keyword
MENU ▼
Read by QxMD icon Read
search

Adaptation

keyword
https://www.readbyqxmd.com/read/29145629/the-reactome-pathway-knowledgebase
#1
Antonio Fabregat, Steven Jupe, Lisa Matthews, Konstantinos Sidiropoulos, Marc Gillespie, Phani Garapati, Robin Haw, Bijay Jassal, Florian Korninger, Bruce May, Marija Milacic, Corina Duenas Roca, Karen Rothfels, Cristoffer Sevilla, Veronica Shamovsky, Solomon Shorser, Thawfeek Varusai, Guilherme Viteri, Joel Weiser, Guanming Wu, Lincoln Stein, Henning Hermjakob, Peter D'Eustachio
The Reactome Knowledgebase (https://reactome.org) provides molecular details of signal transduction, transport, DNA replication, metabolism, and other cellular processes as an ordered network of molecular transformations-an extended version of a classic metabolic map, in a single consistent data model. Reactome functions both as an archive of biological processes and as a tool for discovering unexpected functional relationships in data such as gene expression profiles or somatic mutation catalogues from tumor cells...
November 14, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29145610/transition-to-an-aquatic-habitat-permitted-the-repeated-loss-of-the-pleiotropic-klk8-gene-in-mammals
#2
Nikolai Hecker, Virag Sharma, Michael Hiller
KLK8 (also called neuropsin) is a serine protease that plays distinct roles in the skin and hippocampus. In the skin, KLK8 influences keratinocyte proliferation and desquamation, and activates antimicrobial peptides in sweat. In the hippocampus, KLK8 affects memory acquisition. Here, we examined the evolution of KLK8 in mammals and discovered that, out of 70 placental mammals, KLK8 is exclusively lost in three independent fully-aquatic lineages, comprising dolphin, killer whale, minke whale and manatee. In addition, while the sperm whale has an intact KLK8 reading frame, the gene evolves neutrally in this species...
November 14, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29145591/asia-consensus-statement-on-nccn-clinical-practice-guideline-for-bladder-cancer
#3
Hiroyuki Nishiyama
The Asia Consensus Statement (ACS) on the NCCN Guideline (NCCN-ACS) for treatment of bladder cancer version 1.2016 is designed to provide documentation of modifications of the 'parent' NCCN Guideline: Bladder Cancer (Version 2.2015). When considering ethnic differences or differences in health regulatory environments between Western and Asian countries, a process of adaptation to match the circumstances is helpful for utilizing the guidelines. The NCCN-ACS for bladder cancer consist of 11 ACSs, focused on diagnosis, imaging, surgical treatment, adjuvant intravesical chemotherapy or immunotherapy, periopererative (neodjuvant or adjuvant) chemotherapy and radiation oncology including bladder preservation...
November 14, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29145523/cross-cultural-validation-of-the-brazilian-portuguese-version-of-the-pain-vigilance-and-awareness-questionnaire
#4
Fernanda Salloume Sampaio Bonafé, João Marôco, Juliana Alvares Duarte Bonini Campos
AIMS: To cross-culturally adapt the Pain Vigilance and Awareness Questionnaire (PVAQ) to the Brazilian Portuguese language, to evaluate its psychometric properties when applied to Brazilian pain-free adults and to adults with different pain profiles, and to compare the PVAQ factor scores of different groups using a new method for calculating the overall scores for vigilance, attention to pain, and awareness of changes in pain. METHODS: A total of 1,143 adults (79% women; mean ± standard deviation [SD] age of 38...
November 16, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29145485/adolescents-perception-of-parental-feeding-practices-adaptation-and-validation-of-the-comprehensive-feeding-practices-questionnaire-for-brazilian-adolescents-the-cfpq-teen
#5
Ângela Bein Piccoli, Lucas Neiva-Silva, Clarisse Pereira Mosmann, Dara Musher-Eizenman, Lucia C Pellanda
BACKGROUND: Parental feeding practices may play a key role in dietary habits and nutritional status of adolescents, but research from adolescents' point of view on this topic is scarce. OBJECTIVE: To adapt and validate an instrument of parental feeding practices as perceived by adolescents in a Brazilian setting. METHODS: The Comprehensive Feeding Practices Questionnaire was translated into Portuguese and adapted to be answered by adolescents (ages 12 to 18)...
2017: PloS One
https://www.readbyqxmd.com/read/29145451/stromal-interaction-molecule-1-haploinsufficiency-causes-maladaptive-response-to-pressure-overload
#6
Takayoshi Ohba, Hiroyuki Watanabe, Manabu Murakami, Kenji Iino, Takeshi Adachi, Yoshihiro Baba, Tomohiro Kurosaki, Kyoichi Ono, Hiroshi Ito
Stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum Ca2+ sensor, has been shown to control a Ca2+-dependent signal that promotes cardiac hypertrophy. However, whether STIM1 has adaptive role that helps to protect against cardiac overload stress remains unknown. We hypothesized that STIM1 deficiency causes a maladaptive response to pressure overload stress. We investigated STIM1 heterozygous KO (STIM1+/-) mice hearts, in which STIM1 protein levels decreased to 27% of wild-type (WT) with no compensatory increase in STIM2...
2017: PloS One
https://www.readbyqxmd.com/read/29145444/inhibition-of-the-h3k9-methyltransferase-g9a-attenuates-oncogenicity-and-activates-the-hypoxia-signaling-pathway
#7
Jolene Caifeng Ho, Lissa Nurrul Abdullah, Qing You Pang, Sudhakar Jha, Edward Kai-Hua Chow, Henry Yang, Hiroyuki Kato, Lorenz Poellinger, Jun Ueda, Kian Leong Lee
Epigenetic mechanisms play important roles in the regulation of tumorigenesis, and hypoxia-induced epigenetic changes may be critical for the adaptation of cancer cells to the hypoxic microenvironment of solid tumors. Previously, we showed that loss-of-function of the hypoxia-regulated H3K9 methyltransferase G9A attenuates tumor growth. However, the mechanisms by which blockade of G9A leads to a tumor suppressive effect remain poorly understood. We show that G9A is highly expressed in breast cancer and is associated with poor patient prognosis, where it may function as a potent oncogenic driver...
2017: PloS One
https://www.readbyqxmd.com/read/29145419/attitudes-to-mental-illness-among-mental-health-professionals-in-singapore-and-comparisons-with-the-general-population
#8
Qi Yuan, Louisa Picco, Sherilyn Chang, Edimansyah Abdin, Boon Yiang Chua, Samantha Ong, Kah Lai Yow, Siow Ann Chong, Mythily Subramaniam
BACKGROUND: Similar to the general public, mental health professionals sometimes also have negative attitudes towards individuals with mental illness; which could ultimately affect the quality of care received by the patients. This study aims to explore attitudes to mental illness among mental health professionals in Singapore; make comparisons with the general population; and investigate the significant correlates. METHODS: A cross-sectional design was used. Eligible participants were recruited from the Institute of Mental Health, Singapore...
2017: PloS One
https://www.readbyqxmd.com/read/29145191/antioxidants-maintain-cellular-redox-homeostasis-by-elimination-of-reactive-oxygen-species
#9
Long He, Ting He, Shabnam Farrar, Linbao Ji, Tianyi Liu, Xi Ma
Reactive oxygen species (ROS) are produced by living cells as normal cellular metabolic byproduct. Under excessive stress conditions, cells will produce numerous ROS, and the living organisms eventually evolve series of response mechanisms to adapt to the ROS exposure as well as utilize it as the signaling molecules. ROS molecules would trigger oxidative stress in a feedback mechanism involving many biological processes, such as apoptosis, necrosis and autophagy. Growing evidences have suggested that ROS play a critical role as the signaling molecules throughout the entire cell death pathway...
November 17, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29145112/biochar-assisted-thermophilic-co-digestion-of-food-waste-and-waste-activated-sludge-under-high-feedstock-to-seed-sludge-ratio-in-batch-experiment
#10
Qian Li, Manjuan Xu, Gaojun Wang, Rong Chen, Wei Qiao, Xiaochang Wang
Batch experiments were conducted using biochar (BC) to promote stable and efficient methane production from thermophilic co-digestion of food waste (FW) and waste activated sludge (WAS) at feedstock/seed sludge (F/S) ratios of 0.25, 0.75, 1.5, 2.25, and 3. The results showed that the presence of BC dramatically shortened the lag time of methane production and increased the methane production rate with increased organic loading. The higher buffer capacity and large specific surface area of BC promoted microorganism growth and adaption to VFAs accumulation...
November 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29145086/active-learning-for-classifying-data-streams-with-unknown-number-of-classes
#11
Saad Mohamad, Moamar Sayed-Mouchaweh, Abdelhamid Bouchachia
The classification of data streams is an interesting but also a challenging problem. A data stream may grow infinitely making it impractical for storage prior to processing and classification. Due to its dynamic nature, the underlying distribution of the data stream may change over time resulting in the so-called concept drift or the possible emergence and fading of classes, known as concept evolution. In addition, acquiring labels of data samples in a stream is admittedly expensive if not infeasible at all...
October 27, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29145069/the-sultr-gene-family-in-maize-zea-mays-l-gene-cloning-and-expression-analyses-under-sulfate-starvation-and-abiotic-stress
#12
Qin Huang, Meiping Wang, Zongliang Xia
Sulfur is an essential macronutrient required for plant growth, development and stress responses. The family of sulfate transporters (SULTRs) mediates the uptake and translocation of sulfate in higher plants. However, basic knowledge of the SULTR gene family in maize (Zea mays L.) is scarce. In this study, a genome-wide bioinformatic analysis of SULTR genes in maize was conducted, and the developmental expression patterns of the genes and their responses to sulfate starvation and abiotic stress were further investigated...
November 10, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29145028/the-complete-mitochondrial-genome-of-the-alvinocaridid-shrimp-shinkaicaris-leurokolos-decapoda-caridea-insight-into-the-mitochondrial-genetic-basis-of-deep-sea-hydrothermal-vent-adaptation-in-the-shrimp
#13
Shao'e Sun, Ming Hui, Minxiao Wang, Zhongli Sha
Deep-sea hydrothermal vent is one of the most extreme environments on Earth with low oxygen and high levels of toxins. Decapod species from the family Alvinocarididae have colonized and successfully adapted to this extremely harsh environment. Mitochondria plays a vital role in oxygen usage and energy metabolism, thus it may be under selection in the adaptive evolution of the hydrothermal vent shrimps. In this study, the mitochondrial genome (mitogenome) of alvinocaridid shrimp Shinkaicaris leurokolos (Kikuchi & Hashimoto, 2000) was determined through Illumina sequencing...
November 10, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/29145027/differential-gene-expression-in-the-intestine-of-sea-cucumber-apostichopus-japonicus-under-low-and-high-salinity-conditions
#14
Libin Zhang, Qiming Feng, Lina Sun, Kui Ding, Da Huo, Yan Fang, Tao Zhang, Hongsheng Yang
Sea cucumber, Apostichopus japonicus is an important species for aquaculture, and its behavior and physiology can change in response to changing salinity conditions. For this reason, it is important to understand the molecular responses of A. japonicus when exposed to ambient changes in salinity. In this study, RNA-Seq provided a general overview of the gene expression profiles in the intestine of A. japonicus exposed to high salinity (SD40), normal salinity (SD30) and low salinity (SD20) environments. Screening for differentially expressed genes (DEGs) using the NOISeq method identified 109, 100, and 89 DEGs based on a fold change of ≥2 and divergence probability ≥0...
November 4, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/29145021/production-of-chemicals-using-dynamic-control-of-metabolic-fluxes
#15
REVIEW
Peng Xu
Engineered microbial cell factories are constantly experiencing metabolic imbalance due to nutrients depletion, metabolites buildup, evolutionary pressure or genetic instability. It is important to equip the engineered cell factory with sensor-regulator system to enable cell adjust metabolism and respond to the changing environment. Dynamically allocating cellular resources and optimally controlling pathway expression have proved as promising strategies to manage the tradeoff between cell growth and product formation as well as improve the cost-competitiveness of industrial fermentation...
November 13, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29145007/sleep-preserves-original-and-distorted-memory-traces
#16
Scott A Cairney, Shane Lindsay, Ken A Paller, M Gareth Gaskell
Retrieval facilitates the long-term retention of memories, but may also enable stored representations to be updated with new information that is available at the time of retrieval. However, if information integrated during retrieval is erroneous, future recall can be impaired: a phenomenon known as retrieval-induced distortion (RID). Whether RID causes an "overwriting" of existing memory traces or leads to the co-existence of original and distorted memory traces is unknown. Because sleep enhances memory consolidation, the effects of sleep after RID can provide novel insights into the structure of updated memories...
October 16, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29144996/new-roles-and-controls-of-mast-cells
#17
REVIEW
Eric Espinosa, Salvatore Valitutti
Mast cells are innate immune cells implicated in immune surveillance and defense. They are filled with secretory granules where a vast array of molecules endowed with multiple biological activities are stored. The process of granule secretion, named degranulation, is a tightly controlled biological phenomenon that allows mast cells to rapidly and efficiently release bioactive mediators in response to extracellular stimuli. MC degranulation allows fighting pathogens, limiting envenomation and contributes to tissue homeostasis...
November 13, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29144977/birthplace-in-australia-processes-and-interactions-during-the-intrapartum-transfer-of-women-from-planned-homebirth-to-hospital
#18
Deborah Fox, Athena Sheehan, Caroline Homer
OBJECTIVE: the aim of the study was to explore the views and experiences of women, midwives and obstetricians on the intrapartum transfer of women from planned homebirth to hospital in Australia. DESIGN: a Constructivist Grounded Theory approach was taken, to conceptualise the social interactions and processes grounded in the data. SETTING: urban and regional areas in four states of south-eastern Australia. PARTICIPANTS: semi-structured qualitative interviews were conducted with 36 women, midwives and obstetricians who had experienced an intrapartum homebirth transfer within three years prior to the interview...
November 2, 2017: Midwifery
https://www.readbyqxmd.com/read/29144837/evolution-of-alternative-adaptive-immune-systems-in-vertebrates
#19
Thomas Boehm, Masayuki Hirano, Stephen J Holland, Sabyasachi Das, Michael Schorpp, Max D Cooper
Adaptive immunity in jawless fishes is based on antigen recognition by three types of variable lymphocyte receptors (VLRs) composed of variable leucinerich repeats, which are differentially expressed by two T-like lymphocyte lineages and one B-like lymphocyte lineage. The T-like cells express either VLRAs or VLRCs of yet undefined antigen specificity, whereas the VLRB antibodies secreted by B-like cells bind proteinaceous and carbohydrate antigens. The incomplete VLR germline genes are assembled into functional units by a gene conversion-like mechanism that employs flanking variable leucine-rich repeat sequences as templates in association with lineage-specific expression of cytidine deaminases...
November 16, 2017: Annual Review of Immunology
https://www.readbyqxmd.com/read/29144825/salt-hypertension-and-immunity
#20
A Justin Rucker, Nathan P Rudemiller, Steven D Crowley
The link between inappropriate salt retention in the kidney and hypertension is well recognized. However, growing evidence suggests that the immune system can play surprising roles in sodium homeostasis, such that the study of inflammatory cells and their secreted effectors has provided important insights into salt sensitivity. As part of the innate immune system, myeloid cells have diverse roles in blood pressure regulation, ranging from prohypertensive actions in the kidney, vasculature, and brain, to effects in the skin that attenuate blood pressure elevation...
November 16, 2017: Annual Review of Physiology
keyword
keyword
17087
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"