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Therapeutic effect

Jieyu Wang, Jun Li, Ruifang Chen, Xin Lu
BACKGROUND: To compare the survival impact of several lymph node staging methods and therapeutic role of lymphadenectomy in patients with epithelial ovarian cancer who had undergone lymphadenectomy. METHODS: Data were retrospectively collected from the Surveillance, Epidemiology, and End Results program between 1988 and 2013. RESULTS: An increasing number of resected lymph nodes (RLNs) was associated with a significant improvement in survival of FIGO stage II and III disease...
August 18, 2018: Cancer Medicine
Ekaterina Pylaeva, Mozhgan Dehghan Harati, Ilona Spyra, Sharareh Bordbari, Sarah Strachan, Basant Kumar Thakur, Benedikt Höing, Cindy Franklin, Julia Skokowa, Karl Welte, Dirk Schadendorf, Agnes Bankfalvi, Sven Brandau, Stephan Lang, Jadwiga Jablonska
Tumor-associated neutrophils regulate many processes associated with tumor progression, and depending on the microenvironment, they can exhibit pro- or antitumor functions. However, the molecular mechanisms regulating their tumorigenicity are not clear. Using transplantable tumor models, we showed here that Nicotinamide Phosphoribosyltransferase (NAMPT), a molecule involved in CSF3R downstream signaling, is essential for tumorigenic conversion of tumor-associated neutrophils and their pro-angiogenic switch...
August 19, 2018: International Journal of Cancer. Journal International du Cancer
Dennis Paliga, Fabian Raudzus, Stephen H Leppla, Rolf Heumann, Sebastian Neumann
The orphan transcription factor nuclear receptor-related 1 protein (Nurr1, also known as NR4A2) plays a key role in embryonic development and maintenance of mesencephalic dopaminergic neurons in the substantia nigra. Nurr1 deficiency is associated with Parkinson's disease where dopaminergic neurons degenerate suggesting that counter-regulation of Nurr1 activity may have therapeutic effects. Here, we bacterially expressed and isolated a human Nurr1 fusion protein containing a N-terminal cell delivery domain derived from detoxified anthrax lethal factor followed by wild type ubiquitin with deubiquitinating enzyme recognition site for intracellular cleavage...
August 18, 2018: Molecular Neurobiology
I V Vakhrushev, S E Novikova, A V Tsvetkova, P A Karalkin, M A Pyatnitskii, V G Zgoda, K N Yarygin
Acute promyelocytic leukemia, a form of acute myeloid leukemia, is characterized by cell differentiation arrest at the promyelocyte stage. Current therapeutic options include administration of all trans-retinoic acid (ATRA), but this treatment produces many side effects. ATRA is known to induce differentiation of leukemic cells into granulocytes, but the mechanism of this process is poorly studied. We performed comparative proteomic profiling of HL-60 promyelocytic cells at different stages of ATRA-induced differentiation to identify differentially expressed proteins by high-resolution mass spectrometry and relative quantitative analysis without isotope labels...
August 18, 2018: Bulletin of Experimental Biology and Medicine
A P Lykov, O V Poveshchenko, N A Bondarenko, M A Surovtseva, I I Kim, N P Bgatova
We studied the effect of intravenous administration of biomedical cell product (bone marrow mesenchymal stem cells and media conditioned by these cells) on histological picture of the small intestine in mice with DSS-induced inflammation. It was shown that biomedical cell product promoted recovery of the intestinal mucosa in DSS-induced inflammation.
August 18, 2018: Bulletin of Experimental Biology and Medicine
Takayuki Katsuno, Tomohiro Masuda, Shoji Saito, Noritoshi Kato, Takuji Ishimoto, Sawako Kato, Tomoki Kosugi, Naotake Tsuboi, Hiroshi Kitamura, Toyonori Tsuzuki, Yasuhiko Ito, Shoichi Maruyama
BACKGROUND: Recent reports have described the efficacy of rituximab in treating steroid-dependent nephrotic syndrome (SDNS) in pediatric patients. However, few reports describe data regarding adult-onset SDNS. We investigated the efficacy of rituximab for the management of adult-onset SDNS. METHODS: We performed a retrospective cohort study investigating eight patients with adult-onset SDNS who were treated with rituximab. Clinical data were obtained at the initiation of rituximab therapy...
August 18, 2018: Clinical and Experimental Nephrology
Arash Haghikia, Johannes Schwab, Jens Vogel-Claussen, Dominik Berliner, Tobias Pfeffer, Tobias König, Carolin Zwadlo, Valeska Abou Moulig, Annegret Franke, Marziel Schwarzkopf, Philipp Ehlermann, Roman Pfister, Guido Michels, Ralf Westenfeld, Verena Stangl, Uwe Kühl, Edith Podewski, Ingrid Kindermann, Michael Böhm, Karen Sliwa, Denise Hilfiker-Kleiner, Johann Bauersachs
BACKGROUND: Right ventricular (RV) dysfunction predicts adverse outcome in peripartum cardiomyopathy (PPCM). We recently demonstrated beneficial effects associated with the prolactin release inhibitor bromocriptine at different doses when added to standard heart failure therapy in PPCM. Here, we evaluated for the first time the therapeutic potential of bromocriptine particularly in PPCM patients with RV involvement. METHODS: In this study, 40 patients with PPCM were included, of whom 24 patients had reduced RV ejection fraction (RVEF < 45%)...
August 18, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Xiaobin Li, Dengying Wu, Zhichao Hu, Jiangwei Xuan, Xiaoxia Ding, Gang Zheng, Zhenhua Feng, Wenfei Ni, Aimin Wu
BACKGROUND/AIMS: Osteoarthritis is a degenerative joint disease characterized by cartilage degeneration and a chondrocyte inflammatory response that induces an inflammatory environment closely linked to extracellular matrix (ECM) degradation. Ligustilide (LIG) is a major component of the herb Radix Angelicae Sinensis, with demonstrated anti-inflammatory effects. To confirm whether LIG has an equally inhibitory effect on inflammation in human osteoarthritis chondrocytes, we performed in vivo and in vitro experiments to validate the above conjectures and determine the relevant mechanisms...
August 17, 2018: Cellular Physiology and Biochemistry
Yang Xu, Jie Xu, Yanfang Yang, Lei Zhu, Xubin Li, Weipeng Zhao
BACKGROUND/AIMS: The chondroitin sulfate proteoglycan serglycin (SRGN), a hematopoietic cell granule proteoglycan, has been implicated in promoting tumor metastasis; however, the underlying mechanisms remain to be elucidated. The present study aimed to investigate the SRGN gene expression and its regulation as downstream signaling of hypoxia-inducible transcription factor 1 alpha (HIF-1α) in colorectal cancer (CRC) cells and tissues. METHODS: The expression of SRGN was analyzed in CRC specimens for its correlation with progression and metastasis...
August 17, 2018: Cellular Physiology and Biochemistry
Hongluan Yu, Cuiqin Fan, Lejin Yang, Shuyan Yu, Qiqi Song, Peng Wang, Xueqin Mao
BACKGROUND/AIMS: Ginsenoside Rg1 has been demonstrated to exhibit neuroprotective effects in various studies. This study aimed to investigate the neuronal mechanisms underlying the neuroprotective and antidepressant-like effects of ginsenoside Rg1 in a rat model of depression. METHODS: Chronic unpredictable mild stress was used to induce depression-like behaviors in rats. Transmission electron microscopy was used to observe neuronal synapses within the basolateral amygdala (BLA)...
August 17, 2018: Cellular Physiology and Biochemistry
Yixiu Zhao, Xin Zhang, Jing Luan, Buchang Zhao, Na An, Na Sun, Xinhui Wang, Tao Zhao, Yanhong Sun, Zidong Donna Fu, Yan Zhang, Yan Zhang
BACKGROUND/AIMS: Shenxian-shengmai (SXSM) oral liquid, a Chinese patent compound medicine, has been used to treat sinus bradyarrhythmias induced by mild sick sinus syndrome in clinical practice. Myocardial ischemia, in particular in serious or right coronary-related heart diseases, can cause bradyarrhythmias and cardiac dysfunction. Moreover, reperfusion of ischemic myocardium is associated with additional myocardial damage known as myocardial ischemia-reperfusion (I/R) injury. This study was designed to evaluate the effects of SXSM on bradyarrhythmias and cardiac dysfunction induced by myocardial I/R injury, and to explore the underlying mechanisms...
August 17, 2018: Cellular Physiology and Biochemistry
Jihua Fu, Chen Li, Guangli Zhang, Xin Tong, Haiwei Zhang, Jie Ding, Yingying Ma, Ru Cheng, Shanshan Hou, Shanshan An, Xin Li, Shaoxin Ma
BACKGROUND/AIMS: Previously, we confirmed that liver-synthesized 5-HT rather than non-liver 5-HT, acting on the 5-HT2 receptor (5-HT2R), modulates lipid-induced excessive lipid synthesis (ELS). Here, we further revealed the effects of the hepatocellular 5-HT system in diabetes-related disorders. METHODS: Studies were conducted in male ICR mice, human HepG2 cells, and primary mouse hepatocytes (PMHs) under gene or chemical inhibition of the 5-HT system, key lipid metabolism, and inflammation-related factors...
August 17, 2018: Cellular Physiology and Biochemistry
Paula Müller, Heiko Lemcke, Robert David
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic approach for the treatment of cardiovascular diseases. Since the first transplantation into human patients, several stem cell types have been applied in this field, including bone marrow derived stem cells, cardiac progenitors as well as embryonic stem cells and their derivatives. However, results obtained from clinical studies are inconsistent and stem cell-based improvement of heart performance and cardiac remodeling was found to be quite limited...
August 17, 2018: Cellular Physiology and Biochemistry
Zhangfei Wang, Man Fang, Juan Li, Ruining Yang, Jianping Du, Yiqin Luo
BACKGROUND/AIMS: The correlation between platelet levels and clinical outcomes has received increasing attention, but it is not yet clear whether and how platelet levels affect the therapeutic response in non-small cell lung cancer (NSCLC). In the current study, we aimed to explore the role of platelet levels in responsive to platinum-based chemotherapy and investigated the underlying mechanism. METHODS: We evaluated the possibility of platelet level as a biomarker for response to platinum-based therapy in NSCLC by retrospective analysis of NSCLC patients...
August 17, 2018: Cellular Physiology and Biochemistry
Veronica Vella, Maria Luisa Nicolosi, Patrizia Cantafio, Michele Massimino, Rosamaria Lappano, Paolo Vigneri, Roberto Ciuni, Pietro Gangemi, Andrea Morrione, Roberta Malaguarnera, Antonino Belfiore
Patients with thyroid cancers refractory to radioiodine (RAI) treatment show a limited response to various therapeutic options and a low survival rate. The recent use of multikinase inhibitors has also met limited success. An alternative approach relies on drugs that induce cell differentiation, as the ensuing increased expression of the cotransporter for sodium and iodine (NIS) may partially restore sensitivity to radioiodine. The inhibition of the ERK1/2 pathway has shown some efficacy in this context. Aggressive thyroid tumors overexpress the isoform A of the insulin receptor (IR-A) and its ligand IGF-2; this IGF-2/IR-A loop is associated with de-differentiation and stem-like phenotype, resembling RAI refractory tumors...
August 18, 2018: Endocrine-related Cancer
Lautaro Zubeldia-Brenner, Catalina De Winne, Sofia Perrone, Santiago Andres Rodriguez-Segui, Christophe Willems, Ana Maria Ornstein, Isabel Maria Lacau-Mengido, Hugo Vankelecom, Carolina Cristina, Damasia Becú-Villalobos
Preclinical and clinical studies support that Notch signaling may play an important oncogenic role in cancer, but there is scarce information for pituitary tumors. We therefore undertook a functional study to evaluate Notch participation in pituitary adenoma growth. Tumors generated in nude mice by subcutaneous GH3 somatolactotrope cell injection were treated in vivo with DAPT, a γ-secretase inhibitor, thus inactivating Notch signaling. This treatment led to pituitary tumor reduction, lower prolactin and GH tumor content, and a decrease in angiogenesis...
August 18, 2018: Endocrine-related Cancer
Barry D Wright, Cindy Cooper, Alexander J Scott, Lucy Tindall, Shehzad Ali, Penny Bee, Katie Biggs, Trilby Breckman, Thompson E Davis Iii, Lina Gega, Rebecca Julie Hargate, Ellen Lee, Karina Lovell, David Marshall, Dean McMillan, M Dawn Teare, Jonathan Wilson
INTRODUCTION: Specific phobias (intense, enduring fears of an object or situation that lead to avoidance and severe distress) are highly prevalent among children and young people. Cognitive-behavioural therapy (CBT) is a well-established, effective intervention, but it can be time consuming and costly because it is routinely delivered over multiple sessions during several months. Alternative methods of treating severe and debilitating phobias in children are needed, like one-session treatment (OST), to reduce time and cost, and to prevent therapeutic drift and help children recover quickly...
August 17, 2018: BMJ Open
Anning Li, Shuangmin Ji, Weihua Yue, Hao Yan, Fang Dong, Canjun Ruan, Wenbiao Li, Wei Lu, Dai Zhang, Chuanyue Wang
OBJECTIVE: Olanzapine is an atypical antipsychotic drug commonly used for the treatment of schizophrenia. However, there are still many complications associated with the use of olanzapine, and researchers continually strive to improve the handling of data from regular therapeutic drug monitoring (TDM). The objective of this study is to optimise the individualised treatment of olanzapine by establishing a population pharmacokinetics (PopPK) model in Chinese patients with schizophrenia...
August 17, 2018: BMJ Open
Juan Wang, Jian Pang, Huiling Li, Jie Long, Fang Fang, Junxiang Chen, Xuejin Zhu, Xudong Xiang, Dongshan Zhang
The role of p53 in renal fibrosis is still controversial, and its underlying mechanisms remain not clear. Here, we showed that the pharmacological inhibition and genetic deletion of p53 in proximal tubular cells can attenuate renal dysfunction, tubular epithelial disruption, and interstitial fibrosis in db/db and STZ-induced diabetic nephrology (DN) mice. In human renal proximal tubule (human kidney 2 [HK-2]) cells, inhibition of p53 by PIF reduced the high glucose (HG)-induced extracellular matrix (ECM) accumulation and reversed the inhibitory effect of HG on mRNA expression levels of lncRNA zinc finger E-box binding homeobox1-antisense RNA 1 (ZEB1-AS1) and ZEB1...
July 31, 2018: Molecular Therapy. Nucleic Acids
Alexander Egle, Lisa Pleyer, Thomas Melchardt, Tanja Nicole Hartmann, Richard Greil
Chronic lymphocytic leukemia (CLL) treatment has come a long way in the last two decades, producing increases in tumor control to the point of generating sizeable numbers of patients with undetectable minimal residual disease and creating overall survival benefits in randomized comparisons. Most of this has been achieved by limited-term treatment approaches including chemotherapeutic and immune-therapeutic drugs. More recently, novel therapies targeting signaling pathways essential for the survival of the neoplastic clones have opened avenues that provide disease control in long-term treatment designs, mostly without producing deep remissions...
August 10, 2018: Cancer Treatment Reviews
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