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prednisone long term effects

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https://www.readbyqxmd.com/read/30020020/medical-adherence-in-patients-with-systemic-lupus-erythematosus-in-germany-predictors-and-reasons-for-non-adherence-a-cross-sectional-analysis-of-the-lula-cohort
#1
G Chehab, G M Sauer, J G Richter, R Brinks, R Willers, R Fischer-Betz, B Winkler-Rohlfing, M Schneider
Objective Adherence to medication has a major impact on treatment control and success especially in chronic diseases but often remains unrecognized. Besides clinical, socioeconomic, disease-related and treatment-related parameters, general and personal health beliefs, as well as perception of health, can affect adherence. Our aim was to investigate the adherence to lupus-specific medications in German lupus patients and to assess influencing factors including detrimental or beneficial effects of health perceptions and beliefs...
September 2018: Lupus
https://www.readbyqxmd.com/read/30002799/successful-management-of-kaposiform-hemangioendothelioma-with-long-term-sirolimus-treatment-a-case-report-and-review-of-the-literature
#2
Matteo Chinello, Daniela Di Carlo, Francesca Olivieri, Rita Balter, Massimiliano De Bortoli, Virginia Vitale, Ada Zaccaron, Elisa Bonetti, Alice Parisi, Simone Cesaro
Background: Kaposiform Hemangioendothelioma (KHE) is a rare vascular tumour of the infancy and the first decade of life. It is locally aggressive and potentially life threatening when associated with consumptive coagulopathy, known as Kasabach-Merritt syndrome (KMS). No consensus or guideline for the therapy has been reached because of the lack of prospective trials, and the different standard care suggestions are based on retrospective case series. Case report: We report the case of a 9-month-old male with KHE and KMS in which the initial response, obtained with prednisone and vincristine, was subsequently consolidated and strengthened by long-term treatment with sirolimus, a mTOR inhibitor...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29998211/long-term-treatment-with-infliximab-in-pediatric-vogt-koyanagi-harada-disease
#3
Gustavo A Budmann, Ludmila García Franco, Alejandra Pringe
Purpose: To report a case of pediatric Vogt-Koyanagi-Harada (VKH) successfully treated with infliximab and methotrexate for ten years. Observations: A 9-year-old Hispanic girl with VKH disease, was successfully treated with oral methotrexate 15 mg/week and oral prednisone 40 mg/day (1mg/kg/day). But when oral prednisone was tapered to 10 mg/day over a 3-month period, inflammation recurred. Patient was considered as corticosteroid-dependent thus infliximab 7mg/kg/pulse was started on days 0, 15, 60 and every 60 days thereafter...
September 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29978586/retrospective-analysis-of-the-usefulness-of-a-protocol-with-high-dose-methotrexate-in-polymyalgia-rheumatica-results-of-a-single-center-cohort-of-100-patients
#4
Luca Quartuccio, Giorgia Gregoraci, Miriam Isola, Salvatore De Vita
AIM: The aim of the present study was to define subsets of patients suffering from polymyalgia rheumatica, where methotrexate (MTX) up to 20 mg/week might be more effective. METHODS: A total of 100 patients with polymyalgia rheumatica treated with MTX were studied. The criteria for MTX introduction were: (i) relapse during the first month of therapy, when tapering glucocorticoids (GC); (ii) requiring long-term GC (i.e. >24 consecutive months); (iii) requiring ≥5 mg/day of prednisone equivalents after 4 months of GC therapy; (iv) GC-related side-effects; and (v) a high risk of GC-related side-effects...
July 6, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29954931/a-phase-ii-iii-randomized-multicenter-trial-of-prednisone-sirolimus-vs-prednisone-sirolimus-calcineurin-inhibitor-for-treatment-of-chronic-graft-versus-host-disease-bmt-ctn-0801
#5
Paul A Carpenter, Brent R Logan, Stephanie J Lee, Daniel J Weisdorf, Laura Johnston, Luciano J Costa, Carrie L Kitko, Javier Bolaños-Meade, Stefanie Sarantopoulos, Amin M Alousi, Sunil Abhyankar, Edmund K Waller, Adam Mendizabal, Jiaxi Zhu, Kelly A O'Brien, Aleksandr Lazaryan, Juan Wu, Eneida R Nemecek, Steven Z Pavletic, Corey S Cutler, Mary M Horowitz, Mukta Arora
Initial therapy of chronic graft-versus-host disease is prednisone ± calcineurin-inhibitor, but most patients respond inadequately. In a randomized, adaptive phase 2/3 multicenter trial we studied whether prednisone/sirolimus or prednisone/sirolimus/photopheresis was more effective than prednisone/sirolimus/calcineurin-inhibitor for treating chronic graft-versus-host disease in treatment-naive or early inadequate responders. Primary endpoints were proportions of subjects alive without relapse or secondary therapy with 6-month complete or partial response in phase-2, or with 2-year complete response in phase-3...
June 28, 2018: Haematologica
https://www.readbyqxmd.com/read/29932254/long-term-immunosuppression-for-cns-mouse-xenotransplantation-effects-on-nigrostriatal-neurodegeneration-and-neuroprotective-carotid-body-cell-therapy
#6
Javier Villadiego, Sonia Romo-Madero, Roberto García-Swinburn, Nela Suárez-Luna, Alfonso Bermejo-Navas, Miriam Echevarría, Juan J Toledo-Aral
BACKGROUND: The use of long-term immunosuppressive treatments on neural transplantation has been controversial during the last decades. Although nowadays there is a consensus about the necessity of maintaining a permanent state of immunosuppression to preserve the survival of cerebral grafts, little is known about the effects that chronic immunosuppression produces both on the neurodegenerative process and on transplants function. METHODS: Here, we establish a new immunosuppressive protocol, based on the discontinuous administration of CsA (15 mg/kg; s...
June 22, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29925692/double-stranded-rna-innate-immune-response-activation-from-long-term-adeno-associated-virus-vector-transduction
#7
Wenwei Shao, Lauriel F Earley, Zheng Chai, Xiaojing Chen, Junjiang Sun, Ting He, Meng Deng, Matthew L Hirsch, Jenny Ting, R Jude Samulski, Chengwen Li
Data from clinical trials for hemophilia B using adeno-associated virus (AAV) vectors have demonstrated decreased transgenic coagulation factor IX (hFIX) expression 6-10 weeks after administration of a high vector dose. While it is likely that capsid-specific cytotoxic T lymphocytes eliminate vector-transduced hepatocytes, thereby resulting in decreased hFIX, this observation is not intuitively consistent with restored hFIX levels following prednisone application. Although the innate immune response is immediately activated following AAV vector infection via TLR pathways, no studies exist regarding the role of the innate immune response at later time points after AAV vector transduction...
June 21, 2018: JCI Insight
https://www.readbyqxmd.com/read/29883261/muscle-mirnaome-shows-suppression-of-chronic-inflammatory-mirnas-with-both-prednisone-and-vamorolone
#8
Alyson A Fiorillo, Christopher B Tully, Jesse M Damsker, Kanneboyina Nagaraju, Eric P Hoffman, Christopher R Heier
Corticosteroids are highly prescribed and effective anti-inflammatory drugs, but the burden of side effects with chronic use significantly detracts from patient quality of life, particularly in children. Developing safer steroids amenable to long-term use is an important goal for treatment of chronic inflammatory diseases such as Duchenne muscular dystrophy (DMD). We have developed vamorolone (VBP15), a first-in-class dissociative glucocorticoid receptor (GR) ligand that shows the anti-inflammatory efficacy of corticosteroids without key steroid side effects in animal models...
June 8, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29843820/successful-treatment-of-primary-bone-marrow-hodgkin-lymphoma-with-brentuximab-vedotin-a-case-report-and-review-of-the-literature
#9
Keiki Nagaharu, Masahiro Masuya, Yuki Kageyama, Takanori Yamaguchi, Ryugo Ito, Keiki Kawakami, Masafumi Ito, Naoyuki Katayama
BACKGROUND: Hodgkin lymphoma usually presents with sequential enlargement of peripheral lymph nodes, and bone marrow invasion rarely occurs (approximately 3-5%). However, several cases have been reported as "primary" bone marrow Hodgkin lymphoma, especially among patients with human immunodeficiency virus and the elderly. This type of Hodgkin lymphoma is characterized by no peripheral lymphadenopathies and has been reported to have poorer prognosis. CASE PRESENTATION: A 38-year-old Japanese man was admitted to our hospital because of fever of unknown origin and pancytopenia without lymphadenopathies...
May 30, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29787923/epileptic-spasms-evidence-for-oral-corticosteroids-and-implications-for-low-and-middle-income-countries
#10
REVIEW
Sharika V Raga, Jo M Wilmshurst
Implementation of international guidelines for the treatment of epileptic spasms, is challenging when access to adrenocorticotrophic hormone (ACTH) and vigabatrin is restricted, especially in Low and Middle Income Countries (LMIC). Oral corticosteroids are alternative interventions but evidence for the optimal agent, dose, duration, efficacy and long-term effects is lacking. A systematic review of the literature was performed to assess the quality of evidence of prednisone and prednisolone (oral corticosteroids) for the management of epileptic spasms...
July 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29775447/-mycophenolate-mofetil-mmf-as-the-first-choice-immunosuppressive-drug-in-treatment-of-steroid-dependent-nephrotic-syndrome-in-children
#11
Iwona Ogarek, Elżbieta Szczęsny-Choruz, Ewa Wierzchowska-Słowiaczek, Joanna Kwinta-Rybicka, Zofia Stec, Anna Moczulska, Katarzyna Wilkosz, Dorota Drożdż
Most children diagnosed with nephrotic syndrome show favourable response to corticosteroid therapy, nonetheless 30% of patients have frequent relapses or a steroid-dependent course of disease. Cyclophosphamide, cyclosporin A or MMF are being used in treatment of steroid-dependent nephrotic syndrome in search of a drug with highest long-term effectiveness and least amount of side effects. AIM: The aim of study was to assess of the efficacy of MMF as the first choice immunosuppressive drug in children with nephrotic syndrome after determining a steroid-dependency...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29722038/long-term-abiraterone-withdrawal-syndrome
#12
S Marin, R Querol, L Campins, M Miarons, A Font, P Lianes
WHAT IS KNOWN AND OBJECTIVE: Abiraterone acetate (AA) is an androgen receptor axis inhibitor, indicated together with prednisone, for metastatic castration-resistant prostate cancer. Withdrawal syndrome for classical antiandrogen treatments is well known, but not so known for AA. Abiraterone withdrawal syndrome (AWS) could be related to simultaneous prednisone discontinuation or to an androgenic effect of AA metabolites. CASE DESCRIPTION: A case is described of a patient with long-term AWS without prednisone discontinuation...
May 2, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29603428/retrospective-analysis-of-frontline-treatment-efficacy-in-elderly-patients-with-diffuse-large-b-cell-lymphoma
#13
Chieh-Lung Cheng, Jia-Hau Liu, Sheng-Chieh Chou, Ming Yao, Jih-Luh Tang, Hwei-Fang Tien
OBJECTIVES: To investigate the effectiveness of 2 chemotherapeutic regimens, bendamustine plus rituximab (BR) or reduced-dose cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab (RD-R-CHOP), in elderly patients with treatment-naïve diffuse large B-cell lymphoma. METHODS: A retrospective study was conducted to investigate the efficacy and safety of 2 frontline regimens, BR and RD-R-CHOP, in patients aged ≥75 years unfit for R-CHOP. RESULTS: From January 2011 to December 2015, 26 patients received BR and 34 RD-R-CHOP...
July 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29590007/prospective-international-randomized-phase-ii-study-of-low-dose-abiraterone-with-food-versus-standard-dose-abiraterone-in-castration-resistant-prostate-cancer
#14
Russell Z Szmulewitz, Cody J Peer, Abiola Ibraheem, Elia Martinez, Mark F Kozloff, Bradley Carthon, R Donald Harvey, Paul Fishkin, Wei Peng Yong, Edmund Chiong, Chadi Nabhan, Theodore Karrison, William D Figg, Walter M Stadler, Mark J Ratain
Purpose Abiraterone acetate (AA) is a standard of care for metastatic castration-resistant prostate cancer (CRPC). Despite a large food effect, AA was administered under fasting conditions in its pivotal trials. We sought to test the hypothesis that low-dose AA (LOW; 250 mg with a low-fat meal) would have comparable activity to standard AA (STD; 1,000 mg fasting) in patients with CRPC. Patients and Methods Patients (n = 72) with progressive CRPC from seven institutions in the United States and Singapore were randomly assigned to STD or LOW...
May 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29579308/the-effect-of-albendazole-treatment-on-non-seizure-outcomes-in-patients-with-symptomatic-neurocysticercosis
#15
Kriti Thapa, Matthew L Romo, Arturo Carpio, Denise Leslie, Howard Andrews, W Allen Hauser, Elizabeth A Kelvin
Background: There is little information about the impact of anthelminthic treatment on clinical symptoms other than seizures in neurocysticercosis (NC). We investigated the effect of albendazole on non-seizure symptoms experienced by patients with NC. Methods: Data are from a randomized controlled trial comparing albendazole plus prednisone with placebo plus prednisone for treatment of NC among 173 patients with active or transitional NC cysts and new-onset symptoms...
February 1, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29527848/corticosteroid-therapy-in-combination-with-antibiotics-for-erysipelas
#16
Michal Solomon, Aviv Barzilai, Hila Elphasy, Henri Trau, Sharon Baum
BACKGROUND: Erysipelas, an acute infection of the dermal and subcutaneous tissue, is normally treated with antibiotics. Previous data indicated that treatment with prednisone in combination with antibiotics results in significant acceleration of the healing phase. OBJECTIVES: To investigate the effectiveness of corticosteroids combined with antibiotics for the treatment of erysipelas. METHODS: A retrospective study was conducted on hospitalized patients diagnosed with erysipelas between 2004 and 2011 at the Department of Dermatology at Sheba Medical Center, Israel...
March 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29526468/long-term-effectiveness-of-ra-1-a-standardized-ayurvedic-medicine-as-a-monotherapy-and-in-combination-with-disease-modifying-anti-rheumatic-drugs-in-the-treatment-of-rheumatoid-arthritis
#17
Arvind Chopra, Manjit Saluja, Toktam Kianifard, Deepa Chitre, Anuradha Venugopalan
BACKGROUND: Data on long term use of Ayurvedic drugs is sparse. They may prove useful if combined with modern medicine in certain clinical situations (integrative medicine). We present the results of a long term observational study of RA-1 (Ayurvedic drug) used in the treatment of rheumatoid arthritis (RA). MATERIALS AND METHODS: On completion of a 16 week randomized controlled study, 165 consenting volunteer patients were enrolled into a three year open label phase (OLP) study...
March 8, 2018: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29456648/immunosuppressive-effects-of-hydroxychloroquine-and-artemisinin-combination-therapy-via-the-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway-in-lupus-nephritis-mice
#18
Ning Liang, Yanchun Zhong, Jie Zhou, Bihao Liu, Ruirui Lu, Yezhi Guan, Qi Wang, Chunlin Liang, Yu He, Yuan Zhou, Jianping Song, Jiuyao Zhou
Lupus nephritis (LN) is one of the most common and severe manifestations of systemic lupus erythematosus, leading to permanent renal damage and chronic kidney disease. Hydroxychloroquine (HCQ) serves a protective role against lupus-associated clinical manifestations and medical complications; however, it results in numerous adverse reactions, limiting its long-term use. The aim of the present study was to investigate the combined effect of HCQ and artemisinin (ART) on LN, and to elucidate the underlying mechanisms...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29360414/early-chemotherapy-intensification-with-escalated-beacopp-in-patients-with-advanced-stage-hodgkin-lymphoma-with-a-positive-interim-positron-emission-tomography-computed-tomography-scan-after-two-abvd-cycles-long-term-results-of-the-gitil-fil-hd-0607-trial
#19
Andrea Gallamini, Corrado Tarella, Simonetta Viviani, Andrea Rossi, Caterina Patti, Antonino Mulé, Marco Picardi, Alessandra Romano, Maria Cantonetti, Giorgio La Nasa, Livio Trentin, Silvia Bolis, Davide Rapezzi, Roberta Battistini, Daniela Gottardi, Paolo Gavarotti, Paolo Corradini, Michele Cimminiello, Corrado Schiavotto, Guido Parvis, Roberta Zanotti, Guido Gini, Andrés J M Ferreri, Piera Viero, Maurizio Miglino, Atto Billio, Abraham Avigdor, Alberto Biggi, Federico Fallanca, Umberto Ficola, Michele Gregianin, Agostino Chiaravalloti, Giuseppe Prosperini, Fabrizio Bergesio, Stephane Chauvie, Chiara Pavoni, Alessandro Massimo Gianni, Alessandro Rambaldi
Purpose To investigate the progression-free survival (PFS) of patients with advanced Hodgkin lymphoma (HL) after a risk-adapted treatment strategy that was based on a positive positron emission tomography scan performed after two doxorubicin, vinblastine, vincristine, and dacarbazine (ABVD) cycles (PET2). Patients and Methods Patients with advanced-stage (IIB to IVB) HL were consecutively enrolled. After two ABVD cycles, PET2 was performed and centrally reviewed according to the Deauville five-point scale. Patients with a positive PET2 were randomly assigned to four cycles of escalated bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) followed by four cycles of standard BEACOPP with or without rituximab...
February 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29303024/bortezomib-in-combination-with-dose-adjusted-epoch-etoposide-prednisone-vincristine-cyclophosphamide-and-doxorubicin-induces-long-term-survival-in-patients-with-plasmablastic-lymphoma-a-retrospective-analysis
#20
Christopher Dittus, Natalie Grover, Steven Ellsworth, Xianming Tan, Steven I Park
Plasmablastic lymphoma (PBL) is a rare and aggressive form of B-cell non-Hodgkin lymphoma. This subtype of lymphoma has a post-germinal center cell-of-origin called the plasmablast, and the immunophenotype is more consistent with that of a plasma cell than a lymphocyte. Because of these unique features, PBL is notoriously difficult to treat. Case reports and small reviews have evaluated the addition of agents directed against plasma cell disorders in combination with traditional lymphoma-directed regimens. We describe the largest case series to date, with the longest follow-up, evaluating bortezomib in combination with etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (V-EPOCH) for the treatment of PBL...
January 5, 2018: Leukemia & Lymphoma
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