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https://www.readbyqxmd.com/read/30265157/amyotrophic-lateral-sclerosis-in-nordland-county-norway-2000-2015-prevalence-incidence-and-clinical-features
#1
Espen Benjaminsen, Karl B Alstadhaug, Marie Gulsvik, Farid K Baloch, Francis Odeh
OBJECTIVE: There are some indications of increasing incidence of amyotrophic lateral sclerosis (ALS). Awareness of cognitive impairment in ALS has increased in recent years. We describe the epidemiology and clinical features of ALS in a county in northern Norway over a period of 15 years. METHODS: All patients with motor neuron disease (MND) living in Nordland County in the period 2000-2015 were identified and the medical records were scrutinized. The average annual incidence was calculated for the whole period and for five-year periods...
September 28, 2018: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/30065759/surveillance-of-first-generation-h1-antihistamine-use-for-older-patients-with-dementia-in-japan-a-retrospective-cohort-study
#2
Toshiki Maeda, Akira Babazono, Takumi Nishi
Background: This study aimed to investigate the rate of first-generation H1-antihistamines use for older adults with dementia in Japan. Methods: The study design was retrospective cohort using claims data between fiscal years 2010 and 2013. Subjects were 75 years or older, diagnosed with dementia, and given H1-antihistamines orally during the study period after being diagnosed with dementia. We investigated the cumulative number of oral H1-antihistamines administered and the relationship between first-generation H1-antihistamine use and each explanatory variable using crude and adjusted odds ratio...
2018: Current Gerontology and Geriatrics Research
https://www.readbyqxmd.com/read/29606569/preoperative-dementia-is-associated-with-increased-cost-and-complications-after-vascular-surgery
#3
J Hunter Mehaffey, Robert B Hawkins, Margaret C Tracci, William P Robinson, Kenneth J Cherry, John A Kern, Gilbert R Upchurch
OBJECTIVE: Dementia represents a major risk factor for medical complications and has been linked to higher rates of complication after surgery. Given the systemic nature of vascular disease, medical comorbidities significantly increase cost and complications after vascular surgery. We hypothesize that the presence of dementia is an independent predictor of increased postoperative complications and higher health care costs after vascular surgery. METHODS: The Vascular Quality Initiative database was queried for all patients undergoing vascular surgery at a single academic medical center from 2012 to 2017...
October 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29523431/electroconvulsive-therapy-and-risk-of-dementia-in-patients-with-affective-disorders-a-cohort-study
#4
Merete Osler, Maarten Pieter Rozing, Gunhild Tidemann Christensen, Per Kragh Andersen, Martin Balslev Jørgensen
BACKGROUND: Electroconvulsive therapy (ECT) is the most effective treatment for severe episodes of mood disorders. Temporary memory loss is a common side-effect, but ongoing discussions exist regarding potential long-term adverse cognitive outcomes. Only a few studies have examined the frequency of dementia in patients after ECT. The aim of this study was to examine the association between ECT and risk of subsequent dementia in patients with a first-time hospital diagnosis of affective disorder...
April 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29017626/case-series-of-mild-behavioral-impairment-toward-an-understanding-of-the-early-stages-of-neurodegenerative-diseases-affecting-behavior-and-cognition
#5
Alicja Cieslak, Eric E Smith, John Lysack, Zahinoor Ismail
Mild behavioral impairment (MBI) is characterized by later life acquired, sustained, and impactful neuropsychiatric symptoms (NPS) of any severity that cannot be better accounted for by other formal medical and psychiatric nosology. MBI is an "at risk" state for incident cognitive decline and dementia, and for some, MBI is the index manifestation of neurodegeneration, observed in advance of cognitive impairment. Initially described in Frontotemporal Dementia (FTD), MBI evolved to describe a preclinical stage of all cause dementia, and has been operationalized in the International Society to Advance Alzheimer's Research and Treatment-Alzheimer's Association (ISTAART-AA) proposed research diagnostic criteria...
February 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/28331300/dementia-and-delirium-the-outcomes-in-elderly-hip-fracture-patients
#6
Christina A Mosk, Marnix Mus, Jos Pam Vroemen, Tjeerd van der Ploeg, Dagmar I Vos, Leon Hgj Elmans, Lijckle van der Laan
BACKGROUND: Delirium in hip fractured patients is a frequent complication. Dementia is an important risk factor for delirium and is common in frail elderly. This study aimed to extend the previous knowledge on risk factors for delirium and the consequences. Special attention was given to patients with dementia and delirium. METHODS: This is a retrospective cohort study performed in the Amphia Hospital, Breda, the Netherlands. A full electronic patient file system (Hyperspace Version IU4: Epic, Inc...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27895069/association-between-poorer-cognitive-function-and-reduced-objectively-monitored-medication-adherence-in-patients-with-heart-failure
#7
Mary A Dolansky, Misty A W Hawkins, Julie T Schaefer, Abdus Sattar, John Gunstad, Joseph D Redle, Richard Josephson, Shirley M Moore, Joel W Hughes
BACKGROUND: Subclinical cognitive impairment is prevalent in heart failure (HF); however, its role in important clinical outcomes, such as HF treatment adherence, is unclear. Given the complex polypharmacy in HF treatment, cognitive deficits may be important in predicting medication management. Thus, the objective of the current study was to examine the impact of cognitive function on medication adherence among community-dwelling patients with HF using objective assessments. METHODS AND RESULTS: A prospective observational cohort design of 309 community-dwelling patients with HF (59...
December 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27820226/the-impact-of-hospital-visiting-hour-policies-on-pediatric-and-adult-patients-and-their-visitors
#8
Lisa Smith, Jennifer Medves, Margaret B Harrison, Joan Tranmer, Brett Waytuck
BACKGROUND: Policies concerning restricted or open visiting hours are being challenged in health care institutions internationally, with no apparent consensus on the appropriateness of the visiting hour policies for pediatric and adult patients. The rules that govern practice are often based on the institutional precedent and assumptions of staff, and may have little or no evidence to support them. Policy and practice related to visiting hours is of pressing concern in Canada, and in Ontario specifically, following the reaction to the Severe Acute Respiratory Syndrome (SARS) outbreak in 2003 and subsequent changes in visiting policies in most health care settings...
2009: JBI Library of Systematic Reviews
https://www.readbyqxmd.com/read/27596721/clinical-frailty-adds-to-acute-illness-severity-in-predicting-mortality-in-hospitalized-older-adults-an-observational-study
#9
Roman Romero-Ortuno, Stephen Wallis, Richard Biram, Victoria Keevil
AIM: Frail individuals may be at higher risk of death from a given acute illness severity (AIS), but this relationship has not been studied in an English National Health Service (NHS) acute hospital setting. METHODS: This was a retrospective observational study in a large university NHS hospital in England. We analyzed all first non-elective inpatient episodes of people aged ≥75years (all specialties) between October 2014 and October 2015. Pre-admission frailty was assessed with the Clinical Frailty Scale (CFS) of the Canadian Study on Health & Aging, and AIS in the Emergency Department was measured with a Modified Early Warning Score (ED-MEWS<4 was considered as low acuity, and ED-MEWS≥4 as high acuity)...
November 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27553364/the-assessment-and-management-of-pain-in-patients-with-dementia-in-hospital-settings-a-multi-case-exploratory-study-from-a-decision-making-perspective
#10
MULTICENTER STUDY
Valentina Lichtner, Dawn Dowding, Nick Allcock, John Keady, Elizabeth L Sampson, Michelle Briggs, Anne Corbett, Kirstin James, Reena Lasrado, Caroline Swarbrick, S José Closs
BACKGROUND: Pain is often poorly managed in people who have a dementia. Little is known about how this patient population is managed in hospital, with research to date focused mainly on care homes. This study aimed to investigate how pain is recognised, assessed and managed in patients with dementia in a range of acute hospital wards, to inform the development of a decision support tool to improve pain management for this group. METHODS: A qualitative, multi-site exploratory case study...
August 24, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27476067/treatment-of-sleep-disorders-in-dementia
#11
REVIEW
Sharon Ooms, Yo-El Ju
Sleep and circadian disorders occur frequently in all types of dementia. Due to the multifactorial nature of sleep problems in dementia, we propose a structured approach to the evaluation and treatment of these patients. Primary sleep disorders such as obstructive sleep apnea should be treated first. Comorbid conditions and medications that impact sleep should be optimally managed to minimize negative effects on sleep. Patients and caregivers should maintain good sleep hygiene, and social and physical activity should be encouraged during the daytime...
September 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27299496/-effects-of-a-stepwise-approach-to-behavioural-problems-in-dementia-a-cluster-randomised-controlled-trial
#12
RANDOMIZED CONTROLLED TRIAL
M J C Pieper, A L Francke, J T van der Steen, E J A Scherder, J W R Twisk, C R Kovach, W P Achterberg
OBJECTIVE: To investigate whether implementation of a stepwise multidisciplinary intervention ('STA OP!' ['STAND UP!']) is effective in reducing behavioural problems and depressive symptoms in nursing home residents with advanced dementia. DESIGN: Cluster randomised controlled trial. METHOD: We implemented the STA OP! protocol on the intervention units by training the entire multidisciplinary team. This team was trained in all 6 steps of the protocol during five 3-hour sessions...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27158877/early-onset-dementia-frequency-diagnostic-procedures-and-quality-indicators-in-three-european-tertiary-referral-centers
#13
Elles Konijnenberg, Seyed-Mohammad Fereshtehnejad, Mara Ten Kate, Maria Eriksdotter, Philip Scheltens, Peter Johannsen, Gunhild Waldemar, Pieter Jelle Visser
BACKGROUND: Early-onset dementia (EOD) is a rare condition, with an often atypical clinical presentation, and it may therefore be challenging to diagnose. Specialized memory clinics vary in the type of patients seen, diagnostic procedures applied, and the pharmacological treatment given. The aim of this study was to investigate quality-of-care indicators in subjects with EOD from 3 tertiary memory clinics in 3 European countries. METHODS: We included 1325 newly diagnosed EOD patients, ages 65 years or younger, between January 1, 2007 and December 31, 2013, from the Danish Dementia Registry (Rigshospitalet, Copenhagen), the Swedish Dementia Registry ("SveDem", Karolinska University Hospital, Stockholm), and the Amsterdam Dementia Cohort (VU University Medical Center)...
April 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27076525/undiagnosed-long-term-cognitive-impairment-in-acutely-hospitalised-older-medical-patients-with-delirium-a-prospective-cohort-study
#14
Thomas A Jackson, Alasdair M J MacLullich, John R F Gladman, Janet M Lord, Bart Sheehan
BACKGROUND: delirium and dementia are common in the general hospital, being present in nearly 50% of older unselected admissions to hospital. Cognitive impairment is a risk factor for delirium, but the prevalence of previously undiagnosed cognitive impairment (dementia or mild cognitive impairment) in patients with delirium is unknown. METHODS: we performed a prospective cohort study of people over 70 years admitted to hospital with delirium to establish the prevalence of previously unrecognised prior cognitive impairment...
July 2016: Age and Ageing
https://www.readbyqxmd.com/read/26859891/economic-impact-of-dementia-by-disease-severity-exploring-the-relationship-between-stage-of-dementia-and-cost-of-care-in-taiwan
#15
Li-Jung Elizabeth Ku, Ming-Chyi Pai, Pei-Yu Shih
OBJECTIVE: Given the shortage of cost-of-illness studies in dementia outside of the Western population, the current study estimated the annual cost of dementia in Taiwan and assessed whether different categories of care costs vary by severity using multiple disease-severity measures. METHODS: This study included 231 dementia patient-caregiver dyads in a dementia clinic at a national university hospital in southern Taiwan. Three disease measures including cognitive, functional, and behavioral disturbances were obtained from patients based on medical history...
2016: PloS One
https://www.readbyqxmd.com/read/26508846/falls-in-hospital-and-new-placement-in-a-nursing-home-among-older-people-hospitalized-with-acute-illness
#16
David Basic, Tabitha J Hartwell
PURPOSE: To examine the association between falls in hospital and new placement in a nursing home among older people hospitalized with acute illness. MATERIALS AND METHODS: This prospective cohort study of 2,945 consecutive patients discharged alive from an acute geriatric medicine service used multivariate logistic regression to model the association between one or more falls and nursing home placement (primary analysis). Secondary analyses stratified falls by injury and occurrence of multiple falls...
2015: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/26297124/combined-therapy-of-di-huang-yi-zhi-with-donepezil-in-patients-with-parkinson-s-disease-dementia
#17
RANDOMIZED CONTROLLED TRIAL
Chao Gu, Ting Shen, Hongmei An, Canxing Yuan, Jie Zhou, Qing Ye, Tao Liu, Xiuwei Wang, Tianli Zhang
Here we conducted a randomized and double-blind study attempting to explore the safety and efficacy of combined therapy of Di-Huang-Yi-Zhi (DHYZ) with donepezil in treating Parkinson's disease dementia (PDD). Sixty PDD patients were included and randomly divided into control group and DHYZ group. All patients were given donepezil (5 mg last for a month, then 10 mg for the rest months, once daily), while patients in DHYZ group were additionally administrated with DHYZ (150 ml, twice daily). The measurement subjects included mini-mental state examination (MMSE), Montreal cognitive assessment (MoCA), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), the Barthel Index for activities of daily living (ADL) and Traditional Chinese medical (TCM) symptoms before and after treatment in this study...
October 8, 2015: Neuroscience Letters
https://www.readbyqxmd.com/read/26264921/from-bitopic-inhibitors-to-multitarget-drugs-for-the-future-treatment-of-alzheimer-s-disease
#18
REVIEW
Daniel I Pérez, Ana Martínez, Carmen Gil, Nuria E Campillo
Dementia is one of the main causes of the disease burden in developed regions. According to the World Health Organization (WHO), it will become the world's second leading cause of death by the middle of the century, overtaking cancer. This will have a dramatic impact on medical care, and have important social and economic implications, unless more effective preventive procedures or treatments become available. Alzheimer's disease (AD) is the most common cause of dementia, accounting for approximately 50-75% of all dementias worldwide, followed by vascular dementia, mixed dementia, and Lewy body dementia...
2015: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/26246950/geriatric-patients-with-fractures-below-the-hip-are-medically-similar-to-geriatric-patients-with-hip-fracture
#19
Gregory J Della Rocca, Harmeeth S Uppal, Marilyn E Copeland, Brett D Crist, David A Volgas
The objective of this study was to compare a cohort of geriatric patients with operatively managed isolated fractures below the hip to a cohort of geriatric patients with operatively managed isolated hip fractures. All patients greater than 59 years of age admitted to our institution for surgical care of an isolated lower extremity fracture during a 3-year period were included. Patients were divided into 2 cohorts: BTH (fracture below the subtrochanteric region of the femur) and HIP (proximal femoral fracture at subtrochanteric region or proximal)...
March 2015: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/26224726/education-research-changing-medical-student-perceptions-of-dementia-an-arts-centered-experience
#20
Hannah J Roberts, James M Noble
BACKGROUND: Medical students' comfort level working with dementia is poorly understood, and may impact subsequent experiences with patients and caregivers. Early experiences that take place in a nonmedical setting may allow students to gain a more comprehensive understanding of quality of life and disease management in everyday life. METHODS: We studied Columbia University preclinical medical students' perceptions of dementia relative to attending a nonclinical art-centered, museum-based experience designed for people with dementia and their caregivers...
August 25, 2015: Neurology
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