Yael Haberman, Phillip Minar, Rebekah Karns, Phillip J Dexheimer, Sudhir Ghandikota, Samuel Tegge, Daniel Shapiro, Brianne Shuler, Suresh Venkateswaran, Tzipi Braun, Allison Ta, Thomas D Walters, Robert N Baldassano, Joshua D Noe, Joel Rosh, James Markowitz, Jennifer L Dotson, David R Mack, Richard Kellermayer, Anne M Griffiths, Melvin B Heyman, Susan S Baker, Dedrick Moulton, Ashish S Patel, Ajay S Gulati, Steven J Steiner, Neal LeLeiko, Anthony Otley, Maria Oliva-Hemker, David Ziring, Ranjana Gokhale, Sandra Kim, Stephen L Guthery, Stanley A Cohen, Scott Snapper, Bruce J Aronow, Michael Stephens, Greg Gibson, Jonathan R Dillman, Marla Dubinsky, Jeffrey S Hyams, Subra Kugathasan, Anil G Jegga, Lee A Denson
BACKGROUND AND AIMS: Ileal strictures are the major indication for resective surgery in Crohn's disease (CD). We aimed to define ileal gene programs present at diagnosis linked with future stricturing behavior during five year follow-up, and to identify potential small molecules to reverse these gene signatures. METHODS: Antimicrobial serologies and pre-treatment ileal gene expression were assessed in a representative subset of 249 CD patients within the RISK multicenter pediatric CD inception cohort study, including 113 that are unique to this report...
August 8, 2020: Journal of Crohn's & Colitis