
October 18, 2018: International Journal of Surgery
Snigdha Jain, Daniel Kuriakose, Ilaina Edelstein, Bilal Ansari, Garrett Oldland, Swetha Gaddam, Khuzaima Javaid, Pritika Manaktala, Jonathan Lee, Rachana Miller, Scott R Akers, Julio A Chirinos
OBJECTIVES: This study researched right atrial (RA) deformation indexes and their association with all-cause mortality among subjects with or without heart failure (HF). BACKGROUND: Although left atrial dysfunction is well described in HF, patterns of RA dysfunction and their prognostic implications are unclear. Cardiac magnetic resonance (CMR) imaging can provide excellent visualization of the RA. We used CMR to characterize RA phasic function in HF and to assess its prognostic implications...
October 12, 2018: JACC. Cardiovascular Imaging
Iman Asaria, Manuel O Lagravère
INTRODUCTION: To identify changes in the adolescent mandibular canal (MC) using cone-beam computer tomography (CBCT) by locating three-dimensional (3D) anatomical landmarks in the mandible for later growth and treatment applications. METHODS: Two CBCT images taken 1.5-2 years apart for 50 patients (ages 11-17) were landmarked using AVIZO® . Six core landmarks were placed relative to the right and left MCs. Three-dimensional coordinates (x, y, z) were obtained. Average distances between paired landmarks were measured using a paired samples t-test...
October 17, 2018: International Orthodontics
Hadis Dashtestani, Rachel Zaragoza, Hamed Pirsiavash, Kristine M Knutson, Riley Kermanian, Joy Cui, J Douglas Harrison, Milton Halem, Amir Gandjbakhche
Individuals differ in the extent to which they make decisions in different moral dilemmas. In this study, we investigated the relationship between functional brain activities during moral decision making and psychopathic personality traits in a healthy population. We measured the hemodynamic activities of the brain by functional near-infrared spectroscopy (fNIRS). FNIRS is an evolving non-invasive neuroimaging modality which is relatively inexpensive, patient friendly and robust to subject movement. Psychopathic traits were evaluated through a self-report questionnaire called the Psychopathic Personality Inventory Revised (PPI-R)...
October 18, 2018: Behavioural Brain Research
Sergio Berti, Luigi Emilio Pastormerlo, Simona Celi, Marcello Ravani, Giuseppe Trianni, Elisa Cerone, Gennaro Santoro
No abstract text is available yet for this article.
October 12, 2018: JACC. Cardiovascular Interventions
Faheemullah Beg, Colin M Barker, William A Zoghbi
No abstract text is available yet for this article.
October 12, 2018: JACC. Cardiovascular Interventions
Yuki Orimoto, Hiroyuki Ishibashi, Ikuo Sugimoto, Tetsuya Yamada, Yuki Maruyama, Makiyo Hagihara, Tsuneo Ishiguchi
A persistent sciatic artery (PSA) is a rare congenital vascular anomaly that occurs in approximately 0.01 to 0.06% of the population. We encountered a patient with aneurysms in the common iliac-internal iliac artery continuous to an occluded right PSA. The patient was an 85-year-old male in whom intermittent claudication of the right lower limb appeared 3 months ago. The right ankle brachial index (ABI) was 0.48. On contrast CT, the right PSA was present and was occluded over the popliteal artery. The right superficial femoral artery was hypoplastic...
October 18, 2018: Annals of Vascular Surgery
Courtney Pollack, Gavin R Price
The dominant model of number processing suggests the existence of a Number Form Area (NFA) in the inferior temporal gyrus (ITG) that supports the processing of Arabic digits as visual symbols of number. However, studies have produced inconsistent evidence for the presence and laterality of digit-specific ITG activity. Furthermore, whether any such activity relates to mathematical competence is unknown. This study investigated these two issues using functional magnetic resonance imaging. Thirty-two adults performed digit and letter detection tasks and reading and math tests...
October 18, 2018: NeuroImage
Vassiliki Sinopoulou, Morris Gordon, Paul Rutter
BACKGROUND: Increases in patients seeking advice at pharmacies has led to pharmacy staff engaging in diagnostic behaviours. Approaches to diagnosis include using mnemonics and clinical reasoning. OBJECTIVES: The primary aim of this review was to assess the degree to which the criteria researchers use to evaluate diagnostic performance in pharmacy consultations, in studies that have simulated patients or vignettes, conform with a clinical reasoning and a mnemonic framework...
October 11, 2018: Research in Social & Administrative Pharmacy: RSAP
Vishnu Parthasarathy, Brian Snyder, Robert Saddawi-Konefka
BACKGROUND: In the winter months, one often sees a large increase in the volume of patients presenting to emergency departments with acute pharyngitis. While most cases of acute pharyngitis are benign, a rare minority can be life threatening. CASE REPORT: We report a case of epiglottis with a concomitant peritonsillar abscess (PTA) in an adult who presented to the emergency department with a sore throat. Computed tomography (CT) scan showed epiglottitis with a developing left PTA...
October 17, 2018: Journal of Emergency Medicine
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