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https://www.readbyqxmd.com/read/29145709/defining-a-unified-vascular-phenotype-in-systemic-sclerosis
#1
REVIEW
Yannick Allanore, Oliver Distler, Marco Matucci-Cerinic, Christopher P Denton
Microcirculation impairment and related vasculopathy is a hallmark of systemic sclerosis. Digital ulcers are second only to Raynaud's phenomenon as a vascular complication occurring in scleroderma patients. Digital ulcers are painful and generate disability. Furthermore, patients may develop recurrent digital ulcers and one may ask whether the outcomes of such patients might be different to those of unaffected ones. Recently several registries have provided relevant information about digital ulcers. Male sex and severe skin disease seem to be the main associated factors observed in several registries...
November 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29145698/illicit-drug-use-illicit-drug-use-disorders-and-drug-overdose-deaths-in-metropolitan-and-nonmetropolitan-areas-united-states
#2
EDITORIAL
Karin A Mack, Christopher M Jones, Michael F Ballesteros
PROBLEM/CONDITION: Drug overdoses are a leading cause of injury death in the United States, resulting in approximately 52,000 deaths in 2015. Understanding differences in illicit drug use, illicit drug use disorders, and overall drug overdose deaths in metropolitan and nonmetropolitan areas is important for informing public health programs, interventions, and policies. REPORTING PERIOD: Illicit drug use and drug use disorders during 2003-2014, and drug overdose deaths during 1999-2015...
December 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29145694/engineered-and-natural-promoters-and-chromatin-modifying-elements-for-recombinant-protein-expression-in-cho-cells
#3
REVIEW
Nadiya Romanova, Thomas Noll
Promoters play a pivotal role in integrating and processing the signals related to transcription initiation. Strong natural viral promoters, such as hCMV or SV40E, have been routinely employed to achieve a high rate of gene expression in ubiquitously used Chinese hamster ovary (CHO) cells. However, viral promoters are susceptible to epigenetic silencing and lack precise regulation levers. This has paved the way to more sensible control elements: endogenous, inducible and synthetic promoters. In this review we summarise and discuss the use of natural viral, mammalian and endogenous promoters, as well as recent advances in synthetic promoters and inducible systems for protein expression in CHO cells...
November 16, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29145559/prenatal-alcohol-exposure-and-suspected-hearing-impairment-among-children-a-population-based-retrospective-cohort-study
#4
Satomi Yoshida, Calistus Wilunda, Takeshi Kimura, Masato Takeuchi, Koji Kawakami
Aims: This study aimed to examine the association between prenatal alcohol exposure and hearing impairment among Japanese children using early childhood health check-up data. Methods: This retrospective cohort study used population-based health check-up data for children who were born between April 2000 and March 2013 in Hofu city, Japan. Logistic regression models were used to evaluate the association between prenatal alcohol exposure and hearing impairment among children at the age of 36 months...
November 14, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29145518/the-prehistory-of-biology-preprints-a%C3%A2-forgotten-experiment-from-the-1960s
#5
Matthew Cobb
In 1961, the National Institutes of Health (NIH) began to circulate biological preprints in a forgotten experiment called the Information Exchange Groups (IEGs). This system eventually attracted over 3,600 participants and saw the production of over 2,500 different documents, but by 1967, it was effectively shut down following the refusal of journals to accept articles that had been circulated as preprints. This article charts the rise and fall of the IEGs and explores the parallels with the 1990s and the biomedical preprint movement of today...
November 2017: PLoS Biology
https://www.readbyqxmd.com/read/29145446/large-scale-climatic-effects-on-traditional-hawaiian-fishpond-aquaculture
#6
Daniel McCoy, Margaret A McManus, Keliʻiahonui Kotubetey, Angela Hiʻilei Kawelo, Charles Young, Brandon D'Andrea, Kathleen C Ruttenberg, Rosanna ʻAnolani Alegado
Aquaculture accounts for almost one-half of global fish consumption. Understanding the regional impact of climate fluctuations on aquaculture production thus is critical for the sustainability of this crucial food resource. The objective of this work was to understand the role of climate fluctuations and climate change in subtropical coastal estuarine environments within the context of aquaculture practices in He'eia Fishpond, O'ahu Island, Hawai'i. To the best of our knowledge, this was the first study of climate effects on traditional aquaculture systems in the Hawaiian Islands...
2017: PloS One
https://www.readbyqxmd.com/read/29145202/exploring-the-association-between-statin-use-and-the-risk-of-parkinson-s-disease-a-meta-analysis-of-observational-studies
#7
Tahmina Nasrin Poly, Md Mohaimenul Islam, Bruno Andreas Walther, Hsuan-Chia Yang, Phung-Anh Nguyen, Chih-Wei Huang, Syed-Abdul Shabbir, Yu-Chuan Jack Li
BACKGROUND: Parkinson's disease (PD) is a progressive disorder of the central nervous system. The prevalence of PD varies considerably by age group; it has a higher prevalence in patients aged 60 years and more. Several studies have shown that statin, a cholesterol-lowering medication, reduces the risk of developing PD, but evidence for this is so far inconclusive. The objective of this study is to evaluate the association between statin use and the risk of developing PD. METHODS: PubMed, EMBASE, and the bibliographies of articles were searched for studies published between January 1, 1990, and January 1, 2017, which reported on the association between statin use and PD...
November 16, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29145131/removal-of-the-precursors-of-n-nitrosodiethylamine-ndea-an-emerging-disinfection-byproduct-in-drinking-water-treatment-process-and-its-toxicity-to-adult-zebrafish-danio-rerio
#8
Jian Zheng, Tao Lin, Wei Chen
N-nitrosodiethylamine (NDEA) is one of the emerging nitrogenous disinfection byproducts with probable cytotoxicity, genotoxicity, and carcinogenesis. Its potential toxicological effects have received extensive attention but remain to be poorly understood. In this study, changes in NDEA precursors in drinking water treatment process were studied using the trial of its formation potential (FP), and the toxicity induced by NDEA to adult zebrafish was investigated. NDEA FP in the raw water of Taihu Lake ranged from 46...
October 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/29145093/proteomic-profile-and-toxicity-pathway-analysis-in-zebrafish-embryos-exposed-to-bisphenol-a-and-di-n-butyl-phthalate-at-environmentally-relevant-levels
#9
Xing Dong, Xuchun Qiu, Shunlong Meng, Hai Xu, Xiangyang Wu, Ming Yang
Bisphenol A (BPA) and di-n-butyl phthalate (DBP) are well-known endocrine-disrupting chemicals (EDCs) that have human health risks. Chronic exposure to BPA and DBP increases the occurrence of human disease. Despite the potential for exposure in embryonic development, the mechanism of action of BPA and DBP on vertebrate development and disease still remains unclear. In the present study, we identified proteins and protein networks that are perturbed by BPA and DBP during zebrafish (Danio rerio) development. Zebrafish embryos were exposed to environmentally relevant levels of BPA (10 μg/L) and DBP (50 μg/L) for 96 h...
November 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/29144960/cervical-cancer-screening-experiences-among-chinese-american-immigrant-women-in-the-united-states
#10
Jin Young Seo, Junxin Li, Kun Li
OBJECTIVE: To understand the experiences and perceptions of having cervical cancer screening tests and to explore the extant barriers to having the tests among first-generation Chinese American women in the United States. DESIGN: Qualitative, descriptive, phenomenological research. SETTING: Los Angeles, California. PARTICIPANTS: Snowball and purposive sampling of 12 Chinese American immigrant women ages 20 to 65 years...
November 13, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29144814/self-blood-glucose-monitoring-underestimates-hyperglycemia-and-hypoglycemia-as-compared-to-continuous-glucose-monitoring-in-type-1-and-type-2-diabetes
#11
Devna Mangrola, Christine Cox, Arianne S Furman, Sridevi Krishnan, Sidika E Karakas
OBJECTIVE: When glucose records from self-blood glucose monitoring (SBGM) do not reflect estimated average glucose from HgBA1, or when patients' clinical symptoms are not explained by their SBGM records, clinical management of diabetes becomes a challenge. Our objective was to determine the magnitude of differences in glucose values reported by SBGM vs. documented by continuous glucose monitoring (CGM). METHODS: The CGM was conducted by a clinical diabetes educator/registered nurse by the clinic protocol, using the Medtronic iPRO2™ system...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29144758/on-the-density-dependence-of-the-integral-equation-coarse-graining-effective-potential
#12
Mohammadhasan Dinpajooh, Marina Giuseppina Guenza
Coarse-graining (CG) procedures provide computationally efficient methods for investigating the corresponding long time- and length-scale processes. In the bottom-up approaches, the effective interactions between the CG sites is obtained using the information from the atomistic simulations, but reliable CG procedures are required to preserve the structure and thermodynamics. In this regard, the integral equation coarse-graining (IECG) method is a promising approach that uses the first-principles Ornstein-Zernike equation in liquid state theory to determine the effective potential between CG sites...
November 16, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29144594/on-the-origin-of-obesity-identifying-the-biological-environmental-and-cultural-drivers-of-genetic-risk-among-human-populations
#13
REVIEW
A Qasim, M Turcotte, R J de Souza, M C Samaan, D Champredon, J Dushoff, J R Speakman, D Meyre
Genetic predisposition to obesity presents a paradox: how do genetic variants with a detrimental impact on human health persist through evolutionary time? Numerous hypotheses, such as the thrifty genotype hypothesis, attempt to explain this phenomenon yet fail to provide a justification for the modern obesity epidemic. In this critical review, we appraise existing theories explaining the evolutionary origins of obesity and explore novel biological and sociocultural agents of evolutionary change to help explain the modern-day distribution of obesity-predisposing variants...
November 16, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29144444/benthic-habitat-mapping-using-multispectral-high-resolution-imagery-evaluation-of-shallow-water-atmospheric-correction-techniques
#14
Francisco Eugenio, Javier Marcello, Javier Martin, Dionisio Rodríguez-Esparragón
Remote multispectral data can provide valuable information for monitoring coastal water ecosystems. Specifically, high-resolution satellite-based imaging systems, as WorldView-2 (WV-2), can generate information at spatial scales needed to implement conservation actions for protected littoral zones. However, coastal water-leaving radiance arriving at the space-based sensor is often small as compared to reflected radiance. In this work, complex approaches, which usually use an accurate radiative transfer code to correct the atmospheric effects, such as FLAASH, ATCOR and 6S, have been implemented for high-resolution imagery...
November 16, 2017: Sensors
https://www.readbyqxmd.com/read/29144409/how-well-can-we-extract-the-permanent-displacement-from-low-cost-mems-accelerometers
#15
Jyh Cherng Jan, Wei-An Chao, Yih-Min Wu, Chien-Chih Chen, Cheng-Horng Lin
Following the recent establishment of a high-density seismic network equipped with low-cost micro-electro-mechanical system (MEMS) P-wave-alert-device (P-Alert) by the earthquake early warning (EEW) research group at the National Taiwan University, a large quantity of strong-motion records from moderate-magnitude earthquakes (ML > 6) around Taiwan has been accumulated. Using a data preprocessing scheme to recover the dynamic average embedded within the P-Alert data, we adopted an automatic baseline correction approach for the P-Alert accelerograms to determine the coseismic deformation (Cd)...
November 16, 2017: Sensors
https://www.readbyqxmd.com/read/29144292/the-response-of-nitrous-oxide-emissions-to-different-operating-conditions-in-activated-sludge-wastewater-treatment-plants-in-southeastern-brazil
#16
Renato P Ribeiro, Rodrigo F Bueno, Roque P Piveli, Débora C Kligerman, William Z de Mello, Jaime L M Oliveira
The continuous measurements of N2O emissions from the aeration tanks of three activated sludge wastewater treatment plants (WWTPs) operated with biological nitrogen removal (BNR) and non-BNR were performed during the different operating conditions of several parameters, such as aeration, dissolved oxygen (DO) profiling and organic shock loading (with landfill leachate). The nitrification process is the main driving force behind N2O emission peaks. There are indications that the variation of the air flow rate influenced N2O emissions; high N2O emissions denote over-aeration conditions or incomplete nitrification, with accumulation of NO2(-) concentrations...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29144288/gas-composition-of-sludge-residue-profiles-in-a-sludge-treatment-reed-bed-between-loadings
#17
Julie D Larsen, Steen M Nielsen, Charlotte Scheutz
Treatment of sludge in sludge treatment reed bed systems includes dewatering and mineralization. The mineralization process, which is driven by microorganisms, produces different gas species as by-products. The pore space composition of the gas species provides useful information on the biological processes occurring in the sludge residue. In this study, we measured the change in composition of gas species in the pore space at different depth levels in vertical sludge residue profiles during a resting period of 32 days...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29144284/integrated-assessment-and-scenarios-simulation-of-urban-water-security-system-in-the-southwest-of-china-with-system-dynamics-analysis
#18
Su Yin, Guan Dongjie, Su Weici, Gao Weijun
The demand for global freshwater is growing, while global freshwater available for human use is limited within a certain time and space. Its security has significant impacts on both the socio-economic system and ecological system. Recently, studies have focused on the urban water security system (UWSS) in terms of either water quantity or water quality. In this study, water resources, water environment, and water disaster issues in the UWSS were combined to establish an evaluation index system with system dynamics (SD) and geographic information systems (GIS)...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29144250/case-not-closed-prescription-errors-12-years-after-computerized-physician-order-entry-implementation
#19
Gili Kadmon, Michal Pinchover, Avichai Weissbach, Shirley Kogan Hazan, Elhanan Nahum
OBJECTIVE: To assess the prolonged impact of computerized physician order entry (CPOE) on medication prescription errors in pediatric intensive care patients. STUDY DESIGN: This observational study was conducted at a pediatric intensive care unit in which a CPOE (Metavision, iMDsoft, Israel) with a limited clinical decision support system was implemented between 2004 and 2007. Since then, no changes were made to the systems. We analyzed 2500 electronic prescriptions (1250 prescriptions from 2015 and 1250 prescriptions from 2016)...
November 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29144076/the-let-s-beat-the-bug-campaign-a-statewide-active-public-education-against-bed-bugs-in-minnesota
#20
Amelia K Shindelar
Bed bugs continue to affect society and place a burden on public health systems. Experiences of the Let’s Beat the Bug! campaign are presented to help information networks prepare personnel to effectively address questions about this pest. Following recommendations from the Minnesota state bed bug working group, an information line was established and the Web site (www.bedbugs.umn.edu) was revised. Data from both services were analyzed by geographic region and type of information requested. InformationLine primarily assisted people who had issues dealing with failed treatments and landlord reluctance to take effective measures against this pest...
March 2017: Journal of Environmental Health
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