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Is Ulcerative colitis reversible

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https://www.readbyqxmd.com/read/30106158/sinomenine-alleviates-dextran-sulfate-sodium%C3%A2-induced-colitis-via-the-nrf2-nqo%C3%A2-1-signaling-pathway
#1
Yan Zhou, Hanyang Liu, Jun Song, Liang Cao, Liming Tang, Chunjian Qi
Sinomenine (SIN), a pure alkaloid isolated from Sinomenium acutum, has been widely used in arthritis for its anti‑inflammatory effect, but little is known about the effect of SIN on human ulcerative colitis (UC). In the present study, the effect and mechanism of SIN was examined in a dextran sulfate sodium (DSS)‑induced murine colitis model, which mimics human UC. Oral administration of SIN significantly suppressed the elevated disease activity index and ameliorated colonic histological damage in a DSS‑induced colitis model...
August 10, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30097122/eupatilin-ameliorates-dextran-sulphate-sodium-induced-colitis-in-mice-partly-through-promoting-ampk-activation
#2
Kai Zhou, Rui Cheng, Bei Liu, Lei Wang, Haifeng Xie, Chaofeng Zhang
BACKGROUND: Despite the higher morbidity of ulcerative colitis (UC), available treatments remain unsatisfactory in recent years. A natural flavone eupatilin (Eup) is known to inhibit the intestinal contraction. PURPOSE: The protective role of Eup in intestinal inflammation remains unclear. This study attempted to determine the bioactivity of Eup against colitis and clarify the mechanism of action. STUDY DESIGN: The in vitro effects of Eup on lipopolysaccharide-induced human THP-M macrophage activation and tumour necrosis factor-α (TNF-α)-damaged intestinal epithelial (NCM460) cells were explored to clarify its potential protective effects...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30073476/the-surgical-treatment-of-acute-and-severe-diversion-colitis-mimicking-ulcerative-colitis-a-case-report
#3
Nao Kakizawa, Shingo Tsujinaka, Yasuyuki Miyakura, Rina Kikugawa, Fumi Hasegawa, Hideki Ishikawa, Sawako Tamaki, Jun Takahashi, Toshiki Rikiyama
BACKGROUND: Diversion colitis (DC) is characterized by nonspecific inflammation in the remaining colon or rectum, and loss of the fecal stream plays a major role in the disease's development. Although the majority of patients are asymptomatic, medical and/or surgical treatment is required for those who are symptomatic. There is a particular interest on how to manage patients with acute and severe clinical presentations, but the pathogenesis is not fully understood. We report the rare case of a man with acute and severe DC mimicking ulcerative colitis (UC) with extra-intestinal manifestations that was successfully managed with surgical treatment...
August 2, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/30060937/biosimilars-in-ulcerative-colitis-when-and-for-who
#4
REVIEW
Akos Ilias, Lorant Gonczi, Zuszsanna Kurti, Peter L Lakatos
The introduction of biological agents has revolutionized the management of ulcerative colitis (UC). Biosimilars are considered to be equivalent to the reference biologic products in terms of pharmacokinetic properties, clinical effectiveness and safety and have now been approved in inflammatory bowel diseases (IBD). CT-P13 was the first biosimilar to infliximab that obtained regulatory approval by the EMA and US FDA. Accumulating data on biosimilars led to an increased acceptance amongst practicing gastroenterologists and their use can be associated with a potential reduction in healthcare costs...
February 2018: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/30054005/minimally-invasive-surgery-and-stoma-related-complications-after-restorative-proctocolectomy-for-ulcerative-colitis-a-two-centre-comparison-with-open-approach
#5
Francesco Colombo, Gianluca Pellino, Francesco Selvaggi, Fabio Corsi, Guido Sciaudone, Gianluca M Sampietro, Diego Foschi
BACKGROUND: Although the creation of a stoma reduces the risk of septic pouch complications following ileal pouch-anal anastomosis (IPAA), the stoma itself and its reversal can give rise to substantial morbidity during the two- or three-stage concept. Aim of study is to compare stoma-related complications in Ulcerative Colitis patients undergoing laparoscopic versus open IPAA. METHODS: We collected data on 250 IPAA patients from two Italian Centres between 2005 and 2015...
July 24, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29992013/reversible-rituximab-induced-rectal-kaposi-s-sarcoma-misdiagnosed-as-ulcerative-colitis-in-a-patient-with-hiv-negative-follicular-lymphoma
#6
Emilien Billon, Anne-Marie Stoppa, Lena Mescam, Massimo Bocci, Audrey Monneur, Delphine Perrot, François Bertucci
Background: Kaposi's sarcoma is a low-grade mesenchymal angioproliferative tumor, most commonly observed in immunocompromised individuals, such as HIV-infected patients. Iatrogenic Kaposi's sarcoma occurs in patients undergoing immunosuppressive therapies. Rituximab is a chimeric monoclonal antibody targeted against the pan B cell marker CD20. Because of its immunosuppressive effects through reduction of mature B-cells, it may exacerbate Kaposi's sarcoma in HIV-positive patients. Rituximab-related Kaposi's sarcomas have been previously reported in only two HIV-negative patients and were treated surgically...
2018: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29989105/an-inhibitor-of-casein-kinase-1%C3%AE%C2%B5-%C3%AE-pf670462-prevents-the-deterioration-of-dextran-sodium-sulfate-induced-ulcerative-colitis-caused-by-uvb-eye-irradiation
#7
Keiichi Hiramoto, Yurika Yamate, Emiko Kasahara, Eisuke F Sato
Although we previously reported the exacerbation of dextran sodium sulfate (DSS)-induced ulcerative colitis by ultraviolet (UV) B eye irradiation, we do not yet understand the mechanism behind this phenomenon. In this study, we examined the relationship between the deterioration of DSS-induced ulcerative colitis and clock genes. We induced a mouse model of ulcerative colitis by administering DSS for 5 days, and administered UVB eye irradiation on each day of the DSS treatment period. The DSS-induced ulcerative colitis was deteriorated by the UVB eye irradiation...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29923651/hepcidin-in-newly-diagnosed-inflammatory-bowel-disease-in-children
#8
Eva Karaskova, Jana Volejnikova, Dusan Holub, Maria Velganova-Veghova, Lucie Sulovska, Vladimír Mihal, Monika Horvathova, Dagmar Pospisilova
AIM: Hepcidin is a central regulator of iron homeostasis. Its production is also influenced by systemic inflammation. The aims of this study were to compare hepcidin levels in paediatric patients newly diagnosed with Crohn's disease (CD) and ulcerative colitis (UC) and to determine the association of hepcidin levels with laboratory and clinical parameters of inflammatory bowel disease (IBD) activity. METHODS: Children with newly diagnosed IBD between January 2012 and September 2016 were enrolled in this comparative cross-sectional study...
June 20, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29922677/phospholipase-a-2-of-microbiota-as-pathogenetic-determinant-to-induce-inflammatory-states-in-ulcerative-colitis-therapeutic-implications-of-phospholipase-a-2-inhibitors
#9
Wolfgang Stremmel, Simone Staffer, Nicole Stuhrmann, Hongying Gan-Schreier, Annika Gauss, Nina Burger, Daniel Hornuss
Background: Attack by commensal microbiota is one component of induction of inflammatory episodes in ulcerative colitis (UC). In UC, the mucus layer is intrinsically devoid of phosphatidylcholine (PC) resulting in low hydrophobicity which facilitates bacterial invasion. Colonic ectophospholipase-carrying bacterial strains are likely candidates to further thinning the PC mucus barrier and to precipitate inflammatory episodes. Objective: To evaluate the effect of phospholipase A2 (PLA2 ) inhibitors on inflammation in a genetic UC mouse model...
March 2018: Inflammatory Intestinal Diseases
https://www.readbyqxmd.com/read/29912405/alphae-integrin-expression-is-increased-in-the-ileum-relative-to-the-colon-and-unaffected-by-inflammation
#10
Ryan Ichikawa, Christopher A Lamb, Jeff Eastham-Anderson, Alexis Scherl, Laura Raffals, William A Faubion, Miriam R Bennett, Anna K Long, John C Mansfield, John A Kirby, Mary E Keir
Background: Recent findings suggest that αE expression is enriched on effector T cells and that intestinal αE+ T cells have increased expression of inflammatory cytokines. αE integrin expression is a potential predictive biomarker for response to etrolizumab, a monoclonal antibody against β7 integrin that targets both α4β7 and αEβ7. We evaluated the prevalence and localisation of αE+ cells as well as total αE gene expression in healthy subjects and inflammatory bowel disease patients...
June 15, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29879879/novel-cytoprotective-mediator-stable-gastric-pentadecapeptide-bpc-157-vascular-recruitment-and-gastrointestinal-tract-healing
#11
Predrag Sikiric, Rudolf Rucman, Branko Turkovic, Marko Sever, Robert Klicek, Bozo Radic, Domagoj Drmic, Mirjana Stupnisek, Marija Misic, Lovorka Batelja Vuletic, Katarina Horvat Pavlov, Ivan Barisic, Antonio Kokot, Marina Peklic, Sanja Strbe, Alenka Boban Blagaic, Ante Tvrdeic, Dinko Stancic Rokotov, Hrvoje Vrcic, Mario Staresinic, Sven Seiwerth
Years ago, we revealed a novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157, particular anti-ulcer peptide that heals different organs lesions when given as a therapy, native in human gastric juice while maintaining GI- tract mucosal integrity, already tested in trials (ulcerative colitis and now multiple sclerosis). The stomach cytoprotection is the most fundamental concept, stomach cell protection and endothelium protection are largely elaborated, but so far cell, protection and endothelium protection outside of the stomach were not implemented in the therapy...
June 7, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29688474/increase-in-processing-factors-is-involved-in-skewed-microrna-expression-in-patients-with-ulcerative-colitis-who-develop-small-intestine-inflammation-after-pouch-surgery
#12
Hadas Sherman Horev, Keren M Rabinowitz, Hofit Elad, Revital Barkan, Shay Ben-Shachar, Metsada Pasmanik Chor, Iris Dotan
Background: A large-scale increase in microRNA (miRNA) expression was observed in patients with ulcerative colitis who underwent pouch surgery and developed inflammation of the pouch (pouchitis). In this study, we assessed miRNA expression in these patients and investigated how regulation of its expression changes in the setting of pouchitis. Methods: Autologous samples that included mucosal biopsies, peripheral blood cells, and plasma were collected from the patients...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29529198/a-novel-topical-ppar%C3%AE-agonist-induces-ppar%C3%AE-activity-in-ulcerative-colitis-mucosa-and-prevents-and-reverses-inflammation-in-induced-colitis-models
#13
Stéphanie Da Silva, Åsa V Keita, Sofie Mohlin, Sven Påhlman, Vassilia Theodorou, Ingrid Påhlman, Jan P Mattson, Johan D Söderholm
Background: Peroxisome proliferator-activated receptor-gamma (PPARγ) exerts anti-inflammatory effects and is therefore a potential target in ulcerative colitis (UC). A novel PPARγ agonist (AS002) developed for local action was evaluated ex vivo in biopsies from UC patients and in vivo in mice with low-grade dextran sodium sulfate (DSS)- and trinitrobenzene sulfonic acid (TNBS)-induced colitis. Methods: Colonic biopsies from UC patients (n = 18) and healthy controls (n = 6) were incubated with AS002 or rosiglitazone (positive control) to measure mRNA expression of the PPARγ-responsive gene ADIPOPHILIN and protein levels of UC-related cytokines (enzyme-linked immunosorbent assay)...
March 19, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29391821/isolation-and-gene-expression-profiling-of-intestinal-epithelial-cells-crypt-isolation-by-calcium-chelation-from-in-vivo-samples
#14
Aine Balfe, Grainne Lennon, Aonghus Lavelle, Neil G Docherty, J Calvin Coffey, Kieran Sheahan, Desmond C Winter, P Ronan O'Connell
Aim: The epithelial layer within the colon represents a physical barrier between the luminal contents and its underlying mucosa. It plays a pivotal role in mucosal homeostasis, and both tolerance and anti-pathogenic immune responses. Identifying signals of inflammation initiation and responses to stimuli from within the epithelial layer is critical to understanding the molecular pathways underlying disease pathology. This study validated a method to isolate and analyze epithelial populations, enabling investigations of epithelial function and response in a variety of disease setting...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29337777/rescue-diverting-loop-ileostomy-an-alternative-to-emergent-colectomy-in-the-setting-of-severe-acute-refractory-ibd-colitis
#15
Tara A Russell, Aaron J Dawes, Danielle S Graham, Stephanie A K Angarita, Christina Ha, Jonathan Sack
BACKGROUND: Severe acute refractory colitis has traditionally been an indication for emergent colectomy in IBD, yet under these circumstances patients are at elevated risk for complications because of their heightened inflammatory state, nutritional deficiencies, and immunocompromised state. OBJECTIVE: We hypothesized that rescue diverting loop ileostomy may be a viable alternative to emergent colectomy, providing the opportunity for colonic healing and patient optimization before more definitive surgery...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29164668/ameliorative-effects-of-riboflavin-on-acetic-acid-induced-colonic-injury-in-rats
#16
Berna Karakoyun, Büşra Ertaş, Meral Yüksel, Dilek Akakın, Özge Çevik, Göksel Şener
Riboflavin (RF) has been found to be a promising antioxidant and/or anti-inflammatory agent in several studies. However, the effect of RF against acetic acid (AA)-induced colonic injury is currently unknown. This study aimed to investigate the potential antioxidant and protective effects of RF in a rat model of ulcerative colitis. Starting immediately after the colitis induction (AA+RF group) or 1 week before the colitis induction (RF+AA+RF group), the rats were treated with RF (25 mg/kg per day; p.o.) for 3 days...
June 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29034305/fecal-zonulin-is-elevated-in-crohn-s-disease-and-in-cigarette-smokers
#17
Karin Malíčková, Irena Francová, Milan Lukáš, Martin Kolář, Eva Králíková, Martin Bortlík, Dana Ďuricová, Lenka Štěpánková, Kamila Zvolská, Alexandra Pánková, Tomáš Zima
OBJECTIVES: Human zonulin is a protein that increases permeability in the epithelial layer of the small intestine by reversibly modulating the intercellular tight junctions. There is not sufficient information available about zonulin's participation in inflammatory bowel diseases (IBD). The aim of this study was therefore to investigate fecal and serum zonulin in IBD patients and its relation to the disease localization, behavior and smoking status. DESIGN AND METHODS: Forty IBD patients and forty healthy persons were examined for fecal and serum zonulin concentrations by competitive ELISA (DRG International Inc)...
December 2017: Practical Laboratory Medicine
https://www.readbyqxmd.com/read/28985852/development-of-a-total-colectomy-and-ileorectal-anastomosis-rat-model-to-evaluate-colonic-metaplasia
#18
Kathleen M Schieffer, Lisa S Poritz, Gregory S Yochum, Walter A Koltun
BACKGROUND: Ulcerative colitis is an idiopathic inflammatory condition of the colon that may require surgical intervention including proctocolectomy and either ileal pouch-anal anastomosis or in the pediatric population, low ileorectal anastomosis (IRA). Often, subsequent physiologic alteration (or colonic metaplasia) occurs in the anastomosed small bowel that includes changes in mucin content, villous blunting, and increased expression of WNT5A, a marker of colonic crypt regeneration...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28667683/pouch-failures-following-ileal-pouch-anal-anastomosis-for-ulcerative-colitis
#19
A Mark-Christensen, R Erichsen, S Brandsborg, F R Pachler, C B Nørager, N Johansen, J H Pachler, O Thorlacius-Ussing, M D Kjaer, N Qvist, L Preisler, J Hillingsø, J Rosenberg, S Laurberg
AIM: Ileal pouch-anal anastomosis is a procedure offered to patients with ulcerative colitis who opt for restoration of bowel continuity. The aim of this study was to determine the risk of pouch failure and ascertain the risk factors associated with failure. METHOD: The study included 1991 patients with ulcerative colitis who underwent ileal pouch-anal anastomosis in Denmark in the period 1980-2013. Pouch failure was defined as excision of the pouch or presence of an unreversed stoma within 1 year after its creation...
January 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28614642/-technology-surgical-intervention-in-ulcerative-colitis-modeling-descending-part-of-the-colon-in-rats-line-wistar
#20
A D Kim, S A Petuhova, Ye Y U Chashkova, O A Gol'dberg, L R Shedoeva
BACKGROUND: Ulcerative colitis (UC) is a chronic immune inflammatory condition of the colon with an unknown aetiology, leading to disability and reduced quality of life of patients. UC primarily affects young adults. In most cases, inflammatory bowel disease (iBD) debuts at reproductive age. The incidence of UC and severe clinical course has increased overall across the world. The study of the mechanisms of pathogenesis and aetiology of this disease contributes to the development of new effective methods of treatment...
2016: Experimental & Clinical Gastroenterology
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