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Quality of life in schizophrenia patients

Mike J Crawford, Lavanya Thana, Jennie Parker, Oliver Turner, Kwek Pei Xing, Mary McMurran, Paul Moran, Timothy Weaver, Barbara Barrett, Amy Claringbold, Paul Bassett, Rahil Sanatinia
BACKGROUND: Previous research has demonstrated the clinical effectiveness of long-term psychological treatment for people with some types of personality disorder. However, the high intensity and cost of these interventions limit their availability. Lower-intensity interventions are increasingly being offered to people with personality disorder, but their clinical and cost effectiveness have not been properly tested in experimental studies. We therefore set out to develop a low intensity intervention for people with personality disorder and to test the feasibility of conducting a randomized controlled trial to compare the clinical effectiveness of this intervention with that of treatment as usual (TAU)...
October 10, 2018: Trials
Erin Relyea, Brooke MacDonald, Christina Cattaruzza, Denise Marshall
Schizophrenia is a serious chronic mental illness that results in marginalization and stigma for sufferers. It is the seventh leading cause for disability worldwide. The symptoms of the illness, including hallucinations, delusions, and extremely disordered thinking and behavior, may also introduce barriers to accessing treatment, education, housing, and employment. Little is known about end-of-life care for individuals with schizophrenia. To address this gap, a scoping review was conducted to enhance understanding of hospice and palliative care for patients with schizophrenia...
October 10, 2018: Journal of Palliative Care
Chiraz Azaiez, Aurélie Millier, Christophe Lançon, Emilie Clay, Pascal Auquier, Pierre-Michel Llorca, Mondher Toumi
Background : Schizophrenia negative symptoms (SNS) contribute substantially to poor functional outcomes, loss in productivity and poor quality of life. It is unclear which instruments may be used for assessing quality of life in patients with SNS. Objective : The objective of this review was to identify instruments assessing health-related quality of life (HRQoL) validated in patients with SNS and to assess their level of validation. Data sources : We conducted a systematic literature review in Medline and the ISPOR database in March 2016 to identify studies on the quality of life in patients with SNS published by March 2016...
2018: Journal of Market Access & Health Policy
Richard I G Holt, Rebecca Gossage-Worrall, Daniel Hind, Michael J Bradburn, Paul McCrone, Tiyi Morris, Charlotte Edwardson, Katharine Barnard, Marian E Carey, Melanie J Davies, Chris M Dickens, Yvonne Doherty, Angela Etherington, Paul French, Fiona Gaughran, Kathryn E Greenwood, Sridevi Kalidindi, Kamlesh Khunti, Richard Laugharne, John Pendlebury, Shanaya Rathod, David Saxon, David Shiers, Najma Siddiqi, Elizabeth A Swaby, Glenn Waller, Stephen Wright
BACKGROUND: Obesity is a major challenge for people with schizophrenia.AimsWe assessed whether STEPWISE, a theory-based, group structured lifestyle education programme could support weight reduction in people with schizophrenia. METHOD: In this randomised controlled trial (study registration: ISRCTN19447796), we recruited adults with schizophrenia, schizoaffective disorder or first-episode psychosis from ten mental health organisations in England. Participants were randomly allocated to the STEPWISE intervention or treatment as usual...
September 25, 2018: British Journal of Psychiatry: the Journal of Mental Science
Kristin S Cadenhead, Amedeo Minichino, Skylar Kelsven, Jean Addington, Carrie Bearden, Tyrone D Cannon, Barbara A Cornblatt, Dan Mathalon, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, Ming Tsuang, Elaine F Walker, Scott W Woods, Jeff Yao
OBJECTIVE: Patients with schizophrenia have a high prevalence of metabolic disorders and cardiovascular mortality. It is possible that a vulnerability to metabolic abnormalities is associated with risk for psychosis, symptoms and functionality. In this study, we evaluate demographic information, cardiometabolic indices, symptoms and functioning in an antipsychotic free cohort at Clinical High Risk (CHR) for psychosis from the NAPLS Omega 3 fatty acid clinical trial. METHOD: Subjects received physical exams and metabolic monitoring prior to randomization into the Omega 3 versus Placebo trial...
September 21, 2018: Schizophrenia Research
Patricia Fernández-Sotos, Elena Navarro, Iosune Torio, Mónica Dompablo, Antonio Fernández-Caballero, Roberto Rodriguez-Jimenez
Social cognition is an important research field in psychiatry due to its relevance in the functioning and quality of life of patients. The objective of this work is to conduct a systematic mapping review of pharmacological strategies for improving social cognition deficits. Publications from 2006 to 2016 were reviewed in Scopus, PsycINFO, PubMed, and Embase. From the initial 1059 publications obtained, a final number of 110 were selected. The results show an increasing interest in pharmacological approaches in different medical fields (especially psychiatry, pharmacology, and endocrinology, with schizophrenia and autism as the most studied disorders), as can be observed in the progressive increase in the number of publications, the high degree of scientific evidence, and the high impact factor of publications...
September 11, 2018: Psychiatry Research
Marc Krause, Maximilian Huhn, Johannes Schneider-Thoma, Philipp Rothe, Robert C Smith, Stefan Leucht
Elderly patients with schizophrenia are a particularly vulnerable group often excluded from clinical trials. Currently there is no evidence-synthesis about the efficacy and safety of antipsychotics in this subgroup. We reviewed all randomized-controlled-trials, about antipsychotics in elderly schizophrenics (last search Dec 12, 2017). Pairwise meta-analyses were conducted. The primary outcome was overall symptoms. Secondary outcomes included positive symptoms, negative symptoms, response, dropouts, quality of life, social functioning and side-effects...
September 20, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Mayasah Al-Nema, Anand Gaurav, Gabriel Akowuah
The major complaint that most of the schizophrenic patients' face is the cognitive impairment which affects the patient's quality of life. The current antipsychotic drugs treat only the positive symptoms without alleviating the negative or cognitive symptoms of the disease. In addition, the existing therapies are known to produce extrapyramidal side effects that affect the patient adherence to the treatment. PDE10A inhibitor is the new therapeutic approach which has been proven to be effective in alleviating the negative and cognitive symptoms of the disease...
September 8, 2018: Computational Biology and Chemistry
Aurelie Tinland, Laurent Boyer, Sandrine Loubière, Tim Greacen, Vincent Girard, Mohamed Boucekine, Guillaume Fond, Pascal Auquier
Objective: This study aimed to determine the following: 1) the proportion of women in the homeless population with schizophrenia (SZ) or bipolar disorder (BD), in addition to the trajectory of their homelessness (ie, homelessness history, number of nights spent without home during the 180 past nights) and the characteristics of their illnesses compared to men (ie, illness severity, suicide risk, physical health status, and quality of life [QoL]); 2) whether these women were victimized more frequently than similarly situated men; 3) the impact of victimization on these women in terms of illness severity, suicide risk, physical health status, and QoL; and lastly 4) the differences and overlap of homeless women with SZ and BD...
2018: Neuropsychiatric Disease and Treatment
Luis Lores, Alfonso Monje, Manel Bergada, Elisabeth Arellano, Julian Rodríguez-Larrea, Marc Miravitlles
Purpose: Psychiatric patients present an elevated rate of smoking, and the smoking habit is related to a high morbidity and mortality in this collective. The aim of this study was to determine the prevalence of smoking in patients admitted for psychiatric disorders and its relationship with respiratory disease, the prevalence of COPD, and alterations in the quality of life. Patients and methods: A cross-sectional, observational study was conducted and detailed information on smoking and respiratory symptomatology was obtained...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Emine Aydin, Erkan Aydin, Özlem Devrim Balaban, Hüseyin Yumrukçal, Murat Erkiran
Introduction: Compliance with drug treatment is an important issue in schizophrenia for which many scales have been devised. Turkish version of the Drug Attitude Inventory is frequently employed due to ease of use and high predictive value, although it is not as accurate as blood level testing.To determine the validity and reliability of the Turkish version of the Drug Attitude Inventory-10. Methods: Eighty-two schizophrenia patients were included in the study. Subjects were evaluated using Drug Attitude Inventory-10, a Sociodemographic Data Form, Positive and Negative Symptom Scale PANNS, Social Functioning Scale, and Quality of Life Scale for schizophrenia patients...
September 2018: Noro Psikiyatri Arsivi
Munevver Hacioglu Yildirim, Ejder Akgun Yildirim, Elif Carpar, Tuba Coskun, Derya Ipekcioglu, Gulsum Canturk
OBJECTIVE: Failure to achieve expected level of motor functioning may be a significant contributor to social withdrawal and further attenuation of life quality in patients with schizophrenia. Hand functioning is one of the most crucial entities in that manner. This study aimed to reveal this question by means of comparing patients with schizophrenia and bipolar disorder who are receiving similar antipsychotic psychopharmacological agents along with healthy control subjects. METHODS: 99 patients with schizophrenia were compared to 40 patients with bipolar disorder matched according to the received pharmacotherapy comprising similar antipsychotics and 81 medication-free socio-demographically matched healthy control subjects...
August 29, 2018: Comprehensive Psychiatry
Felice Iasevoli, Camilla Avagliano, Benedetta Altavilla, Annarita Barone, Mariateresa Ciccarelli, Luigi D'Ambrosio, Danilo Notar Francesco, Eugenio Razzino, Michele Fornaro, Andrea de Bartolomeis
Here, we used Receiver Operating Characteristic (ROC) curve analysis to determine whether clinical factors may aid predicting the categorization of schizophrenia patients as Treatment Resistant (TRS) or antipsychotic responsive schizophrenia (ARS). Patients with an established condition of TRS or ARS were assessed for: clinical presentation and course; neurological soft signs (NES); psychopathology by PANSS; cognitive performances; quality of life scale (QLS); functional capacity; social functioning (PSP and SLOF scales)...
August 31, 2018: Psychiatry Research
Shu-Mei Wang, Li-Chieh Kuo, Wen-Chen Ouyang, Hsiao-Man Hsu, Hui-Ing Ma
Background/Objective: Patients with schizophrenia not only have psychiatric symptoms, but also have movement problems, which might also be associated with their reduced quality of life. Little is known about how to improve their movement performance for patients. Manipulating object size and distance is common in occupational therapy practice to evaluate and optimize reaching performance in patients with physical disabilities, but effects of the manipulation in patients with schizophrenia remain unclear...
June 2018: Hong Kong Journal of Occupational Therapy: HKJOT
Juliana Onwumere, Filipa Amaral, Lucia R Valmaggia
BACKGROUND: Psychotic disorders are severe mental health conditions that adversely affect the quality of life and life expectancy. Schizophrenia, the most common and severe form of psychosis affects 21 million people globally. Informal caregivers (families) are known to play an important role in facilitating patient recovery outcomes, although their own health and well-being could be adversely affected by the illness. The application of novel digital interventions in mental health care for patient groups is rapidly expanding; interestingly, however, far less is known about their role with family caregivers...
September 5, 2018: JMIR Mental Health
Myrlene S Aigbogun, Sizhu Liu, Siddhesh A Kamat, Christophe Sapin, Amy M Duhig, Leslie Citrome
Objective: This study used a decision-analytic framework to assess the cost-effectiveness of brexpiprazole vs comparator branded therapies for reducing relapses and hospitalizations among adults with schizophrenia from a US payer perspective. Methods: An economic model was developed to assess patients with stable schizophrenia initiating treatment with brexpiprazole (1-4 mg), cariprazine (1-6 mg), or lurasidone (40-80 mg) over a 1-year period. After 6 months, patients remained on treatment or discontinued due to relapse, adverse events, or other reasons...
2018: ClinicoEconomics and Outcomes Research: CEOR
Rohit Sharma, Atul Kabra, M M Rao, P K Prajapati
Neuropsychiatric and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, depression, epilepsy, schizophrenia, and anxiety pose a major public health problem and are associated with the considerable burden of disease, suicides, physical comorbidities, high economic costs, and poor quality of life. There is a recent upsurge in global interest toward the field of herbal or traditional medicine and these drugs are gaining popularity both in developing and developed countries because of their natural origin and fewer side effects...
August 21, 2018: Current Pharmaceutical Design
Junwen Zhou, Aurélie Millier, Mondher Toumi
Background : Economic models are broadly used in the economic evaluation of antipsychotics in schizophrenia. Our objective was to summarize the structure of these models. Methods : Model-based economic evaluations of antipsychotics in schizophrenia were identified through Medline and Embase. General information was extracted including analysis type, model type, perspective, population, comparator, outcome, and timeframe. Model-specific structures for decision tree (DT), cohort- and patient-level Markov model (CLMM, PLMM), and discrete-event simulation (DES) models were extracted...
2018: Journal of Market Access & Health Policy
Li Lu, Liang-Nan Zeng, Qian-Qian Zong, Wen-Wang Rao, Chee H Ng, Gabor S Ungvari, Jun Li, Feng-Rong An, Yu-Tao Xiang
The impact of schizophrenia on quality of life (QOL) is significantly influenced by sociocultural factors. This meta-analysis systematically compared QOL between patients with schizophrenia and healthy controls in China. PubMed, PsycINFO, Embase, Chinese National Knowledge Infrastructure (CNKI), SinoMed and WanFang databases were searched to identify case-control studies. Standardized mean differences (SMDs) and 95% confidence interval (CI) were calculated using random effect models. Eighteen case-control studies comparing QOL between schizophrenia patients (n = 2,425) and healthy controls (n = 2,072) were included in the analyses...
October 2018: Psychiatry Research
Sükran Ertekin Pinar Rn PhD, Havva Tel Rn PhD
The study was conducted to determine the effects of music on auditory hallucination and quality of life in schizophrenic patients. The sample of this randomised controlled study consisted of 28 patients (14 experimental and 14 control groups) hospitalised with a diagnosis of schizophrenia (DSM-IV) and auditory hallucination. The study data were collected with the Information Form, The Scale for the Assessment of Positive Symptoms (SAPS), Characteristics of Auditory Hallucinations Questionnaire, and The World Health Organization Quality of Life Scale (WHOQOL-BREF)...
August 15, 2018: Issues in Mental Health Nursing
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