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Misdiagnosis of schizophrenia

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https://www.readbyqxmd.com/read/30210889/a-27-month-old-boy-with-polyuria-and-polydipsia
#1
Yvonne Lee, Erica Winnicki, Lavjay Butani, Stephanie Nguyen
Psychogenic polydipsia is a well-described phenomenon in those with a diagnosed psychiatric disorder such as schizophrenia and anxiety disorders. Primary polydipsia is differentiated from psychogenic polydipsia by the lack of a clear psychotic disturbance. We present a case of a 27-month-old boy who presented with polyuria and polydipsia. Laboratory studies, imaging, and an observed water deprivation test were consistent with primary polydipsia. Polydipsia resolved after family limited his fluid intake and began replacing water drinking with other transition objects and behaviors for self-soothing...
2018: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/30090859/a-bayesian-approach-to-modeling-risk-of-hospital-admissions-associated-with-schizophrenia-accounting-for-underdiagnosis-of-the-disorder-in-administrative-records
#2
Eileen M Stock, James D Stamey, John E Zeber, Alexander W Thompson, Laurel A Copeland
Schizophrenia is a debilitating serious mental illness characterized by a complex array of symptoms with varying severity and duration. Patients may seek treatment only intermittently, contributing to challenges diagnosing the disorder. A misdiagnosis may potentially bias and reduce study validity. Thus we developed a statistical model to assess the risk of 1-year hospitalization for patients diagnosed with schizophrenia, accounting for when schizophrenia is underreported in administrative databases. A retrospective study design identified patients seeking care during 2010 within an integrated health care system from the Health Maintenance Organization Research Network located in the southwestern United States...
February 2018: Computational psychiatry
https://www.readbyqxmd.com/read/29942729/off-label-sodium-oxybate-in-childhood-narcolepsy-a-comprehensive-report
#3
Jeffrey A Miskoff, Moiuz Chaudhri
Narcolepsy is a sleep disorder that can manifest in childhood or adolescence by causing excessive sleepiness, hallucinations, sleep attacks, or cataplexy. There is often a significant delay in diagnosis with the mean time being 15 years from the onset of symptoms, which may lead to further exacerbations and a high comorbidity burden. Although narcolepsy is predominantly associated with loss of hypocretin (orexin), the role of genetics is poorly understood and, therefore, is complementary to the diagnosis but not confirmatory...
April 24, 2018: Curēus
https://www.readbyqxmd.com/read/29736129/analysis-of-misdiagnosis-of-bipolar-disorder-in-an-outpatient-setting
#4
Hui Shen, Li Zhang, Chuchen Xu, Jinling Zhu, Meijuan Chen, Yiru Fang
Background: Bipolar disorder is a mental illness with a high misdiagnosis rate and commonly misdiagnosed as other mental disorders including depression, schizophrenia, anxiety disorders, obsessive-compulsive disorders, and personality disorders, resulting in the mistreatment of clinical symptoms and increasing of recurrent episodes. Aims: To understand the reasons for misdiagnosis of bipolar disorder in an outpatient setting in order to help clinicians more clearly identify the disease and avoid diagnostic errors...
April 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29734005/complexity-analysis-of-spontaneous-brain-activity-in-mood-disorders-a-magnetoencephalography-study-of-bipolar-disorder-and-major-depression
#5
Alberto Fernández, Ali H Al-Timemy, Francisco Ferre, Gabriel Rubio, Javier Escudero
BACKGROUND AND PURPOSE: The lack of a biomarker for Bipolar Disorder (BD) causes problems in the differential diagnosis with other mood disorders such as major depression (MD), and misdiagnosis frequently occurs. Bearing this in mind, we investigated non-linear magnetoencephalography (MEG) patterns in BD and MD. METHODS: Lempel-Ziv Complexity (LZC) was used to evaluate the resting-state MEG activity in a cross-sectional sample of 60 subjects, including 20 patients with MD, 16 patients with BD type-I, and 24 control (CON) subjects...
July 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29527766/racial-disparities-in-bipolar-disorder-treatment-and-research-a-call-to-action
#6
REVIEW
Margaret O Akinhanmi, Joanna M Biernacka, Stephen M Strakowski, Susan L McElroy, Joyce E Balls Berry, Kathleen R Merikangas, Shervin Assari, Melvin G McInnis, Thomas G Schulze, Marion LeBoyer, Carol Tamminga, Christi Patten, Mark A Frye
OBJECTIVES: Health disparities between individuals of African and European ancestry are well documented. The disparities in bipolar disorder may be driven by racial bias superimposed on established factors contributing to misdiagnosis, including: evolving empirically based diagnostic criteria (International Classification of Diseases [ICD], Research Diagnostic Criteria [RDC] and Diagnostic and Statistical Manual [DSM]), multiple symptom domains (i.e. mania, depression and psychosis), and multimodal medical and additional psychiatric comorbidity...
September 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29297320/automatic-schizophrenic-discrimination-on-fnirs-by-using-complex-brain-network-analysis-and-svm
#7
Hong Song, Lei Chen, RuiQi Gao, Iordachescu Ilie Mihaita Bogdan, Jian Yang, Shuliang Wang, Wentian Dong, Wenxiang Quan, Weimin Dang, Xin Yu
BACKGROUND: Schizophrenia is a kind of serious mental illness. Due to the lack of an objective physiological data supporting and a unified data analysis method, doctors can only rely on the subjective experience of the data to distinguish normal people and patients, which easily lead to misdiagnosis. In recent years, functional Near-Infrared Spectroscopy (fNIRS) has been widely used in clinical diagnosis, it can get the hemoglobin concentration through the variation of optical intensity...
December 20, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28980099/prevalence-of-schizophrenia-spectrum-disorders-in-average-iq-adults-with-autism-spectrum-disorders-a-meta-analysis
#8
Jorge Lugo Marín, Montserrat Alviani Rodríguez-Franco, Vinita Mahtani Chugani, María Magán Maganto, Emiliano Díez Villoria, Ricardo Canal Bedia
Since their separation as independent diagnostics, autism spectrum disorders (ASD) and schizophrenia spectrum disorders (SSD) have been conceptualized as mutually exclusive disorders. Similarities between both disorders can lead to misdiagnosis, especially when it comes to average-IQ adults who were not identified during childhood. The aim of this review was to examine the occurrence of SSD in average-IQ adults with ASD. Electronic and manual searches identified a total of 278 references, of which 10 were included in a meta-analysis...
January 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28678848/mental-health-literacy-survey-of-non-mental-health-professionals-in-six-general-hospitals-in-hunan-province-of-china
#9
MULTICENTER STUDY
Qiuxia Wu, Xiaoyang Luo, Shubao Chen, Chang Qi, Jiang Long, Yifan Xiong, Yanhui Liao, Tieqiao Liu
BACKGROUND: Mental illness has brought great economic burden related to misdiagnosis by non-mental health professionals in general hospitals. The aim of this study was to explore non-mental health professionals' conceptions related to the identification of mental illness and perceived treatments, first aid and prognosis. METHODS: In 2014-2015, we presented 1123 non-mental health professionals from six general hospitals in Hunan Province with one of three vignettes describing a person with schizophrenia, depression, or generalized anxiety disorder...
2017: PloS One
https://www.readbyqxmd.com/read/28620812/case-study-of-first-episode-schizophrenia-in-pregnancy-and-postpartum
#10
Kristopher A Kast, Smita Agarkar
Patients with first-episode psychosis of peripartum onset commonly prove to have a mood-disorder diathesis; however, a proportion of cases represent first-episode schizophrenia. We present such a case and discuss the clinical relevance of recognizing this small but important population of new mothers. These patients are at considerable risk of misdiagnosis, resulting in ineffective maintenance therapy, poorer recovery of function, and development of treatment resistance. Accurate diagnosis in the peripartum period will impact treatment decisions and long-term therapy...
August 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28327583/duration-of-untreated-bipolar-disorder-a-multicenter-study
#11
MULTICENTER STUDY
Ling Zhang, Xin Yu, Yi-Ru Fang, Gabor S Ungvari, Chee H Ng, Helen F K Chiu, Hui-Chun Li, Hai-Chen Yang, Qing-Rong Tan, Xiu-Feng Xu, Gang Wang, Yu-Tao Xiang
Little is known about the demographic and clinical differences between short and long duration of untreated bipolar disorder (DUB) in Chinese patients. This study examined the demographic and clinical features of short (≤2 years) and long DUB (>2 years) in China. A consecutively recruited sample of 555 patients with bipolar disorder (BD) was examined in 7 psychiatric hospitals and general hospital psychiatric units across China. Patients' demographic and clinical characteristics were collected using a standardized protocol and data collection procedure...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28170299/gender-dysphoria-and-co-existing-psychosis-review-and-four-case-examples-of-successful-gender-affirmative-treatment
#12
REVIEW
Julia H Meijer, Guus M Eeckhout, Roy H T van Vlerken, Annelou L C de Vries
PURPOSE: Controversy exists as to if, and when, gender affirmative (GA) treatment should be offered to individuals with gender dysphoria (GD) and co-existing psychosis. Concerns exist regarding a high risk of misdiagnosis, regret afterward due to impulsive decision making, and deterioration of psychotic symptoms. This case series aims at extending the sparse literature on GA treatment in this population by identifying challenges in diagnosis and treatment and offering recommendations to overcome them...
April 2017: LGBT Health
https://www.readbyqxmd.com/read/28072411/the-early-growth-response-protein-1-mir-30a-5p-neurogenic-differentiation-factor-1-axis-as-a-novel-biomarker-for-schizophrenia-diagnosis-and-treatment-monitoring
#13
S Liu, F Zhang, Y Y Shugart, L Yang, X Li, Z Liu, N Sun, C Yang, X Guo, J Shi, L Wang, L Cheng, K Zhang, T Yang, Y Xu
To date, diagnosis of schizophrenia is still based on clinical interviews and careful observations, which is subjective and variable, and can lead to misdiagnosis and/or delay in diagnosis. As early intervention in schizophrenia is important in improving outcomes, objective tests that can be used for schizophrenia diagnosis or treatment monitoring are thus in great need. MicroRNAs (miRNAs) negatively regulate target gene expression and their biogenesis is tightly controlled by various factors including transcription factors (TFs)...
January 10, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/27829400/is-schizophrenia-disappearing-the-rise-and-fall-of-the-diagnosis-of-functional-psychoses-an-essay
#14
Per Bergsholm
BACKGROUND: The categories of functional psychoses build on views of influential professionals. There have long been four main categories - affective, schizophrenic, schizoaffective/cycloid/reactive/polymorphic, and delusional/paranoid psychoses. The last three are included in "psychotic disorders". However, this dichotomy and the distinctions between categories may have been over-estimated and contributed to lack of progress. TEN TOPICS RELEVANT FOR THE DIAGNOSIS OF FUNCTIONAL PSYCHOSES: 1...
November 9, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27238119/schizophrenia-admissions-have-fallen
#15
(no author information available yet)
The incidence of schizophrenia in England and Wales appears to be plummeting, according to research published last week. Doctors from the Institute of Psychiatry in South London say that over the last 34 years, hospital admissions for the condition have fallen by almost 50 per cent. The researchers offer no explanation for their findings, but state that misdiagnosis or greater emphasis on community care are unlikely to account for the results.
March 14, 1990: Nursing Standard
https://www.readbyqxmd.com/read/27011407/atypical-presentation-of-childhood-obsessive-compulsive-disorder
#16
Satyakam Mohapatra, Neelmadhav Rath
Obsessive-compulsive disorder (OCD) is one of the most prevalent psychiatric disorders in children and adolescents. The phenomenology of OCD in children and adolescent is strikingly similar to that of adults. But at times, the presentation of OCD may be so atypical or unusual in children and adolescents that may lead to misdiagnosis or delay in diagnosis. We report a case of 10-year-old child who was initially misdiagnosed with schizophrenia, and treated with antipsychotic for 2 months. But once the core symptoms were recognized as obsessions and compulsions and appropriately treated in the line of OCD, the symptoms resolved significantly...
January 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/26658937/paranoid-thoughts-in-adolescents-with-social-anxiety-disorder
#17
S Pisano, G Catone, A Pascotto, R Iuliano, C Tiano, A Milone, G Masi, A Gritti
Recently, social anxiety disorder (SAD) and paranoia have been demonstrated to be closely related. However, data were primarily drawn from adult community samples or patients with schizophrenia. The present study used a cross-sectional design to evaluate a sample of adolescents with SAD (n = 30, mean age 15.3 ± 0.9 years) compared with an age- and sex-matched group of healthy controls (n = 26, mean age 15.9 ± 1.6 years). The SAD group displayed more frequent and intense paranoid thoughts than the control group (t = 4...
October 2016: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/26441135/towards-a-blood-based-diagnostic-panel-for-bipolar-disorder
#18
Frieder Haenisch, Jason D Cooper, Andreas Reif, Sarah Kittel-Schneider, Johann Steiner, F Markus Leweke, Matthias Rothermundt, Nico J M van Beveren, Benedicto Crespo-Facorro, David W Niebuhr, David N Cowan, Natalya S Weber, Robert H Yolken, Brenda W J H Penninx, Sabine Bahn
BACKGROUND: Bipolar disorder (BD) is a costly, devastating and life shortening mental disorder that is often misdiagnosed, especially on initial presentation. Misdiagnosis frequently results in ineffective treatment. We investigated the utility of a biomarker panel as a diagnostic test for BD. METHODS AND FINDINGS: We performed a meta-analysis of eight case-control studies to define a diagnostic biomarker panel for BD. After validating the panel on established BD patients, we applied it to undiagnosed BD patients...
February 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/26279454/schizophrenia-like-symptoms-in-narcolepsy-type-1-shared-and-distinctive-clinical-characteristics
#19
Giuseppe Plazzi, Chiara Fabbri, Fabio Pizza, Alessandro Serretti
BACKGROUND/AIMS: The occurrence of psychotic symptoms in narcolepsy type 1 (NT1) has been reported as responsible for delayed diagnosis due to the misdiagnosis of schizophrenia. This study aimed to identify shared and distinctive clinical characteristics between NT1 and schizophrenia, with the focus on psychotic symptoms. METHODS: A total of 28 NT1 and 21 schizophrenia patients were included. Hallucination characteristics and PANSS (Positive and Negative Syndrome Scale), HRSD (Hamilton Rating Scale for Depression), DES (Dissociative Experiences Scale), and STAI (State-Trait Anxiety Inventory) scores were collected...
2015: Neuropsychobiology
https://www.readbyqxmd.com/read/25934167/clinical-significance-of-auditory-target-p300-subcomponents-in-psychosis-differential-diagnosis-symptom-profiles-and-course
#20
Greg Perlman, Dan Foti, Felicia Jackson, Roman Kotov, Eduardo Constantino, Greg Hajcak
BACKGROUND: Reduced auditory target P300 amplitude is a leading biomarker for psychotic disorders, although its relevance for differential diagnosis and link to specific clinical features (symptom profiles, functional impairment, and course) are unclear. This study aims to clarify the clinical significance of auditory target P300 using concurrent and retrospective clinical data from a longitudinal cohort with psychosis. METHODS: 92 cases from an epidemiological study of first-admission psychosis were assessed using an auditory oddball paradigm at 15-year follow-up along with 44 never-psychotic adults...
July 2015: Schizophrenia Research
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