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Yuanyuan Zhou, Xia Zheng, Jiaojiao Lu, Wei Chen, Xu Li, Le Zhao
BACKGROUND/AIMS: The Warburg effect is one of the main energy metabolism features supporting cancer cell growth. 20(S)-Rg3 exerts anti-tumor effect on ovarian cancer partly by inhibiting the Warburg effect. microRNAs are important regulators of the Warburg effect. However, the microRNA regulatory network mediating the anti-Warburg effect of 20(S)-Rg3 was largely unknown. METHODS: microRNA deep sequencing was performed to identify the 20(S)-Rg3-influenced microRNAs in SKOV3 ovarian cancer cells...
March 16, 2018: Cellular Physiology and Biochemistry
Morteza Karimzadeh, Neda Manouchehri, Dariush Saberi, Khodabakhsh Niknam
All 66 conformers of guanylurea were optimized and frequency calculations were performed at M06-2X/6-311++G(d,p) level of theory. Theses conformers were categorized into five tautomers, and the most stable conformer of each tautomer were found. Geometrical parameters indicated that these tautomers have almost planar structure. Complete stepwise tautomerism were studied through both intramolecular proton transfer routs and internal rotations. Results indicated that the proton transfer routs involving four-membered heterocyclic structures were rate-determining steps...
March 6, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Min Cheng, Guangming Zeng, Danlian Huang, Cui Lai, Yang Liu, Chen Zhang, Jia Wan, Liang Hu, Chengyun Zhou, Weiping Xiong
The presence of antibiotics in aquatic environments has attracted global concern. Fenton process is an attractive yet challenging method for antibiotics degradation, especially when such a reaction can be conducted at neutral pH values. In this study, a novel composite Fe/Co catalyst was synthesized via the modification of steel converter slag (SCS) by salicylic acid-methanol (SAM) and cobalt nitrate (Co(NO3 )2 ). The catalysts were characterized by N2 -Brunauer-Emmett-Teller (BET), X-ray diffraction (XRD), Fourier transform infrared (FT-IR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS)...
March 10, 2018: Water Research
Natalia Crespo Tapia, Heidy M W den Besten, Tjakko Abee
Listeria monocytogenes is a food-borne pathogen that can grow as a biofilm on surfaces. Biofilm formation in food-processing environments is a big concern for food safety, as it can cause product contamination through the food-processing line. Although motile aerobic bacteria have been described to form biofilms at the air-liquid interface of cell cultures, to our knowledge, this type of biofilm has not been described in L. monocytogenes before. In this study we report L. monocytogenes biofilm formation at the air-liquid interface of aerobically grown cultures, and that this phenotype is specifically induced when the media is supplemented with glycerol as a carbon and energy source...
March 15, 2018: International Journal of Food Microbiology
Khushboo Patel, Basant Roondhe, Shweta D Dabhi, Prafulla K Jha
Recently predicted and grown new single element two dimensional (2D) material borophene gathered tremendous research interest due to its structural, electronic and other properties. Using first principles based dispersion corrected density functional calculations, we have studied interaction of two toxic gases phosgene (COCl2 ) and carbon monoxide (CO) with borophene to understand the role of borophene as biosensor and carriers in drug delivery. The sensing behaviour of borophene towards COCl2 and CO has been studied by calculating the binding energy and electronic density of states (DOS)...
March 7, 2018: Journal of Hazardous Materials
Shahid Khan, Jonathan M Scholey
Cells from all three domains of life on Earth utilize motile macromolecular devices that protrude from the cell surface to generate forces that allow them to swim through fluid media. Research carried out on archaea during the past decade or so has led to the recognition that, despite their common function, the motility devices of the three domains display fundamental differences in their properties and ancestry, reflecting a striking example of convergent evolution. Thus, the flagella of bacteria and the archaella of archaea employ rotary filaments that assemble from distinct subunits that do not share a common ancestor and generate torque using energy derived from distinct fuel sources, namely chemiosmotic ion gradients and FlaI motor-catalyzed ATP hydrolysis, respectively...
March 19, 2018: Current Biology: CB
Wei Wu, Jin Wang, Peter Ercius, Nicomario Courtney Wright, Danielle Marie Leppert-Simenauer, Robert A Burke, Madan Dubey, Avinash M Dongare, Michael Thompson Pettes
Transition metal dichalcogenides (TMDs) are particularly sensitive to mechanical strain as they are capable of experiencing high atomic displacements without nucleating defects to release excess energy. Promising for photonic applications, it has been shown that as certain phases of layered TMDs MX2 (M=Mo, W; X=S, Se, Te) are scaled to a thickness of one monolayer, the photoluminescence response is dramatically enhanced due to the emergence of a direct electronic band gap, compared with their multi-layer or bulk counterparts which typically exhibit indirect band gaps...
March 20, 2018: Nano Letters
Gracjana Leonowicz, Kamil F Trzebuniak, Paulina Zimak-Piekarczyk, Ireneusz Ślesak, Beata Mysliwa-Kurdziel
Unbound tetrapyrroles, i.e. protochlorophyllide (Pchlide), chlorophyllide and chlorophylls, bring the risk of reactive oxygen species (ROS) being generated in the initial stages of angiosperm deetiolation due to inefficient usage of the excitation energy for photosynthetic photochemistry. We analyzed the activity of superoxide dismutases (SODs) in etiolated wheat (Triticum aestivum) leaves and at the beginning of their deetiolation. Mn-SOD and three isoforms of Cu/Zn-SODs were identified both in etiolated and greening leaves of T...
2018: PloS One
Christina Pedersen, Trine Porsgaard, Maria Thomsen, Mette Marie Rosenkilde, Nikolaj Kulahin Roed
Insulin is a vital part of diabetes treatment, whereas glucagon is primarily used to treat insulin-induced hypoglycemia. However, glucagon is suggested to have a central role in the regulation of body weight, which would be beneficial for diabetic patients. Since the glucagon effect on blood glucose is known to be transient, it is relevant to investigate the pharmacodynamics of glucagon after repeated dosing. In the present study, we used telemetry to continuously measure blood glucose in streptozotocin induced diabetic Sprague-Dawley rats...
2018: PloS One
Vyacheslav A Trofimov, Tatiana M Lysak, Evgenii M Trykin
We discuss a novel type of surface soliton-aberrated surface soliton-appearance in a nonlinear one dimensional photonic crystal and a possibility of this surface soliton formation in two dimensional photonic crystal. An aberrated surface soliton possesses a nonlinear distribution of the wavefront. We show that, in one dimensional photonic crystal, the surface soliton is formed at the photonic crystal boundary with the ambient medium. Essentially, that it occupies several layers at the photonic crystal boundary and penetrates into the ambient medium at a distance also equal to several layers, so that one can infer about light energy localization at the lateral surface of the photonic crystal...
2018: PloS One
Tomasz Tański, Wiktor Matysiak
The purpose of this paper was to produce SiO₂ and TiO₂ nanowires via the electrospinning process from a polyvinylpyrrolidone (PVP)/Tetraethyl orthosilicate (TEOS)/Titanium (IV) butoxide (TNBT)/dimethylformamide (DMF) and ethanol (EtOH) solution. The as-obtained nanofibers were calcined at temperatures ranging from 400 °C to 600 °C in order to remove the organic phase. The one-dimensional ceramic nanostructures were studied using a scanning electron microscope (SEM) and a transmission electron microscope (TEM) to analyze the influence of the used temperature on the morphology and structures of the obtained ceramic nanomaterials...
March 20, 2018: Nanomaterials
Ali Hassan Sodhro, Arun Kumar Sangaiah, Gul Hassan Sodhro, Sonia Lohano, Sandeep Pirbhulal
Rapid progress and emerging trends in miniaturized medical devices have enabled the un-obtrusive monitoring of physiological signals and daily activities of everyone's life in a prominent and pervasive manner. Due to the power-constrained nature of conventional wearable sensor devices during ubiquitous sensing (US), energy-efficiency has become one of the highly demanding and debatable issues in healthcare. This paper develops a single chip-based wearable wireless electrocardiogram (ECG) monitoring system by adopting analog front end (AFE) chip model ADS1292R from Texas Instruments...
March 20, 2018: Sensors
David Perez-Diaz-de-Cerio, Ángela Hernández-Solana, Antonio Valdovinos, Jose Luis Valenzuela
Timing points used in running races and other competition events are generally based on radio-frequency identification (RFID) technology. Athletes' times are calculated via passive RFID tags and reader kits. Specifically, the reader infrastructure needed is complex and requires the deployment of a mat or ramps which hide the receiver antennae under them. Moreover, with the employed tags, it is not possible to transmit additional and dynamic information such as pulse or oximetry monitoring, alarms, etc. In this paper we present a system based on two low complex schemes allowed in Bluetooth Low Energy (BLE): the non-connectable undirected advertisement process and a modified version of scannable undirected advertisement process using the new capabilities present in Bluetooth 5...
March 20, 2018: Sensors
Luis Cruz-Piris, Diego Rivera, Ivan Marsa-Maestre, Enrique de la Hoz, Juan R Velasco
Internet growth has generated new types of services where the use of sensors and actuators is especially remarkable. These services compose what is known as the Internet of Things (IoT). One of the biggest current challenges is obtaining a safe and easy access control scheme for the data managed in these services. We propose integrating IoT devices in an access control system designed for Web-based services by modelling certain IoT communication elements as resources. This would allow us to obtain a unified access control scheme between heterogeneous devices (IoT devices, Internet-based services, etc...
March 20, 2018: Sensors
Jong-Min Chae, Keun-Oh Lee, Auezhan Amanov
Microstructural evolution and wear performance of Tantalum (Ta) treated by ultrasonic nanocrystalline surface modification (UNSM) at 25 and 1000 °C were reported. The UNSM treatment modified a surface along with subsurface layer with a thickness in the range of 20 to 150 µm, which depends on the UNSM treatment temperature, via the surface severe plastic deformation (S²PD) method. The cross-sectional microstructure of the specimens was observed by electron backscattered diffraction (EBSD) in order to confirm the microstructural alteration in terms of effective depth and refined grain size...
March 20, 2018: Materials
Vajira R Wanniarachchi, Lettee Dametto, Crystal Sweetman, Yuri Shavrukov, David A Day, Colin L D Jenkins, Kathleen L Soole
Plants have a non-energy conserving bypass of the classical mitochondrial cytochrome c pathway, known as the alternative respiratory pathway (AP). This involves type II NAD(P)H dehydrogenases (NDs) on both sides of the mitochondrial inner membrane, ubiquinone, and the alternative oxidase (AOX). The AP components have been widely characterised from Arabidopsis, but little is known for monocot species. We have identified all the genes encoding components of the AP in rice and barley and found the key genes which respond to oxidative stress conditions...
March 20, 2018: International Journal of Molecular Sciences
Xavier Palomer, Emma Barroso, Javier Pizarro-Delgado, Lucía Peña, Gaia Botteri, Mohammad Zarei, David Aguilar, Marta Montori-Grau, Manuel Vázquez-Carrera
Research in recent years on peroxisome proliferator-activated receptor (PPAR)β/δ indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPARβ/δ activation might help prevent the development of metabolic disorders, including obesity, dyslipidaemia, type 2 diabetes mellitus and non-alcoholic fatty liver disease. This review highlights research findings on the PPARβ/δ regulation of energy metabolism and the development of diseases related to altered cellular and body metabolism...
March 20, 2018: International Journal of Molecular Sciences
Guilong Yan, Haitao Niu, Hua Zhou, Hongxia Wang, Hao Shao, Xueting Zhao, Tong Lin
Auxiliary fields have been used to enhance the performance of needle electrospinning. However, much less has been reported on how auxiliary fields affect needleless electrospinning. Herein, we report a novel needleless electrospinning technique that consists of an aerodynamic field and a second electric field. The second electric field is generated by setting two grounded inductive electrodes near the spinneret. The two auxiliary fields have to be applied simultaneously to ensure working of the electrospinning process...
March 20, 2018: Nanotechnology
André Bonadias Gadelha, Silvia Gonçalves Ricci Neri, Ricardo Jacó de Oliveira, Martim Bottaro, Ana Cristina de David, Baruch Vainshelboim, Ricardo M Lima
Background/Study context: Falls represent the leading cause of accidental deaths in the elderly. Sarcopenia is a geriatric syndrome defined as the loss of muscle mass and strength. However, the association between falls and sarcopenia is still unclear. Thus, the aim of the present study was to investigate the association between different stages of sarcopenia and postural balance, risk of falls, and fear of falling in community-dwelling older women. METHODS: A total of 196 women (68.6 ± 6...
March 20, 2018: Experimental Aging Research
Sunmin Park, Da Sol Kim, Eun Seon Kang, Da Bin Kim, Suna Kang
We evaluated the effects of intracerebroventricular administration(ICV) of brain estrogen and progesterone on menopausal symptoms and their effects on the secretion of follicle-stimulating hormone(FSH) and luteinizing hormone(LH) in estrogen-deficient rats. Three weeks after ovariectomy(OVX) or Sham-operation, OVX rats were given ICV infusions of either 17β-estradiol(4 μg/day; ICV-E), progesterone(0.8 μg/day; ICV-P), or vehicle(control) for 4 weeks. OVX rats in the positive-control group were orally provided 150 μg 17β-estradiol/kg bw/day...
March 20, 2018: American Journal of Physiology. Endocrinology and Metabolism
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