keyword
https://read.qxmd.com/read/32980712/effect-of-selenium-sulfur-interaction-on-the-anabolism-of-sulforaphane-in-broccoli
#1
JOURNAL ARTICLE
Shuxiang Mao, Junwei Wang, Qi Wu, Mantian Liang, Yiming Yuan, Tao Wu, Mingyue Liu, Qiuyun Wu, Ke Huang
The effects of S (as sulphate) and Se (as selenite) treatment (S mM/Se μM: 1/0, 1/50, 1/100, 1/150, 4/0, 4/50, 4/100, and 4/150) on the production of sulforaphane (an anticancer compound), the accumulation of its precursor substance, and the expression of genes related to glucoraphanin biosynthesis in broccoli were examined. Sulforaphane yield and myrosinase activity increased significantly with the combined application of 4 mM S and 100 μM Se on broccoli. Furthermore, the concentrations of glucoraphanin (a sulforaphane precursor) and methionine (a glucoraphanin substrate) slightly changed after Se application...
November 2020: Phytochemistry
https://read.qxmd.com/read/32760724/ampk-enhances-transcription-of-selected-nrf2-target-genes-via-negative-regulation-of-bach1
#2
JOURNAL ARTICLE
Katrin Fischhuber, Manuel Matzinger, Elke H Heiss
5'-AMP-activated protein kinase (AMPK) and the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) are main players in the cellular adaptive response to metabolic and oxidative/xenobiotic stress, respectively. AMPK does not only balance the rate of fuel catabolism versus anabolism but also emerges as regulator of gene expression. We here examined the influence of AMPK on Nrf2-dependent gene transcription and the potential interplay of the two cellular stress hubs. Using gene expression analyses in wt and AMPKα1 -/- or Nrf2 -/- mouse embryonal fibroblasts, we could show that AMPK only affected a portion of the entire of Nrf2-dependent transcriptome upon exposure to the Nrf2 activator sulforaphane (Sfn)...
2020: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/26757819/anabolic-and-antiresorptive-modulation-of-bone-homeostasis-by-the-epigenetic-modulator-sulforaphane-a-naturally-occurring-isothiocyanate
#3
JOURNAL ARTICLE
Roman Thaler, Antonio Maurizi, Paul Roschger, Ines Sturmlechner, Farzaneh Khani, Silvia Spitzer, Monika Rumpler, Jochen Zwerina, Heidrun Karlic, Amel Dudakovic, Klaus Klaushofer, Anna Teti, Nadia Rucci, Franz Varga, Andre J van Wijnen
Bone degenerative pathologies like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis. Here we show that sulforaphane (SFN), a naturally occurring isothiocyanate, promotes osteoblast differentiation by epigenetic mechanisms. SFN enhances active DNA demethylation viaTet1andTet2and promotes preosteoblast differentiation by enhancing extracellular matrix mineralization and the expression of osteoblastic markers (Runx2,Col1a1,Bglap2,Sp7,Atf4, andAlpl)...
March 25, 2016: Journal of Biological Chemistry
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