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Seongil Kang, Sangyeol Song, Joosang Lee, Hyekyung Chang, Sanghun Lee
Objectives: Several experimental studies have reported antiobesity and lipid-improving effects of Citrus unshiu . However, clinical studies on its effects are lacking. This study was designed to evaluate the impact of Citrus unshiu peel pellet (CUPP) on obesity and lipid profile. Methods: For 118 patients with body mass index (BMI) > 23 who took Citrus unshiu peel pellet (CUPP) for 4 weeks in a Public Health Center, laboratory and biometric readings before and after CUPP administration were analyzed...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Caleb Araguas Garcia, Francisco Corbi Soler
Tactile information picked up by plantar receptors provides afferent sensory information that is fundamental for controlling body balance. Plantar hyperkeratoses may alter the quality and quantity of such information, thereby modifying balance. AIM: Analyse how plantar hyperkeratosis debridement affects static body balance in subjects of 65 years of age or older. METHODS: In order to analyse the impact of hyperkeratoses on balance, 50 older people took part in this study...
March 15, 2018: Foot
Ming Kuo, Matthew H E M Browning, Sonya Sachdeva, Kangjae Lee, Lynne Westphal
In the United States, schools serving urban, low-income students are among the lowest-performing academically. Previous research in relatively well-off populations has linked vegetation in schoolyards and surrounding neighborhoods to better school performance even after controlling for important confounding factors, raising the tantalizing possibility that greening might boost academic achievement. This study extended previous cross-sectional research on the "greenness"-academic achievement link to a public school district in which nine out of ten children were eligible for free lunch...
2018: Frontiers in Psychology
David Dolan, Henrik J Jensen, Pedro A M Mediano, Miguel Molina-Solana, Hardik Rajpal, Fernando Rosas, John A Sloboda
The recent re-introduction of improvisation as a professional practice within classical music, however cautious and still rare, allows direct and detailed contemporary comparison between improvised and "standard" approaches to performances of the same composition, comparisons which hitherto could only be inferred from impressionistic historical accounts. This study takes an interdisciplinary multi-method approach to discovering the contrasting nature and effects of prepared and improvised approaches during live chamber-music concert performances of a movement from Franz Schubert's "Shepherd on the Rock," given by a professional trio consisting of voice, flute, and piano, in the presence of an invited audience of 22 adults with varying levels of musical experience and training...
2018: Frontiers in Psychology
Linsong Wang, Tingting Zhang, Zhengsong Pan, Lulu Lin, Guoqing Dong, Min Wang, Ronggui Li
Pine wilt disease, which is caused by the pine wood nematode (PWN), Bursaphelenchus xylophilus, has caused huge damage to pine forests around the world. In this study, we analysed the PWN transcriptome to investigate the expression of genes related to the associated bacterial species Pseudomonas fluorescens and found that the gene adh-1 encoding alcohol dehydrogenase (ADH) was upregulated. The open reading frame of adh-1, which encoded a protein of 352 amino acid residues, was cloned from B. xylophilus. Recombinant ADH with a relative molecular weight of 39 kDa, was present mainly in inclusion bodies and was overexpressed in Escherichia coli BL21 (DE3) and purified after refolding...
October 15, 2018: Parasitology
Yahong Han, Zhenbiao Xu, Yanan Liu, Da Wei, Jing Zhang, Le Xue, Xiangmin Zhang, Jie Qin, Hongkuan Deng, Linxia Song
Y-box binding protein (YB protein) is an ancient conserved multifunctional DNA/RNA-binding protein. A novel YB protein DjY2 gene from planarian Dugesia japonica was cloned by RACE method and characterized. This cDNA contains 689 bp with a putative open reading frame of 197 amino acids. It has a predicted molecular mass of 22.14 kDa and an isoelectric point of 9.67. Whole-mount in situ hybridization and relative quantitative real-time PCR were used to study the spatial and temporal expression pattern of DjY2 in the process of planarian regeneration...
October 9, 2018: Biochemical and Biophysical Research Communications
Christina Ralph-Nearman, Ruth Filik
OBJECTIVE: Many theories have been put forward suggesting key factors underlying the development and maintenance of eating disorders, such as: unhealthy food-related cognitive biases, negative body attitude, and perfectionism; however, underlying cognitive processes associated with eating disorder symptomatology remain unclear. We used eye-tracking during reading as a novel implicit measure of how these factors may relate to eating disorder symptomatology. METHOD: In two experiments, we monitored women's eye movements while they read texts in which the characters' emotional responses to food-, body image-, and perfectionism-related scenarios were described...
October 12, 2018: International Journal of Eating Disorders
Jorge L Cavalcante Neto, Cristina C de Oliveira, Ana L Greco, Antonio R Zamunér, Roberta C Moreira, Eloisa Tudella
INTRODUCTION: Although virtual reality (VR) is an increasingly popular approach within studies that propose interventions for children with developmental coordination disorder (DCD), evidence on the effectiveness of VR remains debatable. The aim of this study was to synthesise evidence on the effectiveness of VR interventions for motor performance improvement in children with DCD. EVIDENCE ACQUISITION: Searches were conducted in the MEDLINE/PubMed, Scopus, Web of Science and ERIC databases to select studies published from 1 January 2006 to 30 November 2017...
October 4, 2018: European Journal of Physical and Rehabilitation Medicine
Michael W Sourial, Joshua Ebel, Nathaly Francois, Geoffrey N Box, Bodo E Knudsen
During laser lithotripsy, energy is transmitted to both the stone and the surrounding fluid. As the energy is delivered, the temperature will rise. Temperatures ≥60  °  C can cause protein denaturation. The objective of this study is to determine the time it takes from body temperature (37°C) to 60°C at various laser power settings. A Flexiva TracTip 200 optical fiber was submerged alongside a negative temperature coefficient-type thermistor in 4 mL of saline in a glass test tube. A Lumenis VersaPulse Powersuite 100-W holmium:yttrium aluminum garnet laser was activated at 0...
October 2018: Journal of Biomedical Optics
Nurul Atiqah Abu Bakar, Nazar Luqman, Essam Shaaban, Hanif Abdul Rahman
Background Existing evidence, predominantly from Western countries, has demonstrated that athletes' hearts undergo structural, physiological, and electrical changes, leading to abnormal electrocardiogram readings that are said to be training-related. Athletes with non-training-related electrocardiographic abnormalities risk developing sudden cardiac death. The lack of studies on this issue in the Asian population warrants further exploration. Therefore, the aim of this study was to estimate the prevalence and predictive factors contributing to electrocardiogram abnormalities among athletes in Brunei...
October 9, 2018: Asian Cardiovascular & Thoracic Annals
Mengyu Tian, Ning Yang, Lu Zhang, Qiang Fu, Fenghua Tan, Chao Li
Galectins, a family of evolutionary conserved β-galactoside-binding proteins, have been characterized in a wide range of species. Galectin-3 is the only member in the chimera type, which is a monomeric lectin with one CRD domain. A growing body of evidence have indicated vital roles of galectin-3 in innate immune responses against infection. Here, one galectin-3 gene was captured in turbot (SmLgals3) with a 1203 bp open reading frame (ORF). In comparison to other species, SmLgals3 showed the highest similarity and identity to large yellow croaker and medaka, respectively...
October 6, 2018: Fish & Shellfish Immunology
Astrid-Helene Ravn Jørgensen, Simon Francis Thomsen, Hans Christian Ring
We read with great interest the article by Theut Riis et al.1 , in which HS patients with high body mass index (BMI) is compared with HS patients with low BMI to investigate differences in disease characteristics. They found that patients with low and high BMI could represent two clinically different subtypes. There is an increasing awareness that the clinical presentation of HS is heterogeneous, and that different phenotypes may occur. Hypothetically, HS subtypes may reflect different etiology and prognosis and therefore, may require different therapeutic approaches...
October 4, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Yuuki Horii, Takahiko Shiina, Yasutake Shimizu
Some rodents including squirrels and hamsters undergo hibernation. During hibernation, body temperature drops to only a few degrees above ambient temperature. The suppression of whole-body energy expenditure is associated with regulated, but not passive, reduction of cellular metabolism. The heart retains the ability to beat constantly, although body temperature drops to less than 10 °C during hibernation. Cardiac myocytes of hibernating mammals are characterized by reduced Ca2+ entry into the cell membrane and a concomitant enhancement of Ca2+ release from and reuptake by the sarcoplasmic reticulum...
2018: Advances in Experimental Medicine and Biology
Victor Anderson, Aled Jones, Rupert Read
No abstract text is available yet for this article.
October 2018: Nature
Hefan Miao, Jiapeng Zhou, Qi Yang, Fan Liang, Depeng Wang, Na Ma, Bodi Gao, Juan Du, Ge Lin, Kai Wang, Qianjun Zhang
Background: For a proportion of individuals judged clinically to have a recessive Mendelian disease, only one heterozygous pathogenic variant can be found from clinical whole exome sequencing (WES), posing a challenge to genetic diagnosis and genetic counseling. One possible reason is the limited ability to detect disease causal structural variants (SVs) from short reads sequencing technologies. Long reads sequencing can produce longer reads (typically 1000 bp or longer), therefore offering greatly improved ability to detect SVs that may be missed by short-read sequencing...
2018: Hereditas
Stefan Klöppel, Shan Yang, Elias Kellner, Marco Reisert, Bernhard Heimbach, Horst Urbach, Jennifer Linn, Stefan Weidauer, Tamara Andres, Maximilian Bröse, Jacob Lahr, Niklas Lützen, Philipp T Meyer, Jessica Peter, Ahmed Abdulkadir, Sabine Hellwig, Karl Egger
The identification of pathological atrophy in MRI scans requires specialized training, which is scarce outside dedicated centers. We sought to investigate the clinical usefulness of computer-generated representations of local grey matter (GM) loss or increased volume of cerebral fluids (CSF) as normalized deviations (z-scores) from healthy aging to either aid human visual readings or directly detect pathological atrophy. Two experienced neuroradiologists rated atrophy in 30 patients with Alzheimer's disease (AD), 30 patients with frontotemporal dementia (FTD), 30 with dementia due to Lewy-body disease (LBD) and 30 healthy controls (HC) on a three-point scale in 10 anatomical regions as reference gold standard...
September 19, 2018: NeuroImage: Clinical
Karen G Lloyd, Andrew D Steen, Joshua Ladau, Junqi Yin, Lonnie Crosby
To describe a microbe's physiology, including its metabolism, environmental roles, and growth characteristics, it must be grown in a laboratory culture. Unfortunately, many phylogenetically novel groups have never been cultured, so their physiologies have only been inferred from genomics and environmental characteristics. Although the diversity, or number of different taxonomic groups, of uncultured clades has been studied well, their global abundances, or numbers of cells in any given environment, have not been assessed...
September 2018: MSystems
Yu Kawakami, Rachel Sielski, Toshiaki Kawakami
Mouse body temperature measurement is of paramount importance for investigating allergies and anaphylactic symptoms. Rectal probes for temperature readings is common, and they have been proven to be accurate and invaluable in this regard. However, this method of temperature measurement requires the mice to be anesthetized in order to insert the probe without injury to the animal. This limits the ability to observe other phenotypes of the mouse simultaneously. In order to investigate other phenotypes while measuring temperatures, rectal probes are not ideal, and another method is desired...
September 14, 2018: Journal of Visualized Experiments: JoVE
Byung-Kwon Choi, Tajhal Dayaram, Neha Parikh, Angela D Wilkins, Meena Nagarajan, Ilya B Novikov, Benjamin J Bachman, Sung Yun Jung, Peter J Haas, Jacques L Labrie, Curtis R Pickering, Anbu K Adikesavan, Sam Regenbogen, Linda Kato, Ana Lelescu, Christie M Buchovecky, Houyin Zhang, Sheng Hua Bao, Stephen Boyer, Griff Weber, Kenneth L Scott, Ying Chen, Scott Spangler, Lawrence A Donehower, Olivier Lichtarge
Scientific progress depends on formulating testable hypotheses informed by the literature. In many domains, however, this model is strained because the number of research papers exceeds human readability. Here, we developed computational assistance to analyze the biomedical literature by reading PubMed abstracts to suggest new hypotheses. The approach was tested experimentally on the tumor suppressor p53 by ranking its most likely kinases, based on all available abstracts. Many of the best-ranked kinases were found to bind and phosphorylate p53 ( P value = 0...
October 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
Masaya Mochizuki
Previous studies have indicated that temporal concepts such as the past and future are associated with horizontal (left-right) space. This association has been interpreted as reflecting left-to-right writing systems. The Japanese language, however, is written both horizontally and vertically and, when texts are presented vertically, the sequence of columns runs from right to left. This study examines whether the associations between time and space are changed by the direction of the character strings using a word categorization task...
September 27, 2018: International Journal of Psychology: Journal International de Psychologie
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