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Hyponatremia stroke

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https://www.readbyqxmd.com/read/27829716/association-of-hyponatremia-with-in-hospital-outcomes-in-infective-endocarditis-a-5-year-review-from-an-indian-intensive-care-unit
#1
Saraschandra Vallabhajosyula, Muralidhar D Varma, Shashaank Vallabhajosyula, Saarwaani Vallabhajosyula
Hyponatremia is commonly noted with cardiovascular disorders, but its role in infective endocarditis (IE) is limited to being a marker of increased morbidity in IE patients with intravenous drug use. This was a 5-year retrospective review from an Indian Intensive Care Unit (ICU). Patients >18 years with IE and available serum sodium levels were included in the study. Pediatric and pregnant patients were excluded from the study. Hyponatremia was defined as admission sodium <135 mmol/L. Detailed data were abstracted from the medical records...
October 2016: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27754188/sp-05-1-should-the-target-for-blood-pressure-reduction-be-lower-in-adults-with-hypertension-and-a-history-of-cardiovascular-disease
#2
Paul Whelton
BACKGROUND: Choice of the optimal target for blood pressure (BP) reduction during treatment of patients with hypertension, including those with underlying co-morbid conditions, is an important challenge in clinical practice. The Systolic Blood Pressure Intervention Trial (SPRINT) was designed to provide guidance in selection of a Systolic BP target during treatment of hypertension. METHODS: Adults ≥50 years old with hypertension and at least one additional risk factor for cardiovascular disease (CVD), but excluding persons with diabetes mellitus, prior stroke, or advanced chronic kidney disease (CKD) were randomly assigned to intensive therapy (intensive), targeting a systolic BP (SBP) <120 mmHg, or standard therapy (standard), targeting a SBP <140 mmHg...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754163/sy-11-3-hypertension-in-women-more-dangerous-than-in-men
#3
Suzanne Oparil
Heart disease, stroke, and kidney failure are leading causes of death worldwide, and hypertension is a significant risk factor for each. Hypertension is less common in women, compared to men, in those younger than 45 years of age. This trend is reversed in those 65 years and older. In the US between 2011-2014, the prevalence of hypertension in women and men by age group was 6% vs 8% (18-39 years), 30% vs 35% (40-59 years), and 67% vs 63% (60 years and over). Awareness, treatment, and control rates differ between genders with women being more aware of their diagnosis (85% vs 80%), more likely to take their medications (81% vs 71%) and more frequently having controlled hypertension (55% vs 49%)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27727945/incidence-of-hyponatremia-and-its-correlation-to-outcome-in-stroke-patients
#4
T N Dubey, K K Kawre, R S Maniram, R Singh Saxena, Lalji Patel
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27643145/sp-05-1-should-the-target-for-blood-pressure-reduction-be-lower-in-adults-with-hypertension-and-a-history-of-cardiovascular-disease
#5
Paul Whelton
BACKGROUND: Choice of the optimal target for blood pressure (BP) reduction during treatment of patients with hypertension, including those with underlying co-morbid conditions, is an important challenge in clinical practice. The Systolic Blood Pressure Intervention Trial (SPRINT) was designed to provide guidance in selection of a Systolic BP target during treatment of hypertension. METHODS: Adults ≥50 years old with hypertension and at least one additional risk factor for cardiovascular disease (CVD), but excluding persons with diabetes mellitus, prior stroke, or advanced chronic kidney disease (CKD) were randomly assigned to intensive therapy (intensive), targeting a systolic BP (SBP) <120 mmHg, or standard therapy (standard), targeting a SBP <140 mmHg...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643118/sy-11-3-hypertension-in-women-more-dangerous-than-in-men
#6
Suzanne Oparil
Heart disease, stroke, and kidney failure are leading causes of death worldwide, and hypertension is a significant risk factor for each. Hypertension is less common in women, compared to men, in those younger than 45 years of age. This trend is reversed in those 65 years and older. In the US between 2011-2014, the prevalence of hypertension in women and men by age group was 6% vs 8% (18-39 years), 30% vs 35% (40-59 years), and 67% vs 63% (60 years and over). Awareness, treatment, and control rates differ between genders with women being more aware of their diagnosis (85% vs 80%), more likely to take their medications (81% vs 71%) and more frequently having controlled hypertension (55% vs 49%)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27521199/subarachnoid-hemorrhage-an-update
#7
REVIEW
Jeremy S Dority, Jeffrey S Oldham
Subarachnoid hemorrhage (SAH) is a debilitating, although uncommon, type of stroke with high morbidity, mortality, and economic impact. Modern 30-day mortality is as high as 40%, and about 50% of survivors have permanent disability. Care at high-volume centers with dedicated neurointensive care units is recommended. Euvolemia, not hypervolemia, should be targeted, and the aneurysm should be secured early. Neither statin therapy nor magnesium infusions should be initiated for delayed cerebral ischemia. Cerebral vasospasm is just one component of delayed cerebral edema...
September 2016: Anesthesiology Clinics
https://www.readbyqxmd.com/read/27456897/-hypovolemic-hyponatremia-at-the-onset-of-severe-ischemic-stroke-as-a-predictor-of-adverse-outcome
#8
V I Ershov, A N Chirkov
AIM: To study the prognostic value of disturbances of the water and electrolyte homeostasis in the acute stage of ischemic stroke (II) and their impact on the course and outcome. MATERIAL AND METHODS: Disturbances of the water and electrolyte homeostasis associated with plasma sodium fluctuations were studied in 150 patients with severe II. RESULTS: The poor outcome was associated with plasma osmolarity >297 mOsmol/L and plasma sodium concentration >155 mOsmol/L in the first day of severe II and with >303 mOsmol/L and >161 mOsmol/L, respectively, in the 3rd and 5th days...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27438797/early-effects-of-enteral-urea-on-intracranial-pressure-in-patients-with-acute-brain-injury-and-hyponatremia
#9
Filippo Annoni, Vito Fontana, Serge Brimioulle, Jacques Creteur, Jean-Louis Vincent, Fabio S Taccone
BACKGROUND: Hyponatremia occurs commonly after acute brain injury and is often due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Urea administration is 1 therapeutic option. METHODS: In our Department, enteral urea is routinely administered to patients with acute brain injury who develop hyponatremia consistent with SIADH and do not respond to an initial sodium load. We reviewed the records of all patients over a 2-year period, who had acute brain injury, received enteral urea because of hyponatremia, and had intracranial pressure (ICP) monitoring using an intraventricular catheter...
July 19, 2016: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/27267762/electrolyte-disturbances-and-risk-factors-of-acute-kidney-injury-patients-receiving-dialysis-in-exertional-heat-stroke
#10
Bancha Satirapoj, Suramanat Kongthaworn, Panbubpa Choovichian, Ouppatham Supasyndh
BACKGROUND: Exertional heat stroke (EHS) is a life-threatening illness and leads to multi-organ dysfunction including acute kidney injury (AKI). The clinical significance of abnormal electrolytes and renal outcomes in ESH patients has been poorly documented. We aim to exhibit the electrolyte abnormalities, renal outcomes and risk factors of patients with AKI receiving dialysis in EHS. METHODS: A retrospective cohort study in EHS patients between 2003 and 2014 were conducted...
2016: BMC Nephrology
https://www.readbyqxmd.com/read/26648963/periprocedural-risk-of-stroke-is-elevated-in-patients-with-end-stage-renal-disease-on-hemodialysis
#11
Laurel Cherian, James Conners, Shawna Cutting, Vivien H Lee, Sarah Song
OBJECTIVE: To describe the most common clinical factors and stroke etiologies in a case series of patients with end-stage renal disease on hemodialysis (ESRD/HD) with transient ischemic attack (TIA) or ischemic stroke (IS). BACKGROUND: Prior studies have shown that patients on HD are at an elevated risk of stroke, but these studies have focused on the overall stroke risk. This case series sought to determine the percentage of acute ischemic events that occur during or immediately after HD...
September 2015: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/26565425/exertional-heat-stroke-and-susceptibility-to-malignant-hyperthermia-in-an-athlete-evidence-for-a-link
#12
Mathias Poussel, Philippe Guerci, Pierre Kaminsky, Marie Heymonet, Nathalie Roux-Buisson, Julien Faure, Emilien Fronzaroli, Bruno Chenuel
OBJECTIVE: To describe the possible association (pathophysiologic and clinical features) between exertional heat stroke (EHS) and malignant hyperthermia (MH). BACKGROUND: Both EHS and MH are acute and life-threatening disorders. It has repeatedly been shown that EHS can occur in well-trained patients with known MH-associated mutation in the RYR1 gene in the absence of any extreme environmental conditions or extreme physical activity, thereby supporting a possible link between EHS and MH...
November 2015: Journal of Athletic Training
https://www.readbyqxmd.com/read/26435982/short-term-safety-and-tolerability-of-a-fixed-dose-combination-of-olmesartan-amlodipine-and-hydrochlorothiazide
#13
J C Mohan, Rishi Jain, Vijay Chamle, Amit Bhargava
OBJECTIVE: To assess the short term safety and tolerability of a fixed dose combination (FDC) of olmesartan, amlodipine and hydrochlorothiazide (OAH) in real-world clinical setting in India. MATERIALS AND METHODS: Physicians were requested to provide eight weeks observational clinical event data of the patients prescribed with FDC of Olmesartan (20/40mg), Amlodipine (5mg) and hydrochlorothiazide (12.5mg) in the prescription event monitoring (PEM) forms. Data on patients' demographics, indication for FDC, concomitant medication and other relevant history was also collected and was analysed with descriptive statistics...
August 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26298426/mild-hyponatremia-hypernatremia-and-incident-cardiovascular-disease-and-mortality-in-older-men-a-population-based-cohort-study
#14
S G Wannamethee, A G Shaper, L Lennon, O Papacosta, P Whincup
AIM: To examine the association between serum sodium concentration and incident major cardiovascular disease (CVD) outcomes and total mortality in older men. METHODS AND RESULTS: A prospective study of 3099 men aged 60-79 years without a history of cardiovascular disease followed up for an average 11 years during which there were 528 major CVD events (fatal coronary heart disease [CHD] and non-fatal MI, stroke and CVD death) and 873 total deaths. A U shaped relationship was seen between serum sodium concentration and major CVD events and mortality...
January 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/26275173/arginine-vasopressin-receptor-blocker-conivaptan-reduces-brain-edema-and-blood-brain-barrier-disruption-after-experimental-stroke-in-mice
#15
Emil Zeynalov, Susan M Jones, Jeong-Woo Seo, Lawrence D Snell, J Paul Elliott
BACKGROUND: Stroke is a major cause of morbidity and mortality. Stroke is complicated by brain edema and blood-brain barrier (BBB) disruption, and is often accompanied by increased release of arginine-vasopressin (AVP). AVP acts through V1a and V2 receptors to trigger hyponatremia, vasospasm, and platelet aggregation which can exacerbate brain edema. The AVP receptor blockers conivaptan (V1a and V2) and tolvaptan (V2) are used to correct hyponatremia, but their effect on post-ischemic brain edema and BBB disruption remains to be elucidated...
2015: PloS One
https://www.readbyqxmd.com/read/26227564/are-early-seizures-predictive-of-epilepsy-after-a-stroke-results-of-a-population-based-study
#16
Anna Serafini, Gian Luigi Gigli, Giorgia Gregoraci, Francesco Janes, Iacopo Cancelli, Stefano Novello, Mariarosaria Valente
BACKGROUND: In addition to determining the cumulative incidence and risk factors for early seizures (ES), late seizures (LS) and post stroke epilepsy (PSE), we aimed at checking if ES represented a risk factor for epilepsy and if early treatment after ES prevented the occurrence of subsequent seizures. METHODS: This study was part of a 2-year prospective community-based registry of all cerebrovascular events in the district of Udine (153,312 inhabitants), North-Eastern Italy, between April 1, 2007 and March 31, 2009...
2015: Neuroepidemiology
https://www.readbyqxmd.com/read/26178714/hyponatremia-predicts-mortality-after-stroke
#17
Roy L Soiza, Kirsten Cumming, Allan B Clark, Joao H Bettencourt-Silva, Anthony K Metcalf, Kristian M Bowles, John F Potter, Phyo K Myint
BACKGROUND: Hyponatremia, the commonest electrolyte imbalance encountered in clinical practice, is associated with adverse outcomes. Despite this, understanding of the association between hyponatremia and stroke mortality outcome is limited. AIMS: To investigate the association between admission serum sodium and mortality at various time-points after stroke. METHODS: Cases of acute stroke admitted to Norfolk and Norwich University Hospital consecutively from January 2003 until June 2013 were included, with mortality outcomes ascertained until the end of December 2013...
October 2015: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/26076838/hyponatremia-following-esclicarbazepine-therapy
#18
Durgesh K Gupta, Sanjeev K Bhoi, Jayantee Kalita, Usha K Misra
PURPOSE: To evaluate the safety of eslicarbazepine acetate (ESL) in new onset elderly poststroke seizure patients, especially with respect to hyponatremia. METHOD: In a two year, single center open labeled observational study of ESL in patients with imaging proven stroke with new onset post stroke seizure were included. ESL was titrated between 400mg and 1200 mg once daily during 1 month observation period. The titrated dose of ESL was continued during 96-week maintenance period...
July 2015: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/25823940/factors-associated-with-discharge-to-home-versus-discharge-to-institutional-care-after-inpatient-stroke-rehabilitation
#19
MULTICENTER STUDY
Vu Q C Nguyen, Janet PrvuBettger, Tami Guerrier, Mark A Hirsch, J George Thomas, Terrence M Pugh, Charles F Rhoads
OBJECTIVE: To examine sociodemographic and clinical characteristics independently associated with discharge home compared with discharge to a skilled nursing facility (SNF) after acute inpatient rehabilitation. DESIGN: Retrospective cohort study. SETTING: Three tertiary accredited acute care rehabilitation facilities. PARTICIPANTS: Adult patients with stroke (N=2085). INTERVENTIONS: Not applicable...
July 2015: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/25499669/moderate-to-large-increases-in-perioperative-serum-sodium-concentration-associated-with-adverse-neurologic-events-after-continuous-flow-left-ventricular-assist-device-implantation
#20
Michael Mazzeffi, Christopher Paciullo, J David Vega, Duc Nguyen, Michael Connor
OBJECTIVE: It was hypothesized that preoperative hyponatremia is associated with increased 30-day mortality after left ventricular assist device placement, and that large increases in sodium concentration are associated with adverse neurologic events and 30-day mortality. DESIGN: Data were collected retrospectively on all patients having continuous flow left ventricular assist device implantation between January 1, 2009 and March 31, 2013. Preoperative variables, operative variables, and perioperative sodium concentrations were recorded...
April 2015: Journal of Cardiothoracic and Vascular Anesthesia
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