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Information system

Adam Wright, Pamela M Neri, Skye Aaron, Thu-Trang T Hickman, Francine L Maloney, Daniel A Solomon, Dustin McEvoy, Angela Ai, Kevin Kron, Gianna Zuccotti
Background: Microbiology laboratory results are complex and cumbersome to review. We sought to develop a new review tool to improve the ease and accuracy of microbiology results review. Methods: We observed and informally interviewed clinicians to determine areas in which existing microbiology review tools were lacking. We developed a new tool that reorganizes microbiology results by time and organism. We conducted a scenario-based usability evaluation to compare the new tool to existing legacy tools, using a balanced block design...
March 17, 2018: Journal of the American Medical Informatics Association: JAMIA
Brener Santos Silva, Hiago Victor Coelho, Ricardo Bezerra Cavalcante, Valéria Conceição de Oliveira, Eliete Albano de Azevedo Guimarães
OBJECTIVE: To carry out the National Immunization Program Information System (SIPNI) accessability assessment (EA), considering the description of the intervention, the elaboration of the theoretical-logical model and the identification of the evaluative questions. METHOD: A single case study with a qualitative approach, based on the system of seven elements proposed by Thurston and Ramaliu (2005). The SIPNI and the context of analysis, the vaccination rooms, were defined as the case...
2018: Revista Brasileira de Enfermagem
Suelayne Gonçalves do Nascimento, Cleonice Patrícia Andrade Lima de Carvalho, Ricarlly Soares da Silva, Conceição Maria de Oliveira, Cristine Vieira do Bonfim
OBJECTIVE: To describe occurrences of mortality due to cervical cancer in Recife (PE), in northeastern Brazil. METHOD: This was a time-series ecological study using data from the Mortality Information System (SIM) regarding the total number of deaths due to cervical cancer (C53 ICD10) that occurred between 2000 and 2012. RESULTS: It was observed that the risk of death due to this form of cancer was higher among women over 60 years of age, those of mixed skin color (53...
2018: Revista Brasileira de Enfermagem
Lilian Vieira Oliveira, Thais Souza Maia, Karla Zancopé, Murilo de Souza Menezes, Carlos José Soares, Camilla Christian Gomes Moura
The presence of residues within the root canal after post-space preparation can influence the bond strength between resin cement and root dentin when using fiberglass posts (FGPs). Currently, there is no consensus in the literature regarding what is the best solution for the removal of debris after post-space preparation. This systematic review involved "in vitro" studies to investigate if cleaning methods of the root canal after post-space preparation can increase the retention of FGPs evaluated by the push-out test...
March 15, 2018: Brazilian Oral Research
Masanori Takabayashi, Hassaan Majeed, Andre Kajdacsy-Balla, Gabriel Popescu
Tissue refractive index provides important information about morphology at the nanoscale. Since the malignant transformation involves both intra- and inter-cellular changes in the refractive index map, the tissue disorder measurement can be used to extract important diagnosis information. Quantitative phase imaging (QPI) provides a practical means of extracting this information as it maps the optical path-length difference (OPD) across a tissue sample with sub-wavelength sensitivity. In this work, we employ QPI to compare the tissue disorder strength between benign and malignant breast tissue histology samples...
2018: PloS One
Jo Durham, Lisa Schubert, Lisa Vaughan, Cameron D Willis
BACKGROUND: Middle ear disease (otitis media) is endemic among Aboriginal and Torres Strait Islander children in Australia and represents an important cause of hearing loss. The disease is the result of a mix of biological, environmental and host risk factors that interact in complex, non-linear ways along a dynamic continuum. As such, it is generally recognised that a holistic, systems approach is required to reverse the high rates of otitis media in Aboriginal and Torres Strait Islander children...
2018: PloS One
Joanna X Wu, Chad B Wilsey, Lotem Taylor, Gregor W Schuurman
Birds in U.S. national parks find strong protection from many longstanding and pervasive threats, but remain highly exposed to effects of ongoing climate change. To understand how climate change is likely to alter bird communities in parks, we used species distribution models relating North American Breeding Bird Survey (summer) and Audubon Christmas Bird Count (winter) observations to climate data from the early 2000s and projected to 2041-2070 (hereafter, mid-century) under high and low greenhouse gas concentration trajectories, RCP8...
2018: PloS One
Shouhua Wang, Yanqing Li, Chaozhuo Li, Yijun Qiao, Shuling He
BACKGROUND The aim of this study was to determine the need for supportive care among women suffering from breast cancer in China and to identify its potential determinants to inform the development of effective and efficient healthcare services across different settings. MATERIAL AND METHODS In a tertiary-care hospital in Weifang, China, between July 2015 and January 2016, all women attending the Breast Cancer Clinic for regular physical examinations after treatment for breast cancer were consecutively recruited...
March 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Jeremy C Smith, Pan Tan, Loukas Petridis, Liang Hong
Dynamic neutron scattering directly probes motions in biological systems on femtosecond to microsecond timescales. When combined with molecular dynamics simulation and normal mode analysis, detailed descriptions of the forms and frequencies of motions can be derived. We examine vibrations in proteins, the temperature dependence of protein motions, and concepts describing the rich variety of motions detectable using neutrons in biological systems at physiological temperatures. New techniques for deriving information on collective motions using coherent scattering are also reviewed...
March 21, 2018: Annual Review of Biophysics
Pradipta Ray, Andrew Torck, Lilyana Quigley, Andi Wangzhou, Matthew Neiman, Chandranshu Rao, Tiffany Lam, Ji-Young Kim, Tae Hoon Kim, Michael Q Zhang, Gregory Dussor, Theodore J Price
Molecular neurobiological insight into human nervous tissues is needed to generate next generation therapeutics for neurological disorders like chronic pain. We obtained human Dorsal Root Ganglia (DRG) samples from organ donors and performed RNA-sequencing (RNA-seq) to study the human DRG (hDRG) transcriptional landscape, systematically comparing it with publicly available data from a variety of human and orthologous mouse tissues, including mouse DRG (mDRG). We characterized the hDRG transcriptional profile in terms of tissue-restricted gene co-expression patterns and putative transcriptional regulators, and formulated an information-theoretic framework to quantify DRG enrichment...
March 20, 2018: Pain
Chu K Yao, Asaf Rotbart, Jian Z Ou, Kourosh Kalantar-Zadeh, Jane G Muir, Peter R Gibson
Excessive hydrogen sulfide (H2 S) production from gut microbial metabolism may have clinically important relevance in the pathogenesis of gut disorders, including ulcerative colitis. However, little is known regarding factors that alter its production. Using a newly-designed in vitro gas-profiling technology, the study aimed to verify real-time H2 S measurement reproducibility and thereafter, assess its production following exposure to dietary factors and 5-aminosalicylate acid (5-ASA). Measurements of H2 S, carbon dioxide, hydrogen and methane measurements were compared between gas-profiling systems...
March 21, 2018: Gut Microbes
Melanie Laura Lawrence, James R Smith, Jamie Andrew Davies
The mesonephros of mammals is a transient renal structure that contributes to various aspects of mammalian fetal development including the male reproductive system, hematopoietic stem cells and vascular endothelial cells. The mesonephros develops from the intermediate mesoderm and forms tubules that are segmented in a similar way to the nephrons of the permanent kidney (but lacking loops of Henle). Early studies have suggested that the mesonephros in marsupials and some placental mammals may perform an excretory function, but these studies have not directly shown active transport of organic anions and cations...
March 21, 2018: American Journal of Physiology. Renal Physiology
Kyungwoo Kim, Kyujin Jung
OBJECTIVES: We investigated public health emergency management networks during the recent outbreak of Middle East respiratory syndrome coronavirus that affected more than 17 000 people in South Korea. METHODS: We administered a survey to 169 organizations in order to map the pattern of communication and response networks during the Middle East respiratory syndrome outbreak. We also conducted 11 semistructured interviews with national, regional, and local government officials to comprehend inhibiting and facilitating factors in risk communication and response to the system...
March 1, 2018: Asia-Pacific Journal of Public Health
Mahalia A C Serrano, Bo Zhao, Huan He, Sankaran Thayumanavan, Richard W Vachet
Efficient and controlled release of peptides bound to polymeric reverse micelle assemblies can be achieved through the cooperative effects of disassembly and disruption of charge-charge interactions. Through the examination of various peptides and polymer architectures, we have identified the factors that affect the release efficiency of the electrostatically bound peptides. Peptide guests and polymers with a greater number of complementary charges result in less efficient release than peptides and polymers with lower numbers of charges...
March 21, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Mika Ishigaki, Paralee Puangchit, Yui Yasui, Akane Ishida, Hiroki Hayashi, Yoshihiko Nakayama, Hideya Taniguchi, Ichiro Ishimaru, Yukihiro Ozaki
In the present study, we successfully obtained non-staining blood flow images of a developing fish egg embryo using optical interference caused by the Doppler shift. The spectral distribution of light reflected by moving objects such as the heart and red cells was found to be different from that of the incident light because of the Doppler effect. Interference between different frequency components was observed in an interferogram through heterodyne interaction using an imaging-type two-dimensional Fourier spectroscopic system, and information on the intensities of the spectral components was obtained by Fourier transformation...
March 21, 2018: Analytical Chemistry
Nathalie Devillier
The Law on the Modernization of our Health System passed in 2016 exteds the scope of the medical secrecy by creating the patients' shared health record. All health professionnals involved in the care pathway have an access to all recorded information. The patient can access to it via a dedicated Internet website. The implementing decrees of this facility determine the modalities to share the information and frame the creation of this automated processing of personal data. At last, this law creates an open and secure access to helath data in the interest of collectivity...
October 27, 2017: Journal International de Bioéthique et D'éthique des Sciences
Fanny Girard, Mathieu Peret, Natacha Dumont, Vasilica Badets, Sylvie Blanc, Kristaq Gazeli, Cédric Noël, Thierry Belmonte, Laurent Marlin, Jean-Pierre Cambus, Guillaume Simon, Neso Sojic, Bernard Held, Stéphane Arbault, Franck Clément
The understanding of plasma-liquid interactions is of major importance, not only in physical chemistry, chemical engineering and polymer science, but in biomedicine as well as to better control the biological processes induced on/in biological samples by Cold Atmospheric Plasmas (CAPs). Moreover, plasma-air interactions have to be particularly considered since these CAPs propagate in the ambient air. Herein, we developed a helium-based CAP setup equipped with a shielding-gas device, which allows the control of plasma-air interactions...
March 21, 2018: Physical Chemistry Chemical Physics: PCCP
I V Damulin
The article addresses gait disturbances in the elderly. It emphasizes that the system that maintains the balance in resting conditions and gait is based on the hierarchical principle and its function depends on the maintenance of integration between vestibular, visual and somatosensory information as well as on cognitive functions. Walking depends on the integrity of frontal-subcortical neuronal circles that support regulatory functions. The main pathogenetic mechanisms of age-related disturbances of balance and gait are a decrease in the efficacy of spinal motorneurons activation caused by Ia-afferentation, a decrease in cortical activation and excitability of corticospinal pathways and in the intensity of intracortical inhibition...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Fang-Yu Liu, Te-Cheng Hsu, Patrick Choong, Min-Hsuan Lin, Yung-Jen Chuang, Bor-Sen Chen, Che Lin
BACKGROUND: Regeneration is an important biological process for the restoration of organ mass, structure, and function after damage, and involves complex bio-physiological mechanisms including cell differentiation and immune responses. We constructed four regenerative protein-protein interaction (PPI) networks using dynamic models and AIC (Akaike's Information Criterion), based on time-course microarray data from the regeneration of four zebrafish organs: heart, cerebellum, fin, and retina...
March 19, 2018: BMC Systems Biology
Roxanne Saucier, Daniel Wolfe, Nabarun Dasgupta
INTRODUCTION: An extended-release injectable naltrexone suspension (Vivitrol® ) was approved in USA in 2010 for the prevention of relapse to opioid dependence. Concerns, raised at the time of approval, about rebound overdose risk following the last dose, have not been adequately studied. We sought to determine the time period of concern for fatal overdose associated with Vivitrol. METHODS: We performed a retrospective case review of Vivitrol spontaneous reports (October 2010-March 2016) in the US Food and Drug Administration Adverse Event Reporting System via the Freedom of Information Act...
March 20, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
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