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Roberta Ronchi, Irene Rossi, Elena Calzolari, Nadia Bolognini, Giuseppe Vallar
Prism adaptation is a well-known method used to investigate brain plasticity, and a promising technique for the rehabilitation of unilateral spatial neglect (USN). Only little evidence about the mechanisms of prism adaptation (PA) in patients with left-brain damage is on record, and about putative differences of PA, and the aftereffects (AEs), between patients with left and right brain damage. In the present study, PA and the AEs were assessed in 30 brain-damaged patients, 20 with right-sided lesions (10 with and 10 without USN), and 10 with left-sided lesions without USN, as well as in a control group of 24 age-matched participants...
November 1, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Navin Cooray, Fernando Andreotti, Christine Lo, Mkael Symmonds, Michele T M Hu, Maarten De Vos
This study aims to develop automated diagnostic tools to aid in the identification of rapid-eye-movement (REM) sleep behaviour disorder (RBD). Those diagnosed with RBD enact their dreams and therefore present an abnormal characteristic of movement during REM sleep. Several methods have been proposed for RBD detection that use electromyogram (EMG) recordings and manually annotated sleep stages to objectively quantify abnormal REM movement. In this work we further develop these proven techniques with additional features that incorporate the relationship of muscle movement between sleep stages and general sleep architecture...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Hossein Sanjari Moghaddam, Mahsa Dolatshahi, Elaheh Salardini, Mohammad Hadi Aarabi
OBJECTIVE: Although olfaction dysfunction is now considered as an established clinical marker of prodromal Parkinson disease (PD), little is known about the neural underpinnings of olfaction dysfunction in the prodromal phase of PD. The aim of this study was to examine the microstructural association of olfaction in prodromal PD compared to early stage drug-naïve PD patients. METHODS: Diffusion MRI connectometry was conducted on 18 early PD and 17 prodromal PD patients to investigate the differences in group in terms of altered connectivity, i...
November 1, 2018: Neurological Sciences
Alberto Romagnolo, Maurizio Zibetti, Aristide Merola, Daniela Canova, Marianna Sarchioto, Elisa Montanaro, Carlo Alberto Artusi, Fabrizio Vallelonga, Simona Maule, Leonardo Lopiano
BACKGROUND: Falls represent one of the main complications of Parkinson's disease (PD), significantly lowering quality of life. Cardiovascular autonomic neuropathy (cAN) is one of the key contributing factors to PD-associated falls. However, a direct quantification of its impact on the risk of falling in PD is still lacking. In this 12-month prospective study, we sought to evaluate the association between cAN and falls. METHODS: Fifty consecutive patients were evaluated with a standardized battery of autonomic testing, Unified Parkinson's Disease Rating Scale, push and release (P&R) test, timed up and go test, freezing of gait (FOG) questionnaire, Montreal cognitive assessment (MoCA)...
October 31, 2018: Journal of Neurology
Chaoran Ma, Milena Pavlova, Junjuan Li, Ying Liu, Yujie Sun, Zhe Huang, Shouling Wu, Xiang Gao
Objective: To systematically examine the association between alcohol intake and likelihood of having probable rapid eye movement sleep behavior disorder (pRBD) 6 years later. Methods: The study included 11,905 participants (mean age: 47.7 years) of the Kailuan Study, free of stroke, cancer, Parkinson disease, dementia, and head injury in 2006. We determined pRBD using a validated RBD questionnaire-Hong Kong in 2012. Amounts and types of alcohol intake were collected with questionnaire...
October 2018: Annals of Clinical and Translational Neurology
Raffaele Ferri, Debora Aricò, Filomena I I Cosentino, Bartolo Lanuzza, Giacomo Chiaro, Mauro Manconi
Objective: To assess the presence of increased REM-related motor activity during sleep, by questionnaires for REM sleep behavior disorder (RBD), in subjects with "isolated" REM sleep without atonia (RWA). Subjects and Methods: Two-hundred-and-forty-nine patients were consecutively enrolled, with age ≥18 years, sharing bedroom with a roommate, and without a severe health, neurologic or cognitive problem. Motor activity during sleep was assessed by means of the RBD Screening Questionnaire (RBDSQ) and the RBD questionnaire-Hong Kong (RBDQ-HK)...
September 15, 2018: Sleep
Shuangwu Liu, Dongchao Shen, Hongfei Tai, Ning Su, Qingyun Ding, Hanhui Fu, Kang Zhang, Zhili Wang, Mingsheng Liu, Yan Huang, Liying Cui
Objective: To evaluate the frequency and clinical features of restless legs syndrome (RLS) in a group of Chinese patients with amyotrophic lateral sclerosis (ALS). Methods: 109 Patients included in this study fulfilled the revised El Escorial diagnostic criteria for clinically definite, probable and lab-supported probable ALS, and a group of 109 control subjects was matched for age and sex to the ALS group. Disease severity was assessed by the revised ALS functional rating scale (ALSFRS-R). The diagnosis of RLS was made according to the criteria of the International RLS Study Group...
2018: Frontiers in Neurology
Kamila Weissová, Jitka Škrabalová, Kateřina Skálová, Kateřina Červená, Zdeňka Bendová, Eva Miletínová, Jana Kopřivová, Karel Šonka, Daniela Dudysová, Aleš Bartoš, Jitka Bušková
OBJECTIVE: To evaluate changes in the expression of clock genes and melatonin levels in patients with idiopathic REM sleep behavior disorder (RBD) as a potential early stage of synucleinopathies. METHODS: We assessed the rhythmicity of circadian clock genes using real time-quantitative polymerase chain reaction and 24-h blood melatonin profiles using radio-immunoassay in 10 RBD patients and nine age-matched controls. RESULTS: The RBD patients did not show circadian rhythmicity for clock genes Per2, Bmal1, and Nr1d1 but the rhythmicity of Per 1 remained, and the amplitude of Per3 was diminished...
August 9, 2018: Sleep Medicine
Lana M Chahine, Liz Urbe, Chelsea Caspell-Garcia, Dag Aarsland, Roy Alcalay, Paolo Barone, David Burn, Alberto J Espay, Jamie L Hamilton, Keith A Hawkins, Shirley Lasch, James B Leverenz, Irene Litvan, Irene Richard, Andrew Siderowf, Christopher S Coffey, Tanya Simuni, Daniel Weintraub
INTRODUCTION: Several characteristics associated with increased risk for Parkinson's disease (PD) have been identified, including specific genotypes and various non-motor symptoms. Characterizing non-motor features, such as cognitive abilities, among individuals considered at-risk for PD is essential to improving prediction of future neurodegeneration. METHODS: Participants belonging to the following cohorts of the Parkinson Progression Markers Initiative (PPMI) study were included: de novo PD with dopamine transporter binding deficit (n = 423), idiopathic REM sleep behavior disorder (RBD, n = 39), hyposmia (n = 26) and non-PD mutation carrier (NMC; Leucine-rich repeat kinase 2 (LRRK2) G2019S (n = 88) and glucocerebrosidase (GBA) gene (n = 38) mutations))...
2018: PloS One
Katherine C Hughes, Xiang Gao, Jessica M Baker, Christopher Stephen, Iris Y Kim, Linda Valeri, Michael A Schwarzschild, Alberto Ascherio
BACKGROUND: Several non-motor features may individually contribute to identify prodromal Parkinson's disease (PD), but little is known on how they interact. METHODS: We conducted a case-control study nested within the Health Professionals Follow-up Study in a large cohort of men age 40-75 at recruitment in 1986. Cases (n=120) had confirmed PD, were <85 in January 2012, returned a 2012 questionnaire with questions on probable rapid eye movement sleep behaviour disorder (RBD) and constipation sent to all cohort participants and completed in 2014 the Brief Smell Identification Test and a questionnaire assessing parkinsonism and other non-motor PD features (including depressive symptoms, excessive daytime sleepiness, impaired colour vision and body pain)...
August 3, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Shuangwu Liu, Yan Huang, Hongfei Tai, Kang Zhang, Zhili Wang, Dongchao Shen, Hanhui Fu, Ning Su, Jiayu Shi, Qingyun Ding, Mingsheng Liu, Yuzhou Guan, Jing Gao, Liying Cui
OBJECTIVE: To examine the frequency and clinical features of excessive daytime sleepiness (EDS) and its association with cognitive and behavioural impairments in patients with amyotrophic lateral sclerosis (ALS). METHODS: We conducted a cross-sectional investigation to explore the frequency and clinical features of EDS in a group of 121 Chinese patients with ALS compared with 121 age-matched and sex-matched healthy subjects. EDS was diagnosed using the Epworth Sleepiness Scale (ESS)...
October 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Ahmed Al-Qassabi, Amélie Pelletier, Seyed-Mohammad Fereshtehnejad, Ronald B Postuma
BACKGROUND: Autonomic dysfunctions including sudomotor abnormalities commonly occur in early Parkinson's disease (PD), but little is known about potential sudomotor abnormalities in idiopathic REM Sleep Behavior Disorder (iRBD), a strong prodromal marker of PD. OBJECTIVE: Our aim was to assess sudomotor dysfunction by galvanic skin response using SudoScan, as well as other autonomic markers in 49 iRBD, 40 PD (21 with RBD, 19 without), 20 atypical parkinsonisms, and 41 age-matched controls...
2018: Journal of Parkinson's Disease
Srishti Shrestha, Freya Kamel, David M Umbach, Zheng Fan, Laura E Beane Freeman, Stella Koutros, Michael Alavanja, Aaron Blair, Dale P Sandler, Honglei Chen
INTRODUCTION: Dream enacting behavior (DEB) during REM sleep is a characteristic feature of REM sleep behavior disorder (RBD), the most specific prodromal symptom for Parkinson's disease (PD) and related synucleinopathies. METHODS: We screened for DEB among 20,591 male farmers in 2013-2015 using a validated question, and examined its association with pesticide uses and other potential risk factors reported about twenty years ago in 1993-1997. We reported odds ratios (OR) and 95% confidence intervals (CI) from multivariable logistic regression models...
July 10, 2018: Parkinsonism & related Disorders
Karim Jamal, Stéphanie Leplaideur, Chloé Rousseau, Lucie Chochina, Annelise Moulinet-Raillon, Isabelle Bonan
Asymmetrical postural behaviors are frequently observed after a stroke. They are due in part to the sensorimotor deficit, but they could also be related to a disorder of the representation of the body in space. The objective was to determine whether the asymmetrical postural behaviors of chronic stroke patients are related with a disruption of the perception of spatial frame. 30 chronic stroke patients (mean age 60.3 year ± 10, mean delay post-stroke 4.78 year ± 3), 15 patients with right brain damage (RBD) and 15 patients with left brain damage (LBD), and 20 healthy subjects participated in the study...
August 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Dieter Kunz, Frederik Bes
INTRODUCTION: REM sleep behavior disorder (RBD) is considered a prodromal phase of α-synucleinopathy like Parkinson disease (PD). PD is characterized by a progressive decline of dopamine (DA) in the striatum. Here we report the surprising increase in DA transporter density over successive years in an RBD patient treated with melatonin. CASE PRESENTATION: A then 72-year-old man was clinically suspected to suffer from PD in 2011. DA transporter scintigraphy (DaTSCAN) revealed reduced DA transporter density, and the patient was diagnosed with developing PD...
2017: Neuropsychobiology
Avner Thaler, Noa Bregman, Tanya Gurevich, Tamara Shiner, Yonatan Dror, Ofir Zmira, Ziv Gan-Or, Anat Bar-Shira, Mali Gana-Weisz, Avi Orr-Urtreger, Nir Giladi, Anat Mirelman
OBJECTIVE: Mutations in the glucocerebrosidase (GBA) gene are divided into mild and severe (mGBA, sGBA) based on their contribution to the phenotype of Gaucher disease (GD) among homozygotes. We conducted a longitudinal analysis of Parkinson's disease (PD) patients carrying mutations in the GBA gene to better characterize genotype-phenotype correlations. METHODS: Patients underwent a comprehensive assessment of medical, neurological, cognitive and non-motor functions...
May 17, 2018: Parkinsonism & related Disorders
David R Shprecher, Charles H Adler, Nan Zhang, Joseph G Hentz, Geidy E Serrano, Brittany N Dugger, Holly A Shill, Rodolfo Savica, John N Caviness, Marwan N Sabbagh, Christine M Belden, Erika Driver-Dunckley, Shyamal H Mehta, Lucia I Sue, Kathryn J Davis, Edward Zamrini, Thomas G Beach
Inability to accurately diagnose Lewy type alpha-synucleinopathy (LTS) pre-mortem has been a major obstacle to clinical care and research. Probable REM sleep behavior disorder (PRBD) diagnosed with support of instruments such as the Mayo Sleep Questionnaire (MSQ) may provide a cost effective means of predicting LTS. Since 2007, 602 subjects in the Arizona Study of Aging and Neurodegenerative Disorders had clinician assessment for PRBD (298 with, 304 without support of the MSQ), completed cognitive and movement examinations, and had neuropathological assessment...
May 17, 2018: Parkinsonism & related Disorders
Lucie Barateau, Isabelle Jaussent, Régis Lopez, Elisa Evangelista, Sofiene Chenini, Meriem Benkiran, Denis Mariano-Goulart, Yves Dauvilliers
The pathophysiology of rapid eye movement sleep behavior disorder (RBD) associated with narcolepsy type 1 (NT1) is still poorly understood, potentially distinct from idiopathic RBD (iRBD), but may share affected common pathways. We investigated whether MIBG cardiac uptake differs between iRBD and NT1 comorbid with RBD. Thirty-four patients with NT1-RBD and 15 patients with iRBD underwent MIBG cardiac scintigraphy. MIBG uptake was measured by calculating the early and delayed heart to mediastinum (H/M) ratios...
May 8, 2018: Scientific Reports
Daphné Génier Marchand, Ronald B Postuma, Frédérique Escudier, Jessie De Roy, Amélie Pelletier, Jacques Montplaisir, Jean-François Gagnon
OBJECTIVE: We describe the progression of cognitive decline and identify the predictive values of cognitive tests in three groups of REM sleep behavior disorder (RBD) patients classified at their last follow-up as having Parkinson's disease (PD), dementia with Lewy bodies (DLB), or still-idiopathic. METHODS: Patients (n = 109) underwent polysomnographic, neurological, and neuropsychological assessments. We used linear mixed-model analyses to compare the progression of cognitive test performance between the three groups over a 3-year prodromal period, and performed linear regressions for a 6-year prodromal period...
May 2018: Annals of Neurology
Jun-Ying Huang, Jin-Ru Zhang, Yun Shen, Hui-Jun Zhang, Yu-Lan Cao, Cheng-Jie Mao, Ya-Ping Yang, Jing Chen, Chun-Feng Liu, Jie Li
Background: Rapid eye movement (REM) sleep behavior disorder (RBD) and obstructive sleep apnea (OSA) are the most common sleep disorders in Parkinson's disease (PD). The aim of this study was to identify whether RBD could alleviate OSA severity in PD patients and its effect on cognitive impairment. Methods: From February 2014 to May 2017, we recruited 174 PD patients from the Second Affiliated Hospital of Soochow University, all of whom underwent polysomnography (PSG)...
April 20, 2018: Chinese Medical Journal
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