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Quality of life in schizophrenia patients

Jibi A Jacob, Anju Kuruvilla
Background: Patients with schizophrenia hold a variety of explanatory models of illness that influence different aspects of their life including their understanding of the disease, ability to cope and sense of well-being. Aim: To study the association of explanatory models and quality of life in patients with schizophrenia. Materials and Methods: One hundred and thirty consecutive patients with schizophrenia attending a psychiatric outpatient clinic were recruited in the study and administered the Positive and Negative Symptom Scale (PANSS), the modified Short Explanatory Model Interview (SEMI) and the World Health Organization Quality of Life-BREF (WHOQOL-BREF) Scale to assess severity of psychosis, explanatory models of illness, and quality of life...
July 2018: Indian Journal of Psychological Medicine
Cristina Domenech, Corrado Bernasconi, Maria Victoria Moneta, Anna-Lena Nordstroem, Paula Cristobal-Narvaez, Ellen Vorstenbosch, Jesus Cobo, Susana Ochoa, Josep Maria Haro
Health-related quality of life (HRQoL) in patients with schizophrenia is related to the severity of psychiatric symptoms. The objective of this study is to analyze whether the symptoms that influence HRQoL are similar in women and men. Data were part of the Pattern study, an international observational investigation which collected data from 1379 outpatients with schizophrenia. Patients were evaluated with the Mini International Neuropsychiatric Inventory, the Clinical Global Impression-Schizophrenia, and the Positive and Negative Syndrome Scale (PANSS), and reported their quality of life using the Schizophrenia Quality of Life Scale (SQLS), the Short Form-36 (SF-36), and the EuroQol-5 Dimension (EQ-5D)...
August 7, 2018: Archives of Women's Mental Health
Waleed M Sweileh, Samah W Al-Jabi, Sa'ed H Zyoud, Nasr Y Shraim, Fathi M A Anayah, Ansam F Sawalha, Adham S AbuTaha
OBJECTIVES: Medication non-adherence is a worldwide problem. The aim of this study was to assess the global research output, research trends and topics that shaped medication adherence research. METHODS: A bibliometric methodology was applied. Keywords related to 'medication adherence' were searched in Scopus database for all times up to 31 December 2017. Retrieved data were analyzsd, and bibliometric indicators and maps were presented. KEY FINDINGS: In total, 16 133 documents were retrieved...
July 25, 2018: International Journal of Pharmacy Practice
Susel Góngora Alonso, Isabel de la Torre-Díez, Sofiane Hamrioui, Miguel López-Coronado, Diego Calvo Barreno, Lola Morón Nozaleda, Manuel Franco
Data Mining in medicine is an emerging field of great importance to provide a prognosis and deeper understanding of disease classification, specifically in Mental Health areas. The main objective of this paper is to present a review of the existing research works in the literature, referring to the techniques and algorithms of Data Mining in Mental Health, specifically in the most prevalent diseases such as: Dementia, Alzheimer, Schizophrenia and Depression. Academic databases that were used to perform the searches are Google Scholar, IEEE Xplore, PubMed, Science Direct, Scopus and Web of Science, taking into account as date of publication the last 10 years, from 2008 to the present...
July 21, 2018: Journal of Medical Systems
F Markus Leweke, Juliane K Mueller, Bettina Lange, Stefan Fritze, Cristina E Topor, Dagmar Koethe, Cathrin Rohleder
The term schizophrenia describes a group of multifaceted psychiatric conditions causing significant impairment of the quality of life of affected patients. Although multiple pharmacological treatment options exist, e.g. first- or second-generation antipsychotics, these therapeutics often cause disturbing side effects, such as extrapyramidal symptoms, prolactin increase, sexual dysfunction and/or metabolic syndrome. Furthermore, cognitive impairments and negative symptoms, two factors significantly influencing the course and outcome, are not sufficiently addressed by the available antipsychotics...
July 2018: CNS Drugs
Afaf H Khalil, Gihan ELNahas, Hisham Ramy, Karim Abdel Aziz, Hussien Elkholy, Reem El-Ghamry
OBJECTIVE: To study the effect of a culturally adapted, structured family intervention on symptom severity, medication attitudes and knowledge, social functioning and quality of life in patients with schizophrenia. METHODS: Thirty subjects with schizophrenia were selected to receive 14 sessions of a culturally adapted behavioural family psychoeducational programme (BFPEP). Another 30 subjects received standard treatment as usual (STU) for 6 months. Pre- and post-intervention outcomes were assessed using the Positive and Negative Syndrome Scale (PANSS), Drug Attitude Inventory 10-item scale (DAI-10), Quality of Life Scale (QLS) and Social Functioning Questionnaire (SFQ)...
July 17, 2018: International Journal of Psychiatry in Clinical Practice
Anna Alonso-Solís, Katya Rubinstein, Iluminada Corripio, Erika Jaaskelainen, Annika Seppälä, Vincenzo Alberto Vella, Johanna Caro-Mendivelso, Asaf Caspi, Matti Isohanni, Zsolt Unoka, Shenja Van der Graff, Kinga Farkas, Elena Huerta-Ramos, Silvia Marcó-García, Matthias Stevens, Tanguy Coenen, Margarita Hospedales, Jesús Berdún, Eva M Grasa
INTRODUCTION: Treatment-resistant schizophrenia (TRS) is a severe form of schizophrenia. In the European Union, approximately 40% of people with schizophrenia have TRS. Factors such as the persistence of positive symptoms or higher risk of comorbidities leave clinicians with a complex scenario when treating these patients. Intervention strategies based on mHealth have demonstrated their ability to support and promote self-management-based strategies. Mobile therapeutic attention for treatment-resistant schizophrenia ( m-RESIST), an innovative mHealth solution based on novel technology and offering high modular and flexible functioning, has been developed specifically for patients with TRS and their caregivers...
July 16, 2018: BMJ Open
M Tréhout, S Dollfus
Schizophrenia is a severe chronic mental disorder that mainly manifests by positive symptoms, negative symptoms, disorganized behavior and thought and cognitive impairments. Taken together, these symptoms have substantial impact on quality of life, well-being and functional outcome. Patients with schizophrenia have dramatically higher levels of cardiovascular and metabolic morbidity than the general population due to poor physical fitness and to sedentary lifestyle. They have a reduced life expectancy, and an excess mortality being two or three times more than that in the general population...
July 5, 2018: L'Encéphale
Michael S Ritsner, Herman Farkash, Boris Rauchberger, Avi Amrami-Weizman, Xavier Y Zendjidjian
This cross-sectional study compared the levels of needs, care satisfaction, quality of life, and social support of compulsory admitted patients with severe mental disorders to a comparable group of voluntary admitted patients. One hundred and twenty-five patients with schizophrenia and schizoaffective disorder were admitted to a hospital by district psychiatrist order (DPO), court observation order (COO), or voluntary (VA). Participants were assessed before discharge using questionnaires, and psychiatric rating scales...
May 13, 2018: Psychiatry Research
Apostolos Tsiachristas, Felicity Waite, Daniel Freeman, Ramon Luengo-Fernandez
Background: Sleep problems are pervasive in people with schizophrenia, but there are no clinical guidelines for their treatment. The Better Sleep Trial (BEST) concluded that suitably adapted cognitive-behavioural therapy (CBT) is likely to be highly effective, although its cost-effectiveness is unknown. Aims: To assess the potential cost-effectiveness of CBT for sleep disorders in patients with schizophrenia. Method: An economic evaluation of the BEST study with a 6-month time horizon was used to establish the cost-effectiveness of CBT plus usual care in terms of costs per quality-adjusted life year (QALY) gained...
May 2018: BJPsych Open
Hisham Rami, Hanan Hussien, Menan Rabie, Walaa Sabry, Marwa El Missiry, Reem El Ghamry
Although a growing body of evidence supports the effectiveness of behavioral family therapies for patients with schizophrenia, few studies have been carried out on the effectiveness of such programs for Egyptian patients. The current study translated and culturally adapted the Behavioral Family Psycho-Education Program (BFPEP) and conducted a preliminary efficacy evaluation for outpatients suffering from schizophrenia. Thirty patients received 14 sessions of culturally adapted Program (CA-BFPEP) and 30 received treatment as usual; all were followed up for 6 months...
January 1, 2018: Transcultural Psychiatry
Xingwei Luo, Samuel F Law, Xiang Wang, Jingzheng Shi, Wu Zeng, Xiaoqian Ma, Wendy Chow, Shiyan Liu, Wei Zhao, Xiaoli Liu, Shuqiao Yao, Michael R Phillips
BACKGROUND: Assertive Community Treatment (ACT) is an evidence-based treatment program for people with severe mental illness developed in high-income countries. We report the first randomized controlled trial of ACT in mainland China. METHODS: Sixty outpatients with schizophrenia with severe functional impairments or frequent hospitalizations were randomly assigned to ACT (n = 30) or standard community treatment (n = 30). The severity of symptoms and level of social functioning were assessed at baseline and every 3 months during the 1-year study...
July 2, 2018: Psychological Medicine
Raquel Costa, Tânia Bastos, Michel Probst, André Seabra, Sandra Abreu, Estela Vilhena, Simon Rosenbaum, Philip B Ward, Rui Corredeira
In people with schizophrenia several factors are associated with poor quality of life (QoL), namely, lifestyle-related factors and psychological factors. However, there has been little research on the impact of these factors on QoL. Therefore, the relation between lifestyle-related factors, psychological factors, and QoL in people with schizophrenia was assessed. A cross-sectional study was conducted among 115 patients (25% women, 50% inpatients). QoL was measured by World Health Organisation Quality of Life- Brief Version...
June 18, 2018: Psychiatry Research
Francesco Pietrini, Giulio D'Anna, Lorenzo Tatini, Gabriela Alina Talamba, Costanza Andrisano, Enrico Calderani, Mara Manetti, Paolo Rossi Prodi, Valdo Ricca, Andrea Ballerini
BACKGROUND: To present real-world evidence on the effects of switching from oral to long-acting injectable (LAI) antipsychotic maintenance treatment (AMT) in a sample of clinically stable patients with schizophrenia, with regard to subjective experience of treatment, attitude towards drug and quality of life. METHODS: 50 clinically stable adult schizophrenic outpatients were recruited. At the time of enrolment (T0), all patients were under a stabilized therapy with a single oral second-generation antipsychotic (SGA) and were switched to the equivalent maintenance regimen with the long-acting formulation of the same antipsychotic...
June 26, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
Irina Papazova, Wolfgang Strube, Benedikt Becker, Bettina Henning, Tobias Schwippel, Andreas J Fallgatter, Frank Padberg, Ulrich Palm, Peter Falkai, Christian Plewnia, Alkomiet Hasan
Deficits in various cognitive processes, such as working memory, are characteristic for schizophrenia, lowering patients' functioning and quality of life. Recent research suggests that transcranial direct stimulation (tDCS) applied to the dorsolateral prefrontal cortex (DLPFC) may be a potential therapeutic intervention for cognitive deficits in schizophrenia. Here, we examined the effects of online tDCS to the DLPFC on working memory (WM) performance in 40 schizophrenia patients in two separate experiments with a double blind, sham-controlled, cross-over design...
June 25, 2018: Schizophrenia Research
Christian G Widschwendter, Georg Kemmler, Maria A Rettenbacher, Nursen Yalcin-Siedentopf, Alex Hofer
BACKGROUND: Non-adherence to medication remains a major challenge in the long-term management of patients with schizophrenia. Next to lack of insight into the illness, adverse effects of antipsychotic drugs, cognitive deficits, poor therapeutic alliance, reduced quality of life, missing social support, and negative attitudes toward medication are predictors of non-adherence. This study examined potential correlations between attitudes toward antipsychotic drug therapy, subjective well-being, and symptom change in patients with chronic schizophrenia...
June 28, 2018: BMC Psychiatry
Ilaria Cuomo, Georgios D Kotzalidis, Simone de Persis, Daria Piacentino, Filippo Perrini, Emanuela Amici, Sergio De Filippis
Background: To overcome nonadherence in patients with psychosis switch to long-acting injectable (LAI) antipsychotic formulations is adopted. Most oral versus LAI comparisons showed similar antipsychotic responses. Psychoses often overlap with substance use disorder (SUD). Head-to-head LAI comparisons have hitherto focused only on non-comorbid populations. Objective: The objective of this study was to compare two LAIs, administered for 12 months, in initially hospitalized patients with psychosis comorbid with SUD in their clinical and quality of life (QoL) outcomes...
2018: Neuropsychiatric Disease and Treatment
Muneto Izuhara, Hiroyuki Matsuda, Ami Saito, Maiko Hayashida, Syoko Miura, Arata Oh-Nishi, Ilhamuddin Abdul Azis, Rostia Arianna Abdullah, Keiko Tsuchie, Tomoko Araki, Arauchi Ryousuke, Misako Kanayama, Sadayuki Hashioka, Rei Wake, Tsuyoshi Miyaoka, Jun Horiguchi
The authors present the case of a 38-year-old man with schizophrenia and with severe insomnia, who attempted suicide twice during oral drug therapy with risperidone. The patient slept barely 2 or 3 h per night, and he frequently took half days off from work due to excessive daytime sleepiness. As a maladaptive behavior to insomnia, he progressively spent more time lying in bed without sleeping, and he repeatedly thought about his memories, which were reconstructed from his hallucinations. His relatives and friends frequently noticed that his memories were not correct...
2018: Frontiers in Psychiatry
Masashi Ohta, Masahito Nakataki, Tomoya Takeda, Shusuke Numata, Takeo Tominaga, Naomi Kameoka, Hiroko Kubo, Makoto Kinoshita, Kanae Matsuura, Maki Otomo, Naoya Takeichi, Masafumi Harada, Tetsuro Ohmori
Purpose: Quality of life (QOL) is an important clinical outcome for patients with schizophrenia, and recent studies have focused on subjective QOL. We evaluated the causal relationship between psychosocial aspect of subjective QOL, symptoms, cognitive functions, and salience network (SN) dysfunction in schizophrenia using structural equation modeling (SEM). Patients and methods: We performed a cross-sectional study of 21 patients with symptomatically stabilized schizophrenia and 21 age-, sex-, and education level-matched healthy controls who underwent resting-state functional magnetic resonance imaging...
2018: Neuropsychiatric Disease and Treatment
Pronab Ganguly, Abdrabo Soliman, Ahmed A Moustafa
Individuals with schizophrenia lead a poor quality of life, due to poor medical attention, homelessness, unemployment, financial constraints, lack of education, and poor social skills. Thus, a review of factors associated with the holistic management of schizophrenia is of paramount importance. The objective of this review is to improve the quality of life of individuals with schizophrenia, by addressing the factors related to the needs of the patients and present them in a unified manner. Although medications play a role, other factors that lead to a successful holistic management of schizophrenia include addressing the following: financial management, independent community living, independent living skill, relationship, friendship, entertainment, regular exercise for weight gained due to medication administration, co-morbid health issues, and day-care programmes for independent living...
2018: Frontiers in Public Health
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